Impembelelo yoxinzelelo lweHomeostasis yoMzimba

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Wonke umntu uyasebenzisana uxinzelelo ngaxa lithile ebomini babo. Nokuba ludliwanondlebe lomsebenzi, ixesha elibekiweyo, iprojekthi, okanye uvavanyo, uxinzelelo lukhona ukugcina umzimba usebenza kwimeko nganye umzimba ohamba kuyo. Uxinzelelo lunokunceda ukulawula umzimba inkqubo yomzimba kunye noncedo i-metabolism ye-homeostasis njengoko umzimba ukwandisa amandla awo imini yonke. Xa usebenzisana uxinzelelo olungapheliyo kunokubangela ukungasebenzi kakuhle kwemetabolism emzimbeni njengokuphazamiseka kwamathumbu, ukudumba, kunye nokunyuka kwamanqanaba eswekile yegazi. Uxinezeleko olungapheliyo lusenokuchaphazela isimo sengqondo nempilo yomntu, indlela atya ngayo, nomgangatho wokulala. Inqaku lanamhlanje liza kujonga ukuba uxinzelelo luyinto entle okanye embi, iwuchaphazela njani umzimba, kunye neziphumo zento eyenziwa kukuxinezeleka okungapheliyo emzimbeni. Thumela izigulana kubaboneleli abaqinisekisiweyo, abanezakhono ezikhethekileyo kunyango lwamathumbu kubantu abaphethwe yi-autonomic neuropathy. Sikhokela izigulana zethu ngokubhekisa kubaboneleli bethu bezonyango abanxulumeneyo ngokusekelwe kuvavanyo lwabo xa kufanelekile. Sifumanisa ukuba imfundo ibalulekile ekubuzeni imibuzo eqondayo kubaboneleli bethu. UDkt Alex Jimenez DC unikezela ngolu lwazi njengenkonzo yemfundo kuphela. isikhanyeli

 

Ngaba i-inshorensi yam ingayihlawula? Ewe, kunokwenzeka. Ukuba akuqinisekanga, nali ikhonkco kubo bonke ababoneleli beinshorensi esibakhuselayo. Ukuba unemibuzo okanye iinkxalabo, nceda ufowunele uDkt Jimenez kwi-915-850-0900

Ngaba Ukuba Noxinzelelo Kulungile Okanye Kubi?

 

Ngaba uziva unexhala ngalo lonke ixesha? Kuthekani ngokuziva iintloko ezibuhlungu ezihlala ziyinkathazo? Ukuziva ucinezelekile kwaye ulahlekelwe ingqwalasela okanye inkuthazo? Yonke le miqondiso ziimeko ezicinezelayo umntu atyhubela kuzo. Izifundo zophando ziye zachaza uxinzelelo okanye i-cortisol njengehomoni yomzimba ebonelela ngeempembelelo ezahlukeneyo kwimisebenzi eyahlukeneyo kwinkqubo nganye. I-Cortisol yi-glucocorticoid yokuqala evela kwi-adrenal cortex. Ngelo xesha, i-HPA (i-hypothalamus-pituitary-adrenal) i-axis inceda ukulawula ukuveliswa kunye nokukhutshwa kwale hormone kuwo wonke umzimba. Ngoku i-cortisol inokuba luncedo kwaye ibe yingozi emzimbeni, kuxhomekeka kwimeko umntu akuyo. Izifundo zophando ezongezelelweyo zikhankanyiwe ukuba i-cortisol iqala kwaye ichaphazela ingqondo kunye nomzimba wonke njengoko uxinzelelo olukwimo ebukhali lunokubangela ukuba umzimba ulungelelanise kwaye uphile. Iimpendulo ezibukhali ezivela kwi-cortisol zivumela i-neural, i-cardiovascular, i-immune, kunye nomsebenzi we-metabolic emzimbeni. 

 

Ichaphazela njani iMetabolism yoMzimba?

Ngoku i-cortisol ichaphazela imetabolism yomzimba xa ilawulwa kumjikelo ocothayo, ozinzileyo wokulala owehlisa ihomoni ekhupha i-corticotropin (CRH) kunye nokwandisa ihomoni yokukhula (GH). Izifundo zophando zibonisile ukuba xa i-adrenal glands ikhupha i-cortisol, iqala ukuba nentsebenziswano eyinkimbinkimbi kunye ne-hypothalamus kunye ne-pituitary glands kwi-nervous and endocrine systems. Oku kubangela ukuba umsebenzi we-adrenal kunye ne-thyroid emzimbeni udityaniswe ngokusondeleyo ngelixa uphantsi kolawulo lwe-hypothalamus kunye neehomoni zetropiki. Idlala lengqula likhuphisana namalungu eadrenal ngetyrosine. Izifundo zophando zifumene ukuba i-tyrosine isetyenziselwa ukuvelisa i-cortisol phantsi koxinzelelo ngelixa ikhusela umsebenzi wokuqonda ukuhla osabela kuxinzelelo lomzimba. Nangona kunjalo, xa umzimba ungakwazi ukuvelisa i-tyrosine eyaneleyo, inokubangela i-hypothyroidism kwaye ibangele ukuba ihomoni ye-cortisol ibe yinto engapheliyo.

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Isishwankathelo Ngoxinzelelo-Ividiyo

Ngaba ukhe waphathwa yintloko ebuhlungu evele ivele nje? Ngaba usoloko utyeba okanye wehla emzimbeni? Ngaba uziva unexhala okanye uxinzelelo olusoloko luchaphazela ubuthongo bakho? Ezi zonke ziimpawu kunye neempawu zamanqanaba akho e-cortisol ajika abe kwimeko yawo engapheliyo. Le vidiyo ingentla ibonisa ukuba yintoni uxinzelelo oluyenzayo emzimbeni wakho kunye nendlela enokubangela ngayo iimpawu ezingafunekiyo. Xa kukho uxinzelelo olungapheliyo emzimbeni, i-axis ye-HPA (i-neuro-endocrine) ayilungelelananga ngenxa ye-activators-mediated activators ezibandakanyeka kwizifo ze-thyroid ezizimeleyo (AITD). Xa kukho uxinzelelo olungapheliyo emzimbeni, lunokubangela ukuveliswa okugqithisileyo kweekhompawundi ezivuthayo emzimbeni kunokuvelisa i-IR. Izinto ezivuthayo zingonakalisa okanye zingasebenzi i-insulin receptors ezikhokelela ekunganyangekiyo kwe-insulin. Oku ke kunegalelo ekuqhekekeni kwento enye okanye ngaphezulu efunekayo ukuze kugqitywe inkqubo yokuthutha i-glucose emzimbeni.

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Iziphumo zeCortisol engapheliyo eMzimbeni

 

Xa kukho uxinzelelo olungapheliyo emzimbeni kwaye aluzange luphathwe okanye luncitshiswe ngokukhawuleza, kunokukhokelela kwinto eyaziwa ngokuba ngumthwalo we-allostatic. Umthwalo we-Allostatic uchazwa njengokunxitywa kunye nokukrazula komzimba kunye nengqondo ngenxa yokusebenza ngokugqithiseleyo okungapheliyo okanye ukungasebenzi kweenkqubo zomzimba ezibandakanyekayo kwimingeni yokusingqongileyo kunye nokuziqhelanisa. Izifundo zophando zibonisile ukuba umthwalo we-allostatic ubangela ukukhuselwa okugqithisileyo kweehomoni ezifana ne-cortisol kunye ne-catecholamine ukuphendula kuxinzelelo olungapheliyo oluchaphazela umzimba. Oku kubangela ukuba i-axis ye-HPA yenze enye yezinto ezimbini: ukusebenza ngokugqithisileyo okanye ukusilela ukuvala emva kweziganeko ezinoxinzelelo ezibangela ukuphazamiseka kokulala. Eminye imiba eyenziwa luxinzelelo olungapheliyo emzimbeni inokubandakanya:

• Ukonyuka kwemfihlo ye-insulin kunye nokubekwa kwamafutha
• Ukutshintsha ukusebenza komzimba
• I-Hypothyroidism (i-adrenal exhausing)
• Ukugcinwa kwesodium kunye namanzi
• Ukulahleka kobuthongo be-REM
• Ukungazinzi ngokwasengqondweni nangokweemvakalelo
• Ukonyuka kwimiba yengozi ye-cardiovascular

Ezi mpawu zibangela ukuba umzimba ungasebenzi kakuhle, kwaye izifundo zophando ziye zabonisa ukuba iintlobo ezahlukeneyo zoxinzelelo zingonakalisa umzimba. Oku kunokwenza kube nzima kakhulu ukuba umntu ajamelane noxinezeleko aze aluthobe.

isiphelo

Ngokubanzi, uxinzelelo okanye i-cortisol yihomoni efunwa ngumzimba ukuze usebenze ngokuchanekileyo. Uxinzelelo olungapheliyo emzimbeni oluvela kuxinzelelo olwahlukeneyo lunokubangela ukungasebenzi kakuhle kwemetabolism efana ne-hypothyroidism, ukufumana ubunzima, ukunganyangeki kwe-insulin, kunye nesifo se-metabolic, ukubiza ezimbalwa. Uxinzelelo olungapheliyo lunokubangela ukuphazamiseka kokulala kuba i-axis ye-HPA ifakwe intambo kwaye inokubonakala ngathi izolile kancinci. Xa abantu beqala ukufumana iindlela zokujongana naba baxinzelelo bahlukeneyo, banokunciphisa amanqanaba abo oxinzelelo babuyele kwisiqhelo kwaye bangabi noxinzelelo.

 

Ucaphulo

Jones, uCarol, kunye noChristopher Gwenin. "Inqanaba leCortisol Dysregulation kunye nokuBanda kwayo-Ngaba yiwotshi yeAlam yeNdalo?" Iingxelo zePhysical, John Wiley and Sons Inc., Jan. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC7749606/.

McEwen, uBruce S. "Iimpembelelo eziPhakathi zeHormones zoxinzelelo kwiMpilo kunye neSifo: Ukuqonda iZiphumo eziKhuselayo kunye nezonakalisayo zoxinzelelo kunye nabalamli boxinzelelo." I-European Journal ye-Pharmacology, ILayibrari yeSizwe yezeMithi yase-US, nge-7 Epreli 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2474765/.

McEwen, Bruce S. “Uxinzelelo okanye Uxinzelelo: Yintoni Umahluko?” Ijenali yengqondo kunye neNeuroscience: JPN, ILayibrari yeSizwe yezeMithi yase-US, ngo-Septemba 2005, www.ncbi.nlm.nih.gov/pmc/articles/PMC1197275/.

URodriquez, uErik J, kunye nabanye. "Umthwalo we-Allostatic: Ukubaluleka, abaMakishi, kunye nokuMiselwa kwaManqaku kuBantu abaNcinci kunye noMahluko." Ijenali yeMpilo yeDolophu: Incwadana yeNew York Academy of Medicine, Springer US, Matshi 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6430278/.

UThau, uLauren, kunye nabanye. "IPhysiology, Cortisol-Statpearls-NCBI Bookshelf." Ku: StatPearls [Internet]. Isiqithi saseTreasure (FL), StatPearls Publishing, 6 Septemba 2021, www.ncbi.nlm.nih.gov/books/NBK538239/.

Oselula, uSimon N. “L-Tyrosine ukuthomalalisa iimpembelelo zoxinzelelo?” Ijenali yengqondo kunye neNeuroscience: JPN, ILayibrari yeSizwe yaseMelika yoNyango, ngoMeyi 2007, www.ncbi.nlm.nih.gov/pmc/articles/PMC1863555/.

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