Uxinzelelo oluxhasayo
I-Back Clinic Oxidative Stress Chiropractic kunye neQela leMithi eliSebenzayo. Uxinzelelo lwe-oxidative luchazwa njengokuphazamiseka kwibhalansi phakathi kokuveliswa kwe-oxygen esebenzayo (i-radicals yamahhala) kunye nokukhusela i-antioxidant. Ngamanye amazwi, kukungalingani phakathi kokuveliswa kwee-radicals zamahhala kunye nokukwazi komzimba ukuchasana okanye ukukhupha imiphumo eyingozi ngokusebenzisa i-neutralization yi-antioxidants. Uxinzelelo lwe-oxidative lukhokelela kwiimeko ezininzi ze-pathophysiological emzimbeni. Ezi ziquka izifo ze-neurodeergenerative, oko kukuthi, isifo sika-Parkinson, isifo se-Alzheimer, ukuguqulwa kofuzo, i-cancer, i-syndrome engapheliyo, i-syndrome e-fragile X, intliziyo kunye nokuphazamiseka kwemithambo yegazi, i-atherosclerosis, ukungaphumeleli kwentliziyo, ukuhlaselwa yintliziyo kunye nezifo ezivuthayo. I-oxidation iyenzeka phantsi kweemeko ezininzi:
iiseli zisebenzisa i-glucose ukwenza amandla
i-immune system ilwa neebhaktheriya kunye nokudala ukuvuvukala
imizimba inokukhupha izinto ezingcolileyo, i-pesticides, kunye nomsi wecuba
Kukho izigidi zeenkqubo ezenzeka emzimbeni wethu nangaliphi na ixesha elinokubangela ukukhutshwa kwe-oxidation. Nazi iimpawu ezimbalwa:
Ukukhathala
Ukulahleka kweememori kunye nenkohlakalo yengqondo
Intlungu kunye okanye intlungu
Ukuguquka kunye neenwele ezimvu
Ukuncipha kwamehlo
Intloko kunye novelwano kwingxolo
Ukungahambi kakuhle kwizifo
Ukukhetha ukutya okuphilayo kunye nokuphepha i-toxins kwindawo yakho kwenza umahluko omkhulu. Oku, kunye nokunciphisa uxinzelelo, kunokuba luncedo ekunciphiseni i-oxidation.
by UGqr Alex Jimenez | Heart Health, Uxinzelelo oluxhasayo
Kubantu abafuna ukuphucula impilo yentliziyo, ngaba ukutya iiprunes kunokunceda ukuxhasa impilo yentliziyo?
IiPrunes kunye neMpilo yeNtliziyo
I-prunes, okanye i-plums eyomileyo, ziziqhamo ezityebileyo zefiber ezinomsoco ngakumbi kunezotsha ezitsha kwaye zinceda ukugaya kunye nokuhamba kwamathumbu. (UEllen Lever et al., 2019) Uphando olutsha lubonisa ukuba banokunikela ngaphezu kokugaya kunye nokuxhamla, ngokwezifundo ezitsha ezivezwe kwi-American Society for Nutrition. Ukutya iiprunes imihla ngemihla kunokuphucula amanqanaba e-cholesterol kwaye kunciphise uxinzelelo lwe-oxidative kunye nokuvuvukala.
- Ukutya iiprunes ezintlanu ukuya kwezili-10 ngosuku kunokuxhasa impilo yentliziyo.
- Iinzuzo zempilo yentliziyo yokusetyenziswa rhoqo zabonwa kumadoda.
- Kwabasetyhini abasele bekhulile, ukutya rhoqo iiprunes akuzange kube nempembelelo embi kwi-cholesterol epheleleyo, iswekile yegazi kunye namanqanaba e-insulin.
- Olunye uphononongo lufumene ukuba ukutya i-50-100 grams okanye i-prunes emihlanu ukuya kweshumi imihla ngemihla yayinxulumene nokunciphisa ingozi yesifo senhliziyo. (Mee Young Hong et al., 2021)
- Ukuncipha kwekholesteroli kunye neziphawuli zokudumba kube ngenxa yokuphuculwa kwamanqanaba e-antioxidant.
- Isigqibo yayikukuba iiprunes zinokuxhasa impilo yentliziyo.
IiPrunes kunye neePlum eziTsha
Nangona uphando lucebise ukuba i-prunes inokuxhasa impilo yentliziyo, oko akuthethi ukuba i-plums entsha okanye ijusi ye-prune inokubonelela ngeenzuzo ezifanayo. Nangona kunjalo, akukho zifundo ezininzi malunga neenzuzo zeplums ezitsha okanye ijusi yeprune, kodwa kunokwenzeka ukuba zingenza njalo. Noko ke, uphando olongezelelekileyo luyafuneka. I-plums ezitsha ezomisiweyo emoyeni oshushu ziphucula ixabiso lesondlo kunye nobomi beshelufu yesiqhamo, nto leyo ingaba isizathu sokuba inguqulelo eyomileyo igcine izondlo ezininzi. (UHarjeet Singh Brar et al., 2020)
- Abantu banokufuneka batye iiplum ezininzi ukuze bafumane izibonelelo ezifanayo.
- Ukutya i-5-10 prunes kubonakala kulula kunokuzama ukulinganisa umlinganiselo ofanayo, okanye ngaphezulu, we-plums entsha.
- Kodwa nayiphi na inketho iyacetyiswa endaweni yejusi yeprune njengoko iziqhamo ezipheleleyo zinefayibha ezininzi, zenza umzimba uzive ugcwele, kwaye zisezantsi kwiikhalori.
Iingenelo Kubantu Abaselula Ngamnye
Uninzi lophando lwenziwe kubasetyhini kunye namadoda asemva kwe-postmenopausal ngaphezulu kwe-55, kodwa abantu abancinci banokuzuza ngokutya iiprunes. Ukutya okutyebileyo kwiziqhamo kunye nemifuno kuthathwa njengempilo, ngoko ke ukongeza iiprunes ekutyeni komntu kuya kongeza kwiinzuzo zempilo. Kubantu abangazithandiyo iiprunes, iziqhamo ezinjengee-apile kunye namaqunube nazo ziyacetyiswa kwimpilo yentliziyo. Nangona kunjalo, iziqhamo zenza inxalenye enye yokutya, kwaye kubalulekile ukugxila ekutyeni okunokulinganisela kunye nemifuno, imifuno, kunye neoli enempilo yentliziyo. IiPrunes ziqulethe ifayibha eninzi, ngoko ke abantu bayacetyiswa ukuba bongeze ngokucothayo kwimisebenzi yabo yemihla ngemihla, njengoko ukongeza kakhulu ngaxeshanye kunokukhokelela ekuqaqambeni, ukudumba, kunye/okanye. ukuqothulwa.
Ukoyisa ukungaphumeleli kweNtliziyo eCandekileyo
Ucaphulo
Lever, E., Scott, S. M., Louis, P., Emery, P. W., & Whelan, K. (2019). Isiphumo se-prunes kwi-stool output, ixesha lokuhamba kwamathumbu kunye ne-microbiota yesisu: Ulingo olulawulwa ngokungahleliwe. Isondlo seklinikhi (Edinburgh, Scotland), 38 (1), 165-173. doi.org/10.1016/j.clnu.2018.01.003
Hong, M. Y., Kern, M., Nakamichi-Lee, M., Abbaspour, N., Ahouraei Far, A., & Hooshmand, S. (2021). Ukusetyenziswa kwePlum eyomileyo iPhucula i-Cholesterol epheleleyo kunye ne-Antioxidant Capacity kunye nokunciphisa ukuvuvukala kwiMpilo yabasetyhini be-Postmenopausal. Ijenali yokutya kwamayeza, i-24 (11), i-1161-1168. doi.org/10.1089/jmf.2020.0142
UHarjeet Singh Brar, uPrabhjot Kaur, uJayasankar Subramanian, uGopu R. Nair & Ashutosh Singh (2020) Isiphumo sokuNyangwa kweMichiza ekomisweni kweKinetics kunye neFiziyo-khemikhali yeempawu zePlums zaseYurophu ezimthubi, iJenali yeHlabathi yeNzululwazi yeSiqhamo, 20:sup2, S252-S279-S , DOI: 10.1080/15538362.2020.1717403
by UGqr Alex Jimenez | Chiropractic, Ubuhlungu obungapheliyo, Iimeko eziPhathwayo, impilo, Uxinzelelo oluxhasayo, istres, Unyango, yokuzonwabisa, I-Viscerosomatic Reflex, Ukuphila
intshayelelo
UDkt Alex Jimenez, DC, ubonisa indlela uxinzelelo olungapheliyo olunokuchaphazela ngayo umzimba kunye nendlela ehambelana ngayo nokuvuvukala kule nxalenye ye-2. Icandelo 1 ivavanye ukuba uxinzelelo lunxulumana njani neempawu ezahlukeneyo ezichaphazela amanqanaba emfuza omzimba. Icandelo 2 lijonga indlela ukuvuvukala kunye noxinzelelo olungapheliyo olunxibelelana ngayo nezinto ezahlukeneyo ezinokukhokelela kuphuhliso lomzimba. Sithumela izigulana zethu kubaboneleli bezonyango abaqinisekisiweyo ababonelela ngonyango olukhoyo kubantu abaninzi abanengxaki yoxinzelelo olungapheliyo oluhambelana ne-cardiovascular, endocrine, kunye ne-immune system echaphazela umzimba kunye nokuphuhlisa ukudumba. Sikhuthaza ngamnye kwizigulane zethu ngokuzikhankanya kubaboneleli bezonyango abanxulumeneyo ngokusekelwe kuhlalutyo lwabo ngokufanelekileyo. Siyaqonda ukuba imfundo yindlela eyonwabisayo xa ubuza ababoneleli bethu imibuzo ngokwesicelo sesigulana kunye nokuqonda kwakhe. UDkt Jimenez, DC, usebenzisa le ngcaciso kuphela njengenkonzo yemfundo. isikhanyeli
Lunokusichaphazela Njani Uxinezeleko?
UGqr. Alex Jimenez, DC, unikezela: Uxinzelelo lunokudala iimvakalelo ezininzi ezinokuchaphazela kakhulu uninzi lwethu. Ingaba ngumsindo, ukukhungatheka, okanye ukudakumba, uxinzelelo lunokwenza nabani na afikelele kwinqanaba lokuphuka kwaye abangele iimeko ezinokuthi ziphuhliseke zibe yimiba ye-cardiovascular. Ngoko ke abo bantu banomgangatho ophezulu womsindo, xa ujonga uncwadi lwe-cardiovascular, banethuba elincinci lokusinda. Umsindo ngumdlali ombi. Umsindo ubangela i-arrhythmia. Olu phononongo lujongwe, ngoku sinabantu abane-ICDs kunye ne-defibrillators, sinokubeka iliso ezi zinto. Kwaye siyabona ukuba umsindo unokubangela i-ventricular arrhythmias kwizigulane. Kwaye kulula ukulandela ngoku, ngobunye betekhnoloji yethu.
Umsindo udibaniswe neziqephu ze-atrial fibrillation. Xa ucinga ngayo, kukugalela kweadrenaline emzimbeni kwaye kubangele ukuxinana kwemithambo. Inyusa izinga lokubetha kwentliziyo. Zonke ezi zinto zinokukhokelela kwi-arrhythmia. Kwaye akunyanzelekanga ukuba ibe yi-AFib. Ingaba zii-APC kunye neeVPC. Ngoku, uphando olunomdla kakhulu luye lwaphuma malunga ne-telomerase kunye ne-telomeres. I-telomeres zi-caps ezincinci kwi-chromosomes, kwaye i-telomerase yi-enzyme edityaniswe nokwakheka kwe-telomere. Kwaye ngoku, sinokuqonda ngolwimi lwesayensi, kwaye siqala ukusebenzisa iteknoloji kunye nokusebenzisa isayensi ngendlela esingenakuze siyenze ngaphambili ukuqonda impembelelo yoxinzelelo kwi-telomeres kunye ne-telomerase enzymes.
Izinto ezikhokelela kuxinzelelo olungapheliyo
UGqr. Alex Jimenez, DC, unikezela: Ngoko ke omnye wabantu abaphambili ukuba bafunde oku ngowokuphumelela iBhaso leNobel, uGqr. Elizabeth Blackburn. Kwaye into ayithethileyo kukuba esi siphetho, kwaye siza kubuyela kwezinye zezifundo zakhe. Usixelela ukuba i-telomeres yeentsana ezivela kwabasetyhini kwi-utero yayinoxinzelelo oluninzi okanye yayimfutshane kubomi obuncinci xa kuthelekiswa noomama abangenayo iimeko ezifanayo zoxinzelelo. Uxinzelelo lwengqondo kamama ngexesha lokukhulelwa lunokuthi lube nefuthe lenkqubo ekuphuhliseni inkqubo yebhayoloji ye-telomere esele ibonakala ekuzalweni njengoko kubonakaliswa kukumiselwa kobude betelemetry yeleukocyte esandula kuzalwa. Ke abantwana banokungena beshicilelwe, kwaye nokuba benjenjalo, oku kunokuguqulwa.
Kuthekani ngocalucalulo lobuhlanga ezi bhokisi zilapha zibonisa ucalulo oluphezulu lobuhlanga olukhokelela kubude obuphantsi be-telomere, uninzi lwethu olukhe lwacinga ngalo. Ke, ubude obufutshane be-telomere bukhokelela kumngcipheko owongeziweyo womhlaza kunye nokufa ngokubanzi. Amazinga omhlaza wesifo somhlaza angama-22.5 kwi-1000 yomntu-iminyaka kwiqela le-telomere elifutshane kakhulu, ivesi 14.2 kwiqela eliphakathi, kunye ne-5.1 kwiqela elide le-telomere. I-telomeres emfutshane inokukhokelela ekungazinzini kwechromosome kwaye ibangele ukwakheka komhlaza. Ngoko, ngoku siyaqonda, ngolwimi lwesayensi, impembelelo yoxinzelelo kwi-enzyme ye-telomerase kunye nobude be-telomere. Ngokutsho kukaGqr. Elizabeth Blackburn, 58 abafazi premenopausal ababenyamekela abantwana babo abagulayo ezingapheliyo abasetyhini ababenabantwana abasempilweni. Aba basetyhini babuzwa ukuba balubona njani uxinzelelo kubomi babo nokuba luyayichaphazela na impilo yabo ngokuchaphazela ukuguga kweeseli zabo.
Lowo ngumbuzo wophononongo njengoko bejonge ubude be-telomere kunye ne-telomerase enzyme, kwaye yile nto bayifumeneyo. Ngoku, igama eliphambili apha liyabonwa. Asimele sigwebe uxinezeleko lomnye nomnye. Uxinzelelo lobuqu, kwaye ezinye zeempendulo zethu zisenokuba zemfuza. Ngokomzekelo, umntu onayo i-homozygous comps kunye ne-sluggish gene ingaba nexhala kakhulu kunomntu ongenayo le polymorphism yofuzo. Umntu one-MAOA kwi-MAOB unokuba nexhala ngakumbi kunomntu ongenayo loo polymorphism yofuzo. Ke kukho icandelo lemfuzo kwimpendulo yethu, kodwa into ayifumeneyo yayibonwa ngoxinzelelo lwengqondo. Kwaye inani leminyaka yokunyamekela abantwana abagula ngokungapheliyo lalidibene nobude obufutshane be-telomere kunye nomsebenzi omncinci we-telomerase, ukubonelela ngesibonakaliso sokuqala sokuba uxinzelelo lunokuchaphazela ukugcinwa kwe-telomere kunye nokuphila ixesha elide.
Indlela yokuguqula iMpendulo yethu yoxinzelelo?
UGqr. Alex Jimenez, DC, unikezela: Oko kunamandla, kwaye abaninzi ababoneleli bezempilo baphantsi koxinzelelo oluthile. Kwaye umbuzo ngulo, yintoni esinokuyenza ukuguqula impendulo yethu? UFramingham uphinde wajonga ukudakumba kwaye wachaza ukudakumba kweklinikhi njengomngcipheko omkhulu weziganeko zentliziyo kunye neziphumo ezibi kunokutshaya, isifo sikashukela, i-LDL ephezulu, kunye ne-HDL ephantsi, ephambeneyo ngenxa yokuba sichitha lonke ixesha lethu kwezi zinto. Ukanti, asichithi xesha lininzi sijongana neemeko zeemvakalelo zesifo semithambo. Oku kuchaphazeleka ukudakumba, uluhlu lwempahla, uvavanyo olulula lokuhlola ukudakumba, ukujonga abantu abanamanqanaba aphezulu okudakumba ngokuchasene namanqanaba aphantsi okudakumba. Kwaye unokubona ukuba njengoko usuka kwinqanaba eliphantsi ukuya kwelona nqanaba liphezulu, njengoko usebenza ngendlela yakho, ithuba lokusinda liba lincinci.
Kwaye uninzi lwethu luneethiyori zethu zokuba kutheni le nto isenzeka. Kwaye kungenxa yokuba ukuba sidakumbile, asithi, "Owu, ndiza kutya amahlumela e-brussels, kwaye ndiza kuthatha ezo vitamin B, kwaye ndiza kuphuma ndiyokuzilolonga, kwaye ndiza kwenza ukucamngca. " Ke i-post-MI ezimeleyo yomngcipheko wesiganeko kukudakumba. Ingqondo yethu malunga nokudakumba isenza singakwazi ukusebenza ngokuqhelekileyo kwaye sinokwenza imizimba yethu iphuhlise imiba echaphazela amalungu ethu abalulekileyo, imisipha kunye namalungu. Ngoko, ukudakumba ngumdlali omkhulu, njengoko i-75% yokufa kwe-post-MI inxulumene nokudakumba, akunjalo? Ngoko ujonge izigulane, ngoku, kufuneka ubuze umbuzo: Ngaba kukudandatheka okubangela ingxaki, okanye kukugula kwe-cytokine esele ikhokele kwisifo senhliziyo esibangela ukudakumba? Kufuneka siyifake phakathi yonke le nto.
Kwaye olunye uphononongo lujonge ngaphezulu kwe-4,000 yabantu abangenaso isifo se-coronary kwisiseko. Kukonyuka ngakunye kwamanqaku amahlanu kwisikali sokudakumba, loo mngcipheko wenyuka nge-15%. Kwaye abo banamanqaku aphezulu okudakumba babene-40% ephezulu yezinga lesifo se-coronary kunye ne-60% ephezulu yokufa. Ngoko ubukhulu becala wonke umntu ucinga ukuba sisigulo se-cytokine esikhokelela kwi-MI, isifo se-vascular, kunye nokudakumba. Kwaye ke, ewe, xa unomsitho, kwaye uphume kunye nothotho lwemiba ejikelezileyo, siyazi ukuba abantu abadakumbileyo banokunyuka ngokuphindwe kabini ekufeni, ukonyuka kahlanu ekufeni emva kokuhlaselwa yintliziyo, kwaye iziphumo ezibi ngotyando. Kunje, yintoni eza kuqala, inkukhu okanye iqanda?
Uxinezeleko Lunxulunyaniswa Njani Noxinzelelo Olungapheliyo?
UGqr. Alex Jimenez, DC, unikezela: Wonke ugqirha wotyando uyayazi le nto. Abafuni ukwenza utyando kubantu abadandathekileyo. Bayazi ukuba isiphumo asikho sihle, kwaye ewe, akunakwenzeka ukuba balandele kuzo zonke iingcebiso zethu ezisebenzayo zamayeza. Ngoko ke zeziphi ezinye zeendlela zokungasebenzi kakuhle kwe-autonomic ziye zavavanywa ukuguquguquka kwesantya sentliziyo kunye namanqanaba aphantsi e-omega-3s, anefuthe elinzulu kwingqondo, kunye namazinga aphantsi e-vitamin D. Kukho ezo cytokines ezivuthayo esithetha ngazo malunga nokungazifumani. ubuthongo okubuyisela, kwaye uninzi lwezigulana zethu zentliziyo zine-apnea. Kwaye khumbula, musa ukucinga nje ukuba izigulana zentliziyo enzima ezineentamo ezishinyeneyo ezimfutshane; inokukhohlisa kakhulu. Kwaye kubaluleke kakhulu ukujonga ubume bobuso kwaye, ngokuqinisekileyo, uxhulumaniso loluntu, oluyi-sauce eyimfihlo. Ke ngaba i-autonomic dysfunction yindlela? Olunye uphononongo lujonge ukuguquguquka kwesantya sentliziyo kubantu abane-MI yamva nje, kwaye bajonge abantu abangaphezu kwama-300 abanoxinzelelo kunye nabo bangenaxinzelelo. Bafumanise ukuba izalathi ezine zokuguquguquka kwentliziyo ziya kuncipha kubantu abanoxinzelelo.
Ukudumba kwamathumbu kunye noxinzelelo olungapheliyo
UGqr. Alex Jimenez, DC, unikezela: Ke apha amaqela amabini abantu abanesifo sentliziyo kunye nokuguquguquka kwesantya sentliziyo, ukunyuka ukuya phezulu njenge-etiology enokwenzeka. Enye yezinto ezininzi ezinokuchaphazela uxinzelelo olungapheliyo emzimbeni yindlela i-gut microbiome edlala ngayo indima yayo kuxinzelelo lwe-oxidative. Amathumbu zizinto zonke, kwaye uninzi lwezigulana zentliziyo ziyahleka kuba zibuza iingcali zabo zentliziyo, “Kutheni undikhathalele ngamathumbu am microbiome? Kutheni le nto ichaphazela intliziyo yam?” Ewe, konke ukudumba kwamathumbu kubangela ukugula kwe-cytokine. Kwaye yintoni eninzi kuthi esiyilibeleyo ukusukela kwisikolo sezonyango kukuba uninzi lwee-neurotransmitters zethu ziphuma emathunjini. Ke ukudumba okungapheliyo kunye nokuvezwa kwi-cytokines evuthayo kubonakala kukhokelela kutshintsho ekusebenzeni kwe-dopamine kunye ne-basal ganglia, ebonakaliswa luxinzelelo, ukudinwa, kunye nokucotha kwengqondo. Ke asinakugxininisa indima yokudumba kunye nokudakumba ngokwaneleyo ukuba sijonga kwi-acute coronary syndrome kunye nokudakumba, nto leyo eyayanyaniswa namanqaku aphezulu okudumba, i-CRP ephezulu, i-HS ephantsi, ukuguquguquka kwesantya sentliziyo esezantsi, kunye nento engazange ibonwe ngaphambili. uya kuhlolwa esibhedlele, nto leyo kukunqongophala kwesondlo.
Kwaye kule meko, bajonge kumanqanaba e-omega-3 kunye ne-vitamin D, ngoko ke ubuncinci, isheke le-omega-3 kunye nenqanaba le-vitamin D liqinisekisiwe kuzo zonke izigulane zethu. Kwaye ngokuqinisekileyo, ukuba unokufumana uxilongo olupheleleyo lokudumba okubangelwa luxinzelelo. Enye imeko ekufuneka uyijonge xa kufikwa kuxinzelelo-olubangelwa ukudumba yi-osteoporosis kumalungu. Abantu abaninzi abane-osteoporosis baya kuba nokulahleka kwemisipha, ukungasebenzi komzimba, amanqatha ajikeleze umgca ophakathi, kunye neswekile yegazi ephezulu ihambelana nokuguga, kwaye inokuvela kumanqanaba aphezulu e-cortisol emzimbeni.
Imingcipheko yesifo senhliziyo ye-cortisol iphezulu ngokuphindwe kabini kubantu abathatha iidosi eziphezulu ze-steroids. Izixa ezincinci ze-steroids azinawo umngcipheko ofanayo, ngoko ke ayisiyonto inkulu. Ngokuqinisekileyo, sizama ukukhupha izigulane zethu kwi-steroids. Kodwa ingongoma apha kukuba i-cortisol i-hormone yoxinzelelo kwaye i-hormone yoxinzelelo ephakamisa uxinzelelo lwegazi kwaye ibeka ubunzima kumgca ophakathi, isenza sibe nesifo seswekile, ibangela ukuxhathisa kwe-insulin, kwaye uluhlu alupheli. Ke, i-cortisol ngumdlali omkhulu, kwaye xa kufikwa kumayeza asebenzayo, kufuneka sijonge kwiimvavanyo ezahlukeneyo ezibhekiselele kumanqanaba aphakamileyo e-cortisol njengobuzaza bokutya, ivalve yesitulo seentsuku ezi-3, i-nutra-valve, kunye noxinzelelo lwe-adrenal. uvavanyo lwesalathisi ukujonga ukuba kuqhubeka ntoni na ngezigulane. Xa kukho inkqubo ye-nervous enovelwano kunye ne-cortisol ephezulu, sixoxe ngayo yonke into ukusuka kwi-coagulopathy ukuya ekunciphiseni ukuguquguquka kwentliziyo, ukutyeba okuphakathi, isifo seswekile kunye noxinzelelo lwegazi.
Ubudlelwane babazali kunye noxinzelelo olungapheliyo
UGqr. Alex Jimenez, DC, unikezela: Kwaye ukuvula inkqubo ye-renin-angiotensin konke kunxulunyaniswa noxinzelelo. Makhe sijonge kolu phando lujonge abafundi be-Harvard Medical abali-126, kwaye balandelwa iminyaka engama-35, uphando olude. Kwaye bathi, yintoni imeko yesifo esibalulekileyo, isifo sentliziyo, umhlaza, uxinzelelo lwegazi? Kwaye babuza aba bafundi imibuzo elula kakhulu, bebuyintoni ubudlelwane bakho nomama wakho kunye notata wakho? Ngaba yayikufutshane kakhulu? Ngaba kwakufudumele kwaye kunobuhlobo? Ngaba yayinonyamezelo? Ngaba bekuxinene kwaye kubanda? Yile nto abayifumeneyo. Bafumanise ukuba ukuba abafundi bachonge ubudlelwane babo nabazali babo njengengxaki ye-100% yengozi enkulu yempilo. Kwiminyaka engamashumi amathathu anesihlanu kamva, ukuba bathi kushushu kwaye kuvaliwe, iziphumo zayinqumla loo pesenti kwisiqingatha. Kwaye kuya kunceda ukuba ucinga malunga nokuba yintoni na kwaye yintoni enokuchaza oku, kwaye uya kubona indlela amava amabi obuntwana asenza ngayo sigule kwimizuzu embalwa kunye nendlela esifunda ngayo izakhono zethu zokumelana nabazali bethu.
isiphelo
UGqr. Alex Jimenez, DC, unikezela: Isithethe sethu somoya sivela kubazali bethu rhoqo. Abazali bethu ngabona basoloko besifundisa indlela yokucaphuka okanye yokucombulula ingxabano. Ngoko abazali bethu baye baba nempembelelo enzulu kuthi. Kwaye xa ucinga ngaloo nto, unxibelelwano lwethu nalo alumangalisi kakhulu. Olu luphononongo olulandelayo lweminyaka engama-35.
Ukuxinezeleka okungapheliyo kunokukhokelela kwimibandela emininzi enokuthi ihambelane nokugula kunye nokungasebenzi kakuhle kwimisipha kunye namalungu. Inokuchaphazela inkqubo yamathumbu kwaye ibangele ukuvuvukala ukuba ayikhathalelwanga ngokukhawuleza. Ngoko xa kuziwa kwimpembelelo yoxinzelelo oluchaphazela ubomi bethu bemihla ngemihla, inokuba yimiba emininzi, ukusuka kwiimeko ezingapheliyo ukuya kwimbali yosapho. Ukutya ukutya okunesondlo okuphezulu kwi-antioxidants, ukuzivocavoca, ukwenza ingqondo, kunye nokuya kunyango lwemihla ngemihla kunokunciphisa imiphumo yoxinzelelo olungapheliyo kunye nokunciphisa iimpawu ezihambelanayo ezihambelanayo kwaye zibangele intlungu emzimbeni. Singaqhubeka nohambo lwethu lwezempilo kunye nokuphila kakuhle ngaphandle kweentlungu ngokusebenzisa iindlela ezahlukeneyo zokunciphisa uxinzelelo olungapheliyo emizimbeni yethu.
isikhanyeli
by UGqr Alex Jimenez | Chiropractic, Iimeko eziPhathwayo, impilo, Uxinzelelo oluxhasayo, istres, Unyango, yokuzonwabisa, I-Viscerosomatic Reflex, Ukuphila
intshayelelo
UDkt Alex Jimenez, DC, ubonisa indlela uxinzelelo olunokuchaphazela ngayo abantu abaninzi kwaye ludibanise neemeko ezininzi emzimbeni kule nxalenye ye-2. Sithumela izigulana zethu kubaboneleli bezonyango abaqinisekisiweyo ababonelela ngonyango olufumanekayo oluninzi kubantu abaninzi abanengxaki yoxinzelelo lwegazi ehambelana ne-cardiovascular, endocrine, kunye ne-immune system echaphazela umzimba. Sikhuthaza ngamnye kwizigulane zethu ngokuzikhankanya kubaboneleli bezonyango abanxulumeneyo ngokusekelwe kuhlalutyo lwabo ngokufanelekileyo. Siyaqonda ukuba imfundo yindlela eyonwabisayo xa ubuza ababoneleli bethu imibuzo ngokwesicelo sesigulana kunye nokuqonda kwakhe. UDkt Jimenez, DC, usebenzisa le ngcaciso kuphela njengenkonzo yemfundo. isikhanyeli
Uxinzelelo oluwuchaphazela njani umzimba
UGqr. Alex Jimenez, DC, unikezela: Ngoku wonke umntu usabela ngokwahlukileyo kutshintsho kwimo engqongileyo. Xa kufikelelwa kubantu abaninzi abenza imisebenzi yemihla ngemihla ukususela emsebenzini wabo, ukuvulwa ngeempela-veki, ukuxinana kweemoto, ukubhala iimviwo, okanye ukulungiselela intetho enkulu, umzimba usoloko ukwimo yokuxakeka ngokugqithiseleyo ukusa kwinqanaba lokudinwa ngokweemvakalelo, engqondweni. loo nto ishiya umntu ediniwe kwaye exinezelekile. Kwaye into ephambili kukuqaphela oku ngaphambi kokuba kwenzeke, njengoko sibona le mpembelelo yoxinzelelo kwizigulane zethu kunye nathi. Kwaye into yokuqala ekufuneka uyiqaphele kukuba isiganeko sokuqala sibangela le mpembelelo.
Nokuba siyintoni na isiganeko sokuqala, eyona nto ibalulekileyo yindlela esisijonga ngayo isiganeko. Ithetha ntoni kuthi? Ngaba yimbono yethu? Xa umzimba uhamba kwesi siganeko sokuqala, kunokubangela ukuba imbono iholele kwimpendulo kunye nomphumo kumzimba wethu. Ngoko ukuqonda kuyo yonke into njengoko sithetha ngoxinzelelo kunye nempendulo yoxinzelelo. Ngoku, sineempembelelo zemichiza ezingaphezu kwe-1400 ezenzeka emzimbeni. Ke ngenjongo yale ntetho, siza kuxoxa ngezi zintathu ziphambili: iadrenaline kunye ne-neuro-adrenaline, i-aldosterone, kwaye kunjalo, i-cortisol.
Yaye kutheni ezi zinto zibalulekile? Ngenxa yokuba zonke ezi zinempembelelo enkulu kwisifo senhliziyo. Ngoku, ngo-1990, oogqirha abaninzi babeqala ukuqonda umphumo woxinzelelo kumzimba wenyama. Kwaye kwenzeka ntoni ebantwini xa i-axis ye-HPA yabo ibonisa ukuba basengozini kwaye baqala ukukhukula imizimba yabo ngeehomoni zoxinzelelo? Ewe, sibona i-coagulation ephuculweyo. Sibona utshintsho kwinkqubo ye-renin kunye ne-angiotensin. Iyavuselela. Sibona ukuzuza ubunzima kubantu kunye nokuxhatshazwa kwe-insulin. Yintoni abantu abaninzi abangayiqondiyo kukuba i-lipids iba yinto engaqhelekanga kuxinzelelo. Phantse sonke isigulana sethu siyazi ukuba i-tachycardia kunye ne-arrhythmia zenzeka xa i-adrenaline yethu ihamba, kwaye uxinzelelo lwethu lwegazi luyanda. Ngoku, cinga ngale nto ngolwimi lwamayeza.
Ngeminyaka yoo-1990, oogqirha babenika i-aspirin kunye ne-Plavix ngelo xesha ukuze i-coagulation. Siyaqhubeka nokubonelela nge-ACE kunye nee-ARB kwizigulana zethu. Impembelelo ye-cortisol ibangela ubunzima kunye nokunyanzeliswa kwe-insulin. Sinika iistatins; sinika i-metformin. Sibonelela nge-beta blockers kuloo nto, i-tachycardia, kunye ne-calcium blockers yolo xinzelelo lwegazi oluphezulu. Ke yonke ihomoni enye evulwa ngoxinzelelo, sinechiza esilisebenzisayo ukulinganisa oko. Kwaye ngokungafihlisiyo, iminyaka, sathetha malunga nendlela ezilungileyo ze-beta blockers zentliziyo. Ewe, xa ucinga ngaloo nto, ii-beta blockers ziyayivimba iadrenaline. Ke xa oogqirha bejonga le nto, baqala ukucinga, “Ewe, mhlawumbi kufuneka sicamngce kwaye sicamngce, akunjalo? Sisebenzisa onke la mayeza, kodwa kusenokufuneka sijonge ezinye iindlela zokuguqula indlela esisabela ngayo kuxinzelelo.”
Yintoni iVasoconstriction?
UGqr. Alex Jimenez, DC, unikezela: Asiyi kufunda zonke ezi mpawu kuba zininzi, kodwa zonke zehla kwinto enye. Uxinzelelo. Kufuneka sicinge ngomntu okwingozi yemoto, umzekelo, kwaye loo mntu uyopha. Ngoko ke umzimba mhle kuba udibanisa indlela yokunqanda umntu ukuba angopha okanye i-vasoconstriction. I-Vasoconstriction yakha le mithambo yegazi kwaye yenza iiplatelet zincangathi ukuze zenze ihlwili, kwaye igazi linokuyeka. Oku kwandisa imveliso yentliziyo ngokunyusa izinga lokubetha kwentliziyo kunye nokwandisa i-aldosterone, ebangela ukuba ityuwa kunye nokugcinwa kwamanzi kunyuse uxinzelelo lwegazi. Ke kumntu okwimeko engxamisekileyo yezonyango, njengengozi, ukopha, okanye ukuphulukana nomthamo, obu bubuhle bomzimba womntu. Kodwa ngelishwa, sibona abantu bephila ngolu hlobo, ngokoqobo 24/7. Ngoko siyayazi i-vasoconstriction kunye ne-platelet stickiness, kwaye sibona ukunyuka kwamanqaku okuvuvukala, i-homocysteine, i-CRP, kunye ne-fibrinogen, yonke into eyandisa ingozi ye-cardiovascular.
Sibona impembelelo ye-cortisol, kungekhona nje ukuphakamisa uxinzelelo lwegazi, kungekhona nje ukubangela isifo sikashukela kunye nokuxhatshazwa kwe-insulin, kodwa kunye nokubeka amanqatha esisu kumgca ophakathi. Kwaye ke, njengoko uza kubona kwimizuzu embalwa, kukho unxibelelwano phakathi kweziganeko ezinoxinzelelo kunye ne-arrhythmias efana ne-atrial fibrillation kunye ne-ventricular fibrillation. Okokuqala kwezamayeza, kwi-cardiology, sine-syndrome ebizwa ngokuba yi-takosubo cardiomyopathy, ebizwa ngokuba yi-break heart syndrome. Kwaye le yi-syndrome apho i-myocardium iba yothuka kakhulu ukuya kwinqanaba lokubangela umsebenzi onzima we-ventricular ekhohlo okanye ukungasebenzi kakuhle. Kwaye ngokuqhelekileyo, oku kubangelwa ziindaba ezimbi kunye nesiganeko esichukumisayo ngokweemvakalelo. Kubonakala ngathi umntu ufuna uqhaqho-fakelo lwentliziyo. Ke xa sicinga ngezinto zakudala zomngcipheko weFramingham, sithi, zeziphi ezi zichatshazelwa luxinzelelo?
Iimpawu zoxinzelelo
UGqr. Alex Jimenez, DC, unikezela: Abantu banazo zonke iintlobo zokuziphatha okubi ukuxinzelela, nokuba ngaba abahlobo be-20 kule pakethi yecuba, badla le Cinnabon kuba indenza ndizive kakuhle ngoku, okanye yonke i-cortisol iya kundenza ndityebe kunye nesifo sikashukela. I-Lipids inyuka phantsi koxinzelelo; uxinzelelo lwegazi luyenyuka phantsi koxinzelelo. Ke yonke le miba yomngcipheko ichatshazelwa ziihomoni zoxinzelelo. Kwaye, ngokuqinisekileyo, siyazi ukuba ngokuguqulwa kwenkqubo ye-RAS okanye inkqubo ye-renin-angiotensin, sihlala sibona ukunyuka kwentliziyo. Kwaye oku kuchazwe kakhulu kwiincwadi. Kwaye, kwabo banokusebenza kwigumbi likaxakeka, buza izigulana zakho ukuba bebesenza ntoni ngaphambi kokuba bangene nesiqendu sabo sokungaphumeleli kwentliziyo okanye iintlungu zesifuba. Uza kuva amabali anje, bendibukele imuvi embi, okanye ndibukele imuvi yemfazwe, okanye ndicatshukiswe ngumdlalo webhola, okanye into elolo hlobo.
Siza kuthetha malunga nokuguquguquka kwesantya sentliziyo, okuchatshazelwa luxinzelelo. Kwaye, ngokuqinisekileyo, uxinzelelo luchaphazela amandla ethu okumelana nosulelo. Kwaye siyazi ukuba abantu baphantsi koxinzelelo xa begonyiwe. Umzekelo, iilaser zeCleco ziyasebenza kodwa azivelisi zithinteli-zifo kwisitofu sokugonya xa ziphantsi koxinzelelo. Kwaye, ngokuqinisekileyo, njengoko uza kubona ngomzuzu, uxinzelelo olunzima lunokubangela ukufa kwentliziyo ngokukhawuleza, i-MI, njalo njalo. Ke ngumdlali ongalunganga ongahoywayo. Kwaye uninzi lwezigulane zethu, uxinzelelo luqhuba uloliwe. Ke xa sithetha ngokutya izithole zebrussels kunye necauliflower kwaye, uyazi, uninzi lwemifuno enamagqabi aluhlaza, kwaye umntu uphantsi koxinzelelo olukhulu kangangokuba uzama ukucinga, “Ndiza kuyigqiba njani imini? ” Abeva naziphi na ezinye izinto esizicebisayo.
Ke, uxinzelelo olungapheliyo kunye nokuphazamiseka okuchaphazelayo, nokuba kukudakumba, ukuxhalaba, okanye ukuphakuzela, beka unyawo lwethu kwi-accelerator kwaye uvuselele inkqubo ye-nervous enovelwano. Siyazi ukuba izinto ezifanayo esizibona ngokuguga, njengoko uza kubona ngomzuzu, zinxulunyaniswa nokwanda kwamanqanaba eehomoni zoxinzelelo, ngakumbi i-cortisol. Ke nokuba yi-osteoporosis, ukuncipha kwamathambo, ukungasebenzi kakuhle kwe-endothelial, ukusebenza kweplatelet, uxinzelelo lwegazi, ukutyeba okuphakathi, okanye ukuxhathisa kwe-insulin, oku kuvela kwimpendulo yoxinzelelo. Kwaye kufuneka sibe nesicwangciso sezigulane zethu malunga nendlela yokusingatha oku. I-American Institute of Stress ithi i-75 ukuya kwi-90% yabo bonke ababoneleli bezempilo batyelela ngenxa yeengxaki ezinxulumene noxinzelelo. Kwaye loo ndlela iphezulu kakhulu, kodwa ngokujonga izigulane kunye nalapho bebengena khona, babalisa amabali abo koogqirha babo. Iziphumo ziyafana; akukhathaliseki nokuba ibiyintloko ebuhlungu, ukuxinezeleka kwezihlunu, i-angina, i-arrhythmia, okanye izibilini ezinomsindo; phantse yayisoloko ibangela uxinzelelo.
Uxinzelelo oluqatha nolungapheliyo
UGqr. Alex Jimenez, DC, unikezela: Kukho umahluko phakathi koxinzelelo olubukhali kunye nolungapheliyo ngembono yethu kunye nonxibelelwano lwentlalo. Nangona sifumana amandla athile kumandla aphezulu, uxinzelelo lunokuchaphazela nabani na, kwaye uninzi lwethu lusenokungakwazi ukumelana nalo kakuhle. Ngoko uphononongo olukhulu lwenziwa kwiminyaka emininzi eyadlulayo nguGqr. Ray noHolmes owathi, kwiminyaka engama-50 eyadlulayo, bahlanganisa indlela yokulinganisa iziganeko eziguqula ubomi. Ngoko makhe sijonge iinkalo ezithile, njengeziganeko ezitshintsha ubomi. Zenza njani iziganeko eziguqula ubomi kwaye zibekwa njani? Zeziphi ezinkulu, kwaye zeziphi ezincinci?
Kwaye loo mgangatho ukhokelela njani kwiingxaki ezinkulu zonyango ezinjengomhlaza, ukuhlaselwa yintliziyo, kunye nokufa ngequbuliso kwikamva? Ke bajonga iminyhadala engama-43 etshintsha ubomi, bazibeka kwindawo yokuqala, kwaye baphinda baphinda baphinda baphinda baphinda baphinda babekwa koo-1990. Kwaye inxenye kubo yahlala injalo. Banike amanqaku ohlengahlengiso kumsitho, emva koko bajonga amanani anokuthi adityaniswe nesifo esikhulu. Ngoko, umzekelo, isiganeko esitshintsha ubomi. Inani lokuqala, iiyunithi ezili-100 ezitshintsha ubomi, kukufa kweqabane. Nabani na unokunxulumana naloo nto. Uqhawulo-mtshato lwaluyeyesibini, ukwahlukana kwesithathu, kunye nesiphelo selungu lentsapho elisondeleyo. Kodwa kwakhona uqaphele ukuba ezinye izinto zibekwe kwindawo ezinokuthi, awunokulingana nazo, ukuba sisiganeko esikhulu esitshintsha ubomi esinokuchaphazela impendulo yoxinzelelo njengomtshato okanye umhlalaphantsi.
isiphelo
UGqr. Alex Jimenez, DC, unikezela: Ngoko yayingesiso isiganeko sokwenyani esenza umahluko. Yayikudityaniswa kweziganeko. Kwaye into abayifumene emva kokujonga oogqirha be-67 ukuba unokutshintsha ubomi beyunithi kwindawo ethile phakathi kwe-zero kunye ne-50 enye, kungekhona into enkulu, akukho sigulo esikhulu ngokwenene, kodwa xa ubetha loo manqaku angama-300, kwakukho i-50% ithuba lokugula okukhulu. Ngoko lo mgca wexesha leziganeko ebomini besigulane. Sifuna ukwazi ukuba kwakuqhubeka ntoni ebomini babo xa iimpawu zabo zaqalayo kwaye emva koko sizibuyisele kwangethuba ukuze siqonde indawo ahlala kuyo lo mntu. Impembelelo yoxinzelelo inokwenza abantu abaninzi baphuhlise iimeko ezingapheliyo kwaye bafihle ezinye iimpawu ezinokukhokelela kwiintlungu zemisipha kunye namalungu. Kwicandelo lesi-2, siza kuntywila ngakumbi malunga nokuba ifuthe loxinzelelo luwuchaphazela njani umzimba kunye nempilo yomntu.
isikhanyeli
by UGqr Alex Jimenez | Chiropractic, Ubuhlungu obungapheliyo, Iimeko eziPhathwayo, impilo, Uxinzelelo oluxhasayo, Unyango, yokuzonwabisa, I-Viscerosomatic Reflex, Ukuphila
intshayelelo
UDkt Alex Jimenez, DC, ubonisa indlela i-hypertension echaphazela ngayo umzimba womntu kunye nezizathu ezithile ezinokunyusa uxinzelelo lwegazi kubantu abaninzi kule nxalenye ye-2. Sithumela izigulana zethu kubaboneleli bezonyango abaqinisekisiweyo ababonelela ngonyango olufumanekayo oluninzi kubantu abaninzi abanengxaki yoxinzelelo lwegazi ehambelana nentliziyo kunye nenkqubo yokuzikhusela komzimba echaphazela umzimba. Sikhuthaza ngamnye kwizigulane zethu ngokuzikhankanya kubaboneleli bezonyango abanxulumeneyo ngokusekelwe kuhlalutyo lwabo ngokufanelekileyo. Siyaqonda ukuba imfundo yindlela eyonwabisayo xa ubuza ababoneleli bethu imibuzo ngokwesicelo sesigulana kunye nokuqonda kwakhe. UDkt Jimenez, DC, usebenzisa le ngcaciso kuphela njengenkonzo yemfundo. isikhanyeli
Ujongwa njani Uxinzelelo lwegazi
UGqr. Alex Jimenez, DC, unikezela: Masibuyele kumthi wesigqibo ukuze uqale ukucinga malunga nendlela oya kuyisebenzisa ngayo imodeli yokuya kuyo kwiyeza elisebenzayo kwi-hypertension kunye nendlela oza kuqala ngayo ukuvavanya umntu onoxinzelelo lwegazi kunokuba ubaxelele ukuba uxinzelelo lwegazi luphakanyisiwe. . Ngaba umzimba uphenjelelwa kukudumba, uxinzelelo lwe-oxidative, okanye ukuphendula kwamajoni omzimba? Ngaba ichaphazela umsebenzi we-endothelial okanye i-vascular smooth muscle evela kwezo ndidi zintathu zokuphendula, ukuvuvukala, uxinzelelo lwe-oxidative, okanye impendulo yomzimba? Ngaba sikhetha i-diuretic calcium channel blocker okanye i-ACE inhibitor? Kwaye ukwenza oko, kubaluleke kakhulu kwicandelo lethu lokuqokelela. Ukuthatha imbali yonyango kunye nexesha loxinzelelo lwegazi labo, ufumana inkcazo malunga nomonakalo welungu kwiimibuzo. Ujonge i-anthropometrics yabo.
Oku kuquka le mibuzo ilandelayo:
- Ziziphi iimpawu zokukrala?
- Ziziphi iimpawu zebhayoloji kunye nezalathi zeklinikhi?
Ezo zichazwe ngomthi wesigqibo seklinikhi. Kwaye sele usenza loo nto, uzakwandisa kwaye ulungise kakuhle ilensi yakho koko unokukubona kwisigulana sakho sehypertension. Masiyongeze kuluhlu lwexesha luqala nini uxinzelelo lwegazi? Ixesha elibekiweyo loxinzelelo lwegazi liqala ngenene ngexesha lokubeleka. Kubalulekile ukubuza isigulana sakho ukuba sikwiminyaka yokuqala okanye enkulu yokufunda. Ngaba umama wabo wayenestres? Ngaba bazalwa kwangoko okanye ngaphambi kwexesha? Ngaba bekukho uxinzelelo lwezondlo ekukhulelweni kwabo? Ukuba bayayazi loo nto, unokuba nabantu ababini abanobukhulu obufanayo bezintso, kodwa umntu obengenayo iprotein eyaneleyo ngexesha lokukhulelwa unokuba ne-glomeruli engaphantsi ngama-40%. Ukwazi oko kuya kutshintsha indlela olilungisa ngayo iyeza kumashumi eminyaka kamva ukuba uyazi ukuba banokuba ne-40% ngaphantsi kweglomeruli.
Uluhlu Lwexesha Loxinzelelo Lwegazi
UGqr. Alex Jimenez, DC, unikezela: Ngoko ke kubalulekile ukuthatha ixesha loxinzelelo lwegazi. Kukwabalulekile ke ukuba siqaphele ukuba kwenzeka ntoni xa siqala ukulungelelanisa nokuqokelela idatha ngokusebenzisa ii-biomarkers; i-biomarkers esisiseko iya kukunika imikhondo malunga nokuba banemiba ye-insulin lipids, nokuba baneengxaki nge-vascular reactivity, i-autonomic nervous system balance, ukungalingani, i-coagulation, okanye i-immune toxin effects. Ke le yinto esengqiqweni ukuyiprinta kuba, kwisigulana sakho esinoxinzelelo lwegazi, oku kungenxa yee-biomarkers onokuthi uqalise ukufumana umkhondo wokuba zeziphi iindawo zokungasebenzi kakuhle ezichaphazela ukudumba, uxinzelelo lwe-oxidative, kunye nokuphendula komzimba kunye nendlela ezi mpawu zebhayoloji zibonakalisa oko. ulwazi kuwe. Oku kusengqiqweni ukuba phambi kwakho ukunceda ukutshintsha iingcinga zakho malunga noxinzelelo lwegazi kwaye kukwenza ukuba usulungekise ezinye zeempawu zomntu kwelinye icala le-stethoscope yakho ngendlela eyenzelwe wena ngakumbi, echanekileyo.
Kodwa masiqale kwasekuqaleni. Ngaba isigulane sakho sinoxinzelelo lwegazi oluphezulu? Siyazi ukuba ngokuxhomekeke kwiziphumo zelungu lesiphelo lezinto ezidibene nazo, unokumqhubela umntu uxinzelelo lwegazi oluphezulu kancinci ukuba unomcimbi omkhulu engqondweni nasezintso okanye entliziyweni, kodwa kukho izikhokelo ezithile. Izikhokelo zethu ze-2017 American Heart Association kwiindidi zoxinzelelo lwegazi zidweliswe apha. Baye bawax kwaye bancipha emva naphambili kule minyaka imbalwa idlulileyo, kodwa oku kucace gca. Ukunyusa uxinzelelo lwegazi, nantoni na engaphezulu kwe-120, itshintshe ngokwenene ukuba bangaphi abantu esiqala ukubabona okanye sicinge ngokujongana nezona zizathu zoxinzelelo lwegazi. Ke siza kubuyela koku, ngakumbi kwimeko yokusinceda sijonge indlela esibahlula ngayo abantu abanemiba yoxinzelelo lwegazi.
Iikhrayitheriya zokulinganisa uxinzelelo lwegazi
UGqr. Alex Jimenez, DC, unikezela: Liliphi inyathelo lokuqala? Ngaba uthatha njani uxinzelelo lwegazi kwisigulana sakho? Ngaba bayayijonga ekhaya? Ngaba bazisa loo manani kuwe? Ulujonga njani uxinzelelo lwegazi kwikliniki yakho? Ulufumana njani ufundo oluchanekileyo kwiklinikhi yakho? Nazi iikhrayitheriya zokulinganisa ngokuchanekileyo uxinzelelo lwegazi kunye nemibuzo yokuqwalasela ukuba uyazenza zonke ezi zinto.
- Ngaba uyasibuza isigulana sakho ukuba sikhe sinecaffeine kwiyure yokugqibela?
- Ingaba baye batshaya kwiyure edlulileyo?
- Ngaba baye bachanabeka ekutshayeni ngeyure yokugqibela?
- Ingaba indawo othatha kuyo uxinzelelo lwegazi ifudumele kwaye izolile?
- Ngaba bahleli ngomqolo wabo esekelwe esitulweni iinyawo zabo ziphantsi?
- Ngaba usebenzisa itafile ejikelezayo ukuphumla ingalo yakho kwinqanaba lentliziyo?
- Ngaba bahleli etafileni yeemviwo iinyawo zabo zijinga, kwaye umongikazi oncedisayo uphakamisa ingalo yabo kwaye abeke kwi-axillary fold yabo ukubamba ingalo yabo apho?
- Ngaba iinyawo zabo zisemhlabeni?
- Ngaba baye bahlala apho imizuzu emihlanu?
- Ngaba bebezilolonga kwimizuzu engama-30 edlulileyo?
Unokuba noxinzelelo lwegazi lwe-systolic ukuba yonke into ikwimilinganiselo. Nanku umceli mngeni. Kukho i-10 ukuya kwi-15 yeemilimitha ze-mercury phezulu xa kuthethwa ngokuhlala kunye nokuthatha uxinzelelo lwegazi. Kuthekani ngobungakanani bekhafu? Siyazi kwinkulungwane edlulileyo; abantu abadala abaninzi babenengalo engaphezulu yesangqa esingaphantsi kweesentimitha ezingama-33. Ngaphezulu kwe-61% yabantu ngoku banesangqa sengalo ephezulu ngaphezulu kwama-33 eesentimitha. Ke ubukhulu becuff buhlukile malunga ne-60% yezigulane zakho zabantu abadala, kuxhomekeke kuluntu lwakho. Ngoko kufuneka usebenzise i-cuff enkulu. Ngoko jonga indlela uxinzelelo lwegazi oluqokelelwa ngayo kwiofisi yakho. Masithi uxinzelelo lwegazi lunyukile kwizigulana zakho; ke kufuneka sibuze, iqhelekile? Kakhulu.
Iindidi ezahlukeneyo zoxinzelelo lwegazi
UGqr. Alex Jimenez, DC, unikezela: Ngaba iphakanyisiwe ngenxa yoxinzelelo lwegazi olumhlophe? Ngaba banoxinzelelo lwegazi oluqhelekileyo, olunyuswe ngaphandle kwekliniki, okanye uxinzelelo lwegazi olugqunyiweyo? Okanye ngaba banoxinzelelo lwegazi oluzinzileyo olulucelomngeni? Siza kuthetha ngaloo nto. Ke xa utolika, kubalulekile ukuba uthathele ingqalelo i-ambulatory blood pressure monitoring. Ke ukuba unomntu onoxinzelelo lwegazi kwaye awazi ukuba uxinzelelo lwegazi luyehla kwaye uzama ukufumanisa ukuba ngaba lugcinwe luxinzelelo lwegazi, ungasebenzisa i-24-yure ye-blood monitoring. Uxinzelelo lwegazi emini olungaphezulu kwe-130 ngaphezulu kwe-80 luxinzelelo lwegazi ebusuku, uxinzelelo lwegazi lwasebusuku olungaphezulu kwe-110 ukuya kuma-65 luxinzelelo lwegazi. Ngoko kutheni oku kubalulekile? Umyinge woxinzelelo lwegazi wehla ukuya malunga ne-15% ebusuku ngenxa yomba woxinzelelo lwegazi. Ukungaphumeleli kwehle uxinzelelo lwegazi ngelixa ulele ebusuku kunokubakho iingxaki ezinokuchaphazela umntu imini yonke.
Ukuba isigulane sakho silala ebusuku, kufuneka sehle malunga ne-15% xa silele. Ukuba bane-non-dipping blood pressure, inxulumene ne-comorbidities. Zeziphi ezinye zezo zigulana kuxinzelelo lwegazi olungadipha? Ezinye zeemeko ezinxulumene noxinzelelo lwegazi olungadibaniyo ziquka:
- Isifo senhliziyo esixineneyo
- Izifo Zeenhliziyo
- Isifo seCerebrovascular
- Ukunqongophala kweNtliziyo yeCrows
- Ukungaphumeleli kwezintso okungapheliyo
- Ulwaphulo lweCerebral oluthe cwaka
I-Co-morbidities eNxulunyaniswe Noxinzelelo Lwegazi
UGqr. Alex Jimenez, DC, unikezela: Ezi zizifo ezinxulumene noxinzelelo lwegazi. Sonke siyavuma ukuba uxinzelelo lwegazi oluphezulu alulunganga kuzo zonke ezo meko. Ke xa ujonga amaqela abantu abahlukeneyo okanye ezinye izinto ezihambelanayo, uxinzelelo lwegazi olungatyibiliki luxhaphake kakhulu kubantu ababuthathaka kwi-sodium, abantu abanesifo sezintso, abantu abanesifo seswekile, abantu abashiye i-ventricular hypertrophy, abantu abane-hypertension ye-refractory. okanye inkqubo ye-nervous autonomic dysfunction kwaye ekugqibeleni, i-apnea yokulala. Ke, uxinzelelo lwegazi olungatshoniyo lunyusa unxulumano lwakho nomonakalo wentliziyo ongaphantsi. Kulungile, ukudipha uReverse kuthetha ukuba unoxinzelelo lwegazi kakhulu ebusuku kwaye ukunyuka okunxulumene kakhulu kunokuba ngexesha lasemini kunxulumene kakhulu nestroke esophayo. Kwaye ukuba unomntu onoxinzelelo lwegazi ebusuku, kufuneka uqale ukucinga ngezinto ezifana nemithambo yecarotid kunye nokwanda kwecarotid, ubukhulu be-medial yangaphakathi. Uqala ukucinga nge-hypertrophy ye-ventricular yasekhohlo kwaye unokuyibona kwi-EKG. Nantsi into esiyaziyo ngehypertension yasebusuku. Uxinzelelo lwegazi ebusuku luxinzelelo lwegazi lwasebusuku olungaphezulu kwe-120 ngaphezulu kwe-70. Inxulunyaniswa nokuqikelelwa okukhulu kokugula kwentliziyo kunye nokufa.
Ukuba une-hypertension yasebusuku, yonyusa umngcipheko wokusweleka kwi-cardiovascular disease ngama-29 ukuya kuma-38%. Kufuneka siyazi ukuba kwenzeka ntoni ebusuku xa silele, akunjalo? Ke, loluphi olunye uhlengahlengiso? Olunye uhlengahlengiso kukuqonda ukuba ukuphumla koxinzelelo lwegazi kulawulwa yinkqubo yakho ye-renin-angiotensin. Ukunyuka koxinzelelo lwegazi kulawulwa yinkqubo yakho ye-nervous enovelwano. Ke makhe sithethe malunga nendlela inkqubo yabo ye-angiotensin yezintso eqhuba ngayo uxinzelelo lwasebusuku, kwaye ucinga malunga nokuba ngawaphi amayeza abawathathayo. Unokutshintsha idosi yeyeza ibe kusebusuku. Ewe, uphononongo lubonise ukuba ukuba unoxinzelelo lwegazi ebusuku kwaye ungeyo-dipper, kungcono ukuba uthathe ii-ACE inhibitors, ii-ARBs, i-calcium channel blockers, kunye ne-beta blockers ezithile ebusuku ngaphambi kokulala. Kodwa iyavakala into yokuba awuyi kuhambisa i-diuretics yakho ebusuku, okanye uya kuba nokuphazamiseka kokulala.
Ukujongana noxinzelelo lwegazi lwasemini kunye nasebusuku
UGqr. Alex Jimenez, DC, unikezela: Ke ukuba asijongani noxinzelelo lwegazi lwemini nobusuku, kufuneka sithathele ingqalelo isiphumo somthwalo wegazi. Ithini i-avareji yoxinzelelo lwegazi lwakho lwemini kunye noxinzelelo lwakho lwegazi oluphakathi. Siyazi ukuba umthwalo wegazi kubantu abadala abancinci banoxinzelelo lwegazi malunga ne-9% yexesha. Ke intsingiselo yomthwalo we-systolic imalunga ne-9% xa ithelekiswa nabantu abadala, malunga ne-80% yomthwalo woxinzelelo lwegazi yi-systolic. Kwaye ke xa unomthwalo ophezulu we-systolic, uneengxaki ezininzi kunye nomonakalo wokuphela kwamalungu. Ke le nto sithetha ngayo kukunceda ukuchonga isigulana sakho esinoxinzelelo lwegazi; lithini ixesha labo? Yintoni phenotype yabo? Ngaba banoxinzelelo olukhulu kakhulu emini, okanye banoxinzelelo olukhulu ebusuku? Kufuneka sijonge ukuba yintoni enceda ukulungelelanisa oko.
Nali elinye inqaku, kuphela malunga ne-3.5% yabantu abanoxinzelelo lwegazi abanesizathu sofuzo. Kuphela yi-3.5% yabantu imfuza yabo ebangela uxinzelelo lwegazi. Amandla asezantsi kwe-matrix kunye nokuqaphela ezi patheni, akunjalo? Ngoko ujonga umthambo, ukulala, ukutya, uxinzelelo kunye nobudlelwane. Ke siyazi ukuba ezi zilinganisi zine zokuzimela zinceda ukugqiba uxinzelelo lwegazi. Siza kuvavanya inkqubo ye-angiotensin yezintso, umthamo weplasma apho babambe khona kulwelo oluninzi, umthwalo wetyuwa wesibini, kunye nokungasebenzi kakuhle kwe-endothelial. Ukungahambi kakuhle kuyo nayiphi na kwezi kunokukhokelela kuxinzelelo lwegazi. Besithetha ngenye into enokukhokelela kuxinzelelo lwegazi: ikhonkco phakathi kokumelana ne-insulin kunye noxinzelelo lwegazi.
Oku ngokomzobo kukunika umbono wonxibelelwano lwe-physiologic phakathi kokumelana ne-insulin kunye noxinzelelo lwegazi. Ichaphazela ukwanda kwethoni yovelwano kunye nokwandisa ibhalansi yenkqubo ye-renal-angiotensin. Ke masichithe imizuzu embalwa kwindlela ye-renin-angiotensin i-angiotensinogen ezantsi ukuya kwi-angiotensin yesibini. Sisebenzisa ezi enzymes ngokunika inhibitors kwi-angiotensin-converting enzymes kwizigulana zethu ezinoxinzelelo lwegazi. I-angiotensin ephakanyisiweyo emibini ikhokelela kwi-cardiovascular hypertrophy, ikhokelela kuxinzelelo lwesigaba sovelwano, ukunyuka kwevolumu yegazi, ulwelo lwesodium, ukugcinwa, kunye nokukhululwa kwe-aldosterone. Ngaba unokubuza malunga neempawu zebhayoloji zesigulana sakho? Ngaba unokubuza ukuba banyuse amanqanaba e-renin?
Khangela iMiqondiso
UGqr. Alex Jimenez, DC, unikezela: Ewe, unako. Unokujonga umsebenzi we-plasma renin kunye namanqanaba e-aldosterone. Kubalulekile ukwenza oku ukuba isigulana sakho sinoxinzelelo lwegazi kwaye asizange sifumane iyeza kuba kulapho i-nitrous oxide ibaluleke khona. Apha kulapho i-endothelial nitric oxide synthase yakho ikhona. Apha kulapho unoxinzelelo olupheleleyo kunye ne-hemodynamic. Yilapho ukutya okudliwayo kwe-arginine okanye indawo echaphazela i-nitric oxide idlala indima enjalo kwimpilo yolu luhlu lwe-endothelia. Ukuba uyibeka ndawonye ngandlel’ ithile, ngendlela engummangaliso, okanye ubuncinane kwiliso lengqondo yakho, iya kugubungela iinkundla zentenetya ezintandathu kumntu omdala oqhelekileyo. Yindawo enkulu yomphezulu. Kwaye izinto ezibangela ukungasebenzi kakuhle kwe-endothelial akuzona iindaba ezintsha kubantu kumayeza asebenzayo. Ukonyuka koxinzelelo lwe-oxidative kunye nokudumba zizinto ezimbini esizikhankanyileyo ezidlala isiphumo.
Kwaye emva koko, jonga amanye ala macandelo, i-ADMA yakho iphakanyisiwe kwaye ihambelana nokumelana ne-insulin. Yonke iqala ukwenza kunye kwi-matrix edibeneyo. Ke ujonga i-comorbidity enye kwi-cardiometabolic syndrome, kwaye ichaphazela enye i-comorbidity. Ubona ngequbuliso unxulumano phakathi kwabo okanye i-hyperhomocysteinemia, eyisiphawuli sekhabhoni enye-metabolism, okuthetha ukuba ujonge ukwanela kwe-folate, b12, b6, riboflavin, kunye naloo msebenzi wekhabhoni enye yemetabolism. Ke makhe sijonge ezinye zezi ziphawuli zomngcipheko asakhulayo ukuphucula kunye nomkhondo kwizigulana ezinoxinzelelo lwegazi. Masiphinde siyihlalutye iADMA kwakhona. I-ADMA imele i-asymmetric dimethyl arginine. I-Asymmetric, i-dimethyl arginine yi-biomarker ye-endothelial dysfunction. Loo molekyuli inqanda i-nitric oxide synthase ngelixa iphazamisa umsebenzi we-endothelial, kwaye kuzo zonke i-comorbidities ezinxulumene ne-cardiometabolic syndrome, i-ADMA inokuphakanyiswa.
isiphelo
Ke, njengokuphononongwa okukhawulezayo, i-L-arginine iguqulelwa kwi-nitric oxide nge-nitric oxide synthase, kunye nokwanela kwe-nitric oxide kukhokelela kwi-vasodilation. I-ADMA iyayivala le nguqulelo. Kwaye ukuba amanqanaba akho e-ADMA anyukile kwaye amanqanaba akho e-nitric oxide aphantsi, ke unciphise i-nitric oxide platelet aggregation yonyuka kwi-LDL oxidation. Izinto ezininzi ke zinciphisa i-nitric oxide okanye zinxulunyaniswa namanqanaba asezantsi e-nitric oxide, i-apnea yokulala, i-arginine yokutya ephantsi, iprotheni, ukungoneli kwe-zinc, kunye nokutshaya.
isikhanyeli
by UGqr Alex Jimenez | Chiropractic, LweMpilo, Uxinzelelo oluxhasayo, istres
intshayelelo
Wonke umntu uyasebenzisana uxinzelelo ngaxa lithile ebomini babo. Nokuba ludliwanondlebe lomsebenzi, ixesha elibekiweyo, iprojekthi, okanye uvavanyo, uxinzelelo lukhona ukugcina umzimba usebenza kwimeko nganye umzimba ohamba kuyo. Uxinzelelo lunokunceda ukulawula umzimba inkqubo yomzimba kunye noncedo i-metabolism ye-homeostasis njengoko umzimba ukwandisa amandla awo imini yonke. Xa usebenzisana uxinzelelo olungapheliyo kunokubangela ukungasebenzi kakuhle kwemetabolism emzimbeni njengokuphazamiseka kwamathumbu, ukudumba, kunye nokunyuka kwamanqanaba eswekile yegazi. Uxinezeleko olungapheliyo lusenokuchaphazela isimo sengqondo nempilo yomntu, indlela atya ngayo, nomgangatho wokulala. Inqaku lanamhlanje liza kujonga ukuba uxinzelelo luyinto entle okanye embi, iwuchaphazela njani umzimba, kunye neziphumo zento eyenziwa kukuxinezeleka okungapheliyo emzimbeni. Thumela izigulana kubaboneleli abaqinisekisiweyo, abanezakhono ezikhethekileyo kunyango lwamathumbu kubantu abaphethwe yi-autonomic neuropathy. Sikhokela izigulana zethu ngokubhekisa kubaboneleli bethu bezonyango abanxulumeneyo ngokusekelwe kuvavanyo lwabo xa kufanelekile. Sifumanisa ukuba imfundo ibalulekile ekubuzeni imibuzo eqondayo kubaboneleli bethu. UDkt Alex Jimenez DC unikezela ngolu lwazi njengenkonzo yemfundo kuphela. isikhanyeli
Ngaba i-inshorensi yam ingayihlawula? Ewe, kunokwenzeka. Ukuba akuqinisekanga, nali ikhonkco kubo bonke ababoneleli beinshorensi esibakhuselayo. Ukuba unemibuzo okanye iinkxalabo, nceda ufowunele uDkt Jimenez kwi-915-850-0900
Ngaba Ukuba Noxinzelelo Kulungile Okanye Kubi?
Ngaba uziva unexhala ngalo lonke ixesha? Kuthekani ngokuziva iintloko ezibuhlungu ezihlala ziyinkathazo? Ukuziva ucinezelekile kwaye ulahlekelwe ingqwalasela okanye inkuthazo? Yonke le miqondiso ziimeko ezicinezelayo umntu atyhubela kuzo. Izifundo zophando ziye zachaza uxinzelelo okanye i-cortisol njengehomoni yomzimba ebonelela ngeempembelelo ezahlukeneyo kwimisebenzi eyahlukeneyo kwinkqubo nganye. I-Cortisol yi-glucocorticoid yokuqala evela kwi-adrenal cortex. Ngelo xesha, i-HPA (i-hypothalamus-pituitary-adrenal) i-axis inceda ukulawula ukuveliswa kunye nokukhutshwa kwale hormone kuwo wonke umzimba. Ngoku i-cortisol inokuba luncedo kwaye ibe yingozi emzimbeni, kuxhomekeka kwimeko umntu akuyo. Izifundo zophando ezongezelelweyo zikhankanyiwe ukuba i-cortisol iqala kwaye ichaphazela ingqondo kunye nomzimba wonke njengoko uxinzelelo olukwimo ebukhali lunokubangela ukuba umzimba ulungelelanise kwaye uphile. Iimpendulo ezibukhali ezivela kwi-cortisol zivumela i-neural, i-cardiovascular, i-immune, kunye nomsebenzi we-metabolic emzimbeni.
Ichaphazela njani iMetabolism yoMzimba?
Ngoku i-cortisol ichaphazela imetabolism yomzimba xa ilawulwa kumjikelo ocothayo, ozinzileyo wokulala owehlisa ihomoni ekhupha i-corticotropin (CRH) kunye nokwandisa ihomoni yokukhula (GH). Izifundo zophando zibonisile ukuba xa i-adrenal glands ikhupha i-cortisol, iqala ukuba nentsebenziswano eyinkimbinkimbi kunye ne-hypothalamus kunye ne-pituitary glands kwi-nervous and endocrine systems. Oku kubangela ukuba umsebenzi we-adrenal kunye ne-thyroid emzimbeni udityaniswe ngokusondeleyo ngelixa uphantsi kolawulo lwe-hypothalamus kunye neehomoni zetropiki. Idlala lengqula likhuphisana namalungu eadrenal ngetyrosine. Izifundo zophando zifumene ukuba i-tyrosine isetyenziselwa ukuvelisa i-cortisol phantsi koxinzelelo ngelixa ikhusela umsebenzi wokuqonda ukuhla osabela kuxinzelelo lomzimba. Nangona kunjalo, xa umzimba ungakwazi ukuvelisa i-tyrosine eyaneleyo, inokubangela i-hypothyroidism kwaye ibangele ukuba ihomoni ye-cortisol ibe yinto engapheliyo.
Isishwankathelo Ngoxinzelelo-Ividiyo
Ngaba ukhe waphathwa yintloko ebuhlungu evele ivele nje? Ngaba usoloko utyeba okanye wehla emzimbeni? Ngaba uziva unexhala okanye uxinzelelo olusoloko luchaphazela ubuthongo bakho? Ezi zonke ziimpawu kunye neempawu zamanqanaba akho e-cortisol ajika abe kwimeko yawo engapheliyo. Le vidiyo ingentla ibonisa ukuba yintoni uxinzelelo oluyenzayo emzimbeni wakho kunye nendlela enokubangela ngayo iimpawu ezingafunekiyo. Xa kukho uxinzelelo olungapheliyo emzimbeni, i-axis ye-HPA (i-neuro-endocrine) ayilungelelananga ngenxa ye-activators-mediated activators ezibandakanyeka kwizifo ze-thyroid ezizimeleyo (AITD). Xa kukho uxinzelelo olungapheliyo emzimbeni, lunokubangela ukuveliswa okugqithisileyo kweekhompawundi ezivuthayo emzimbeni kunokuvelisa i-IR. Izinto ezivuthayo zingonakalisa okanye zingasebenzi i-insulin receptors ezikhokelela ekunganyangekiyo kwe-insulin. Oku ke kunegalelo ekuqhekekeni kwento enye okanye ngaphezulu efunekayo ukuze kugqitywe inkqubo yokuthutha i-glucose emzimbeni.
Iziphumo zeCortisol engapheliyo eMzimbeni
Xa kukho uxinzelelo olungapheliyo emzimbeni kwaye aluzange luphathwe okanye luncitshiswe ngokukhawuleza, kunokukhokelela kwinto eyaziwa ngokuba ngumthwalo we-allostatic. Umthwalo we-Allostatic uchazwa njengokunxitywa kunye nokukrazula komzimba kunye nengqondo ngenxa yokusebenza ngokugqithiseleyo okungapheliyo okanye ukungasebenzi kweenkqubo zomzimba ezibandakanyekayo kwimingeni yokusingqongileyo kunye nokuziqhelanisa. Izifundo zophando zibonisile ukuba umthwalo we-allostatic ubangela ukukhuselwa okugqithisileyo kweehomoni ezifana ne-cortisol kunye ne-catecholamine ukuphendula kuxinzelelo olungapheliyo oluchaphazela umzimba. Oku kubangela ukuba i-axis ye-HPA yenze enye yezinto ezimbini: ukusebenza ngokugqithisileyo okanye ukusilela ukuvala emva kweziganeko ezinoxinzelelo ezibangela ukuphazamiseka kokulala. Eminye imiba eyenziwa luxinzelelo olungapheliyo emzimbeni inokubandakanya:
- Ukonyuka kwemfihlo ye-insulin kunye nokubekwa kwamafutha
- Ukutshintsha ukusebenza komzimba
- I-Hypothyroidism (i-adrenal exhausing)
- Ukugcinwa kwesodium kunye namanzi
- Ukulahleka kobuthongo be-REM
- Ukungazinzi ngokwasengqondweni nangokweemvakalelo
- Ukonyuka kwimiba yengozi ye-cardiovascular
Ezi mpawu zibangela ukuba umzimba ungasebenzi kakuhle, kwaye izifundo zophando ziye zabonisa ukuba iintlobo ezahlukeneyo zoxinzelelo zingonakalisa umzimba. Oku kunokwenza kube nzima kakhulu ukuba umntu ajamelane noxinezeleko aze aluthobe.
isiphelo
Ngokubanzi, uxinzelelo okanye i-cortisol yihomoni efunwa ngumzimba ukuze usebenze ngokuchanekileyo. Uxinzelelo olungapheliyo emzimbeni oluvela kuxinzelelo olwahlukeneyo lunokubangela ukungasebenzi kakuhle kwemetabolism efana ne-hypothyroidism, ukufumana ubunzima, ukunganyangeki kwe-insulin, kunye nesifo se-metabolic, ukubiza ezimbalwa. Uxinzelelo olungapheliyo lunokubangela ukuphazamiseka kokulala kuba i-axis ye-HPA ifakwe intambo kwaye inokubonakala ngathi izolile kancinci. Xa abantu beqala ukufumana iindlela zokujongana naba baxinzelelo bahlukeneyo, banokunciphisa amanqanaba abo oxinzelelo babuyele kwisiqhelo kwaye bangabi noxinzelelo.
Ucaphulo
Jones, uCarol, kunye noChristopher Gwenin. "Inqanaba leCortisol Dysregulation kunye nokuBanda kwayo-Ngaba yiwotshi yeAlam yeNdalo?" Iingxelo zePhysical, John Wiley and Sons Inc., Jan. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC7749606/.
McEwen, uBruce S. "Iimpembelelo eziPhakathi zeHormones zoxinzelelo kwiMpilo kunye neSifo: Ukuqonda iZiphumo eziKhuselayo kunye nezonakalisayo zoxinzelelo kunye nabalamli boxinzelelo." I-European Journal ye-Pharmacology, ILayibrari yeSizwe yezeMithi yase-US, nge-7 Epreli 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2474765/.
McEwen, Bruce S. “Uxinzelelo okanye Uxinzelelo: Yintoni Umahluko?” Ijenali yengqondo kunye neNeuroscience: JPN, ILayibrari yeSizwe yezeMithi yase-US, ngo-Septemba 2005, www.ncbi.nlm.nih.gov/pmc/articles/PMC1197275/.
URodriquez, uErik J, kunye nabanye. "Umthwalo we-Allostatic: Ukubaluleka, abaMakishi, kunye nokuMiselwa kwaManqaku kuBantu abaNcinci kunye noMahluko." Ijenali yeMpilo yeDolophu: Incwadana yeNew York Academy of Medicine, Springer US, Matshi 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6430278/.
UThau, uLauren, kunye nabanye. "IPhysiology, Cortisol-Statpearls-NCBI Bookshelf." Ku: StatPearls [Internet]. Isiqithi saseTreasure (FL), StatPearls Publishing, 6 Septemba 2021, www.ncbi.nlm.nih.gov/books/NBK538239/.
Oselula, uSimon N. “L-Tyrosine ukuthomalalisa iimpembelelo zoxinzelelo?” Ijenali yengqondo kunye neNeuroscience: JPN, ILayibrari yeSizwe yaseMelika yoNyango, ngoMeyi 2007, www.ncbi.nlm.nih.gov/pmc/articles/PMC1863555/.
isikhanyeli
by UGqr Alex Jimenez | Chiropractic, Uxinzelelo oluxhasayo, I-Viscerosomatic Reflex, Ukuphila
intshayelelo
Njengoko ihlabathi lihamba rhoqo, abantu abaninzi kufuneka banyamezele iimeko zoxinzelelo ezichaphazela imizimba kunye nempilo yabo. Umzimba ufuna iihomoni ezifana cortisol ukugcina ukusebenza njengoko kuchaphazela i I-immune, i-nervous, i-cardiovascular, kunye ne-musculoskeletal systems, xa sikhankanya ezimbalwa. Omnye umsebenzi obalulekileyo ofunwa ngumzimba yiglucose, efuna amandla ukuze uhlale ushukuma. Iimeko ezibangela ukuba amanqanaba e-cortisol kunye namanqanaba e-glucose anyuke emzimbeni angakhokelela kwimiba engapheliyo efana nesifo seswekile kunye noxinzelelo olungapheliyo. Oku kubangela ukuba umntu abe lusizi kwaye abe kwimeko embi ukuba ayilawulwa ngoko nangoko. Inqaku lanamhlanje livavanya indlela i-cortisol kunye neglucose echaphazela ngayo umzimba kunye nonxibelelwano oludibeneyo phakathi koxinzelelo kunye nesifo seswekile. Thumela izigulana kubaboneleli abaqinisekisiweyo, abanezakhono ezikhethekileyo kulawulo loxinzelelo kunye nonyango lwe-endocrine kubantu abanesifo seswekile. Sikhokela izigulana zethu ngokubhekisa kubaboneleli bethu bezonyango abanxulumeneyo ngokusekelwe kuvavanyo lwabo xa kufanelekile. Sifumanisa ukuba imfundo ibalulekile ekubuzeni imibuzo eqondayo kubaboneleli bethu. UDkt Alex Jimenez DC unikezela ngolu lwazi njengenkonzo yemfundo kuphela. isikhanyeli
Ngaba i-inshorensi yam ingayihlawula? Ewe, kunokwenzeka. Ukuba akuqinisekanga, nali ikhonkco kubo bonke ababoneleli beinshorensi esibakhuselayo. Ukuba unemibuzo okanye iinkxalabo, nceda ufowunele uDkt Jimenez kwi-915-850-0900.
I-Cortisol iwuchaphazela njani umzimba?
Ngaba unengxaki yokulala ebusuku? Kuthekani ngentloko ebuhlungu rhoqo eyinkathazo imini yonke? Okanye ngaba uye waqaphela ukwehla kobunzima obugqithisileyo okanye ukuzuza ubunzima obujikeleze i-middlesection yakho? Ezinye zezi mpawu ziyimiqondiso yokuba i-cortisol yakho kunye namanqanaba eglucose aphezulu kwaye inokuchaphazela umzimba wakho. I-Cortisol yihomoni eveliswa kwinkqubo ye-endocrine kwaye inokuba luncedo okanye ibe yingozi emzimbeni ukuba ayikhangelwa rhoqo. Izifundo zophando zichaze i-cortisol njengenye yeeglucocorticoids ebalaseleyo ekhutshelwe ngaphandle ngenxa yempendulo yeekhemikhali zomzimba, ephawulwa yi-HPA (hypothalamic-pituitary-adrenal) axis inceda imicimbi yokuqonda. Nangona kunjalo, xa amanqanaba e-cortisol eguquka engapheliyo emzimbeni ngenxa yeemeko ezibangela ukuba umzimba ungasebenzi, unokuchaphazela kakhulu umntu kwaye kubangele ukungalingani kwi-axis ye-HPA. Ezinye zeempawu ezikhokelela kwi-cortisol engapheliyo emzimbeni zinokubandakanya:
- Ukungalingani kweHormonal
- Ukuxhathisa kwe-insulin
- Ukutyeba kwakho
- Ukonyuka kwamafutha e-visceral "esisu".
- Ukonyuka kwemveliso ye-cortisol
- Iingxaki zamajoni omzimba
- Ukwalana kunye ne-Asma
- Amalungu avuthayo
- Ukuchacha kakuhle komthambo
Ulwazi olongezelelweyo lunikiwe ukuba ubukho be-cortisol emzimbeni bunokunceda ukwandisa ukufumaneka kweswekile yegazi engqondweni. Nge-cortisol ebonelela ngokusebenza kwamalungu, iswekile yegazi inika amandla kumzimba.
Isebenza njani iCortisol kunye neGlucose eMzimbeni
I-Cortisol inceda ukuvuselela ukuhlanganiswa kweglucose eninzi esibindini, ivumela iprotheyini yebhlokhi ukutyhala i-amino acids kwiswekile yomzimba. Oku kwaziwa njenge-fatty acid liberation biotransformed ibe yiglucose. Xa oku kusenzeka, kunceda ukuvuselela ukugcinwa kwamafutha e-visceral ukuba i-glucose engaphezulu ayisetyenziswanga, ngaloo ndlela ibangela ubunzima. Izifundo zophando zibonisile ukuba ukungabikho kwe-cortisol kunokubangela ukuncipha kwemveliso ye-glucose ye-hepatic emzimbeni. Oku kuya kubangela i-hypoglycemia, apho umzimba ungenayo i-glucose eyaneleyo kwinkqubo yawo. Uphando olongezelelweyo lubonisa ukuba i-cortisol iphendula kuyo nayiphi na i-stressor echaphazela umntu onamanqanaba aphantsi e-glucose kodwa ingaba yinto enhle emva komthwalo we-glucose. Ukulawula i-glucose yomzimba kunye namanqanaba e-cortisol kunokunceda ukuqhubela phambili ukuphuhliswa kwesifo seswekile.
Indlela iCortisol enxulunyaniswa ngayo noHlobo lwesi-2 seswekile-Ividiyo
Ngaba ukhe wajamelana neemeko ezicinezelayo ezibangela ukuba izihlunu zakho ziqine? Kuthekani ngokuva iswekile yegazi lakho nokuba linyukela phezulu okanye lisezantsi? Ngaba uziva iziphumo ezivuthayo kuwo wonke umzimba wakho ozenza zibuhlungu? Uxinzelelo lunokubangela iziphumo ezinobungozi emzimbeni, kusebenze ukuvutha, ukwandisa ithoni yovelwano, kunye nokunciphisa ukuphendula kweglucocorticoid. Ukuxinezeleka kunokudibaniswa nesifo sikashukela, njengoko ividiyo engentla ibonisa indlela i-hormone yoxinzelelo i-cortisol edibaniswa ngayo nesifo seswekile se-2. Uphando lophando lukhankanyile ukuba i-cortisol inokunxulunyaniswa kakubi nobuchwephesha bokumelana ne-insulin, ukwandisa ukusebenza kweeseli ze-beta kunye nokwandisa i-insulin ekhutshwe emzimbeni. Oku kunokuba yingozi kubantu abaninzi abanesifo seswekile esele bekho kwaye bebesoloko bejongene noxinzelelo.
Umdibaniso oManyeneyo phakathi koxinzelelo kunye nesifo seswekile
Unxibelelwano oludibeneyo phakathi koxinzelelo kunye nesifo seswekile luboniswa njenge uphando lophando lufumene ukuba i-pathophysiology yexhala kunye nesifo seswekile yonyuse umngcipheko wokunganyangeki kwe-insulin emzimbeni. Xa umntu ejongene noxinzelelo olungapheliyo, kunokubangela ukuba babe nemiba emininzi efana nale:
- Ukunganyamezelani okubandayo
- Ukuncipha kwengqondo kunye nomoya
- Iimvakalelo zokutya
- Amandla aphantsi imini yonke
Xa oku kusenzeka, umzimba usemngciphekweni omkhulu wokumelana ne-insulin kunye nohlobo lwe-2 yeswekile. Uphando lophando lukhankanyile olo hlobo lwesifo seswekile luphawulwa kukunganyangeki kwe-insulin kunye nokungasebenzi kakuhle kweeseli ze-beta. I-glucocorticoid emzimbeni inokugqithisa kakhulu ukuchaphazela iiseli, ibangele ukungasebenzi. Uphononongo olongezelelweyo lophando luye lwabonisa ukuba naluphi na uxinzelelo olubonwayo lunokuba ngumngcipheko obalulekileyo ongachaphazeli kuphela umzimba, njenge-hypertension, i-BMI (i-index mass body), okanye umgangatho wokutya kodwa unokubangela ukunyuka kohlobo lwe-2 yeswekile. Xa abantu befumana iindlela zokunciphisa uxinzelelo lwabo olungapheliyo, kunokunceda ukulawula amanqanaba e-glucose ekufikeleleni kumanqanaba abalulekileyo.
isiphelo
Uxinzelelo olungapheliyo lomzimba lunokubangela ukunganyangeki kwe-insulin kwaye kubangele ukuba isifo seswekile sibekho ngaphambili. Umzimba udinga i-cortisol kunye neglucose ukuze uhlale usebenza kwaye ube namandla okuhamba. Xa abantu beqala ukuba noxinzelelo olungapheliyo kunye nesifo seswekile, kunokuba nzima ukulawula; nangona kunjalo, ukwenza utshintsho oluncinci kumzimba njengokufumana iindlela zokunciphisa uxinzelelo, ukutya ukutya okunempilo, kunye nokubeka iliso kwizinga le-glucose kunokunceda umzimba ubuyisele amanqanaba e-glucose kunye ne-cortisol eqhelekileyo. Ukwenza oku kunokukhulula abantu abaninzi abafuna ukuqhubeka nohambo lwabo lwezempilo ngaphandle koxinzelelo.
Ucaphulo
UAdam, uTanja C, et al. "I-Cortisol inxulunyaniswe kakubi kunye nokuziva kwe-insulin kwi-Overweight Latino Youth." Umbhalo we-Clinical Endocrinology kunye neMetabolism, Umbutho we-Endocrine, Oct. 2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC3050109/.
UDe Feo, uP, kunye nabanye. "Igalelo leCortisol kuLawulo lweGlucose kuBantu." Ijenali yaseMelika yePhysiology, ILayibrari yeSizwe yezeMithi yase-US, ngoJulayi 1989, yentshutshiso.ncbi.nlm.nih.gov/2665516/.
Hucklebridge, FH, et al. "Ukuvuka kweCortisol impendulo kunye namanqanaba eGlucose yegazi." Sciences soBomi, ILayibrari yeSizwe ka-US yamayeza, 1999, yentshutshiso.ncbi.nlm.nih.gov/10201642/.
UJoseph, uJoshua J, kunye noSherita H Golden. "I-Cortisol Dysregulation: Ikhonkco leBidirectional phakathi koxinzelelo, uxinzelelo, kunye noHlobo lwe-2 yeswekile iMellitus." Izibhengezo zeZiko leSayensi laseNew York, ILayibrari yeSizwe yaseMelika yoNyango, Mar. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5334212/.
Kamba, Aya, et al. "Umanyano phakathi kwamaNqanaba aPhezulu eSerum Cortisol kunye nokuNcitshiswa kweMfihlo ye-insulin kubemi ngokubanzi." PloS One, iThala leeNcwadi loLuntu leNzululwazi, ngoNovemba 18, 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5115704/.
Lee, Do Yup, et al. "Iinkalo zobuGcisa kunye nezoNyango zeCortisol njengeMakishi yeBiochemicals yoxinzelelo olungapheliyo." IiNgxelo zeBMB, Umbutho waseKorea we-Biochemistry kunye ne-Molecular Biology, ngo-Epreli 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4436856/.
UThau, uLauren, kunye nabanye. "IPhysiology, iCortisol." Ku: StatPearls [Internet]. Isiqithi saseTreasure (FL), StatPearls Publishing, 6 Septemba 2021, www.ncbi.nlm.nih.gov/books/NBK538239.
isikhanyeli
by UGqr Alex Jimenez | Chiropractic, Ubuhlungu obungapheliyo, IiOthotics zeenyawo, impilo, Ukunyamekela, Injury, Uxinzelelo oluxhasayo, ulungiso, Unyango, Ukuphila
Umzimba ngumatshini osebenza kakuhle onokunyamezela nantoni na ephoswe endleleni yawo. Nangona kunjalo, xa ifumana ukwenzakala, inkqubo yokuphilisa yendalo yomzimba iya kuqinisekisa ukuba umzimba unokubuyela kwimisebenzi yawo yemihla ngemihla. Inkqubo yokuphilisa yesihlunu esonzakeleyo iyahluka kuwo wonke umzimba. Ngokuxhomekeke ekubeni ungakanani umonakalo kunye nokuba inkqubo yokuphilisa iya kuthatha ixesha elingakanani, umzimba unokubuyela kwiintsuku nje ezimbalwa ukuya kwiinyanga ezimbalwa. Enye yezona nkqubo zibuhlungu zokuphilisa umzimba ekufuneka uzinyamezele kukugqabhuka kwe-calcaneal tendon.
I-Tendon yeCalcaneal
Ithenda ye-calcaneal okanye i-tendon ye-Achilles yi-tendon engqindilili ebekwe ngasemva komlenze. Lo msipha-tendon yeyona nto yenza ukuba umzimba ushukume ngelixa uhamba, ubaleka, okanye utsiba. Akunjalo kuphela, i-tendon ye-calcaneal iyona nto inamandla kakhulu emzimbeni, kwaye idibanisa i-gastrocnemius kunye nemisipha yodwa kwithambo lesithende. Xa i-tendon ye-calcaneal iphukile, inkqubo yokuphulukisa inokuhlala kwiiveki ukuya kwiinyanga ide iphiliswe ngokupheleleyo.
Iimpembelelo zokuPhilisa zoNyango lweLaser ephantsi
Enye yeendlela ezinokunceda inkqubo yokuphilisa i-calcaneal tendons eyonakeleyo lunyango olusezantsi lwelaser. Izifundo zibonise ukuba unyango lwe-laser oluphantsi lunokukhawulezisa ukulungiswa kwe-tendon eyonakalisiweyo emva kwesilonda esincinci. Akunjalo kuphela kodwa ikamaUkwenziwa kwe-ultrasound kunye nonyango oluphantsi lwe-laser luye lwafundiswa ukuba lube ngabasebenzi bomzimba bokunyanga ukwenzakala kwe-tendon. Izifundo zibonise ukuba udibaniso lwe-laser therapy ephantsi kunye ne-ultrasound ineepropati ezinenzuzo ngexesha lokubuyisela inkqubo yokulimala kwe-tendon ye-calcaneal.
Isifundo sifunyenwe ukuba xa izigulane zinyangelwa i-calcaneal tendons, amanqanaba abo e-hydroxyproline ejikeleze indawo enyangweyo anyuswe kakhulu nge-ultrasound kunye ne-laser t ephantsi.unyango. Umzimba wendalo ye-biochemical kunye nezakhiwo ze-biomechanical kwi-tendon eyenzakeleyo yonyuka, ngaloo ndlela ichaphazela inkqubo yokuphilisa. Olunye uphononongo luye lwabonisa ukuba unyango lwe-laser oluphantsi lunokunceda ukunciphisa i-fibrosis kunye nokuthintela uxinzelelo lwe-oxidative kwi-tendon ye-calcaneal ephazamisekile. Uphononongo lwaze lwabonisa ukuba emva kokuba i-tendon ye-calcaneal iphazamisekile, ukuvuvukala, i-angiogenesis, i-vasodilation, kunye ne-matrix ye-extracellular yenziwa kwindawo echaphazelekayo. Ke xa izigulana zinyangwa ngonyango olusezantsi lwelaser malunga neentsuku ezilishumi elinesine ukuya kumashumi amabini ananye, iziphako zazo ze-histological ziyathomalaliswa, kucuthwe ukugxilwa kwe-collagen kunye ne-fibrosis; ukuthintela uxinzelelo lwe-oxidative ekunyuseni emzimbeni.
isiphelo
Ngokubanzi, kuthiwa iziphumo zonyango oluphantsi lwe-laser lunokunceda ukukhawuleza inkqubo yokuphulukisa ukulungisa i-tendon ye-calcaneal. Iziphumo ezithembisayo zibonakalisiwe kuba unyango lwe-laser oluphantsi lunokunceda ukulungisa i-tendon eyonakeleyo, ukunciphisa uxinzelelo lwe-oxidative kunye nokuthintela i-fibrosis ekunyukeni, kubangela iingxaki ezininzi kwi-tendon eyenzakeleyo. Kwaye ngokudityaniswa kwe-ultrasound, i-tendon ye-calcaneal inokubuya ngokukhawuleza ukuze umzimba uqhubeke nemisebenzi yawo yemihla ngemihla ngaphandle kokulimala ixesha elide.
Iingxelo:
UDemir, uHuseyin, et al. "Ukuthelekiswa kweempembelelo zeLaser, i-Ultrasound, kunye ne-Combined Laser + Unyango lwe-Ultrasound kwi-Experimental Tendon Healing." IiLaser kuTyando kunye naMayeza, ILayibrari yeSizwe ka-US yamayeza, 2004, yentshutshiso.ncbi.nlm.nih.gov/15278933/.
UFillipin, uLidiane Isabel, et al. "Unyango lweLaser yenqanaba eliphantsi (LLLT) lunqanda uxinzelelo lwe-Oxidative kunye nokunciphisa i-Fibrosis kwi-Rat Traumatised Achilles Tendon." IiLaser kuTyando kunye naMayeza, Ilayibrari yeSizwe yaseMelika yoNyango, Okthobha 2005, yentshutshiso.ncbi.nlm.nih.gov/16196040/.
U-Oliveira, uFla'via Schlittler, et al. Isiphumo soNyango lweLaser yeNqanaba eliPhantsi (830 Nm … – ILaser yoNyango. I-2009, medical.summuslaser.com/data/files/86/1585171501_uLg8u2FrJP7ZHcA.pdf.
Wood, Viviane T, et al. "Iinguqu ze-Collagen kunye nokulungelelaniswa kwakhona okubangelwa yi-Low-Level Laser Therapy kunye ne-Low-Intensity Ultrasound kwi-Tendon ye-Calcaneal." IiLaser kuTyando kunye naMayeza, ILayibrari yeSizwe ka-US yamayeza, 2010, yentshutshiso.ncbi.nlm.nih.gov/20662033/.
