ClickCease
+ 1-915-850-0900 spinedoctors@gmail.com
Khetha Page

Ukuzila

Iqela lezonyango eliSebenzayo leKlinikhi yokuQala. Ukuzila ukutya kukuzila ukutya okanye ukuncitshiswa kokunye okanye konke ukutya, iziselo, okanye zombini kangangexesha elithile.

  • I-Absolute okanye ukukhawuleza ngokukhawuleza ngokuqhelekileyo kuchazwa njengento yokuzibamba kuzo zonke ukutya kunye ne-liquid kwixesha elichaziweyo.
  • Iti kunye nekhofi emnyama ingatyiwa.
    Ukuzila kwamanzi kuthetha ukungabikho kuzo zonke ukutya nokusela kuphela ngaphandle kwamanzi.
  • Ukutya kunokufikelela kwimida okanye kungabinqanda, ukunciphisa izinto okanye ukutya okuthe ngqo.
  • Kwimeko ye-physiological, inokubhekisa kwisimo somntu ongakhange atye okanye kwimeko ye-Metabolic.
  • Utshintsho lweemetabolic lwenzeka ngexesha lokuzila.

Umzekelo: umntu ukholelwa ukuba uyazila ukutya emva kweeyure ze-8-12 ezidlulileyo ukususela kwisidlo sazo sokugqibela.

Utshintsho lwe-Metabolic ukusuka kwimeko ekhawulezayo luqala emva kokufunxwa kwesidlo, ngokuqhelekileyo iiyure ezingama-3-5 emva kokutya.

Izinzuzo zezeMpilo:

  • Ukukhuthaza ukuLawula i-Blood Sugar Control
  • Ukulwa nokuvutha
  • Ukuphucula impilo yeNtliziyo
  • Triglycerides
  • Amanqanaba e-Cholesterol
  • Ukuthintela izifo ezibangelwa yi-Neurodegenerative Disorders
  • Ukwandisa ukuKhuselwa kweHormone Secretion
  • Metabolism
  • Ukuhla ukusinda
  • Amandla oMzimba

Iintlobo zokutya:

  • Ukukhawuleza kokuxilonga kuthetha ukusuka kwiiyure ze-8-72 (kuxhomekeke kwiminyaka) eqhutywe phantsi koqwalaselo ukuququzelela uphando lweengxaki zempilo, ezifana ne-hypoglycemia.
  • Uninzi lweentlobo zokuzila zenziwa kwiiyure ezingama-24 ukuya kwezingama-72
  • Izibonelelo zempilo zandisa ukwehla kobunzima
  • Ubungcono bobuchopho busebenza.
  • Abantu banokuzila ngokukhawuleza njengenxalenye yenkqubo yonyango okanye vavanyo, njenge-colonoscopy okanye ukusebenza.
  • Ekugqibeleni, inokuba yinxalenye yesiko.

Iimvavanyo zokuxilonga ziyafumaneka ukuze zichonge imeko yokukhawuleza.


Ukuzila ukutya kuyichaphazela njani impilo ye-Digestive kwi-Neurology eSebenzayo

Ukuzila ukutya kuyichaphazela njani impilo ye-Digestive kwi-Neurology eSebenzayo

Impilo yethu yokwetyisa ixhomekeke ekwakhiweni kwe-microbiome yethu esempilweni yamathumbu okanye iibhaktheriya kwiphecana lethu lesisu (GI). Le probiotic iprofayili idlala indima ebalulekileyo kumajoni ethu omzimba kwaye ezi zinokuchaphazela impendulo yethu yokuvuvukala. Kwakhona, ukutya esikutyayo, iihomoni, ii-neurotransmitters, kunye nesimo sethu se-adrenal kunye ne-mitochondrial sinokuchaphazela impilo yethu yokugaya. Iibhaktheriya ezingaqhelekanga okanye ezigqithisileyo zinokubangela imiba emininzi yempilo yokwetyisa. Abaphandi kunye nabasebenzi bezempilo baye bafumanisa ukuba "ukuzila ukutya" kunokunceda ukukhuthaza i-microbiome ye-gut enempilo kunye nokuxhasa impilo yonke yokugaya. �

 

Izifundo ezininzi zibonise ukuba ukusebenzisa ifayibha eyaneleyo kunye nokutya okonyusa inani lebhaktheriya kwiphecana lesisu (GI) linxulunyaniswa nokuphuculwa kobuntununtunu be-insulin kunye nokunciphisa ukusabela komzimba kunye nokudumba, phakathi kwezinye izibonelelo zempilo. Olu phononongo lunye lukwabonise ukuba ukuzila ukutya kunokuba nezi zibonelelo zempilo ezifanayo. Iindidi ezahlukeneyo zokuzila zingasetyenziselwa njengendlela yonyango kwimiba eyahlukeneyo yempilo yokugaya. Ngokwenyani, ezinye izifundo zibonise ukuba ukuzila ukutya kunokuncedisa ekuphuculeni imiba yempilo yokwetyisa njenge-SIBO, i-IBS, kunye namathumbu avuzayo. �

 

Uvavanyo lokuKhawulezisa kunye nokuPhilisa ukutya

UMike Hoaglin, owayesakuba ngumlawuli weklinikhi kumboniso kaDkt Oz kunye nokukhokela kweklinikhi yangoku kwi-uBiome, inkampani ye-biotechnology enceda abaqeqeshi bezempilo kunye nezigulane ziqonde indlela i-gut microbiome echaphazela ngayo impilo yonke kunye nokuphila kakuhle, ibonise ukubaluleka kweebhaktheriya kwisisu sethu (GI). ) iphecana ngokwabelana ngesiphumo sovavanyo azame ngalo kuye. Iinkampani ze-Biotechnology ezifana ne-uBiome zinokumisela iphrofayili yeprobiotic yesigulane, kubandakanywa "impilo" kunye ne-pathogenic microorganisms ezinokudityaniswa nemiba yempilo yokugaya njenge-Crohn's disease kunye ne-ulcerative colitis. �

 

Emva kokufunda indlela ukuzila ukutya okunokunceda ngayo ekuphuculeni amajoni akho omzimba, kusebenze iiseli ze-stem, kunye nokunciphisa umngcipheko wokuba neentlobo ezininzi zomhlaza, uMike wakhuthazeka ukuba azenzele amanzi eentsuku ezintlanu ngokukhawuleza ukuze abone ukuba le ndlela yokutya inokubachaphazela njani amathumbu akhe. microbiome. Kwakhona waphefumlelwa ukuba azi ukuba ukuzila ukutya kunokuchaphazela njani amanqanaba akhe amandla kunye nobukrelekrele bakhe bengqondo kunye nenkungu yobuchopho. Ngokuthumela isampuli ye-stool, wamisela i-spectrum yebhaktheriya kwi-gastrointestinal (GI) iphecana ngaphambi kokuba aqalise inkqubo yokuzila. UMike Hoaglin wayephantsi kweliso likagqirha wakhe osebenzayo. �

 

Ukuqonda Iziphumo zokuzila ukutya

Ngokweziphumo zovavanyo lweprofayili ye-uBiome yeprobiotic, uMike wayene-dysbiosis, ukungalingani ekubunjweni kwe-gut microbiome ehambelana nokuncipha kwezinto eziphilayo zebhaktheriya "ephilileyo" kunye nokwanda kweebhaktheriya "eziyingozi" ezaziwa ngokubangela ukuvutha. UMike Hoaglin ucwangcise iintsuku ezintlanu kwishedyuli yakhe ukuba aqale inkqubo yokuzila ukutya emva kokuba ethethe nogqirha wakhe osebenzayo. Njengoko abantu abaninzi beye bachaza kwiintsuku ezimbalwa zokuqala zokuzila ukutya, uMike wayenexesha elinzima kakhulu lokungatyi ukutya. Wachaza ukuba wayeziva enomsindo kwaye elambile, nangona kunjalo, wayekwazi ukulala. �

 

Ukulamba kukaMike kuye kwadamba ngombulelo ngosuku lwesithathu lwenkqubo yokuzila ukutya kwaye, nangona wayeseneentsuku ezininzi ezishiyekileyo kwindlela yonyango, wayeqonda ukuba yonke inkqubo yokuzila ayizukuba ngumceli mngeni njengoko bekunjalo okokuqala. iintsuku ezimbini, nangona iswekile yegazi lakhe, okanye iswekile, iphantsi. UMike Hoaglin waziva enyuka kumanqanaba akhe amandla ngosuku lwesine lwenkqubo yokuzila ukutya. Waziva ecaca ngakumbi engqondweni njengoko inkqubo yakhe yokwetyisa yayiqalisa ukusebenzisa amafutha njengamandla endaweni yokusebenzisa iswekile, okanye iswekile. Ngokukhawuleza waqaphela ukuba iiseli zakhe ze-stem zasebenza ngexesha leentsuku ezine zenkqubo yokuzila. �

 

UMike wayigqiba inkqubo yokuzila ukutya ngosuku lwesihlanu ngentsimbi yesi-5:00 emva kwemini ngokutya ikomityi yomhluzi wamathambo. Umhluzi wethambo lolunye uhlobo olucetyiswayo lokutya ekuncedeni abantu ukuba baguquke ekuzileni ngenxa yokuba i-amino acids ebalulekileyo, njenge-glutamine kunye ne-glycine, ebonelela ngesondlo kwi-gastrointestinal (GI) iphecana ngokukhawuleza xa iqala ukugaya ukutya kwakhona. Ngaphezu koko, ukongeza ityuwa ye-Himalayan kumhluzi wethambo lakho kunokubonelela ngeeseli zakho ngeeminerali ezongeziweyo. UMike uqhubekile nokutshintsha ekuzileni ukutya ngokutya ukutya okutyebileyo kwezityalo, amafutha asempilweni, kunye nenani elincinci leprotheyini ebhityileyo, kwiinguqu ezinokutya lula. �

 

UMike Hoaglin wavavanya i-microbiome yakhe yamathumbu kulandela inkqubo yakhe yokuzila ukutya kwaye wothuswa luvuyo ngamanyathelo esiphumo seprofayile yakhe yeprobiotic. Ngokovavanyo lwe-uBiome, ukuzila ukutya kuye “kwaseta ngokutsha” i-Mike's gut microbiome, okanye ibhaktheriya ekwiphecana lesisu (GI). Iziphumo zabonisa ukubunjwa okulinganayo kwe-gut microbiome yakhe kwaye wonyusile i-biodiversity yeebhaktheriya "eziphilileyo" kwaye wehla ibhaktheriya "eyingozi". Emva kokugqiba uvavanyo lwakhe, uMike Hoaglin uye waqonda ngakumbi ukuba uhlobo lokutya esikutyayo lunokuchaphazela njani impilo yethu yokwetyisa. �

 

UGqr Alex Jimenez i-Insights Image

Ukuzila ukutya kuyaziwa, yindlela yokutya eyaziwayo, enokuba neendlela ezahlukeneyo zokutya emzimbeni kubantu abaninzi. Abantu abaninzi banokungenelwa kakhulu ngokuzila ukutya. Ukuzila ukutya kungasebenza i-autophagy, okanye inkqubo yendalo yokukhupha iseli, ukunceda ukutshayela iibhaktheriya ezigqithileyo kunye nokutya okungafunekiyo okuphelisiweyo njengenkunkuma, nokwenza iinkqubo ezichasayo zokunciphisa ukuvuvukala noxinzelelo lwe-oxidative. Ngexesha lovavanyo, ukuzila ukutya kwaboniswa ukuba nezibonelelo ezinkulu kwimpilo yokugaya ukutya ngokubanzi. Nangona kunjalo, kubalulekile ukukhumbula ukuba ukuzila ukutya kunokungabi kuko kumntu wonke. Qinisekisa ukuba uthetha nogqirha ofanelekileyo kunye namava ngaphambi kokuzama nayiphi na indlela yokuzila. -Gqr. Alex Jimenez DC, CCST Insight

 


 

Ifom yoVavanyo lweNeototransmitter

[wp-embedder-pack width=”100%” height=”1050px” download=“zonke” download-text="” attachment_id=”52657″ /] �

 

Le fom ilandelayo yoVavanyo lweNeurotransmitter inokugcwaliswa ize ingeniswe kuGqirha Alex Jimenez. Ezi mpawu zilandelayo zidweliswe kule fomu azenzelwanga ukuba zisetyenziswe ekuchongeni nasiphi na isifo, imeko, okanye naluphi na uhlobo lomcimbi wezempilo.

 


 

Impilo yethu yokwetyisa ixhomekeke ekwakhiweni kwe-microbiome yethu esempilweni yamathumbu okanye iibhaktheriya kwiphecana lethu lesisu (GI). Le probiotic iprofayili idlala indima ebalulekileyo kumajoni ethu omzimba kwaye ezi zinokuchaphazela impendulo yethu yokuvuvukala. Kwakhona, ukutya esikutyayo, iihomoni, ii-neurotransmitters, kunye nesimo sethu se-adrenal kunye ne-mitochondrial sinokuchaphazela impilo yethu yokugaya. Iibhaktheriya ezingaqhelekanga okanye ezigqithisileyo zinokubangela imiba emininzi yempilo yokwetyisa. Abaphandi kunye nabasebenzi bezempilo baye bafumanisa ukuba "ukuzila ukutya" kunokunceda ukukhuthaza i-microbiome ye-gut enempilo kunye nokuxhasa impilo yonke yokugaya. Uphononongo oluninzi lubonise ukuba ukusebenzisa ifayibha eyaneleyo kunye nokutya okonyusa inani lebhaktheriya kwiphecana lesisu (GI) linxulunyaniswa nokuphuculwa kobuntununtunu be-insulin kunye nokuncipha kokusabela komzimba kunye nokudumba, phakathi kwezinye izibonelelo zempilo. Olu phononongo lunye lukwabonise ukuba ukuzila ukutya kunokuba nezi zibonelelo zempilo ezifanayo. Iindidi ezahlukeneyo zokuzila zingasetyenziselwa njengendlela yonyango kwimiba eyahlukeneyo yempilo yokugaya. Ngokwenyani, ezinye izifundo zibonise ukuba ukuzila ukutya kunokuncedisa ekuphuculeni imiba yempilo yokwetyisa njenge-SIBO, i-IBS, kunye namathumbu avuzayo. �

 

Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic, musculoskeletal, kunye nemicimbi yezempilo yovalo okanye amanqaku amayeza asebenzayo, izihloko kunye neengxoxo. Sisebenzisa iiprothokholi zempilo ezisebenzayo ukunyanga ukwenzakala okanye ukuphazamiseka kwenkqubo yemusculoskeletal. Iofisi yethu yenze umzamo oqinisekileyo wokubonelela ngezikhokelo ezixhasayo kwaye ichonge isifundo sophononongo esifanelekileyo okanye izifundo ezixhasa izithuba zethu. Sikwenza iikopi zezifundo zophando ezixhasayo ziya kufumaneka ebhodini okanye kuluntu xa luceliwe. Ukuqhubeka nokuxoxa ngomxholo ongentla, nceda ukhululeke ukubuza uGqirha Alex Jimenez okanye unxibelelane nathi apha 915-850-0900.

 

Ikhethwe nguGqirha Alex Jimenez

 

Iingxelo:

  • �Ifuthe lokuzila ukutya kwiMicrobiome yakho.� UNahomi Whittel, Nge-12 Matshi 2019, www.naomiwhittel.com/the-impact-of-fasting-on-your-microbiome/.

 


 

Isihloko esongezelelweyo seNgxoxo: kubuhlungu obungapheliyo

Intlungu engxamisekileyo yimpendulo yendalo yenkqubo yemithambo-luvo enceda ukubonisa ukwenzakala okunokwenzeka. Umzekelo, iimpawu zentlungu zihamba zisuka kwingingqi eyenzakeleyo ngeemithambo kunye nentambo yomqolo ukuya kwingqondo. Ubuhlungu ngokubanzi buba ngaphantsi kokulimala, nangona kunjalo, iintlungu ezingapheliyo zihlukile kunohlobo lwentlungu. Ngentlungu engapheliyo, umzimba womntu uya kuqhubeka uthumela imiqondiso yeentlungu kwingqondo, nokuba umonzakalo uphilile. Intlungu engapheliyo inokuhlala iiveki ezininzi ukuya kwiminyaka eliqela. Iintlungu ezingapheliyo zinokuchaphazela kakhulu ukuhamba kwesigulana kwaye zinokunciphisa ukuguquguquka, ukomelela kunye nonyamezelo.

 

 


 

I-Neural Zoomer Plus yesifo seNeological

I-Neural Zoomer Plus | El Paso, TX Chiropractor

 

Ugqirha Alex Jimenez usebenzisa uthotho lovavanyo ukunceda ukuvavanya izifo ze-neurological. I-Neural ZoomerTM Ukudibana kuluhlu lwee autoantibodies ze-neurological ezinikezela ukwamkelwa okuthile kwe-anti-to-antigen. I-Vulrant Neural ZoomerTM Ukudibanisa kuyilelwe ukuvavanya ukwenziwa kwakhona kwe-antigen ye-48 ye-neurological antigens ngokudibana nezifo ezahlukeneyo ezinxulumene nonyango. IVibrant Neural ZoomerTM Kwaye kujolise ekunciphiseni iimeko zemithambo-luvo ngokuxhobisa abaguli kunye noogqirha ngesixhobo esibalulekileyo sokufumana umngcipheko kwangoko kunye nokugxininiswa okuphuculweyo kuthintelo olusisiseko lomntu.

 

Ubuntununtunu bokutya kwiMpendulo ye-IgG kunye ne-IgA ye-immune

Ukutyiswa kokutya iZoomer | El Paso, TX Chiropractor

 

Ugqirha Alex Jimenez usebenzisa uthotho lovavanyo ukunceda ukuvavanya imiba yezempilo ehambelana neemvakalelo zokutya. I-Zoenser yokutyaTM luluhlu lwe-180 iantianti zokutya ezisetyenziswa ngokuxhaphakileyo ezibonelela ngokubonakalayo kwe-anti-to-antigen. Eli phaneli lilinganisela ubuntununtunu bomntu ngamnye be-IgG kunye ne-IgA kwiimvakalelo zokutya. Ukukwazi ukuvavanya ii-antibodies ze-IgA kubonelela ngolwazi olongezelelekileyo kukutya okunokubangela ukonakala kwe-mucosal. Ukongeza, olu vavanyo lulungile kwizigulana ezinokuthi zihlupheke ngenxa yokulibaziseka kokuphendula kukutya okuthile. Sebenzisa uvavanyo lokuvavanywa kokutya okusekwe kwi-antibody kunokunceda ekubekeni phambili ukutya okuyimfuneko ukuphelisa kunye nokwenza isicwangciso sokutya esenziwe ngokwezifiso kwiimfuno ezithile zesigulana.

 

I-Gut Zoomer ye-Intestinal encinci ye-bacterial overgrowth (SIBO)

IGut Zoomer | El Paso, TX Chiropractor

Ugqirha Alex Jimenez usebenzisa uthotho lweemvavanyo ukunceda ekuvavanyeni impilo ye-gut enxulunyaniswa nokugcwala kwamathumbu esibeleko (SIBO). I-Vulrant Gut ZoomerTM inikeza ingxelo equka iingcebiso zokutya kunye nezinye izongezo zendalo ezifana ne-prebiotics, iprobiotics kunye neepolphenhen. I-gut microbiome ifunyenwe ikakhulu emathunjini amakhulu kwaye ineentlobo ezingaphezu kwe-1000 zeebhaktheriya ezidlala indima ebalulekileyo emzimbeni womntu, ekubumbeni amajoni omzimba kunye nokuchaphazela imetabolism yezakha mzimba ukomeleza isithintelo samathumbu emathunjini (isithintelo samathumbu) ). Kubalulekile ukuba uqonde ukuba inani leebhaktiriya ezihlala kwisisu somntu (GI) lichaphazela njani impilo yezisu kuba ukungalingani emathunjini e-microbiome kunokukhokelela kwisifo se-gastrointestinal (GI), imeko zolusu, ukuphazamiseka komzimba, ukungalingani kwamasosha omzimba. , kunye nokuphazamiseka okuninzi kokudumba.

 


Iilebhu zeDunwoody: ISixol esigcweleyo ngeParasitology | El Paso, TX Chiropractor


I-GI-MAP: I-GI Microbial Assay Plus | El Paso, TX Chiropractor


 

Iifomu zeNkxaso yeMethylation

I-Xymogen Ifomu - El Paso, TX

 

XYMOGEN's Iifomula zeeNgqungquthela zodwa zifumaneka ngokukhetha abaqeqeshi bezempilo abanemvume. Intengiso ye-intanethi kunye nokuhlaziywa kwamafomula e-XYMOGEN ayinqatshelwe.

 

Ngebhongo, UDkt. Alexander Jimenez yenza i-XYMOGEN ifomula ifumaneka kuphela kwizigulane ezingaphantsi kwethu.

 

Nceda ufonele iofisi yethu ukuze sikwazi ukudlulisela udokotela ngokubonisana nokufikelela ngokukhawuleza.

 

Ukuba uyigulane Unyango lwezoNyango kunye neChiropractic Klinikhi, unokubuza malunga ne-XYMOGEN ngokubiza 915-850-0900.

xymogen el paso, tx

Ukuze ube lula kwaye uhlaziywe XYMOGEN iimveliso nceda uphonononge ikhonkco elilandelayo. *I-XYMOGEN-Inkcazo-umxokozelo

 

* Zonke iinkqubo ze-XYMOGEN ezingentla zihlala zisebenza ngokuthe ngqo.

 


 

Umsebenzi we-Neurology: Ukuzila ukutya kunye ne-Autophagy ye-Digestive Health

Umsebenzi we-Neurology: Ukuzila ukutya kunye ne-Autophagy ye-Digestive Health

Izazinzulu kunye noochwephesha bezempilo baqala ukukhanya ukukhanya ngokubaluleka kokudalwa kwe-gut micobiome yethu, okanye ukubakho kweebacteria "ezisempilweni" kwiphecana lethu lesisu (GI). Ngokwezifundo zophando, i-bacterial gut engaqhelekanga okanye egqithisileyo inokuba sesinye sezizathu ezibangelwa zizinto ezahlukeneyo zempilo yokutya, kubandakanya i-SIBO kunye ne-IBS. Ookhokho bethu baquke ukutya okuneswekile njengeyogathi, i-kimchi, kunye ne-sauerkraut njengenxalenye ebalulekileyo yokutya kwabo kwendalo nokulawula ukwakhiwa kweebhaktheriya zabo "ezisempilweni": yintsholongwane.

 

Ukufumana iindlela zokuphucula ngokwemvelo impilo yethu yokugaya ngokugcina iphrofayili "enempilo" yeprobiotic ibe yisihloko esithandwayo kwizizukulwana ezininzi. Ngenxa yoko, ukutya ukutya okunegwele okufana noko kudweliswe ngasentla, kubandakanywa namanye amaqela okutya aneeprobiotics ezongezelelweyo, kunye nokuthatha izongezo zeprobiotic kuye kwanda kakhulu ekuthandeni kwiminyaka yakutshanje. Enye indlela yokuphucula ngokwendalo impilo yokugaya esanda kuthandwa kakhulu kukuzila ukutya, ukuzila ukutya okucwangcisekileyo okanye ukunciphisa ukutya okuninzi okanye konke ngexesha elithile. Ukuzila ukutya kunokunceda ekugqibeleni ukuphucula impilo yonke yokugaya. �

 

Ukuzila ukutya kunokunceda ukuxhasa ukubunjwa okunempilo kwe-gut microbiome yethu kwaye inokusetyenziswa njengendlela yonyango kwiimeko ezahlukeneyo kunye nezifo, ezifana nentloko, i-migraines, i-eczema, i-metabolic syndrome, kunye nokukhuluphala. Izazinzulu kunye nabasebenzi bezempilo bagqibe kwelokuba ukuzila ukutya kunokugxininisa umzimba womntu ngendlela enenzuzo. Olu xinzelelo lunceda iibhaktheriya ezisempilweni kwiphecana lesisu (GI) kuba inceda ukwenza i-autophagy okanye inkqubo yendalo yokukhutshwa kweseli. Kwinqaku elilandelayo, siza kuxubusha indlela ukuzila ukutya kunye ne-autophagy kunokukhuthaza impilo yokugaya. �

 

Ukuzila ukutya kunye nokujonga kwakhona

Iphecana lethu le-gastrointestinal (GI) lihlala linomsebenzi onzima wokuzama ukulungisa iiseli zethu ngelixa sitshayela inkunkuma engagatywanga ukuze isuse njengenkunkuma kuba abantu abaninzi bahlala besitya imini yonke. Abantu abaninzi bachasene ngokupheleleyo nombono wokuzila ukutya, okanye ngokuvumayo ukutsiba isidlo esinye okanye ezibini ngosuku, nangona izibonelelo zayo ngokubhekiselele kwimpilo yethu yokugaya. Ngenxa yokuba kukho iindlela ezahlukeneyo kunye nobuchule bokuzila ukutya, abantu abaninzi banokulandela le ndlela yokutya kwaye bathathe inzuzo yazo zonke izibonelelo zempilo yokugaya. Ukuzila ukutya, nangona kunjalo, ekugqibeleni akunakuba ngumntu wonke. �

 

Ngokwembali, uninzi lwezenzo zonqulo nezokomoya zisebenzisa ukuzila ukutya njengento ebalulekileyo kwinkcubeko yabo ukukhuthaza impilo yonke yokugaya. Okwangoku kukho iindlela ezahlukeneyo zokuzila ukutya kunye neendlela ezisetyenziselwa ukuxhasa inhlalakahle yendalo. Ngaphezu koko, izibonelelo zonyango lokuzila ukutya ngoku zibonwa ngokulula kwizifundo ezininzi zophando. Iindidi ezahlukeneyo zokuzila zingahluka ekugqibeleni ekutyeni okuncinci okanye akukho nto ngexesha elithile lokusela amanzi kuphela ixesha elithile, ngamanye amaxesha ukuya kwiintsuku ezintlanu, njengendlela yokuphucula ngokwemvelo impilo yokugaya. �

 

Ukuzila ukutya okwethutyana, indlela ecwangcisiweyo yokutya elandela ukutshintsha phakathi kokutya okungathintelwanga kunye nokutya okuthintelweyo kangangexesha elithile, yenye yezona ndlela ziqhelekileyo nezisebenzayo zokuzila ukutya kuye wonke umntu. Izazinzulu zijonga ukuzila ukutya okwethutyana kukhuselekile kwaye kuyasebenza kuba uhamba ungatyi nakuphi na ukutya ixesha elifutshane. Uphononongo lophando lubonise ukuba ukusebenzisa ukuzila ukutya okuziiyure ezili-16 yonke imihla kwanele ukwenza isithintelo sekhalori esiyimfuneko ukuze ufumane izibonelelo zokuzila ukutya kunye nokuvula i-autophagy ukunceda ukubuyisela impilo yokwetyisa. �

 

Ukutya okusisi-5:2 yindlela ecwangcisiweyo yokutya apho umntu atya umndilili wokutya kangangeentsuku ezintlanu aze anciphise kakhulu ukutya akutyayo aye kwikota enye yoko kutya kwakhe kwesiqhelo kwezinye iintsuku ezimbini zeveki. Yonke indlela yokuzila ukutya yahlukile kodwa injongo yokuyeka okanye ukunciphisa ukutya kukunika i-microbiome yethu yamathumbu ikhefu kwi-digestion ukuze bakwazi ukugxila ekulungiseni iiseli zethu ngelixa betshayela i-debrid engagxumekiyo kunye neebhaktheriya ezingaphezulu ukuze ziphelise njengenkunkuma. Izifundo zophando zibonisa ukuba ukutya kwe-16:8 inokuba yeyona ndlela ilula yokuzila ukutya okanye ubuchule ekufuneka abantu babulandele. �

 

Ukukhawuleza kunye ne-Autophagy Inkxaso yezeMpilo yokutya

I-pancreas yethu idla ngokubangela ukukhutshwa kweglucagon xa sine-glucose ephantsi yegazi ngelixa ukukhutshwa kwe-insulin kubangelwa ukunceda ukunciphisa amanqanaba aphezulu e-glucose yegazi. I-insulin iyancipha kwaye i-glucagon iyanda ngexesha lokuzila ukutya okuye kwaboniswa ukunceda ukukhuthaza ukuphuculwa kwemetabolism kunye nokubonelela ngamandla, ukuguquka kwemizwelo, kunye nokulahlekelwa kwesisindo. Ukuzila ukutya kwakhona kunceda ukukhuthaza ukubunjwa "okunempilo" kwe-gut microbiome yethu okanye inani lebhaktheriya "ephilileyo" kwiphecana lethu lesisu (GI). Iingcali zenzululwazi ziye zadibanisa ukuzila kunye nokusebenza kwejini exhasa impilo yonke yokugaya. �

 

Impilo egqibeleleyo yokwetyisa kunye neebhaktheriya zamathumbu “ezisempilweni” zibalulekile ekusincedeni ukusikhusela kwiibhaktheriya ezingaqhelekanga okanye ezigqithisileyo, ityhefu, kunye nezinye izinto ezinokuthi ziqalise amajoni omzimba. Ekugqibeleni, ukuzila ukutya kunokuncedisa ukubuyisela ingqibelelo yamathumbu emathunjini ngokulawula ukuvuvukala okunokuthi ekugqibeleni kuncede ukukhusela umzimba womntu ngokuchasene neemeko ezahlukeneyo kunye nezifo ezinxulumene nokuvuvukala. Inzuzo ephambili yokuzila ukutya kukuba inokunyusa i-autophagy okanye inkqubo yendalo ye-cellular detoxification. Ngokuzila ukutya, impilo yamathumbu akho iyaphucuka kwaye unciphisa umngcipheko wakho kwimiba eyahlukeneyo yempilo yokugaya. �

 

UGqr Alex Jimenez i-Insights Image

Ukuzila ukutya kuyaziwa, yindlela yokutya eyaziwayo, enokuba neendlela ezahlukeneyo zokutya emzimbeni kubantu abaninzi. Abantu abaninzi banokungenelwa kakhulu ngokuzila ukutya. Ukuzila ukutya kungasebenza i-autophagy, okanye inkqubo yendalo yokukhupha iseli, ukunceda ukutshayela iibhaktheriya ezigqithileyo kunye nokutya okungafunekiyo okuphelisiweyo njengenkunkuma, nokwenza iinkqubo ezichasayo zokunciphisa ukuvuvukala noxinzelelo lwe-oxidative. Nangona kunjalo, kubalulekile ukukhumbula ukuba ukuzila ukutya kunokungabi kuko kumntu wonke. Qinisekisa ukuba uthetha nogqirha ofanelekileyo kunye namava ngaphambi kokuzama nayiphi na indlela yokuzila. -Gqr Alex Jimenez DC, CCST Insight

 


 

Ifom yoVavanyo lweNeototransmitter

[wp-embedder-pack width=”100%” height=”1050px” download=“zonke” download-text="” attachment_id=”52657″ /] �

 

Le fom ilandelayo yoVavanyo lweNeurotransmitter inokugcwaliswa ize ingeniswe kuGqirha Alex Jimenez. Ezi mpawu zilandelayo zidweliswe kule fomu azenzelwanga ukuba zisetyenziswe ekuchongeni nasiphi na isifo, imeko, okanye naluphi na uhlobo lomcimbi wezempilo.

 


 

Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic, musculoskeletal, kunye nemicimbi yezempilo yovalo okanye amanqaku amayeza asebenzayo, izihloko kunye neengxoxo. Sisebenzisa iiprothokholi zempilo ezisebenzayo ukunyanga ukwenzakala okanye ukuphazamiseka kwenkqubo yemusculoskeletal. Iofisi yethu yenze umzamo oqinisekileyo wokubonelela ngezikhokelo ezixhasayo kwaye ichonge isifundo sophononongo esifanelekileyo okanye izifundo ezixhasa izithuba zethu. Sikwenza iikopi zezifundo zophando ezixhasayo ziya kufumaneka ebhodini okanye kuluntu xa luceliwe. Ukuqhubeka nokuxoxa ngomxholo ongentla, nceda ukhululeke ukubuza uGqirha Alex Jimenez okanye unxibelelane nathi apha 915-850-0900.

 

Ikhethwe nguGqirha Alex Jimenez

 

Iingxelo:

  • �Ifuthe lokuzila ukutya kwiMicrobiome yakho.� UNahomi Whittel, Nge-12 Matshi 2019, www.naomiwhittel.com/the-impact-of-fasting-on-your-microbiome/.

 


 

Isihloko esongezelelweyo seNgxoxo: kubuhlungu obungapheliyo

Intlungu engxamisekileyo yimpendulo yendalo yenkqubo yemithambo-luvo enceda ukubonisa ukwenzakala okunokwenzeka. Umzekelo, iimpawu zentlungu zihamba zisuka kwingingqi eyenzakeleyo ngeemithambo kunye nentambo yomqolo ukuya kwingqondo. Ubuhlungu ngokubanzi buba ngaphantsi kokulimala, nangona kunjalo, iintlungu ezingapheliyo zihlukile kunohlobo lwentlungu. Ngentlungu engapheliyo, umzimba womntu uya kuqhubeka uthumela imiqondiso yeentlungu kwingqondo, nokuba umonzakalo uphilile. Intlungu engapheliyo inokuhlala iiveki ezininzi ukuya kwiminyaka eliqela. Iintlungu ezingapheliyo zinokuchaphazela kakhulu ukuhamba kwesigulana kwaye zinokunciphisa ukuguquguquka, ukomelela kunye nonyamezelo.

 

 


 

I-Neural Zoomer Plus yesifo seNeological

I-Neural Zoomer Plus | El Paso, TX Chiropractor

Ugqirha Alex Jimenez usebenzisa uthotho lovavanyo ukunceda ukuvavanya izifo ze-neurological. I-Neural ZoomerTM Ukudibana kuluhlu lwee autoantibodies ze-neurological ezinikezela ukwamkelwa okuthile kwe-anti-to-antigen. I-Vulrant Neural ZoomerTM Ukudibanisa kuyilelwe ukuvavanya ukwenziwa kwakhona kwe-antigen ye-48 ye-neurological antigens ngokudibana nezifo ezahlukeneyo ezinxulumene nonyango. IVibrant Neural ZoomerTM Kwaye kujolise ekunciphiseni iimeko zemithambo-luvo ngokuxhobisa abaguli kunye noogqirha ngesixhobo esibalulekileyo sokufumana umngcipheko kwangoko kunye nokugxininiswa okuphuculweyo kuthintelo olusisiseko lomntu.

 

Ubuntununtunu bokutya kwiMpendulo ye-IgG kunye ne-IgA ye-immune

Ukutyiswa kokutya iZoomer | El Paso, TX Chiropractor

Ugqirha Alex Jimenez usebenzisa uthotho lovavanyo ukunceda ukuvavanya imiba yezempilo ehambelana neemvakalelo zokutya. I-Zoenser yokutyaTM luluhlu lwe-180 iantianti zokutya ezisetyenziswa ngokuxhaphakileyo ezibonelela ngokubonakalayo kwe-anti-to-antigen. Eli phaneli lilinganisela ubuntununtunu bomntu ngamnye be-IgG kunye ne-IgA kwiimvakalelo zokutya. Ukukwazi ukuvavanya ii-antibodies ze-IgA kubonelela ngolwazi olongezelelekileyo kukutya okunokubangela ukonakala kwe-mucosal. Ukongeza, olu vavanyo lulungile kwizigulana ezinokuthi zihlupheke ngenxa yokulibaziseka kokuphendula kukutya okuthile. Sebenzisa uvavanyo lokuvavanywa kokutya okusekwe kwi-antibody kunokunceda ekubekeni phambili ukutya okuyimfuneko ukuphelisa kunye nokwenza isicwangciso sokutya esenziwe ngokwezifiso kwiimfuno ezithile zesigulana.

 

I-Gut Zoomer ye-Intestinal encinci ye-bacterial overgrowth (SIBO)

IGut Zoomer | El Paso, TX Chiropractor

 

Ugqirha Alex Jimenez usebenzisa uthotho lweemvavanyo ukunceda ekuvavanyeni impilo ye-gut enxulunyaniswa nokugcwala kwamathumbu esibeleko (SIBO). I-Vulrant Gut ZoomerTM inikeza ingxelo equka iingcebiso zokutya kunye nezinye izongezo zendalo ezifana ne-prebiotics, iprobiotics kunye neepolphenhen. I-gut microbiome ifunyenwe ikakhulu emathunjini amakhulu kwaye ineentlobo ezingaphezu kwe-1000 zeebhaktheriya ezidlala indima ebalulekileyo emzimbeni womntu, ekubumbeni amajoni omzimba kunye nokuchaphazela imetabolism yezakha mzimba ukomeleza isithintelo samathumbu emathunjini (isithintelo samathumbu) ). Kubalulekile ukuba uqonde ukuba inani leebhaktiriya ezihlala kwisisu somntu (GI) lichaphazela njani impilo yezisu kuba ukungalingani emathunjini e-microbiome kunokukhokelela kwisifo se-gastrointestinal (GI), imeko zolusu, ukuphazamiseka komzimba, ukungalingani kwamasosha omzimba. , kunye nokuphazamiseka okuninzi kokudumba.

 


Iilebhu zeDunwoody: ISixol esigcweleyo ngeParasitology | El Paso, TX Chiropractor


I-GI-MAP: I-GI Microbial Assay Plus | El Paso, TX Chiropractor


 

Iifomu zeNkxaso yeMethylation

I-Xymogen Ifomu - El Paso, TX

XYMOGEN's Iifomula zeeNgqungquthela zodwa zifumaneka ngokukhetha abaqeqeshi bezempilo abanemvume. Intengiso ye-intanethi kunye nokuhlaziywa kwamafomula e-XYMOGEN ayinqatshelwe.

Ngebhongo, UDkt. Alexander Jimenez yenza i-XYMOGEN ifomula ifumaneka kuphela kwizigulane ezingaphantsi kwethu.

Nceda ufonele iofisi yethu ukuze sikwazi ukudlulisela udokotela ngokubonisana nokufikelela ngokukhawuleza.

Ukuba uyigulane Unyango lwezoNyango kunye neChiropractic Klinikhi, unokubuza malunga ne-XYMOGEN ngokubiza 915-850-0900.

xymogen el paso, tx

Ukuze ube lula kwaye uhlaziywe XYMOGEN iimveliso nceda uphonononge ikhonkco elilandelayo. *I-XYMOGEN-Inkcazo-umxokozelo

 

* Zonke iinkqubo ze-XYMOGEN ezingentla zihlala zisebenza ngokuthe ngqo.

 


 

Umsebenzi we-Neurology: Inzululwazi yokuzila ukutya kwezeMpilo

Umsebenzi we-Neurology: Inzululwazi yokuzila ukutya kwezeMpilo

Kubantu abaninzi, ukuzila ukutya, okanye ingcamango yokweqa ukutya ngokuzithandela ixesha elithile, kunokungabonakali njengendlela ekhangayo kakhulu yokuphucula impilo yokugaya. Kuba uninzi lwabantu lutya malunga nezidlo ezi-3 ngemini, ukutsiba isidlo esinye okanye ezibini ngemini ekugqibeleni kunokubabangela ukuba bazive bemothukile, bediniwe, kwaye badinwe. Nangona kunjalo, kubantu abanemiba yempilo yokwetyisa, efana ne-SIBO, IBS, okanye amathumbu avuzayo, basenokuba sele beziva ezi mpawu, nasemva kokutya izidlo zabo ezi-3 ngosuku. Kweli nqaku, siza kuxubusha indlela ukuzila ukutya kunokuba luncedo kwezinye izigulana kunye nendlela enokunceda ngayo ekuphuculeni impilo yabo yokugaya. �

 

Ukuqonda iNkqubo yokuDaya

 

Inkqubo yokwetyisa iqala inkqubo yokwaphula ukutya ukususela ekutyeni kwethu ukuze kufunxe izondlo, ezifana neevithamini kunye neeminerali. Inkqubo yokwetyisa iya kusebenzisa malunga neepesenti ezingama-25 zeekhalori esizityayo ukuqalisa inkqubo yokwetyisa. Ukwetyisa ukutya kufuna umgudu omkhulu kumzimba womntu kuba uguqula uninzi lwemisebenzi yawo ephambili kwaye utsale izixhobo ezininzi kude kwezinye izakhiwo ukuze wenze nje. Amajoni omzimba asebenza ngalo lonke ixesha sisitya ukutya ukuze sikhusele isisu, okanye i-GI, iphecana kuyo nantoni na nayo yonke into edlulayo. �

 

Xa uzila ukutya, nangona kunjalo, inkqubo yokugaya ingaqala ukuphilisa kunye nokubuyisela umzimba womntu. Ngexesha lokuzila ukutya, umzimba womntu uya kusebenzisa amafutha endaweni yeswekile njengowona mthombo wamandla ombane. Umntu oqhelekileyo une-2,500 Kcal ye-glycogen kuphela yokuyisebenzisa njenge-glucose yamandla ngelixa umntu oqhelekileyo ene-100,000 Kcal yamafutha ukwenzela amandla. Ngaphezu koko, kunokuthatha ixesha ukuba umzimba womntu ulungelelanise ukusebenzisa amanqatha endaweni yeswekile njengowona mthombo wamandla ombane, yiyo loo nto abantu abaninzi besenokungaziva mnandi de kube ziintsuku ezininzi emva kokuba beqalile ukuzila ukutya. Ukuzila ukutya kunokuba nezinye iingenelo ekugqibeleni. �

 

Ukuvutha

 

Ukuvuvukala yenye yezona zizathu eziphambili zeentlobo ezahlukeneyo zeemeko ezingapheliyo kunye nezifo, kubandakanywa nemiba yempilo yokugaya. Ngokwabaphandi kunye nabasebenzi bezempilo, ukudumba sesona sizathu sixhaphakileyo se-SIBO, ukukhula kwebhaktiriya encinci yamathumbu, i-IBS, isifo se-bowel syndrome, kunye namathumbu avuzayo. Izinto ezisingqongileyo, ezinjengeetyhefu, ukutya okucutshungulwayo, iziyobisi kunye/okanye amayeza, utywala, kunye novelwano lokutya okanye ukunganyamezeli konke kunokubangela ukudumba. Ngaphaya koko, uxinzelelo lunokubangela ukudumba kwaye kunokuchaphazela kakhulu inkqubo yokwetyisa kunye nempilo yonke yokugaya. �

 

Akukho kutya ekugqibeleni kuya kudlula kwi-gastrointestinal, okanye i-GI, iphecana ngexesha lokuzila ukutya. Ngaphandle kwamanzi, ukuzila ukutya kunciphisa ukusetyenziswa kwezixhobo ezivuthayo, ngakumbi ukunciphisa ukuvuvukala emzimbeni womntu. Ii-cytokines ezichasayo zisebenza ngelixa i-cytokines e-pro-ukudumba ingasebenzi xa uzila ukutya. Inkqubo yokwetyisa iyazi xa singatyi kwaye ekugqibeleni iyakubangela olu tshintsho lwesakhiwo kunye nokusebenza. Ukuvuvukala kukwanxulunyaniswa ngokusondeleyo noxinzelelo lwe-oxidative. Uxinzelelo lwe-oxidative kunye nokuvuvukala kunokuchaphazela impilo yethu yonke yokugaya. �

 

Uxinzelelo oluxhasayo

 

Ukuzila ukutya kunokunceda ukunciphisa usulelo kunye noxinzelelo lwe-oxidative ngokusebenzisa iintlobo zethu zemfuza. Uxinzelelo lwe-Oxidative lubhekisa kumonakalo owenzeka kwiiseli kunye nezicubu zomzimba womzimba xa utyhilelwe izinto ezahlukeneyo zezendalo, ezinje ngetyhefu. Iiprotheyini, i-lipids, kunye ne-DNA yeeseli zethu zinokuchaphazeleka kukuvuvukala kunye noxinzelelo lwe-oxidative, ukutshintsha ukwakheka kunye nokusebenza kweeseli. Ukutya ii-antioxidants kunokukunceda ukunciphisa ukuvuvukala kunye noxinzelelo lwe-oxidative. Kubalulekile ukuba uqiniseke ukuba usebenzisa i-antioxidants eyaneleyo xa ungazili ukutya ukuthintela ukonakala kweseli ekuqubukeni kunye noxinzelelo lwe-oxidative.

 

Ukuzila ukutya kunye neMMC yezeMpilo

 

Abaphandi kunye nabasebenzi bezempilo bacebise ukuba uphuhliso lwemiba emininzi yempilo yokugaya, kubandakanya i-SIBO, i-IBS, kunye namathumbu avuzayo, inxulunyaniswa nokwanda kwamanqanaba e-oxidative enzymes kunye nokuncipha kwezixa ze-antioxidant enzymes. Nangona kunjalo, owona mthombo uphambili wale miba yempilo yokwetyisa ekugqibeleni ubandakanya i-gut microbiome okanye ibhaktheriya emathunjini. Ukukhula kwebhaktheriya emathunjini amancinci, okanye i-SIBO, ngumba wezempilo wokwetyisa obangelwa kukukhula okugqithileyo kweebhaktheriya emathunjini amancinci, ekugqibeleni kukhokelela ekuvuzeni kwamathumbu okanye amathumbu amathumbu, phakathi kwezinye iingxaki. �

 

Ngokwezifundo zophando kunye nezilingo zeklinikhi, ukuzila ukutya kunokunceda ukutshintsha abantu be-gut microbiome, ukukhuthaza ukulawulwa kweebhaktheriya "eziphilileyo". Le nkqubo yokwetyisa ekugqibeleni ilawulwa yi-motor complex efudukayo okanye i-MMC. I-MMC yinkqubo yokwetyisa elawula kwaye igcine i-gastrointestinal, okanye i-GI, i-contraction ye-tract kulo lonke ixesha lexesha. Indawo efudukayo yemoto inceda ukutshayela ibhaktheriya kunye nobutyobo obungagaywanga ukuze bususwe njengenkunkuma. Iimpawu ze-Neurohormonal, ezifana ne-somatostatin, i-serotonin, i-motilin, kunye ne-ghrelin, ilawula i-MMC xa isitya kwaye izila ukutya. �

 

Umsebenzi we-MMC uxhokonxa xa sizila ukutya okanye siphakathi kokutya. Nje ukuba sitye ukutya, nangona kunjalo, izondlo ezinjengeevithamini kunye neeminerali zinokuchaphazela ukusebenza kwemoto efudukayo, ekugqibeleni yehle xa umsebenzi we-MMC uqalisa, kwaye ngokusisiseko uqalise inkqubo yokwetyisa kwakhona. Ukuba sivumela i-MMC ukuba igqibezele umsebenzi wayo ngexesha lokuzila ukutya, kunokuba nzima kakhulu ukutya, inkunkuma engagatywanga, kunye neebhaktheriya ezigqithisileyo ukuba zihlale kwi-gastrointestinal, okanye i-GI, iphecana. Yiyo loo nto kukhuthazwa ukuzila ukutya njengonyango lwe-SIBO. Nangona kunjalo, ukuzila ukutya akunakufaneleka kumntu wonke. Nangona ukuzila ukutya kunokuba neenzuzo ezahlukeneyo zempilo yokugaya, qiniseka ukuba uqhagamshelane nogqirha ngaphambi kokuba uqalise nayiphi na isicwangciso sonyango okanye inkqubo. �

 

UGqr Alex Jimenez i-Insights Image

Ukuzila ukutya kuyaziwa, indlela yokutya eyaziwayo, enokuba neendlela ezahlukeneyo zokutya kwempilo yabantu abaninzi. Imiba eliqela yempilo yokugaya ukutya, enjenge-SIBO, IBS, kunye nokuthuka okuvuza, inokuxhamla kakhulu ngokuzila ukutya. Ukuqunjelwa sisibalo esincinci samathumbu, okanye i-SIBO, yinto enzima yezempilo ebangela ukuba iibacteria ezigqithisileyo zikhulele emathunjini amancinci. Ukuzila ukutya kungakhuthaza ukufuduka kwemoto yokufuduka, okanye iMMC, ukwenza ukuba kusebenze, ukutshayela iibhaktheriya ezingaphezulu kunye nokugcwala okungafakwanga ukungcola njengenkunkuma, kukwabangela iinkqubo ezichasene nosulelo ukunciphisa uchuku kunye noxinzelelo lwe-oxidative. Nangona kunjalo, ukuzila ukutya kusenokungabi kuye wonke umntu. Qiniseka ukuba uthetha nochwephesha kwaye onamava kwezempilo ngaphambi kokuzila. -Gqr. Alex Jimenez DC, CCST Insight

 


 

Ifom yoVavanyo lweNeototransmitter

 

Le fom ilandelayo yoVavanyo lweNeurotransmitter inokugcwaliswa ize ingeniswe kuGqirha Alex Jimenez. Ezi mpawu zilandelayo zidweliswe kule fomu azenzelwanga ukuba zisetyenziswe ekuchongeni nasiphi na isifo, imeko, okanye naluphi na uhlobo lomcimbi wezempilo.

 


 

Kubantu abaninzi, ukuzila ukutya, okanye ingcamango yokweqa ukutya ngokuzithandela ixesha elithile, kunokungabonakali njengendlela ekhangayo kakhulu yokuphucula impilo yokugaya. Kuba uninzi lwabantu lutya malunga nezidlo ezi-3 ngemini, ukutsiba isidlo esinye okanye ezibini ngemini ekugqibeleni kunokubabangela ukuba bazive bemothukile, bediniwe, kwaye badinwe. Nangona kunjalo, kubantu abanemiba yempilo yokwetyisa, efana ne-SIBO, IBS, okanye amathumbu avuzayo, basenokuba sele beziva ezi mpawu, nasemva kokutya izidlo zabo ezi-3 ngosuku. Kweli nqaku, sixoxe ngendlela ukuzila ukutya kunokuba luncedo kwezinye izigulana kunye nendlela enokunceda ngayo ekuphuculeni impilo yabo yokugaya. �

 

Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic, musculoskeletal, kunye nemicimbi yezempilo yovalo okanye amanqaku amayeza asebenzayo, izihloko kunye neengxoxo. Sisebenzisa iiprothokholi zempilo ezisebenzayo ukunyanga ukwenzakala okanye ukuphazamiseka kwenkqubo yemusculoskeletal. Iofisi yethu yenze umzamo oqinisekileyo wokubonelela ngezikhokelo ezixhasayo kwaye ichonge isifundo sophononongo esifanelekileyo okanye izifundo ezixhasa izithuba zethu. Sikwenza iikopi zezifundo zophando ezixhasayo ziya kufumaneka ebhodini okanye kuluntu xa luceliwe. Ukuqhubeka nokuxoxa ngomxholo ongentla, nceda ukhululeke ukubuza uGqirha Alex Jimenez okanye unxibelelane nathi apha 915-850-0900.

 

Ikhethwe nguGqirha Alex Jimenez

 

Iingxelo:

  • Rory. �Ungawaphilisa njani amathumbu akho ngokuzila ukutya.� Ingca, Isondlo esenziwe ngobuNtu kwi-MSc, i-9 Aug. 2018, www.chewsomegood.com/fasting-ibs/.

 


 

Isihloko esongezelelweyo seNgxoxo: kubuhlungu obungapheliyo

Intlungu engxamisekileyo yimpendulo yendalo yenkqubo yemithambo-luvo enceda ukubonisa ukwenzakala okunokwenzeka. Umzekelo, iimpawu zentlungu zihamba zisuka kwingingqi eyenzakeleyo ngeemithambo kunye nentambo yomqolo ukuya kwingqondo. Ubuhlungu ngokubanzi buba ngaphantsi kokulimala, nangona kunjalo, iintlungu ezingapheliyo zihlukile kunohlobo lwentlungu. Ngentlungu engapheliyo, umzimba womntu uya kuqhubeka uthumela imiqondiso yeentlungu kwingqondo, nokuba umonzakalo uphilile. Intlungu engapheliyo inokuhlala iiveki ezininzi ukuya kwiminyaka eliqela. Iintlungu ezingapheliyo zinokuchaphazela kakhulu ukuhamba kwesigulana kwaye zinokunciphisa ukuguquguquka, ukomelela kunye nonyamezelo.

 

 


 

I-Neural Zoomer Plus yesifo seNeological

I-Neural Zoomer Plus | El Paso, TX Chiropractor

 

Ugqirha Alex Jimenez usebenzisa uthotho lovavanyo ukunceda ukuvavanya izifo ze-neurological. I-Neural ZoomerTM Ukudibana kuluhlu lwee autoantibodies ze-neurological ezinikezela ukwamkelwa okuthile kwe-anti-to-antigen. I-Vulrant Neural ZoomerTM Ukudibanisa kuyilelwe ukuvavanya ukwenziwa kwakhona kwe-antigen ye-48 ye-neurological antigens ngokudibana nezifo ezahlukeneyo ezinxulumene nonyango. IVibrant Neural ZoomerTM Kwaye kujolise ekunciphiseni iimeko zemithambo-luvo ngokuxhobisa abaguli kunye noogqirha ngesixhobo esibalulekileyo sokufumana umngcipheko kwangoko kunye nokugxininiswa okuphuculweyo kuthintelo olusisiseko lomntu.

 

Ubuntununtunu bokutya kwiMpendulo ye-IgG kunye ne-IgA ye-immune

Ukutyiswa kokutya iZoomer | El Paso, TX Chiropractor

 

Ugqirha Alex Jimenez usebenzisa uthotho lovavanyo ukunceda ukuvavanya imiba yezempilo ehambelana neemvakalelo zokutya. I-Zoenser yokutyaTM luluhlu lwe-180 iantianti zokutya ezisetyenziswa ngokuxhaphakileyo ezibonelela ngokubonakalayo kwe-anti-to-antigen. Eli phaneli lilinganisela ubuntununtunu bomntu ngamnye be-IgG kunye ne-IgA kwiimvakalelo zokutya. Ukukwazi ukuvavanya ii-antibodies ze-IgA kubonelela ngolwazi olongezelelekileyo kukutya okunokubangela ukonakala kwe-mucosal. Ukongeza, olu vavanyo lulungile kwizigulana ezinokuthi zihlupheke ngenxa yokulibaziseka kokuphendula kukutya okuthile. Sebenzisa uvavanyo lokuvavanywa kokutya okusekwe kwi-antibody kunokunceda ekubekeni phambili ukutya okuyimfuneko ukuphelisa kunye nokwenza isicwangciso sokutya esenziwe ngokwezifiso kwiimfuno ezithile zesigulana.

 

I-Gut Zoomer ye-Intestinal encinci ye-bacterial overgrowth (SIBO)

IGut Zoomer | El Paso, TX Chiropractor

Ugqirha Alex Jimenez usebenzisa uthotho lweemvavanyo ukunceda ekuvavanyeni impilo ye-gut enxulunyaniswa nokugcwala kwamathumbu esibeleko (SIBO). I-Vulrant Gut ZoomerTM inikeza ingxelo equka iingcebiso zokutya kunye nezinye izongezo zendalo ezifana ne-prebiotics, iprobiotics kunye neepolphenhen. I-gut microbiome ifunyenwe ikakhulu emathunjini amakhulu kwaye ineentlobo ezingaphezu kwe-1000 zeebhaktheriya ezidlala indima ebalulekileyo emzimbeni womntu, ekubumbeni amajoni omzimba kunye nokuchaphazela imetabolism yezakha mzimba ukomeleza isithintelo samathumbu emathunjini (isithintelo samathumbu) ). Kubalulekile ukuba uqonde ukuba inani leebhaktiriya ezihlala kwisisu somntu (GI) lichaphazela njani impilo yezisu kuba ukungalingani emathunjini e-microbiome kunokukhokelela kwisifo se-gastrointestinal (GI), imeko zolusu, ukuphazamiseka komzimba, ukungalingani kwamasosha omzimba. , kunye nokuphazamiseka okuninzi kokudumba.

 


Iilebhu zeDunwoody: ISixol esigcweleyo ngeParasitology | El Paso, TX Chiropractor


I-GI-MAP: I-GI Microbial Assay Plus | El Paso, TX Chiropractor


 

Iifomu zeNkxaso yeMethylation

I-Xymogen Ifomu - El Paso, TX

 

XYMOGEN's Iifomula zeeNgqungquthela zodwa zifumaneka ngokukhetha abaqeqeshi bezempilo abanemvume. Intengiso ye-intanethi kunye nokuhlaziywa kwamafomula e-XYMOGEN ayinqatshelwe.

 

Ngebhongo, UDkt. Alexander Jimenez yenza i-XYMOGEN ifomula ifumaneka kuphela kwizigulane ezingaphantsi kwethu.

Nceda ufonele iofisi yethu ukuze sikwazi ukudlulisela udokotela ngokubonisana nokufikelela ngokukhawuleza.

Ukuba uyigulane Unyango lwezoNyango kunye neChiropractic Klinikhi, unokubuza malunga ne-XYMOGEN ngokubiza 915-850-0900.

xymogen el paso, tx

Ukuze ube lula kwaye uhlaziywe XYMOGEN iimveliso nceda uphonononge ikhonkco elilandelayo. *I-XYMOGEN-Inkcazo-umxokozelo

 

* Zonke iinkqubo ze-XYMOGEN ezingentla zihlala zisebenza ngokuthe ngqo.

 


 

Ukuqonda ukuzila ukutya okungaphakathi

Ukuqonda ukuzila ukutya okungaphakathi

Ngaba uziva:

  • Ukulamba ngeyure okanye ezimbini emva kokutya?
  • Ukufumana ubunzima obungachazwanga?
  • Ukungalingani kweHormonal?
  • Ingqondo ngokubanzi yokuqhakaza?
  • Imvakalelo yokugcwala ngexesha lokutya nasemva kokutya?

Ukuba uhlangabezana nazo naziphi na kwezi meko, ngoko zama ukuqaphela ukuzila ukutya okwexeshana.

Ukusukela oko waziwayo kwiminyaka yakutshanje, ukuzila ukutya okwexeshana yindlela yokutya abantu abaninzi abaye bayisebenzisa kwindlela yabo yokuphila esempilweni. Ngexesha loluntu lokuzingela-abantu, abantu basebenzise le ndlela kangangeenkulungwane njengendlela yokusinda. Izifundo zibonisiwe ukuba abantu babelisebenzisa ngeenjongo zonyango kuyo yonke imbali njengeyeza lokunyanga. I-Roma yamandulo, impucuko yamaGrike kunye namaTshayina basebenzise ukuzila okwenzeka rhoqo kubomi babo bemihla ngemihla. Ukuzila ukutya kuye kwasetyenziswa nakwizizathu zokomoya kwiinkolo ezithile, ezinje ngeBuddhism, i-Islam, nobuKristu njengokuba umntu eyisebenzisa njengendlela yokuzibonakalisa nokuba basondele kwizithixo zabo.

Yintoni Ukuzila ukutya?

Ukutya Ketogenic kunye nokuzila ukutya okungaphakathi | El Paso, TX Chiropractor

Ukuzila ukutya kulapho umntu angasebenzisi ukutya okanye iziselo okungenani iiyure ezilishumi elinambini emini. Xa umntu eqala ukuzila ukutya, baya kuqaphela ukuba i-metabolism yabo kunye ne-hormonal yabo iya kutshintsha emizimbeni yabo. Nantsi lapho Uphando oluzayo ukuba ukuzila ukutya okwethutyana kunokunyusa izibonelelo zempilo ezimangalisayo emzimbeni. Izibonelelo zempilo ezibonelela ukuzila ukutya okwexeshana zibonakalisa ukwehla kobunzima, iimpembelelo zokukhusela kwingqondo, ukuncipha kokuvuvukala kunye nokuphucula i-glucose yegazi kunye namanqanaba e-insulin emzimbeni.

Iindlela ezahlukeneyo

Nazi ezinye iindlela zokuzila oko kubandakanya ukuzila ukutya ukutya kangangeentsuku okanye iiveki. Ngezi ndlela ezahlukeneyo, zibandakanya ixesha elifutshane eliphakathi kwe16 ukuya kwiiyure ze24. Iindidi ezininzi zokuzila ukutya okwethutyana zimiselwa kukunikwa ixesha lokutya kwefestile (ixesha lokutya ukutya) kunye nefestile yokuzila ukutya (xa kuthintela ukutya). Nazi ezinye iindlela zokuzila, kubandakanya:

  • Ukutya okuthintelwe ixesha (i-TRF): Olu hlobo lokuzila luba nexesha lokutya lefestile ukusuka kwi-4 ukuya kwiiyure ze12. Ngomhla oshiyekileyo, amanzi kuphela kwento evunyelwe ukuba isetyenziswe. Umahluko oqhelekileyo wokutya olu hlobo lokuzila yi-16 / 8. Oku kuthetha ukuba umntu kufuneka azile ukutya iiyure ezingama-16 ubuncinci yonke imihla.
  • Ukuqala kwexesha lokuthintela umda (iTRF): Olu luhlobo olwahlukileyo lokuzila okuthintela ixesha okuthintela ukusuka ku-8 am ukuya kwi-2 pm Emva kokuba iiyure ze-6 ziphelile, usuku lokuphumla lwenziwe ngeli xesha lokuzila.
  • Olunye usuku lokuzila ukutya (i-ADF): Olu hlobo lokuzila lubandakanya umntu atye ngenye imini kwaye ngosuku olulandelayo bazila ukutya ngokupheleleyo. Ziyahlula-hlula phakathi kokutya kunye nokuzila ukutya mihla le ukuze zifumane izibonelelo.
  • Ukuzila ukutya okwethutyana (ukuzila ukutya ngebhayisikile): Olu hlobo lokuzila lubandakanya ukuzila ukutya kosuku olunye okanye ezimbini ngeveki kunye nosuku lwesihlanu okanye lwesithandathu lokutya njengoko umntu unqwenela. Ukuhluka kwexesha lokuzila kunokuba yi-5: 2 okanye i-6: 1.
  • Ukuzila ukutya okulungisiweyo: Olu hlobo lokuzila luneendlela ezithile zokuzila ukutya okwexeshana ezifanayo nokuzila ukutya kwemini, kodwa oku kuzila kunokulungiswa kuye nabani na. Umntu unokutya izinto ezincinci-eziphantsi kakhulu-ngexesha lekhanya lokuzila.

Ingaba isebenza kanjani?

Ukuzila ukutya okungaphakathi sisiphumo seenguqu emzimbeni njengoko iipateni zehomoni kunye nemetabolism yamandla ichaphazeleka. Nje ukuba umntu agqibe ukutya, iziqulatho ziyaqhekezwa kwaye ziguqulwe zibe zizakhi, ngoko ke inokufakwa kwigumbi lokugaya ukutya. Kwenzeka ntoni kukuba iicarbohydrate ziqhekezwe kwaye zijike zangena kwiglucose kwaye zangena kwigazi, zisasaza kwizicubu zomzimba njengowona mthombo wamandla. Ihomoni ye-insulin ke inceda ekumiseleni amanqanaba eglucose yegazi ngokutyhala iiseli ukuba zithathe iswekile egazini kwaye zijike zibeyiphuli ukuze umzimba usebenze ngokufanelekileyo.

Ngokuzila ukutya okwexeshana, umntu wenziwa ngesidlo kwaye amanqanaba eglucose abo aphuma emzimbeni. Ukuze amandla afezekise iimfuno zayo umzimba kufuneka uchithe i-glycogen efumaneka kwisibindi kunye nemisipha yamathambo ebangela i-gluconeogeneis. I-Gluconeogenesis kuxa isibindi sivelisa iswekile ye-glucose kwimithombo engeyo-carbohydrate emzimbeni. Ke emva kokuba amanqanaba e-insulin esezantsi emva kweeyure ze-18 zokuzila, inkqubo ebizwa ngokuba yi-lipolysis iqala. Yintoni eyenziwa lipolysis kukuba umzimba uqalisa ukwaphula izinto zamanqatha kwiiasidi zamafutha asimahla. Xa kukho inani eliphantsi leglucose ukuze umzimba uchithe amandla, umzimba ngokwawo uqalise ukusebenzisa amanqatha kunye nee ketones zamandla. I-Ketosis yile ilizwe lemetaboliki apho iiseli ziqala ukunceda ukuqhekeka kwamafutha acid kwaye ziyiguqule ibe yi-ketone acetoacetate kunye ne-beta-hydro butyrate.

Iiseli zemisipha kunye neeseli ze-neuron zisebenzisa ezi ketones ukwenza i-ATP (i-adenosine triphosphate) eyona nto ithwala amandla. Uphando lutshilo ukuba ukusetyenziswa kunye nokufumaneka kwee-acid ezinamafutha zidityaniswe nee-ketones njengokutshintshwa kwamandla kweglucose ziluncedo kwizicubu zomzimba ezibalulekileyo. Oku kubandakanya intliziyo, isibindi, ipancreas nengqondo.

Amazwe amane e-metabolic abangelwa kukuzila ukutya abizwa ngokuba ngumjikelo okondla ngokukhawuleza, kwaye zezi:

  • Imeko yokondliwa
  • Imeko yasemva kokubanjwa
  • Imo yokuzila
  • Imeko yendlala

Iziphumo zomzimba zokuzila ukutya okwexeshana nazo zinokufumaneka ngokulandela ukutya okune-ketogenic, okunamafutha amaninzi kunye nokutya okune-carbohydrate esezantsi. Injongo yokutya kukutshintsha imeko ye-metabolic yomzimba kwi-ketosis.

Izibonelelo zokuzila ukutya

Kukho iitoni zophando ezibonakalise ukuba ukuzila ukutya okwexeshana kunezibonelelo ezahlukeneyo zempilo, kubandakanya:

  • Ukuhla ukusinda
  • Uhlobo lwe-2 yokuthintela isifo seswekile kunye nolawulo
  • Ukuphuculwa komngcipheko we-cardiometabolic
  • Ukucocwa kweselula
  • Ukunciphisa
  • Neuroprotection

Izifundo zibonisiwe ukuba iindlela ezithile ezicetywayo zinoxanduva kwezi zinto zempilo ngokuzila ukutya kwaye zibonakalise ukuba ziyingenelo kwindlela yokuphila yomntu.

isiphelo

Ukuzila ukutya okungaphakathi kuye kwenziwa kangangeenkulungwane kwaye kwafumana ukuthandwa kwiminyaka yakutshanje. Kubandakanya ukuyeka ukutya ukutya kangangexesha elingangeyure ezi-12 ngokulandelelana ngokuguqula iiseli ezinamafutha zibe amandla ukuze umzimba usebenze. Izibonelelo zezempilo ezibonelela ukuzila ukutya okwethutyana ziluncedo kumntu ozama ukugcina impilo esempilweni. Abanye iimveliso nceda ukubonelela ngenkxaso kwinkqubo yesisu kunye nokuqinisekisa ukuba iswekile yemetabolism ikwinqanaba elisempilweni ukuze umzimba usebenze.

Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic, musculoskeletal, kunye nemicimbi yezempilo yovalo okanye amanqaku amayeza asebenzayo, izihloko kunye neengxoxo. Sisebenzisa iiprothokholi zempilo ezisebenzayo ukunyanga ukwenzakala okanye ukuphazamiseka kwenkqubo yemusculoskeletal. Iofisi yethu yenze umzamo oqinisekileyo wokubonelela ngezikhokelo ezixhasayo kwaye ichonge isifundo sophononongo esifanelekileyo okanye izifundo ezixhasa izithuba zethu. Sikwenza iikopi zezifundo zophando ezixhasayo ziya kufumaneka ebhodini okanye kuluntu xa luceliwe. Ukuqhubeka nokuxoxa ngomxholo ongentla, nceda ukhululeke ukubuza uGqirha Alex Jimenez okanye unxibelelane nathi apha 915-850-0900.


Iingxelo:

UDhillon, uKiranjit K. Ibhayiloji, iKetogenesis I-StatPearls [kwi-Intanethi]., I-US National Library of Medicine, i-21 ngo-Ep. 2019, www.ncbi.nlm.nih.gov/books/NBK493179/#article-36345.

Hue, uLouis, kunye noHeinrich Taegtmeyer. Umjikelo weRandle uphinde watyelelwa: iNtloko eNtsha yoMnqwazi omdala Ijenali yaseMelika yePhysology. I-Endocrinology kunye neMetabolism, I-American Physiological Society, ngoSeptemba 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/.

UStockman, uMary-Catherine, et al. Ukuzila ukutya okwexeshana: Ngaba ukulinda kufanelekile kubunzima? Iingxelo zeOpityity okwangoku, I-US National Library of Medicine, ngo-Juni 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5959807/.

UZubrzycki, A, et al. Indima yokutya okuneeCalorie ezisezantsi kunye nokuzila ukutya okungapheliyo kunyango lokutyeba kakhulu kunye nohlobo lwesibini lweswekile. Ijenali yePhysology kunye neFamascology: Ijenali yaseburhulumenteni yePoland Physiological Society, I-US National Library of Medical, Oct. 2018, www.ncbi.nlm.nih.gov/pubmed/30683819.

 

 

 

 

Ukuzila ukutya kunye neCarcer: Iinkqubo zeMolcular And Clinical Application

Ukuzila ukutya kunye neCarcer: Iinkqubo zeMolcular And Clinical Application

UAlessio Nencioni, uIrene Caffa, uSalvatore Cortellino kwaye UValter D. Longo

Thintela | Umngcipheko weeseli zomhlaza ekuphelekeni izondlo kunye nokuxhomekeka kwazo kwii-metabolites ezithile ziimpawu ezibonakalayo zomhlaza. Ukutya okukhawulezayo okanye okukhawulezayo okulinganisa ukutya (i-FMD) kukhokelela kuguquko olubanzi lwezinto zokukhula kunye namanqanaba e-metabolite, ukuvelisa iimeko ezinokunciphisa amandla eeseli zomhlaza ukuba zihlengahlengise kwaye ziphile kwaye oko kuphucula iziphumo zonyango lomhlaza. Ukongeza, ukuzila ukutya okanye i-FMD yonyusa ukumelana ne-chemotherapy ngendlela eqhelekileyo kodwa ingeyiyo iiseli zomhlaza kwaye ikhuthaze ukuvela ngokutsha kwezicubu eziqhelekileyo, ezinokunceda ukuthintela iziphumo ebezingalunganga nezinokubeka ubomi emngciphekweni. Ngelixa ukuzila kunganyamezeleki kwizigulana, zombini izilwanyana kunye nezifundo zeklinikhi zibonisa ukuba imijikelezo yeekhalori eziphantsi ze-FMD zinokwenzeka kwaye zikhuselekile ngokubanzi. Uvavanyo oluninzi lovavanyo lweklinikhi lokuvavanya isantya sokuzila okanye i-FMD kwimicimbi engentle eyonyukayo kunye nakwiziphumo ezifanelekileyo ziyaqhubeka. Sicebisa ukuba indibaniselwano yee-FMDs ngamachiza amayeza amayeza, unyango olungxamisekileyo okanye unyango olunye libonisa isicwangciso esithembisayo sokukhulisa ukusebenza kakuhle kwezonyango, ukuthintela ukufunyanwa komzimba kunye nokunciphisa iziphumo ebezingalindelekanga.

Ukutya kunye nezinto ezinxulumene nokuphila zizinto eziphambili ezichaphazela umngcipheko wokuhlaselwa ngumhlaza, kunye nomhlaza othile oxhomekeke kakhulu kwimikhwa yokutya kunabanye1�9. Ngokuhambelana nale mbono, ukukhuluphala kuqikelelwa kwi-akhawunti ye-14% ukuya kwi-20% yabo bonke abantu ababulawa ngumhlaza eUnited. I-States7, ekhokelela kwizikhokelo kwisondlo kunye nokusebenza komzimba ukunciphisa umngcipheko wokukhula Umhlaza6. Ukongeza, unikwe amandla okuvela kweeseli zomhlaza, kodwa hayi izihlunu eziqhelekileyo, ukungathobeli imiqondiso echasene nokukhula (ngenxa yeenguqulelo ze-oncogenic) izidlo ezithile ezinomda weekhalori nazo zinokuba yinxalenye yothintelo lomhlaza kwaye, mhlawumbi, kunyango lomhlaza njengendlela yokunyusa ukusebenza kunye nokunyamezelana kweearhente zomhlaza10 11,12.

Nangona kule minyaka ilishumi idlulileyo siye sabona utshintsho olungakhange lubekho kunye nenkqubela phambili kunyango lomhlaza14,15, kusekho isidingo esibaluleke ngakumbi kwaye, iindlela zonyango kuba amathumba kodwa kwakhona, kwaye kubaluleke kakhulu, ngeendlela zamacebo okunciphisa iziphumo ebezingalindelekanga zonyango lomhlaza15,16. Umcimbi weziganeko ezichasayo zonyango (i-TEAEs) sesinye sezona ngxaki ziphambili kwi-oncology15,16 yezonyango. Ngapha koko, uninzi lwezigulana ezinomhlaza zinamava amachaphaza amdaka kunye / okanye nexesha elide lonyango olunomhlaza, olunokuthi lufune isibhedlele kunye nonyango olunobukrakra (olunjengamayeza okubulala iintsholongwane, haematopoietic izinto zokukhula kwaye utofelo-gazi) kwaye luchaphazela kakhulu ubomi babo (umzekelo, ichemotherapyindended i-peripheral neuropathy) 16. Ke, iindlela ezifanelekileyo zokunciphisa ubuthi ziyalungiswa kwaye kulindeleke ukuba zibe nefuthe elikhulu kwezonyango, kwezentlalo nakwezomnotho15,16.

Ukunyanzela iiseli ezinempilo ukuba zingene kwicandelo elicothayo kunye nemo ekhuselweyo ebakhuselayo kwizithuko ezinobuthi ezivela kumachiza e-anticancer ngelixa beziva iintlobo ezahlukeneyo zeseli zomhlaza kwezi zonyango i -11,12,17. Oku kufunyaniswa kuthetha ukuba ungenelelo olulodwa lokutya lunokunceda ekujonganeni neenkalo ezahlukeneyo nezilinganayo zonyango lomhlaza.

Kule nqaku yeembono, sixoxa ngesimo sebhayoloji sokutya okanye sokulinganisa ukutya (ii-FMD) ukugcwala ii-TEAE kodwa sikhusela kunye nokunyanga umhlaza. Sikwabonisa imiqolomba yale ndlela yokuvavanya18,19 kunye nezifundo ezipapashiweyo neziqhubekayo apho kuye kwenziwa khona ukutya okanye ii-FMD kwizigulana ezinomhlaza.

Inkqubo yoPhulo lokuZila ukutya

Ukuzila ukutya kukhokelela kutshintsho emsebenzini weendlela ezininzi ze-metabolic ezinxulunyaniswa notshintsho kwimodi ekwaziyo ukuvelisa amandla kunye neemetabolism zisebenzisa imithombo yekhabhoni ekhutshwa ngokuyintloko kwizicubu zeadipose nakwinxalenye yomsipha. Utshintsho kumanqanaba okujikeleza kwehomoni kunye neemetabolites ziguqulela ekunciphiseni kwesahlulo seseli kwaye umsebenzi we-metabolic iiseli eziqhelekileyo kwaye ekugqibeleni zizikhusele kwizithuko ze-chemotherapeutic11,12. Iiseli zomhlaza, ngokungathobeli ii-anti-grow command ezichazwe yile meko yokufa yindlala, zinokuba nesiphumo esichaseneyo neseli eliqhelekileyo kwaye ke ngoko ziye ziveliswe kwi-chemotherapy kunye nolunye unyango lomhlaza.

Inkqubo yokuphendula ngokuKhawuleza

Impendulo ekuzileni ukutya yenziwa ngamanqanaba eswekile ye-glucose, i-insulin, iglucagon, i-hormone yokukhula (GH), IGF1, glucocorticoids kwaye adrenaline. Ngethuba lesigaba sokuqala sokungenisa, esihlala sihlala kwi-6 24hours, amanqanaba e-insulin aqala ukuhla, kunye namanqanaba eglucagon anyuka, ekhuthaza ukonakala kwevenkile zesibindi se-glycogen (ezigqityiweyo emva kweeyure ezingama-24) kunye nesiphumo sokukhutshwa kweswekile yamandla.

I-Glucagon kunye namanqanaba asezantsi e-insulin nawo akhuthaza ukonakala kwe-triglycerides (egcinwe ikakhulu kwizicubu ze-adipose) kwi-glycerol kunye ne-free fatty acids. Ngexesha lokuzila ukutya, uninzi lwezicubu zisebenzisa i-acid ye-eneji, ngelixa ingqondo ixhomekeke kwiswekile nakwimizimba ye-ketone eveliswa zii-hepatocytes (imizimba ye-ketone inokuveliswa kwi-acetyl-CoA eveliswe kwi-acid acid? -Ooxation okanye kwi-ketogenic amino acid). Kwinqanaba le-ketogenic lokuzila ukutya, imizimba ye-ketone ifikelela kumanqanaba e-millimolar, aqala emva kweentsuku ezi-2 3 ukusuka ekuqaleni kokuzila. Ngokudibeneyo ne-glycerol ethathwe ngamanqatha kunye neeamino acid, imizimba ye-ketone iphembelela i-gluconeogenesis, egcina amanqanaba eglucose koxinzelelo malunga ne-4mM (70mg nge-dl), esetyenziswa kakhulu yingqondo.

I-Glucocorticoids kunye ne-adrenaline nayo inegalelo kulungelelwaniso lwe-metabolic adaptation kuyo ukuzila ukudla, ukunceda ukugcina amanqanaba eswekile yegazi kunye nokukhuthaza i-lipolysis20,21. Ngokukodwa, nangona ukuzila ukutya kunokunyusa okwethutyana amanqanaba e-GH (ukunyusa i-gluconeogenesis kunye ne-lipolysis kunye nokunciphisa ukunyuka kwe-glucose), ukuzila ukutya kunciphisa amanqanaba e-IGF1. Ukongeza, phantsi kweemeko zokuzila, i-IGF1 imisebenzi yebhayoloji ithintelwe kwinxalenye yokwanda kwamanqanaba e-insulin-ukukhula ukukhula okubopha iprotein 1 (IGFBP1), ebophelela ukujikeleza i-IGF1 kwaye ithintele ukusebenzisana kwayo kunye ne-receptor22 yokuhambelana kweseli.

Okokugqibela, ukuzila ukutya kunciphisa amanqanaba okujikeleza i-leptin, ihomoni yenziwa ikakhulu yi-adipocytes ethintela indlala, ngelixa inyusa amanqanaba e-adiponectin, enyusa amanqatha e-acid aqhekezayo23,24. Ke, ukuqukumbela, iimpawu eziphambili zempendulo ye-mammaliic kwinkqubo yokuzila ukutya ngamanqanaba asezantsi eglucose kunye ne-insulin, amanqanaba aphezulu eglucagon kunye nemizimba yeketoni, amanqanaba asezantsi e-IGF1 kunye ne-leptin kunye namanqanaba aphezulu e-adiponectin.

Impendulo yeselfowuni kukuzila

Impendulo yeeseli esempilweni ekuzileni iyalondolozwa ngokwendalo kwaye inika ukhuseleko lweseli, kwaye ubuncinci kwimodeli yezinto eziphilayo, ibonakalisiwe ukuba inyuse ixesha lokuphila kunye ne-healthspan12,22,25-31. I-IGF1 uphawu Umdaniso isisitshixo uphawu Indlela ebandakanyekayo ekulamleni iziphumo zokuzila kwinqanaba leselula. Ngaphantsi kwesondlo esiqhelekileyo, ukusetyenziswa kweprotein kunye nokwanda kwamanqanaba e-amino acid anyusa amanqanaba e-IGF1 kwaye akhuthaze umsebenzi we-AKT kunye ne-mTOR, ngokwenyusa ukuhlanganiswa kweprotein. Ngokuchasene noko, ngexesha lokuzila ukutya, amanqanaba e-IGF1 kunye nokwehla komqondiso osezantsi, ukunciphisa ukuthintela okuphakathi kwe-AKT kwezinto ezikhutshelweyo ze-FOXO kunye nokuvumela ezi zinto zikhutshelweyo ukuba zisebenze zofuzo, ezikhokelela ekusebenziseni ii-enzymes ezinjenge-haem oxygenase 1 (HO1), superoxide dismutase ( I-SOD) kunye ne-catalase enemisebenzi ye-antioxidant kunye neziphumo zokukhusela Amanqanaba aphezulu eswekile akhuthaza iprotein kinase A (PKA) uphawu, elawula kakubi i-sensor energy sensor i-AMPK isebenze nge-proteni kinase (AMPK) 35, yona, ethintela ukubonakaliswa kwengcinezelo yokukhutshelwa kwento yokukhula kokukhula kweproteyini ye-1 (EGR1) (Msn2 kunye / okanye neMnn4 kwi-yegwele) 26,36 .

Ukuzila ukutya kunye nesithintelo se-glucose esithintela umsebenzi we-PKA, yonyusa umsebenzi we-AMPK kwaye wenze ukuba kusebenze i-EGR1 kwaye ngaloo ndlela kufezekiswe iziphumo zokukhusela iiseli, kubandakanya nezo zikwi-myocardium22,25,26. Okokugqibela, ukuzila ukutya kunye nee-FMD (jonga apha ngezantsi ngokwakhiwa kwazo) zikwanakho ukukhuthaza iziphumo ezivuselelayo (Ibhokisi 1) ziindlela zeemolekyuli, ezinye zazo ziye zachaphazeleka kumhlaza, njengokunyuka kwe-autophagy okanye ukwenziwa kwemisebenzi ye-sirtuin22,37-49 .

Umhlaza kunye nokuzila ukutya el paso tx.

Iindlela zokutya kwizifo zomhlaza kwii-FMD

Iindlela zokutya esekwe ekuzileni okuye kwaphandwa kakhulu kwi-oncology, kokubini ngokungxamisekileyo naseklinikhi, kubandakanya ukuzila kwamanzi (ukuyeka konke ukutya neziselo ngaphandle kwamanzi) kunye nee-FMDs 11,12,17,25,26,50-60 (Itheyibhile 1). Idatha yokuqala yeklinikhi ibonisa ukuba ukukhawuleza okungenani kweeyure ezingama-48 kunokufuneka ukuba kufikelelwe kwiziphumo zeklinikhi ezinomdla kwi-oncology, njengokuthintela ukonzakala kwe-chemotherapy eyenzelwe i-DNA kwizicubu ezisempilweni kunye nokunceda ukugcina isigulane umgangatho wobomi ngexesha le-chemotherapy52,53,61.

Umhlaza kunye nokuzila ukutya el paso tx.

Nangona kunjalo, uninzi lwezigulana ziyala okanye zinobunzima ekugqibeni ukuzila kwamanzi, kwaye umngcipheko onokubakho wekhalori eyandisiweyo kunye nokusilela kwemicronutrient okunxulumene nayo kunzima ukuyithethelela. Ii-FMD ziyilelwe ngurhulumente imilinganiselo yokutya ephantsi kakhulu kwiikhalori (Oko kukuthi, phakathi kwe-300 kunye ne-1,100kcal ngosuku), iswekile kunye neeproteni eziphinda zenze uninzi lweziphumo zokuzila ukutya kwamanzi kuphela kodwa ngokuthobela okungcono kwesigulana kunye nokunciphisa umngcipheko wesondlo22,61,62, 3. Ngexesha le-FMD, izigulana zihlala zifumana inani lamanzi elingathintelwanga, amancinci amancinci emifuno yemifuno, iisuphu, iijusi, ii-nut bar, kunye neetafic herbal, kunye nezongezo zemicronutrients. Kwisifundo seklinikhi semijikelezo yenyanga ye-5 yentsuku ye-1 ye-FMD kwizifundo ezisempilweni ngokubanzi, ukutya bekunyamezelwe kakuhle kwaye kuncitshiswe isiqu kunye namafutha omzimba xa ewonke, uxinzelelo lwegazi kunye namanqanaba e-IGF62. Kwiimvavanyo zeklinikhi zangaphambili kunye nokuqhubekayo, ukuzila ukutya okanye ii-FMDs bezilawulwa rhoqo kwiiveki ezi-3 4, umzekelo, ngokudibeneyo neerejimeni zekhemotherapy, kwaye ixesha labo liphakathi kweentsuku ezi-1 ukuya kwezi-5-52,53,58,61,63 . Ngokubalulekileyo, akukho ziganeko zibi kakhulu (inqanaba le-G68 okanye ngaphezulu, ngokwemiGaqo yesiGama esiQhelekileyo yeziganeko eziGwenxa) ezixeliweyo kwezi zifundo3.

Izidlo zeKetogenic

Ukutya kwe-Ketogenic (KDs) ziirejimeni zokutya ezinekhalori eqhelekileyo, amanqatha aphezulu kunye nomxholo we-carbohydrate omncinci69,70. Kwi-classical KD, umlinganiselo phakathi kobunzima bamafutha kunye nobunzima obudibeneyo be-carbohydrate kunye neprotheni yi-4: 1. Inqaku, ii-FMDs nazo zine-ketogenic kuba zinomxholo onamafutha aphezulu kwaye zinamandla okunyusa ukuphakama okukhulu (? 0.5mmol kwilitha nganye) kumanqanaba okujikeleza kwemizimba ye-ketone. Ebantwini, i-KD inokunciphisa i-IGF1 kunye namanqanaba e-insulin (ngaphezulu kwama-20% ukusuka kumaxabiso asisiseko), nangona ezi ziphumo zichaphazeleka ngamanqanaba kunye nohlobo lweecarbohydrate kunye neeprotein kwi-diet71. Ii-KDs zinokunciphisa amanqanaba eglucose egazini, kodwa zihlala zihlala kuluhlu oluqhelekileyo (Oko kukuthi,> 4.4mmol ilitha nganye) 71.

Ngokukodwa, ii-KDs zinokusebenza ngokuthintela ukwanda kweswekile kunye ne-insulin eyenzeka ngokufuthi ekuphenduleni kwi-PI3K inhibitors, eyayicetyisiwe ukunciphisa ukusebenza kwayo72. Ngokwesiko, ii-KDs bezisetyenziselwa ukunyanga isifo sokuwa, ngakumbi ebantwaneni69. Kwiimodeli zegundane, ii-KD zenza iziphumo ze-anticancer, ngakumbi kwi-glioblastoma70,72-86. Izifundo zeklinikhi zibonisa ukuba ii-KDs mhlawumbi azinayo imisebenzi yokunyanga xa zisetyenziswa njengeearhente ezingatshatanga kwizigulana ezinomhlaza kwaye zicebisa ukuba izibonelelo ezinokubakho zokutya kufuneka zifunwe ngokudityaniswa nezinye iindlela, ezinje ngechemotherapy, iradiotherapy, unyango lwe-antiangiogenic, PI3K inhibitors kwaye FMDs72,73.

Ii-KD zaxelwa ukuba zineziphumo ze-neuroprotective kwi-neripheral nerves nakwi-hippocampus87,88. Nangona kunjalo, kuya kuhlala kusekwe ukuba ii-KDs nazo zineziphumo ezinje ngokuzila ukutya okanye ii-FMDs (Ibhokisi 1) kunye nokuba ngaba ii-KDs zinokusetyenziselwa ukukhusela izilwanyana ezanyisayo kwizityhefu zekhemotherapy. Ngokukodwa, iziphumo ezivuselelayo zokuzila ukutya okanye ii-FMDs zibonakala ngathi zandiswa ngotshintsho olusuka kwindlela yokuphendula yindlala, ebandakanya ukwehla kwezinto zeselfowuni kunye nokufa kweeseli ezininzi, kunye nexesha lokutya kwakhona, apho iiseli kunye nezicubu zihamba khona ukwakhiwa ngokutsha22. Ngenxa yokuba ii-KDs azinyanzeli ukungena kwimowudi yendlala, musa ukukhuthaza ukonakala okukhulu kwezinto zangaphakathi kunye nezicubu kwaye azibandakanyi ixesha lokuhlaziya, akunakulindeleka ukuba zibangele uhlobo lokuvuselelwa okulungelelanisiweyo oluqwalaselweyo ngexesha lokuhlaziywa kwe-FMD.

Ukuthintela i-calorie

Ngelixa isithintelo sekhalori enganyangekiyo (i-CR) kunye nokutya okungonelanga kwii-amino acid ezithile zahluke kakhulu kukuzila ukutya okwenziwa ngamaxesha athile, babelana ngokuzila ukutya kunye nee-FMDs isithintelo esikhethiweyo okanye esingaphantsi kwisondlo, kwaye baneziphumo ze-anticancer81,89 112. I-CR ibandakanya ukuncitshiswa okungapheliyo kwama-20-30% kumandla ombane ukusuka kwi-calorie standard yokutya eya kuthi ivumele umntu ukuba agcine ubunzima obuqhelekileyo113,114. Kuyasebenza kakhulu ekunciphiseni umngcipheko wentliziyo kunye neziganeko zomhlaza kwimodeli yezinto eziphilayo, kubandakanya neeprimates108,109,114.

Nangona kunjalo, i-CR inokubangela iziphumo ebezingalindelekanga, ezinje ngotshintsho kwinkangeleko yomzimba, ukwanda kobuntununtunu, amandla anciphisiweyo, izitenxo zokuya exesheni, ukungachumi, ukuphulukana ne-libido, i-osteoporosis, ukupholisa amanxeba kancinci, ukutyeba kokutya, ukuba nochuku, kunye noxinzelelo. Kwizigulana ezinomhlaza, kukho izinto ezixhalabisayo ezinokuthi zonyuse ukungondleki kwaye ngokungathandabuzekiyo kuya kubangela ilahleko egqithisileyo yomzimba ocekeceke18,113-116. I-CR inciphisa amanqanaba eswekile yegazi, nangona ihlala ikuluhlu oluqhelekileyo114. Ebantwini, i-CR engapheliyo ayichaphazeli amanqanaba e-IGF1 ngaphandle kokuba kuthintelwe isithintelo seprotein esimiselweyo117.

Izifundo zibonakalisa ukuba ukunciphisa i-mTORC1 signaling kwi-Paneth iiseli, i-CR yandise ukusebenza kweseli yazo kwaye ikhusela iiseli zesisu zamathumbu kumonakalo weDNA118,119, kodwa akwaziwa ukuba ngaba iimpembelelo zokuvuseleleka kwamanye amalungu zibangelwa yiCR. Ke, idatha efumanekayo iphakamisa ukuba ukuzila ukutya kunye nee-FMD zenze iprofayikhi yokuhlaziya umzimba, yokuhlaziya kunye neyokhuselo eyahlukileyo kwaye inokuba namandla ngakumbi kunale iphakanyiswe yi-KD okanye i-CR.

Ukuzila ukutya kunye nee-FMD kunyango: Iziphumo kumanqanaba ehomoni kunye nemetabolite

Uninzi lweenguqu kumanqanaba okujikeleza kwehomoni kunye neemetabolites ezijongwa ngokuthe gabalala ekuphenduleni ngokukhawuleza zinamandla okukhupha iziphumo ze-antitumour (Oko kukuthi, amanqanaba ancitshisiweyo eglucose, IGF1, insulin kunye leptin kunye namanqanaba akhulayo e-adiponectin) 23,120,121 kunye / okanye ukufikelela ngokukhuselekileyo kwezicubu ezinempilo kwiziphumo ebezingalindelekanga (oko kukuthi, amanqanaba ancitshisiweyo e-IGF1 kunye neglucose). Ngenxa yokuba imizimba ye-ketone inokuthi ithintele i-histone deacetylases (ii-HDAC), ukunyuka okunyanzeliswa ngokukhawuleza kwemizimba ye-ketone kunokunceda ukucothisa ukukhula kwe-tumor kunye nokukhuthaza umahluko ngokusebenzisa iindlela ze-epigenetic122

Nangona kunjalo, i-ketone body acetoacetate ibonakalisiwe ukuba ikhawulezise, ​​endaweni yokunciphisa, ukukhula kwamathumba athile, anje ngee-melanomas ezine-BRAF123 eziguqulweyo. Olu tshintsho apho kukho ubungqina obomeleleyo bendima kwindima yesiphumo sokuzila ukutya kunye nee-FMD ngokuchasene nomhlaza kukuncipha kwamanqanaba e-IGF1 kunye neglucose. Kwinqanaba leemolekyuli, ukuzila ukutya okanye i-FMD kunciphisa i-intracellular signaling cascades kubandakanya IGF1R AKT mTOR S6K kunye ne-cAMP PKA signaling, yonyusa i-autophagy, inceda iiseli eziqhelekileyo ukumelana noxinzelelo kunye nokukhuthaza ukungakhuseleki komzimba25,29,56,124

Ukuchasana noXinzelelo oluNgafaniyo: Ukonyusa Ukunyangwa kweChemotherapy

Ezinye zeast oncogene orthologues, ezinje ngeRas ne-Sch9 (i-orthologue esebenzayo ye-mammalia S6K), ziyakwazi ukunciphisa ukuncipha koxinzelelo kwinto yemodeli27,28. Ukongeza, ukuguqula okuguqukayo kwe-IGF1R, i-RAS, PI3KCA okanye AKT, okanye ukungasebenzi kwe-PTEN, zibakhona kuninzi lwabantu abakwazi ukukhanuka10. Ngokudibeneyo, oku kukhokelele kwi-hypothesis ukuba indlala iya kubangela iziphumo ezichaseneyo nomhlaza ngokuchasene neeseli eziqhelekileyo ngokubhekiselele kumandla abo okumelana noxinzelelo lweeseli, kubandakanya ne-chemotherapeutics. Ngamanye amagama, ukulamba kungakhokelela umahluko uxinzelelo kuxinzelelo (DSR) phakathi kweeseli zomhlaza oqhelekileyo kunye nomhlaza.

Ngokwe-DSR hypothesis, iiseli eziqhelekileyo ziyasabela kwindlala ngokunciphisa ukwanda okunxulunyaniswa kunye ne-ribosome biogenesis kunye / okanye iindibano zemfuza, ezinyanzela iiseli ukuba zingene kwimowudi yokuzilungisa kwaye ibakhusele kumonakalo obangelwe yi-chemotherapy, i-radiotherapy kunye nezinye izinto ezinetyhefu. Ngokwahlukileyo, kwiiseli zomhlaza, le ndlela yokuzigcina iyakhuselwa ngotshintsho lwe-oncogenic, olubangela ukuthintelwa kwendlela yokuphendula ngoxinzelelo12 (Ikhiwane. 1). Iyahambelana nemodeli yeDSR, indlala yexesha elifutshane okanye ukucinywa kweproto-oncogene homologues (Oko kukuthi, iSch9 okanye zombini iSch9 kunye neRas2) ukonyusa ukhuseleko lweSachcharomyces cerevisiae ngokuchasene noxinzelelo lwe-oxidative okanye iziyobisi ze-chemotherapy ukuya kuthi ga kwi-100-fold xa kuthelekiswa neeseli zegwele ezibonisa i-oncogene esebenzayo umfuziselo I-Ras2val19.

Umhlaza kunye nokuzila ukutya el paso tx.

Iziphumo ezifanayo zafunyanwa kwiiseli ezanyisayo: ukubonakaliswa kwimithombo yeendaba esezantsi ye-glucose ekhusela iiseli ze-glia eziphambili ngokuchasene ne-hydrogen peroxide okanye i-cyclophosphamide (iprooxidant chemotherapeutic) kodwa ayizange ikhusele imouse, i-rat kunye ne-glioma yomntu kunye ne-neuroblastoma cell cell. Iyahambelana noku kuqaphela, usuku lwe-2 Ukuzila ukutya kuyinyusa ngempumelelo impilo yeempuku ezanyangwa ngepesidi ephezulu ye-etoposide xa kuthelekiswa neempuku ezingakhawuleziyo kunye nokwandisa ukusinda kwe-neuroblastoma ulungelelaniso iimpuku xa kuthelekiswa ne-mice12 engakhawulezi ukuzala.

Izifundo ezilandelayo ziye zafumanisa ukuba ukunciphisa i-IGF1 ukusayina ekuphenduleni ukuzila kukhusela i-glia ephambili kunye ne-neurons, kodwa hayi iiseli ze-glioma kunye ne-neuroblastoma, ukusuka kwi-cyclophosphamide nakwimixube ye-pro-oxidative kwaye ikhusela imouse embryonic fibroblast kwi-doxorubicin29. Iimpuku zesibindi se-IGF1-deficient (LID), izilwanyana ezi-transgenic ezinesimo se-Igf1 sokususwa kwemfuza esibonisa ukuncitshiswa kwe-70 80% ekujikelezeni amanqanaba e-IGF1 (amanqanaba afanayo nalawo aphunyezwe kukuzila ngokukhawuleza kweeyure ezingama-72 kwiimpuku) ezingama-29,125, zazikhuselwe amayeza amathathu kwamane e-chemotherapy avavanyiwe, kubandakanya i-doxorubicin.

Izifundo ze-Histology zibonise iimpawu ze-doxorubicin-indased cardiac myopathy kuphela kwiimpuku zokulawula unyango lwe-doxorubicin kodwa hayi kwiimpuku ze-LID. Kuvavanyo lwezilwanyana ezinesifo se-melanoma eziphathwe nge-doxorubicin, akukho mahluko ngokubhekisele ekuqhubekeni kwesifo phakathi kolawulo kunye neempuku ze-LID kwajongwa, kubonisa ukuba iiseli zomhlaza azikhuselwanga kwikhemotherapy ngamanqanaba anciphisiweyo e-IGF1. Ukanti, kwakhona, iimpuku ze-LID ezithwele ithumba zibonise ithuba lokusinda elimangalisayo xa kuthelekiswa nezilwanyana zokulawula ngenxa yokukwazi kwabo ukumelana ne-doxorubicin toxicity29. Ke ngoko, xa zizonke, ezi ziphumo ziqinisekisile ukuba i-IGF1 isemgomeni yindlela ephambili yokuzila ukutya ekonyusa ukunyamezelana ngamayeza

Zombini ii-dexamethasone kunye ne-mTOR inhibitors zisetyenziswa kakhulu kunyango lomhlaza, nokuba kungenxa yokusebenza kwawo njenge-anti-emetics kunye anti-allergics (Oko kukuthi, i-corticosteroids) okanye eyabo antitumour iipropati (Oko kukuthi, ii-corticosteroids kunye nee-mTOR inhibitors). Nangona kunjalo, enye yazo ephambili kwaye ihlala ithintela imiphumo emibi hyperglycaemia. Iyahambelana nombono wokonyusa iswekile cAMP PKA uphawu kuncitshiswa ukuxhathisa ubuthi kumachiza amayeza esifo samachiza12,26,126, zombini dexamethasone kwaye I-rapamycin yandisa ubuthi be-doxorubicin kwi-cardiomyocyte yeempuku kunye ne-mice26. Into enomdla kukuba yayinokwenzeka ukuba iphinde iphinde iphinde iphinde iphinde iphinde iphinde ijikeleze i-glucose ejikelezayo ngokuzila okanye nge-insulin injections26.

Olu ngenelelo lunciphisa umsebenzi we-PKA ngelixa lisonyusa imisebenzi ye-AMPK kwaye ngokwenza oko kusebenze i-EGR1, ebonisa ukuba umqondiso we-CAMP-PKA ulamla i-DSR ebangelwe kukuzila nge-EGR1 (ref. 26). I-EGR1 ikwakhuthaza ukubonakaliswa kwee-peptides ze-cardioprotective, ezifana ne-atrial natriuretic peptide (ANP) kunye ne-B-type natriuretic peptide (BNP) kwizicubu zentliziyo, enegalelo ekuchaseni i-doxorubicin. Ngapha koko, ukuzila ukutya kunye / okanye i-FMD inokukhusela iimpuku kwi-doxorubicin-induction cardiomyopathy ngokwandisa i-autophagy, enokuthi ikhuthaze impilo yeselfowuni ngokunciphisa imveliso ye-oksijini esebenzayo (ROS) ngokuphelisa ukungasebenzi kakuhle kwemitochondria kunye nokususwa kwezinto ezinobungozi.

Ukongeza ekunciphiseni i-chemotherapy ukunciphisa ubuthi kwiiseli kunye nokwanda kokusinda kweempuku eziphathwe ngamayeza e-chemotherapy, imijikelezo yokuzila ukudla yokuvuselela umongo wethambo kunye nokuthintela ukunyanzelwa komzimba okubangelwa yi-cyclophosphamide ngendlela enxulumene ne-PKA kunye ne-IGF1-enxulumene25. Ke, iziphumo ezinyanzelekileyo zangaphambi kokubonisa zibonisa amandla okuzila kunye nee-FMDs ukunyusa ukunyamezelana kwe-chemotherapy kunye nokuphepha iziphumo ebezingalindelekanga. Kungenxa yokuba idatha yokuqala yeklinikhi ibolekisa ngenkxaso yoku, kwaye ezi zifundo zangaphambi kokufunda zakha isiseko esomeleleyo sokuvavanya ii-FMDs kuvavanyo lweklinikhi olungenamkhethe kunye neeTEAE njengendawo yokugqibela yokuphela.

Umahluko woxinzelelo loxinzelelo: Ukonyusa ukubulawa kweSeli yomhlaza

Ukuba isetyenziswe yodwa, uninzi lokungenelela kokutya, kubandakanya ukuzila ukutya kunye ne-FMD, kuneziphumo ezinqamlekileyo ngokuchasene nomhlaza. Ngokwe-sensorization sensitization (DSS) eyahlukileyo yoxinzelelo, ukudityaniswa kokuzila okanye i-FMD ngonyango lwesibini kuyathembisa ngakumbi11,12. Le hypothesis icingela ukuba, ngelixa iiseli zomhlaza ziyakwazi ukuziqhelanisa neoksijini kunye nokujongwa kwezondlo, uninzi lweeseli zomhlaza alukwazi ukwenza utshintsho olunokuvumela ukusinda kwimeko yezondlo-enobungozi kunye netyhefu eveliswa yindibaniselwano yokuzila kunye ne-chemotherapy. , umzekelo. Uvavanyo lwangoko lomhlaza webele, i-melanoma kwaye iiseli ze-glioma zifumene ukonyuka okuthe kratya ekubonakalisweni kokungunda okunxulumene ne-geno okanye i-ribosome biogenesis kunye neentlobo zendibano ekuphenduleni i-fast11,12. Olutshintsho luhamba kunye ne-AKT engalindelekanga kunye nokusebenza kweS6K, ubungakanani bokuvelisa iROS kunye nomonakalo weDNA kunye iimvakalelo Kwisiyobisi esonakalisa iDNA (nge-DSS) 11.

Sithatha lempendulo ingalunganga yeeseli zomhlaza kwiimeko eziguqulweyo kubandakanya ukunciphisa i-IGF1 kunye namanqanaba eglucose abangelwa kukuzila ngokukhawuleza okanye i-FMD njengeyona nto iphambili iphantsi kwengqondo antitumour Iipropathi zolu ngenelelo ngoncedo lokutya kunye noncedo lwazo lokwahlulahlula iziphumo zonyango lwe-anticancer kwiiseli eziqhelekileyo xa kuthelekiswa neeseli11,12 (Ikhiwane. 1). Ngokuhambelana ne-DSS hypothesis, imijikelezo yamaxesha athile yokuzila ukutya okanye ii-FMDs zanele ukucothisa ukukhula kweentlobo ezininzi ze ithumba iiseli, ukusukela kwimigca yeseli eqinileyo yethumba ukuya kwiiseli ze-lymphoid leukemia, kwimouse kwaye, okona kubaluleke kakhulu, kukhuthaza iiseli zomhlaza kwii-chemotherapeutics, i-radiotherapy kunye ne-tyrosine kinase inhibitors (TKIs) 11,17,22,25,50,54-57,59,60,124,127,128, XNUMX.

Umhlaza kunye nokuzila ukutya el paso tx.

Ngokunciphisa ukufumaneka kweglucose kunye nokwandisa i-acid ye-fatty? -I-oxidation, ukuzila ukutya okanye ii-FMDs nazo zinokukhuthaza utshintsho olusuka kwi-aerobic glycolysis (isiphumo seWarburg) siye kwi-mitochondrial oxidative phosphorylation kwiiseli zomhlaza, eziyimfuneko ekugcineni ukukhula komhlaza weseli kwezona ndawo zinesondlo-50 (Umzobo 2). Olu tshintsho lukhokelela ekwandeni kwemveliso ye-ROS11 njengesiphumo sokwanda kwemiphunga yokuphefumla kwaye inokubandakanya ukuncitshiswa kweselfox enokubakho ngenxa yokuhla kwe-glutathione synthesis evela kwi-glycolysis kunye ne-pentose phosphate path50. Iziphumo ezidibeneyo zokwandiswa kweROS kunye nokunciphisa ukhuselo lwe-antioxidant kukonyusa uxinzelelo lwe-oxidative kwiiseli zomhlaza kunye nokwandisa umsebenzi we-chemotherapeutics. Ngokukodwa, ngenxa yokuba umsebenzi ophakamileyo we-glycolytic oboniswe yimveliso ephezulu ye-lactate uqikelelo lobundlongondlongo kunye nokuqina kokuqina kweentlobo ezahlukeneyo zomhlaza129, iziphumo ezichasene neWarburg zokuzila ukutya okanye i-FMD zinokubanakho ukusebenza ngokuchaseneyo nomhlaza womhlaza.

Ngaphandle kotshintsho lwe-metabolism, ukuzila ukutya okanye ii-FMD zenza ezinye iinguqu ezinokukhuthaza i-DSS kwiiseli zomhlaza wepancreatic. Ukuzila ukutya kunyusa amanqanaba amabinzana e ulungelelaniso Umthuthi we-nucleoside 1 (ENT1), umthuthi we-gemcitabine kwi-membrane ye-plasma, ekhokelela ekuphuculweni komsebenzi weli chiza128. Kwiiseli zomhlaza wamabele, ukuzila ukutya kubangela i-SUMO2-Mediated kunye / okanye i-SUMO3-Mediated modification ye-REV1, i-DNA polymerase kunye ne-p53-binding protein127. Olu hlengahlengiso linciphisa ukubanakho kwe-REV1 yokuthintela i-p53, ekhokelela kukonyuka kwe-p53-Mediated transcription of pro-apoptotic genes and, finally, to cancer cell demise (Fig. 2). Ukuzila ukutya kukonyusa amandla e-TKI elawulwa ngesiqhelo ukuyeka ukukhula kwesifo somhlaza kunye / okanye ukufa ngokuqinisa i-MAPK signaling inhibition kwaye, ngokwenza njalo, kuthintela i-E2F yokukhuphela into exhomekeke kwimfuza kodwa nasekunciphiseni ukuthathwa kweglucose17,54.

Okokugqibela, ukuzila ukutya kunokunyusa i-leptin receptor kunye naphantsi kwayo uphawu ngeprotein ye-PR / SET domain 1 (PRDM1) kwaye ke kuthintele ukuqalwa kunye nokuguqula ukuqhubela phambili kweseli ye-B kunye ne-T yeseli ye-lymphoblastic ikholera (ZONKE), kodwa ingeyiyo eyokubalasela kakhulu ikholera (AML) 55. Into enomdla kukuba isifundo esizimeleyo sibonakalise ukuba ii-cell cell zandulelayo zibonisa imeko yesithintelo esinganyangekiyo kwiswekile nakwizibonelelo zamandla ezibangelwa zizinto ezikhutshelweyo i-PAX5 kunye ne-IKZF1 (ref. 130). Utshintsho kwiijeni ezifake ezi proteni zimbini, ezikhoyo ngaphezulu kwe-80% yamatyala eseli-B yeseli YONKE, kubonisiwe ukwandisa ukuthathwa kweglucose kunye namanqanaba e-ATP. Nangona kunjalo, ukuyakha ngokutsha i-PAX5 kunye ne-IKZF1 kwi-preB-ZONKE iiseli kukhokelele kwingxaki yamandla kunye nokubhubha kweseli. Uthathiwe kunye nophando lwangaphambili, lo msebenzi ubonakalisa ukuba BONKE banokuba novakalelo kwisithintelo samandla kunye namandla esenziwa kukuzila ukutya, ngokunokwenzeka simele umgqatswa olungileyo weklinikhi kuvavanyo lokusebenza kokuzila ukutya okanye i-FMD.

Ngokukodwa, kunokwenzeka ukuba uninzi lweentlobo zeseli zomhlaza, kubandakanya i-AML29, zinokufumana uxhathiso ngokunqanda utshintsho lwe-metabolic olwenziwe kukuzila ukutya okanye ii-FMDs, ithuba elinokuthi lonyuswe ngakumbi yi-metabolic heterogeneity ebonisa uninzi lomhlaza129. Ke, eyona njongo iphambili kwikamva elikufuphi iya kuba kukuchonga iintlobo zomhlaza ezichaphazeleka kakhulu kwezi nkqubo zokutya kusetyenziswa ii-biomarkers. Kwelinye icala, xa zidityaniswe nonyango oluqhelekileyo, ukuzila ukutya okanye ii-FMD kunqabile ukuba kukhokelele ekufumaneni ukuxhathisa kwimodeli yegundane lomhlaza, kwaye ukumelana nokuzila kunye ne-chemotherapy nako akuqhelekanga kwizifundo ze-vitro, kugxininisa ukubaluleka kokuchonga unyango, xa zidityaniswe nee-FMD, zikhokelela kwiziphumo ezinetyhefu ngokuchasene neeseli zomhlaza ezinobungozi obuncinci kwiiseli eziqhelekileyo kunye nezicubu11,17,50,55.

Ukuphucula ukungasebenzi kwe-Antitumour ngokuZila okanye ngeFDD

Idatha yakutshanje iphakamisa ukuba ukuzila ukutya okanye ii-FMD zizodwa, kwaye nangaphezulu xa zidityaniswa ne-chemotherapy, kubangela ukwanda kwee progenitors ze-lymphoid kunye nokukhuthaza ithumba uhlaselo lomzimba ngeendlela ezahlukeneyo25,56,60,124. I-FMD iyinciphisile intetho ye-HO1, iprotein enika ukhuseleko kumonakalo we-oxidative kunye neapoptosis, kwiiseli zomhlaza kwi-vivo kodwa ibonakalise intetho ye-HO1 kwiiseli eziqhelekileyo124,131. Ukwehliswa kwe-HO1 kwiiseli zomhlaza kulamla i-FMD-indased chemosensitization ngokwandisa i-CD8 + ye-cytotoxicity exhomekeke kwi-tumor, enokuqhutywa kukuthotyelwa kwemiqathango ye-T cells124 (Ikhiwane. 2). Olunye uphononongo, oluqinisekisile ukukwazi ukuzila ukutya okanye ii-FMDs kunye ne-CR mimetics yokuphucula i-anticancer immunosurveillance, oko kuthetha ukuba iziphumo zokuzila ukutya okanye ii-FMD zinokufaka isicelo sokuzimela ngokuzenzekelayo, kodwa kungabinakho ukuzimela, ii-cancer .56. Okokugqibela, uphononongo lwakutshanje lweentsuku ezimbini zokuzila ukutya kwiiveki ezi-2 kwimodeli yomhlaza wekolon ibonise ukuba, ngokwenza i-autophagy kwiiseli zomhlaza, ukuzila ukutya kunciphisa ukubonakaliswa kwe-CD73 kwaye ngenxa yoko kunciphise imveliso ye-immunosuppressive adenosine ngamaseli omhlaza60. Ekugqibeleni, i-CD73 yokuthotyelwa komthetho ngokuzila ukutya yaboniswa ukuthintela utshintsho lwe-macrophage kwi-M2 immunosuppressive phenotype (Ikhiwane. 2). Ngokwesiseko solu phononongo, kuyathandeka ukuqikelela ukuba ii-FMDs kunokuba luncedo ngakumbi endaweni okanye ngokudibeneyo ne-immune checkpoint inhibitors132, izitofu zomhlaza okanye ezinye iziyobisi ezikhuthaza antitumour ukungathathi hlangothi, kubandakanya ezinye eziqhelekileyo ze-chemotherapeutics133.

Ukutya okubulala intsholongwane kwiimodeli zegundane

Ngokubanzi, iziphumo zophononongo lwangaphambi kokuzila ukutya okanye ii-FMD kwiimodeli zomhlaza wezilwanyana, kubandakanya iimodeli zomhlaza we-metastatic (Itheyibhile 2), bonisa ukuba ukuzila ukutya ngamaxesha athile okanye ii-FMDs kufezekisa iziphumo ze-anti-cancer ze-pleiotropic kunye nokwenza umsebenzi we-chemotherapeutics kunye ne-TKIs ngelixa kusenziwa iziphumo zokhuselo kunye nokuhlaziya kumalungu amaninzi22,25. Ukufezekisa iziphumo ezifanayo ngaphandle kokuzila ukutya kunye / okanye ii-FMD kuya kufuna kuqala ukuchongwa kwaye emva koko kusetyenziswe iziyobisi ezininzi ezisebenzayo, ezibizayo nezihlala zinetyhefu kwaye zinokubakho ngaphandle kokufumana ukhuselo lweseli olusempilweni. Kuyaphawuleka ukuba ubuncinci kwizifundo ezibini zokuzila ukutya kunye ne-chemotherapy kungqineke kuphela kongenelelo olunakho ukufezekisa ukubuyela umva ngokupheleleyo okanye ukusinda ixesha elide kwisiqwengana esingaguqukiyo sezilwanyana eziphathwayo11,59

Umhlaza kunye nokuzila ukutya el paso tx.

Ii-KD ezingapheliyo zibonisa a ithumba ukulibaziseka kokukhula kwempembelelo xa isetyenziswa njenge-monotherapy, ngakumbi kwiimodeli zegundane lomhlaza wobuchopho77,78,80 82,84,134. I-Gliomas kwiimpuku ezigcinwe kwi-KD engapheliyo ziye zanciphisa ukubonakaliswa kwe-hypoxia marker carbonic anhydrase 9 kunye ne-hypoxia-inducible factor 1 ?, yehlise into yenyukliya-? iMatrix Metalloproteinase 2 kunye neVimentin) 2. Kwimodeli ye-glioma ye-intracranial yeempuku, iigundane ezondla i-KD ibonakalisile inyukile isisu esisebenzayo iimpendulo ze-immune zangaphakathi kunye nezilungelelanisiweyo ezaziphikiswa ikakhulu zii-CD8 + T zeeseli79. Ii-KDs zibonisiwe ukuphucula umsebenzi we-carboplatin, cyclophosphamide kunye ne-radiotherapy kwi-glioma, umhlaza wemiphunga kwaye Iimodeli zeempuku ze-neuroblastoma73-75,135. Ukongeza, uphononongo lwamva nje lubonisa ukuba i-KD inokuba luncedo ngokudibeneyo ne-PI3K inhibitors72. Ngokuthintela i-insulin uphawu, ezi agents zikhuthaza ukuqhekeka kwe-glycogen esibindini kunye nokuthintela ukuthathwa kweswekile kwithambo lomthambo, ekhokelela kwisikhashana hyperglycaemia kunye nokukhululwa kwe-insulin kwi-pancreas (into eyaziwa ngokuba yi- insulin feedback ). Kwelinye icala, this ukukhulisa kumanqanaba e-insulin, anokuthi athathwe ixesha elide, ngakumbi kwizigulana ezinokunganyangeki kwe-insulin, iphinda isebenze iPI3K mTOR uphawu in amathumba, ngaloo ndlela kuncitshiswe ngamandla izibonelelo ze-PI3K inhibitors. I-KD ibonakaliswe isebenza kakhulu ekuthinteleni ingxelo ye-insulin ekuphenduleni kula machiza kunye nokuphucula imisebenzi yabo ye-anticancer kwimouse. Okokugqibela, ngokutsho kophando kwimodeli ye-cachexia ye-murine tumor-induced cachexia (MAC16 tumors), ii-KDs zinokunceda ukukhusela ilahleko yamafutha kunye non-fat body mass in izigulana ezinomhlaza85.

I-CR inciphise i-tumorigenesis kwiimodeli zomhlaza wemouse yemfuza, iimodeli zegundane kunye ne-tumorigenesis kunye ne-carcinogen ebangela imodeli yegundane yomhlaza, nakwiinkawu91,92,97,98,101,102,104-106,108,109,136-138. Ngokwahlukileyo, uphononongo lufumanise ukuba i-CR ukusuka kubudala obuphakathi inyusa imeko yeeplasma zeeseli kwi-C57Bl / 6 iimpuku139. Nangona kunjalo, kwakwisifundo esinye, i-CR ikwandise ubude bexesha lokuphila malunga ne-15%, kwaye ukonyuka okuqaphelekayo kweziganeko zomhlaza kwabangelwa kukunyuka kwexesha elide leempuku eziphantsi kweCR, ubudala apho ukuvelisa amathumba iimpuku ezenzeka kwiCR zafa kunye nepesenti ye ukuvelisa amathumba iimpuku ezaziphathwa nguCR Ke, ababhali bagqibile ukuba i-CR mhlawumbi iyakugcina ukukhuthaza kunye / okanye ukuqhubela phambili komhlaza osele ukhona we-lymphoid. Uhlalutyo lwe-meta ngokuthelekisa i-CR enganyangekiyo kunye ne-CR ngokuqhubekayo malunga nokukwazi kwabo ukunqanda umhlaza kwiintonga ukugqiba ukuba i-CR esebenzayo isebenza ngakumbi kwiimodeli zemouse ezenzelwe injini, kodwa ayisebenzi kangako kwiimodeli zerhafu eyenzelwe oko ngekhemikhali90. CR yaboniswa ukuba icothe ithumba ukukhula kunye / okanye ukwandisa ukusinda kwegundwane kwiimodeli ezahlukeneyo zemouse zomhlaza, kubandakanya umhlaza we-ovarian kunye ne-pancreatic140,94 kunye ne-neuroblastoma81.

Ngokubalulekileyo, i-CR iphucule umsebenzi wonyango lwe-anticancer kwiimodeli ezininzi zomhlaza, kubandakanya umsebenzi we-antiIGF1R antibody (ganitumab) ngokuchasene nomhlaza wamathumbu141, cyclophosphamide ngokuchasene neeseli ze-neuroblastoma135 kunye ne-autophagy inhibition kwi-xenogwork ye-HRAS-G12Vtransformed infonntwana yeeseli yePum. Nangona kunjalo, i-CR okanye i-KD ngokudibeneyo kunyango lwe-anticancer lubonakala lungasebenzi kakuhle kunokuzila. Uphononongo lwegundwane lufumene ukuba, ngokuchaseneyo nokuzila kuphela, i-CR iyodwa ayikwazanga ukunciphisa ukukhula kwe-gliomas ye-GL100 ekhula ngokungekho sikweni kwaye, kwakhona, ngokuchaseneyo nokuzila kwexesha elifutshane, i-CR ayizange yandise umsebenzi we-cosplatin ngokuchasene ne-subcutaneous 26T4 isifuba tumours1. Kuphononongo olufanayo, ukuzila ukutya kuye kwangqineka kusebenza ngakumbi kune-CR kunye ne-KD ekwandiseni ukunyamezeleka kwe-doxorubicin51. Nangona ukuzila ukutya okanye i-FMD, i-CR kunye ne-KD kunokwenzeka ukuba zisebenze kwaye zilinganise ukugqagqana uphawu iindlela, ukuzila ukutya okanye i-FMD mhlawumbi ichaphazela iindlela ezinjalo ngendlela evuthayo ngexesha lesigaba esibuhlungu sexesha leentsuku ezimbalwa.

Inqanaba lokuthathwa kwakhona ke u bubele Ukuvuselelwa kwe-homeostasis yelungu lomzimba wonke kodwa kwakhona kusebenze kunye neendlela ezinamandla zokukhuthaza ukwamkelwa kunye nokususwa ithumba kunye nokuhlaziya iiseli ezisempilweni. I-CR kunye ne-KD ngamanyathelo ongenelelo angapheliyo akwaziyo ukuthoba umlinganiso kuphela kwindlela yokuziva unezakha-mzimba, ngokunokwenzeka ngaphandle kokufika kwimibandela ethile eyimfuneko yokuphucula iziphumo zamachiza e-anticancer, ngelixa ebeka umthwalo omkhulu kwaye uhlala uncipha ngokuthoba umzimba. I-CR kunye ne-KD njengeerejimeni zokutya ezingapheliyo kwizigulana ezinomhlaza kunzima ukuzenza kwaye zinokuthwala umngcipheko kwimpilo. I-CR inokuthi ikhokelele ekulahlekelweni okunzima kwesisindo somzimba onqabileyo kunye nokuncitshiswa kweehomoni ze-steroid kunye nokusebenza kwe-immune142. Ii-KD ezinganyangekiyo zidityaniswa ngokufanayo nangona zinemiphumela emibi kakhulu143. Ke, ukuzila ukutya ngamaxesha athile kunye nemijikelezo ye-FMD ehlala ixesha elingaphantsi kweentsuku ze-5 ezisetyenzisiweyo kunye nonyango olusemgangathweni lunamandla aphezulu okuphucula unyango lomhlaza ngelixa linciphisa iziphumo zalo ezibi. Ngokukodwa, kuya kubalulekile ukuba ufunde ngesiphumo sokudityaniswa kwee-FMD ezikwixesha elithile, ii-KD ezingapheliyo kwaye Unyango oluqhelekileyo, ngakumbi unyango lwe-cancers enobushushu njenge-glioma.

Ukuzila ukutya kunye nee-FMD ekuthinteleni umhlaza

Izifundo ze-Epidemiological kunye nezifundo kwizilwanyana, kubandakanya i-monkey108,109,144, kwaye abantu bayababoleka bayayixhasa ingcinga yokuba i-CR engapheliyo kunye nokuzila ukutya okwethutyana kunye / okanye i-FMD inokuba nefuthe lokuthintela umhlaza ebantwini. Nangona kunjalo, i-CR ayinakufezekiswa kuluntu ngokubanzi ngenxa yemicimbi yokuthobela kunye neziphumo ebezinokwenzeka ze115. Ke ngoko, ngelixa iingcebiso ezisekwe kubungqina bokutya onokukhetha (okanye ukunqanda) kunye neengcebiso zendlela yokunciphisa umngcipheko womhlaza ziye zisungulwa6,8,9,15, injongo ngoku kukuchonga kwaye, ngokunokwenzeka, ukubekwa emgangathweni okunyamezelweyo, imilinganiselo yokutya esemthethweni enexesha elincinci okanye alikho Iziphumo ebezingalindelekanga kunye nokuvavanya ukusebenza kwabo kuthintela umhlaza kwizifundo zonyango.

Njengoko sekuxoxwe ngaphambili, imijikelezo ye-FMD ibangela ukuba i-IGF1 kunye neglucose kunye nokunyuka kwe-IGFBP1 kunye nemizimba ye-ketone, lutshintsho olufana nolwabangelwa kukuzila ngokukhawuleza kwaye ibe zii-biomarkers ze-reaction22 zokuzila ukutya. Xa i-C57Bl / 6 iimpuku (ezithi ngokuzenzekelayo ziphuhliswe amathumba, ngokuyintloko i-lymphomas, njengoko bekhula) batyiswa i-FMD enjalo kwiintsuku ze-4 kabini ngenyanga eqala kubudala obuphakathi kunye nokutya okukhuselekileyo kwe-aditum kwixesha eliphakathi kwemijikelezo ye-FMD, imeko ye-neoplasms yancitshiswa ukusuka kwi-70% yeempuku kulawulo ukutya kuya malunga ne-40% kwiigundane kwiqela le-FMD (iyonke i-43% yokunciphisa) i-22. Ukongeza, i-FMD ihlehliswe ngaphezulu kweenyanga ze-3 ukwenzeka kwesifo esinxulumene neoplasm, kwaye inani lezilwanyana ezinezilonda ezininzi ezingaqhelekanga zaphindaphindeka kathathu kwiqela lolawulo kunakwiziimpuku ze-FMD, ebonisa ukuba uninzi amathumba kwiigunduzi ze-FMD zazingenaburhalarhume okanye ziluhlaza.

Uphononongo oludlulileyo lokuzila olunye usuku-lokuzila ukutya, olwenziwe kwiigundane ezineminyaka ephakathi iyonke iinyanga ze4, kwafumaniseka ukuba ukuzila ukutya kunciphisa imeko ye-lymphoma, kuyizisa ivela kwi-33% (yolawulo lweempuku) ukuya kwi-0% izilwanyana) i-145, nangona ixesha elifutshane lokufunda alaziwa ukuba ngaba irejimeni yokuzila ukutya iyathintela okanye balibazisa nje ithumba ukuqala. Ngapha koko, enye into yokuzila ukutya imihla ngemihla ibeka imihla ye-15 ngenyanga yokutya okuphela kwamanzi, ngelixa kulingo lwe-FMD oluchazwe apha ngasentla zabekwa kukutya okunikezela ngesixa esilinganiselweyo sokutya ngeentsuku ze-8 kuphela ngenyanga. Emntwini, imijikelezo ye-3 yemihla ngemihla ye-5-FMD kanye ngenyanga yaboniswa ukunciphisa ukutyeba kwesisu kunye nokuphawula ukuvuvukala kunye ne-IGF1 kunye namanqanaba eglucose kwizifundo ezinamanqanaba aphakamileyo ezi zimakishi62, ebonisa ukuba ukusetyenziswa kwe-FMD kusenokwenzeka Iziphumo zokuthintela izifo ezinxulumene nokukhuluphala okanye ezinxulumene nokuvuvukala, kodwa nezinye, izinto ezinomhlaza ebantwini, njengoko kubonisiwe mice22.

Ke ngoko, iziphumo ezithembisayo zezifundo zangaphambi kokuba zidityaniswe nedatha yezonyango kwisiphumo se-FMD kwimiba yomngcipheko ukwaluphala Izifo, kubandakanya umhlaza62, inkxaso mboleko kwizifundo ezenziwa ngokungahleliwe ze-FMD njengesixhobo esinokwenzeka sokuthintela umhlaza, kunye nezinye ukwaluphala iimeko ezingapheliyo, ebantwini.

Ukusetyenziswa kweKliniki kwi-Oncology

Izifundo ezine ezinokwenzeka zokuzila ukutya kunye nee-FMD kwizigulana eziphantsi kwe-chemotherapy ziye zapapashwa njengazo namhlanje52,53,58,61. Kwichungechunge lwe-10 yezigulana ezifunyaniswe ukuba zinomhlaza, kubandakanya isifuba, i-prostate, i-ovari, isibeleko, imiphunga kunye nomhlaza oesophageal, owazinikelayo ngokuzithandela ukuya kwii-140hours ngaphambili kunye / okanye ukuya kwi-56hours kulandela ichemotherapy. ngokuzila ukutya ngokwayo ngaphandle kwendlala kunye nokukhanya kwentloko kuxelwa58. Abo baguli (abathandathu) abakhe bafumana i-chemotherapy kwaye bengakhange bazile ukutya banike ingxelo yokuncipha kukhathala, ubuthathaka kunye neziganeko ezimbi zesisu ngelixa bezila. Ukongeza, kwizigulana apho uvavanyo lomhlaza kunokuvavanywa, ukuzila ukutya akuzange kuthintele ukuncitshiswa kwechemotherapy kumthamo we-tumor okanye kwizimpawu zokumilisa. Kolunye uphononongo, abasetyhini be-13 abane-HER2 (ekwabizwa ngokuba yi-ERBB2) engalunganga, inqanaba II / III umhlaza wamabele ufumana i-neo-adjuential taxotere, i-adriamycin kunye ne-cyclophosphamide (TAC) chemotherapy yenziwa ngokungathandabuzekiyo ukuzila ukutya (amanzi kuphela) i-24hours ngaphambili nasemva kokuqala kwamayeza amayeza kwisondlo ngokwemigaqo esemgangathweni52.

Ukuzila ukutya okwethutyana kwakunyamezeleka kwaye kuncitshisiwe ukwehla kwe-erythrocyte kunye ne-thrombocyte kubalwa kwiintsuku ze-7 emva kwe-chemotherapy. Into enomdla kukuba kolu phononongo, amanqanaba e-H2AX (umakishi womonakalo we-DNA) anyuswe nge-30minutes emva kwe-chemotherapy kwii-leukocyte ezivela kwizigulana ezingazilelanga kodwa hayi kwizigulana ezikhawulezayo. Kwidosi yokunyuka kokuzila kwizigulana ezisebenzisa ichemotherapy esekwe kwiplatinam, izigulana ezingama-20 (ezazinyangelwa ikakhulu i-urothelial, ovarian okanye umhlaza webele) zazicwangciselwe ukukhawuleza i-24, 48 okanye i-72hours (yahlulwe njenge-48hours ngaphambi kwe-chemotherapy kunye ne-24hours emva kwekhemotherapy 53. Iikhrayitheriya zokufezekisa (ezichazwe njengezithathu okanye nangaphezulu kwezifundo ezithandathu kwiqela ngalinye elisebenzisa i-200kcal ngemini ngexesha elikhawulezayo ngaphandle kwetyhefu egqithisileyo) zafezekiswa. Ukuzila ukutya okunxulumene nokuzila babehlala bebakala I-2 okanye ngezantsi, eyona iqhelekileyo kukudinwa, intloko kwaye isiyezi. Njengakwisifundo esandulelayo, ukunciphisa ukonakaliswa kweDNA (njengoko kufunyanwe yi-comet assay) kwii-leukocytes ezivela kwizifundo ezizile ukutya ubuncinci ii-48hours (ngokuthelekiswa nezifundo ezizila ukutya nge-24hours kuphela) zinokubhaqwa kolu vavanyo lincinci. Ukongeza, umkhwa ongathandekiyo ukuya kwinqanaba elincinci le-3 okanye iBanga le-4 neutropenia kwizigulana ezikhawulezela i-48 kunye ne-72hours ngokuthelekisa abo bazila I-24hours nayo yabhalwa.

Kutshanje, uvavanyo lweklinikhi lweklinikhi olungakhethwanga lwenziwa kuvavanywa iziphumo ze-FMD kumgangatho wobomi kunye neziphumo ebezichemotherapy kwizigulana ezi34 zizonke ezinomhlaza webele okanye we-ovarian cancerNNXX. I-FMD yayiquka mihla le ikhalori yokungenisa i- <400kcal, ubukhulu becala ziijusi kunye neebroths, ukuqala iiyure ezingama-36 48 ngaphambi kokuqala kwekhemotherapy kunye nokuhlala kude kube ziiyure ezingama-24 emva kokuphela kwekhemotherapy. Kolu phando, i-FMD ithintele i-chemotherapy ibangele ukunciphisa umgangatho wobomi kwaye yanciphisa nokudinwa. Kwakhona, akukho ziganeko zibi ze-FMD ezixeliweyo. Olunye uvavanyo lwezonyango lwe-FMD ngokudibeneyo ne-chemotherapy okanye ezinye iintlobo zonyango olusebenzayo ziyaqhubeka ngoku kwizibhedlele zase-US nase-Europe, ikakhulu kwizigulana ezifunyenwe zinomhlaza webele okanye we-Prostate63,65-68. Ezi zezifundo zengalo enye yokuhlola ukhuseleko lwe-FMD kunye nokufezekisa okanye ukufundwa kweeklinikhi ngokungahleliwe kugxile kwisiphumo se-FMD kwityhefu ye-chemotherapy okanye kumgangatho wobomi bezigulana ngexesha le-chemotherapy uqobo. Lilonke, ezi zifundo ngoku zibhalise ngaphezulu kwezigulana ze-300, kwaye iziphumo zabo zokuqala kulindeleke ukuba zifumaneke kwi-2019.

Umhlaza kunye nokuzila ukutya el paso tx.

Imiceli mngeni kwikliniki

Isifundo sokuzila ukutya okwethutyana okanye i-FMD kwii-oncology asizizo izinto ezixhalabisayo, ngakumbi ngokubhekisele kwinto yokuba olu hlobo lwerejimeni yendlela yokutya inokuphelisa ukungondleki, isarcopenia, kwaye i-cachexia kwizigulana ezichazwe kwangaphambili okanye ezibuthathaka (umzekelo, abaguli abaphuhlisa i-anorexia njengesiphumo se-chemotherapy) 18,19. Nangona kunjalo, akukho matyala obunzima (ngaphezulu kwebanga lesi-3) lokwehla kobunzima okanye ukungondleki kuxeliweyo kwizifundo zekliniki zokuzila ukutya ngokudibanisa ne-chemotherapy epapashwe njengangoku, kwaye abo baguli bafumana ukwehla kobunzima ngexesha lokuzila bazibuyisa ubunzima babo ngaphambi kokuba Umjikelo olandelayo ngaphandle komonakalo obonakalayo. Nangona kunjalo, sicebisa ukuba i-anorexia yamaxesha ngamaxesha kunye novavanyo lobume besondlo kusetyenziswa iindlela ezikumgangatho wegolide18,19,146 150 kufuneka ibe yinxalenye yezi zifundo kwaye nokuba nakuphi na ukungalunganga kwezondlo kwizigulana ezila ukutya kunye / okanye ii-FMD zilungiswa ngokukhawuleza.

izigqibo

Ukuzila ukutya okwexeshana okanye ii-FMD ngokungaguqukiyo kubonisa iimpembelelo ezinamandla zomhlaza kwimodeli yomhlaza wempuku kubandakanya amandla okwenza i-chemoradiotherapy kunye nee-TKIs kunye nokubangela ukungazinzi komzimba. Imijikelezo ye-FMD inokwenzeka ngakumbi kunendlela yokutya engapheliyo kuba ivumela abaguli ukuba batye ukutya rhoqo ngexesha le-FMD, bagcine ukutya okuqhelekileyo phakathi kwemijikelezo kwaye kungakhokeleli ekulahlekeni kobunzima obukhulu kwaye kunokuba neziphumo ezibi kumajoni omzimba kunye neenkqubo ze-endocrine. Ngokukodwa, njengonyango oluzimeleyo, ukuzila ukutya ngamaxesha athile okanye imijikelezo ye-FMD inokubonisa ukusebenza ngokulinganiselweyo ngokuchasene namathumba amiselweyo. Ngapha koko, kwiimpuku, ukuzila ukutya okanye ii-FMDs zichaphazela ukuqhubekeka kwenani lomhlaza ngokufanayo nakwichemotherapy, kodwa iyodwa, kunqabile ukuba bafanise isiphumo esifunyenwe ngokudibeneyo nesiyobisi somhlaza esinokubangela ukusinda ngaphandle komhlaza11,59. Ke, sicebisa ukuba kukudityaniswa kwemijikelezo ye-FMD yamaxesha athile kunye nonyango olusemgangathweni oluphethe eyona nto iphambili ekukhuthazeni ukusinda komhlaza kwizigulana, njengoko kucetyisiwe yimodeli yegundane11,59 (Ikhiwane.

Olu dibaniso lunokubakho ikakhulu ngenxa yezizathu ezininzi: okokuqala, amayeza omhlaza kunye nolunye unyango lunokusebenza, kodwa icandelo lezigulana aliphenduli kuba iiseli zomhlaza zithatha ezinye iindlela ze-metabolic ezikhokelela ekusindeni. Ezi ndlela zimbi ze-metabolic zinzima ngakumbi ukuzixhasa phantsi kweemeko zokuzila okanye ze-FMD ngenxa yokusilela okanye utshintsho kwiglucose, ii-amino acid ezithile, iihomoni, kunye nezinto zokukhula, kunye nakwezinye iindlela ezingaziwayo ezikhokelela ekufeni kweseli. Okwesibini, ukuzila ukutya okanye i-FMD kunokuthintela okanye kunciphise ukufunyanwa kokunganyangeki. Okwesithathu, ukuzila ukutya okanye i-FMD kukhusela iiseli eziqhelekileyo kunye nezifo kwiziphumo ebezinokubangelwa ziintlobo ezahlukeneyo zamachiza omhlaza. Kwisiseko sobungqina bengqibelelo kunye neklinikhi yokwenzeka, ukhuseleko kunye nokusebenza (ekunciphiseni i-IGF1, i-visceral fat kwaye Imingcipheko yengozi yentliziyo), ii-FMD zikwabonakala njengendlela esebenzayo yokutya ukuze ifundwe kuthintelo lomhlaza. Umngeni obalulekileyo wexesha elizayo iya kuba kukuchonga ezo amathumba abona bagqatswa babalaseleyo ukuba baxhamle ngokuzila ukutya okanye kwii-FMD. Nokuba kwiindidi zomhlaza ezibonakala zingaphenduli ngokukhawuleza ekuzileni okanye kwii-FMD, kusenokwenzeka ukuba zichaze iindlela zokumelana nokungenelela kumachiza okwazi ukubuyisa oosulelo. Kwelinye icala, kufuneka kulunyukiswe ngakumbi ezinye iintlobo zokutya, ngakumbi ukuba ziphezulu kwiikhalori, njengoko zinokukhokelela ekwandeni kwaye kungathinteleki. ukukhula ezithile zomhlaza. Umzekelo, i-KD iyanda ukukhula Imodeli ye-melanoma ene-BRAF eguqukayo kwi-mice123, kwaye kwathiwa ikwakhawulezisa ukuqhubekeka kwesifo kwimodeli ye-AML yeXLUMX.

Ngaphaya koko, kubalulekile ukusebenzisa ii-FMD ngokuqonda kweendlela zokusebenza, kuba amandla abo ukuba isetyenziswe ngokungachanekanga inokuvelisa iziphumo ezibi. Umzekelo, xa iigundane zazikhawuleza kwaye ziphathwa nge-carcinogen enamandla ngaphambi kokuthatha kwakhona, oku kukhokelela ekukhuleni kokugxila kwe-aberrant kwi-ini, kwikholoni kwaye i-rectum xa ithelekiswa nee-rats151,152 ezingakhawuleziyo. Nangona iindlela ezibandakanyekayo kwezi ziphumo zingaqondwa, kwaye ezi zijolise kuzo kungenzeka zingakhange zibekho amathumba, Olu phononongo lubonisa ukuba ubuncinci bexesha elingu-24-48hours phakathi konyango lwe-chemotherapy kunye nokubuyela kwisidlo esiqhelekileyo kubalulekile ukunqanda ukudibanisa imiqondiso yokubuya kwakhona ekhoyo ngexesha lokuphinda usebenze emva kokuzila ukutya kunye namanqanaba aphezulu eziyobisi ezinetyhefu ezinje ngekhemotherapy. Izifundo zeklinikhi zokuzila ukutya okanye i-FMD kwizigulana ezenza inkxaso ye-chemotherapy ukusebenza kwayo kunye nokhuseleko ngokubanzi52,53,58,61. Kwilingo elincinci elincinci elingenamkhethe elibhalise abaguli abangama-34, i-FMD yanceda abaguli bagcina umgangatho wobomi babo ngexesha le-chemotherapy kunye nokunciphisa ukudinwa61. Ukongeza, idatha yokuqala iphakamisa ukubakho kokuzila ukutya okanye ii-FMDs ukunciphisa ichemotherapy eyenziweyo Ukulimala kweDNA kwiiseli ezinempilo kwizigulana52,53.

Izifundo zeklinikhi eziqhubekayo ze-FMDs kwizigulana ezinomhlaza63,65-68 ziya kubonelela ngeempendulo ezomeleleyo zokuba ngaba ukumisela ii-FMD ngamaxesha athile ngokudibanisa ne-arhente yesiqhelo ye-anticancer kuyanceda ukuphucula ukunyamezelana kunye nomsebenzi wale yokugqibela. Kubalulekile ukuba uqaphele ukuba ii-FMDs azizukusebenza ekunciphiseni iziphumo ebezingalindelekanga kunyango kuzo zonke izigulana kwaye ngekhe zisebenze ukuphucula ukusebenza kwazo zonke iindlela zonyango, kodwa zinamandla amakhulu okwenza oko ubuncinci kwinxalenye kwaye mhlawumbi kwinxalenye enkulu yezigulana kunye neziyobisi. Ukunyanga okanye abaguli abangondlekanga okanye abaguli abasemngciphekweni wokungondleki akufuneki babhaliswe kwizifundo zekliniki zokuzila ukutya okanye ii-FMD, kwaye imeko yesondlo sesigulana kunye neanorexia kufuneka zijongwe ngononophelo kuzo zonke izilingo zeklinikhi. Ifanelekile Ukufunxa iiprotein, ii-acids ezibalulekileyo, iivithamini kwaye iiminerali zidibeneyo, apho kunokwenzeka khona, kunye nokukhanya kunye / okanye umthambo omileyo wokusebenza ojolise ekwandiseni umsipha Bunzima kufuneka ifakwe phakathi kwemijikelezo yokuzila okanye ye-FMD ukwenzela ukuba abaguli bagcine ubunzima be-bodyXXUMX esempilweni. Le ndlela yokutya yokutya okuninzi iya kukhulisa izibonelelo zokuzila okanye ze-FMD ngelixa kwangaxeshanye ukhusela izigulana kukungondleki.

Iingxelo:

Isidlo se-Carb esisezantsi-nxu lumene nentliziyo yeRhythm Disorder

Isidlo se-Carb esisezantsi-nxu lumene nentliziyo yeRhythm Disorder

Abantu abafumana iipesenti eziphantsi kakhulu zeekhalori zabo zansuku zonke ezivela kwi-carbohydrates, ezifana neziqhamo, iinkozo, kunye nemifuno yesitashi, ziyakwazi ukuphuhlisa i-fibrillation ye-atrial, okanye i-AFib. Le ngxaki yempilo yenye yezona zinto zixhaphakileyo zentliziyo, ngokuphathelele uphando olutsha olwenziwa kwi-American College of Cardiology ye-68th Scientific Session.

Uphononongo lophando luvavanye iirekhodi zempilo zabantu abaphantse babe li-14,000 bethatha iminyaka engaphezulu kwamashumi amabini nangaphezulu. Abaphandi bazise idatha kwi-Atherosclerosis Risk in Communities, okanye i-ARIC, isifundo sophando esilawulwa ngamaZiko ezeMpilo kaZwelonke aqhutywa ukusuka ngo-1985 ukuya ku-2016. kubo zachongwa nge-AFib ngabaphandi. Iinkcukacha zophando zichazwe apha ngezantsi.

AFib kunye neeCarbohydrates

Abathathi-nxaxheba besifundo baceliwe ukuba baxelele ukusetyenziswa kwansuku zonke kwezinto ze-66 zokutya ezahlukileyo kwi-poll. Abaphandi basebenzisa le ngcaciso ukulinganisa ipesenti yeekhalori ezivela kwi-carbohydrate ukusuka kwintlawulo yekhalori ngamnye. Ii-carbohydrates ziqulethwe kwisiqingatha seekhalori zemihla ngemihla ezithatyathwa ngabathathi-nxaxheba.

Abaphandi baye bahlula abadlali ukuba babe ngamaqela ahlukeneyo ahlukeneyo ngamagqabhadidididididididi aphantsi, ayenzileyo kwaye aphakamileyo, awakuthi iidrobohydrate ziquka ngaphantsi kwe-44.8 iipesenti zeekhalori zabo zemihla ngemihla, zilandelwa yi-44.8 kwi-52.4 ipesenti, ekugqibeleni apho i-carbohydrate ibe ngaphezu kwe-52.4 yepesenti zabo iikhalori zemihla ngemihla, ngokulandelanayo.

Abathathi-nxaxheba abenza ingxelo yokunciphisa i-carbohydrates usetyenziso lwabo babenakho amathuba okuphuhlisa i-AFib, ngokutsho kwabaphandi. Njengoko izibalo zophando olwenziwe kamva, aba bathathi-nxaxheba babekho neepesenti ze-18 ezingenako ukuza kunye ne-AFB xa kuthelekiswa nalabo abaneengxenye ze-carbohydrate ezinomlinganiselo kunye neepesenti ze-16 ezingenako ukuza kunye ne-AFB xa kuthelekiswa nalabo abane-carbohydrat ephezulu yokungenisa. Ezinye izidlo zinganceda ukunciphisa umngcipheko weengxaki zentliziyo.

UDkt Jimenez White Coat

Uhlobo lwe-carbohydrate oyidlayo lunokwenza umehluko omkhulu kwimpilo yakho yonke kunye nokuphila kakuhle. I-carbohydrates edibeneyo igaxwa ngokukhawuleza kunokuba i-carbohydrate elula kwaye ikhupha ukukhutshwa ngokukhawuleza kweswekile, okanye i-glucose, kwigazi. Ii-carbohydrates eziyinkimbinkimbi, ezidla ngokuba zibizwa ngokuthi "ukutya," zibandakanya imifuno, imifuno ye-starchy, okusanhlamvu okupheleleyo kunye nefiber. Ngokomxholo wophando kwinqaku elilandelayo, ukuchitha amaxabiso omgangatho wee-carbohydrate, ezidla ngokubandakanya iziqhamo, imifuno, kunye neengqolowa ezipheleleyo, kunokufaka isandla kwisifo senhliziyo, njenge-fibrillation ye-atrial. Xa kuziwa kwi-carbohydrate, kubalulekile ukudla le macronutrient ebalulekileyo kwimpilo yonke kunye nokuphila kakuhle.

UDkt Alex Jimenez DC, i-CCST Insight

Isondlo se-AFib

Ukuthintela i-carbohydrate ibe yiplani yokulahlekelwa kwesisindo esithandwayo. Izidlo ezininzi, ezifana ne-Paleo kunye nokutya kwe-ketogenic, zigqamisa ukusetyenziswa kwamaprotheni. Ngokutsho kweXiaodong Zhuang, MD, PhD, ugqirha wentliziyo kunye nombhali ophambili wophando, "Impembelelo yexesha elide ye-carbohydrate isithintelo ihlala iphikisana, ngakumbi ngokubhekisele kwimpembelelo yayo kwisifo sentliziyo." "Ukujonga iziphumo ezinokubakho kwi-arrhythmia, uphando lwethu lubonisa ukuba le nkqubo ithandwayo yokulawula ubunzima kufuneka icetyiswe ngononophelo," utshilo kwingxelo epapashwe yi-ACC.

Iziphumo zizalisa uphando lwangaphambili lwezophando, inani elithile eliye ladibanisa iipilisi ze-polyunsaturated kunye ne-high-carbohydrates zokutya ezinokubakho kokufa. Nangona uphando lwangaphambilini lwalucacise ukuba le nxalenye yokutya yathintela imilinganiselo yempembelelo efunyenweyo, uphando olwenziwe ngokwabo aluzange lunqume ezi ziphumo. "Izidlo ezincinane ze-carbohydrates zidibene nomngcipheko omkhulu wokuphuhlisa i-AFIB kungakhathaliseki uhlobo lweenqatha okanye iprotheni ezisetyenziselwa ukufaka indawo ye-carbohydrates," kusho uZhuang.

"Zininzi iindlela ezinokuthi zichaze ukuba kutheni ukunciphisa umda kwiicarbohydrate kunokuba negalelo kwi-AFib," utshilo uZhuang. Enye yeyokuba abantu abatya ukutya okune-carbohydrate ephantsi bahlala betya iziqhamo, imifuno kunye neenkozo. Ngaphandle koku kutya, abantu banokufumana ukudumba okuxhaphakileyo, okunxibelelene ne-AFib. Ngokwesi sifundo sophando, angumbhalo Ingcaciso ekhoyo kukuba ukutya amaninzi kunye neeprotheyini endaweni yezinto eziphathekayo eziphathekayo ezinokwakheka kwe-carbohydrate kungabangela uxinzelelo lwe-oxidative, oluye lwadibaniswa ne-AFib. Isiphumo sinokudityaniswa nomngcipheko owandisiweyo wezinye iintlobo zesifo senhliziyo.

Isicwangciso sokutya seLimi eliPhakathi, esichazwe kwincwadi kaDkt. Valter Longo, sichitha ukusetyenziswa kokutya okucutshungulwayo kunokubangela ukuvuvukala, ukukhuthaza impilo kunye nokuphila ixesha elide. Nangona le nkqubo yokutya ayigxila ekulahlekelweni kwesisindo, ukugxininiswa kwesicwangciso sokutya eside kangakanani kukutya okunempilo. Isicwangciso sokutya seLimi eliPhakathi seNkcazo siye saboniswa ukusiza ukuvuselela ukuhlaziywa kwesiseko se-stem, ukunciphisa amanxeba esiswini, nokuthintela ithambo elihlobene neminyaka kunye nokulahleka kwemisipha, kunye nokwakhiwa kokumelana nokuphuhlisa isifo senhliziyo.

ixesha elide-ukutya-book-new.png

Ukuzila ukutya okufana nokutya, okanye i-FMD, kukuvumela ukuba ube neenzuzo zokutya kwangokwemveli ngaphandle kokulahla umzimba wakho wokutya. Uhlobo oluphambili lwe-FMD kukuba endaweni yokuphelisa ngokupheleleyo ukutya konke iintsuku eziliqela okanye iiveki, uvumela kuphela ikhalori yakho ukuba uyenzele iintsuku ezintlanu ngaphandle kwenyanga. I-FMD inokusetyenziswa kanye ngenyanga ukwenzela ukukhuthaza impilo yonke kunye nokuphila kakuhle.

Nangona nabani na onokulandela i-FMD ngokwabo, i ProLon Ukuzila ukutya ukuxelisa ukutya kunika inkqubo ye-5 yosuku lokutya eye yahlonywa ngamanye kwaye ibhalwe usuku ngalunye, olwenza ukutya okufunayo kwi-FMD ngobungakanani obuchanekileyo kunye nokudibanisa. Inkqubo yokutya iqulethwe ngokulungele ukutya nokulungelelanisa ukutya, ukutya okutsalwa kwezityalo, kubandakanywa imivalo, iisobho, ukutya okutyiwayo, izongezelelo, ukuxiliswa kwamanzi kunye neetas. Ngaphambi kokuqala Ukuzila ukutya kweProLon yokulinganisa ukutya, inkqubo yeentsuku ezi-5 zokutya, okanye nayiphi na indlela yokuguqulwa kwendlela yokuphila echazwe ngasentla, nceda qiniseka ukuthetha nochwepheshe bezempilo ukuze ufumane ukuba le nkqubo yokutya ilungile kuwe.

Ukongezelela, uphando aluzange lubekwe iliso kubathathi-nxaxheba nge-AFib, okanye abantu abane-AFB kodwa abazange bangeniswe esibhedlele. Akuzange kuphande i-subtypes ye-AFib, ngoko ke akungaziwa ukuba izigulane zazinokwenzeka ukuba zifumane iziqendu zokuqhubekayo okanye ukucwangcisa i-AFib. UZhuang wabika ukuba uphando aluzange lubonise imbangela nefuthe. Umvavanyo ongenakulinganiswa unokufuneka ukuba uqinisekise ukuxhamla phakathi kwe-AFib kunye ne-carbohydrates intake ukuvavanya umphumo kubemi abaninzi.

Ubungakanani benkcazelo yethu lukhawulelwe kwi-chiropractic, imiba yempilo yomgudu, kunye namaqaku eyeza asebenzayo, izihloko kunye neengxoxo. Ukuqhubela phambili ukuxoxa ngale ngongentla apha, nceda ukhululeke ukucela uDkt Alex Jimenez okanye uqhagamshelane nathi 915-850-0900 .

Ikhutshwe nguDkt. Alex Jimenez

Ikholi ye-Green Call Now Button H .png

Ingxoxo eyongezelelweyo yesihloko: Ubuhlungu obuBuya buhlungu

Umqolo obuhlungu enye yezona zizathu ezibangeleko zokukhubazeka kunye neentsuku eziphosakeleyo emsebenzini jikelele. Iintlungu ezibuhlungu emva kwesizathu sesibini esivakalayo sokutyelela iofisi yee-dokotela, zibalwa kuphela ngezifo eziphezulu zokuphefumula. Phantse i-80 ipesenti yoluntu iya kubakho ubuhlungu ubuncinane kanye kanye ebomini babo. Umgudu wakho uyisakhiwo esiyinkimbinkimbi esakhiwa ngamathambo, amajoyina, iigaments, kunye nezihlunu, phakathi kwezinye iifomthi ezithambileyo. Ukulimala kunye / okanye imeko ekhutshweyo, njengaye disni, ekugqibeleni unokukhokelela kwiimpawu zentlungu. Ukulimala kwezemidlalo okanye ukulimala kwengozi yeemoto ngokuqhelekileyo kubangelwa yintlungu yokubuhlungu, kodwa ngamanye amaxesha ukuhamba kwezinto ezilula kunokuba neziphumo ezibuhlungu. Ngethamsanqa, ezinye iindlela zokhathalela unyango, ezifana nokunyamekelwa kwe-chiropractic, kunokunceda ukubuyisela intlungu emva kokusetyenziswa kwemilenze kunye nokunyanzeliswa kwemigaqo, ekugqibeleni ukuphucula intlungu.

I-Xymogen Ifomu - El Paso, TX

XYMOGEN's Iifomula zeeNgqungquthela zodwa zifumaneka ngokukhetha abaqeqeshi bezempilo abanemvume. Intengiso ye-intanethi kunye nokuhlaziywa kwamafomula e-XYMOGEN ayinqatshelwe.

Iqhayiya, UDkt. Alexander Jimenez yenza i-XYMOGEN ifomula ifumaneka kuphela kwizigulane ezingaphantsi kwethu.

Nceda ufonele iofisi yethu ukuze sikwazi ukudlulisela udokotela ngokubonisana nokufikelela ngokukhawuleza.

Ukuba uyigulane Iiklinikhi zoNyango kunye neKliniki yeChiropractic, unokubuza malunga ne-XYMOGEN ngokubiza 915-850-0900.

xymogen el paso, tx

Ukuze ube lula kwaye uhlaziywe XYMOGEN mveliso nceda uhlolisise le nxu lumene. *I-XYMOGEN-Inkcazo-umxokozelo

* Zonke iipolisi ze-XYMOGEN ezingentla zihlala zisebenza ngokuthe ngqo.

***

Yeka Ukutya Oku kwaye Misa Ukuhlupheka Okungapheliyo

Yeka Ukutya Oku kwaye Misa Ukuhlupheka Okungapheliyo

Ngaba maxa wambi uvakalelwa kukuba ubuhlungu bakho obungapheliyo buba bunzima emva kokutya ukutya okuthile? Njengokuba kunjalo, uphando luye lwabonisa ukuba ukutya iintlobo ezininzi zokutya kunokubangela impendulo yokuvuvukala emzimbeni womntu. Kwaye sonke siyazi ukuba ukuvuvukala kungaba enye yezizathu ezibalulekileyo zentlungu yakho engapheliyo. Ngaphambi kokuba sixoxe ngezinto zokutya ezinokubangela ukuvuvukala kunye nokutya okunokulwa nokuvuvukala, makhe sixoxe ngokukrakra nokuba ungayilinganisa njani ukuvutha.

Yintoni u kuvimba?

Ukuvuvukala yindlela yokuzivikela yendalo yokhuseleko lomzimba. Isebenza ngokukhusela umzimba womntu kwingozi, ukugula kunye nosulelo. Ukuvuvukala kunceda ukugcina impilo nempilo yonke. Ukuphendulwa kweengxaki kungakhokelela ekuvukeleni. Xa ukhubazekile okanye unesifo, unokubona iimpawu zokuvuvukala: okanye ukuvuvukala, ukubomvu, kunye namabala atshisayo. Nangona kunjalo, ukuvuvukala kungenzeka kubonakala kungenanto. Indlela efanelekileyo yokuxilonga ukuvuvukala kukulinganisa iimveliso ezithile ngeemvavanyo zegazi.

Iprotheyini esebenzayo yeC, okanye i-CRP, into eveliswe sisibindi, yenye yezona zinto zihamba phambili zokuvutha. Amanqanaba e-CRP akhula njengoko ukhenyuza kwanda, ngoko unako ukwazi okuninzi malunga nento eyenzeka ngaphakathi emzimbeni wakho ngokujonga amazinga e-CRP. Ngokutsho kwe-American Heart Association kunye namaziko okuLawula nokuLawula izifo, ukuxinwa kwe-CRP phantsi kwe-1.0 mg / L kubonisa ingozi ephantsi yeengxaki zentliziyo; phakathi kwe-1.0 ukuya kwi-3.0 mg / L iphakamisa umngcipheko wemiba yeentliziyo; kwaye ngaphezu kwe-3.0 mg / L ibonisa umngcipheko omkhulu weengxaki zentliziyo. Amanqanaba athile e-CRP (amakhulu kuno-10 mg / L) angaphakamisa umngcipheko wokuphuhlisa ezinye iinkalo zempilo.

Ezinye ii-biomarkers ezinje ngee-monocyte ezisebenzayo, ii-cytokines, ii-chemokines, iimolekyuli ezahlukeneyo zokubambelela, i-adiponectin, i-fibrinogen, kunye ne-serum amyloid alpha, zezinye ii-biomarkers ezinokulinganiswa kuvavanyo lwegazi ukufumanisa ukudumba. Iimpendulo zokuvuvukala zibandakanya imisebenzi enovelwano, uxinzelelo lwe-oxidative, ukusebenza kwenyukliya kappaB (NF-kB), kunye nemveliso ye-cytokine eqhubayo.

Iiseli zegazi ezimhlophe zidlala indima ebalulekileyo kumzimba womzimba womzimba. Njalo xa ibhaktheriya okanye intsholongwane ingena egazini, amaseli egazi amhlophe, okanye i-leukocytes, ayaqonda kwaye ayitshabalalise abahlaseli bamanye amazwe. Unakho ukukholelwa ukuba inani elisezantsi legazi elimhlophe linokuba luncedo kuba iiseli zegazi ezimhlophe zilwa nentsholongwane, nangona kunjalo, oku akunokwenzeka ukuba kunjalo. Inani lokunyuka kwegazi elimhlophe lingabonisa ukuba kukho enye imbambano yempilo, nangona inani elimhlophe lamaseli egazi aliyona ingxaki ngokwayo.

Ukutya okubangela Ukuvuvukala

Akumangalisi ukuba iintlobo ezifanayo zokutya ezinokubangela ukuvuvukala ngokuqhelekileyo zibhekwa njengento embi kwimpilo yethu, njengama-carbohydrates ahlambulukileyo kunye nee-sodas kunye nokutya okubomvu, kunye nokutya. Ukuvuvukala kuyindlela ebalulekileyo engundoqo edibeneyo nengozi eyongezelelekileyo yezifo ezingapheliyo ezifana nohlobo lwe-2 yesifo seswekile nesifo senhliziyo, phakathi kwezinye izinto zempilo.

Ukutya okungafanelekanga kubangela ukuba inzuzo yesisindo, eyona nto ingengozini yokuvuvukala. Kuphando lwezifundo eziliqela, nangona emva kokuba abaphandi bathathe ukugqithisa kwi-akhawunti, ukuxhamla phakathi kokuvutha kunye nokutya kuhleli, okubonisa ukuba ukunyuka kwesisindo akubanga imbangela yokuvuvukala. Ezinye ukutya zinefuthe elongezelelweyo ekuvukeleni nasekunyuseni ukusetyenziswa kweekorori.

Ukutya okunokubangela ukuvuvukala kufaka:

  • I-carbohydrates ecocekileyo, njengesiqwatho esimhlophe kunye nama-pastries
  • Iifrithi zaseFransi nezinye ukutya okuthosiweyo
  • I-Sodas kunye nezinye iziphuzo ezinoshukela
  • Ukutya okubomvu njengama-burgers kunye ne-steaks kunye nokucutshungulwa inyama njengezinja ezishushu kunye ne-sausage
  • Igargarine, ukufutshane, kunye nesinqumelo

Ukutya okunxamnye nokulwa nokuvutha

Ngaphandle koko, kukho ukutya okulwa nokuvuvukala, kunye nayo, isifo esingapheliyo. Iziqhamo ezithile kunye nemifuno, njengama-blueberries, iipulole kunye nemifuno eluhlaza, ziphezulu kwiipolphen ne-antioxidants, eziyizinto ezinokuthi zineempembelelo ezichasayo. Uphando lwezophando luye lwadibanisa amantongomane kunye nama-biomarkers ayancitshisiweyo kunye nokunciphisa ingozi yesifo sikashukela nesifo senhliziyo. Ikhofi iyakhusela ukuvuvukala, ngokunjalo. Khetha ukutya okuchasayo kwaye unokuphucula impilo yakho yonke kunye nokuphila kakuhle. Khetha ukutya okuvuthayo kwaye unokwandisa umngcipheko wokuvuvukala kunye nentlungu engapheliyo.

Ukutya okunokulwa nokutshaya kubandakanya:

  • iitumato
  • I-oyile ye-olivu
  • Imifuno eluhlaza, njengeipinashi, i-kale, kunye nee-collards
  • Amantonga afana nama-alimondi kunye nama-walnuts
  • Intlanzi enamafutha, njenge-salum, i-tuna, i-mackerel kunye ne-sardines
  • Iintlobo ezinjengama-strawberries, i-blueberries, i-cherries kunye ne-oranges
UDkt Jimenez White Coat

Abaqeqeshi bezempilo bafunda ukuba enye yeendlela eziphambili zokunciphisa ukuvuvukala itholakala. kungekhona kwiphabhinethi yeyeza, kodwa kwifriji. Ukutya okuchasayo kunokusinceda ekunciphiseni impendulo yomzimba womntu. I-immune system idala ukuvuvukala ukukhusela umzimba womntu kwingozi, ukugula kunye nosulelo. Kodwa ukuba ukuvuvukala kuyaqhubeka, kungabangela iintlobo zempilo, kuquka iimpawu zentlungu engapheliyo. Uphando luye lwabonisa ukuba ukutya okuthile kunokuchaphazela imiphumo yokuvuvukala emzimbeni womntu.

UDkt Alex Jimenez DC, i-CCST Insight

Izidlo ezichasayo

Ukunciphisa ukuvuvukala, gxila ekulandeleni ukutya okunempilo ngokubanzi. Ukuba ukhangele ukutya okuchasayo, cinga emva kokutya kweMedithera, ephakamileyo kwiziqhamo, imifuno, i-nut, i-grains epheleleyo, intlanzi kunye namafutha. Isicwangciso sokutya seLimi eliPhakathi, esichazwe kwincwadi ethi nguDkt. Valter Longo, sinokuphelisa ukutya okubangela ukuvuvukala, ukukhuthaza impilo kunye nokuphila ixesha elide. Ukuzila ukutya, okanye i-caloric restriction, kuye kwaziwa ixesha elide ukunciphisa uxinzelelo lwe-oxidative kunye nokunciphisa iindlela zokuguga kwizinto eziphilayo.

ixesha elide-ukutya-book-new.png

Kwaye ukuba ukuzila akusiyo kuwe, isicwangciso sikaDkt. Valter Longo sokutya ixesha elide liquka ukuzila ukudla okufana nokutya, okanye i-FMD, okukuvumela ukuba ufumane izibonelelo zokutya kwangokwempilo ngaphandle kokunciphisa umzimba wakho wokutya. Uhlobo oluphambili lwe-FMD kukuba esikhundleni sokuphelisa konke ukutya ngeentsuku eziliqela okanye kwiiveki, ubeka kuphela i-calorie yakho yokudla iintsuku ezintlanu ngaphandle kwenyanga. I-FMD inokuqhutyelwa kanye ngenyanga ukwenzela ukukhuthaza impilo yonke kunye nokuphila kakuhle kunye nokuncedisa ukunciphisa ukuvuvukala kunye nentlungu engapheliyo.

Nangona nabani na ongakwazi ukulandela i-FMD ngokwabo, uDkt. Valter Longo unika ProLon ukuzila ukutya okufana nokutya, inkqubo ye-5 yemihla ekhutshwe ngabanye kwaye ibhalwe phantsi ukulungiselela ukutya okufunayo kwi-FMD ngobungakanani obuchanekileyo kunye nokudibanisa. Iprogram yokutya iqulethe ukutya okulungele ukulungiswa nokulula, ukutya okutsalwa kwezityalo, kubandakanywa imivalo, isobho, ukutya okuninzi, ukuxhaswa, ukuxiliswa kwamanzi kunye ne teas. Nangona kunjalo, bphambili kuqala Ukuzila ukutya kweProLon yokulinganisa ukutya, inkqubo yeentsuku ezi-5 zokutya, okanye nayiphi na indlela yokuguqulwa kwendlela yokuphila echazwe ngasentla, nceda uqinisekise ukuba uthethe ugqirha ukuze ufumane ukuba unyango olungapheliyo lungakanani.

ProLon Ukutya Ukuxilisa Ukutya Ukutya

Thenga ngoku kuquka i-Free Shipping.png

Ukongezelela ekunciphiseni ukutshaya, ukutya okuninzi ngokwendalo, ukutya okuncinciweyo kunokuba nemiphumo ephawulekayo kwimpilo yakho yempilo kunye nemvakalelo. Ubungakanani benkcazelo yethu lukhawulelwe kwi-chiropractic, imiba yempilo yomgudu, kunye namaqaku eyeza asebenzayo, izihloko kunye neengxoxo. Ukuqhubela phambili ukuxoxa ngale ngongentla apha, nceda ukhululeke ukucela uDkt Alex Jimenez okanye uqhagamshelane nathi 915-850-0900 .

Ikhutshwe nguDkt. Alex Jimenez

Ikholi ye-Green Call Now Button H .png

Ingxoxo eyongezelelweyo yesihloko: Ubuhlungu obuBuya buhlungu

Umqolo obuhlungu enye yezona zizathu ezibangeleko zokukhubazeka kunye neentsuku eziphosakeleyo emsebenzini jikelele. Iintlungu ezibuhlungu emva kwesizathu sesibini esivakalayo sokutyelela iofisi yee-dokotela, zibalwa kuphela ngezifo eziphezulu zokuphefumula. Phantse i-80 ipesenti yoluntu iya kubakho ubuhlungu ubuncinane kanye kanye ebomini babo. Umgudu wakho uyisakhiwo esiyinkimbinkimbi esakhiwa ngamathambo, amajoyina, iigaments, kunye nezihlunu, phakathi kwezinye iifomthi ezithambileyo. Ukulimala kunye / okanye imeko ekhutshweyo, njengaye disni, ekugqibeleni unokukhokelela kwiimpawu zentlungu. Ukulimala kwezemidlalo okanye ukulimala kwengozi yeemoto ngokuqhelekileyo kubangelwa yintlungu yokubuhlungu, kodwa ngamanye amaxesha ukuhamba kwezinto ezilula kunokuba neziphumo ezibuhlungu. Ngethamsanqa, ezinye iindlela zokhathalela unyango, ezifana nokunyamekelwa kwe-chiropractic, kunokunceda ukubuyisela intlungu emva kokusetyenziswa kwemilenze kunye nokunyanzeliswa kwemigaqo, ekugqibeleni ukuphucula intlungu.

I-Xymogen Ifomu - El Paso, TX

XYMOGEN's Iifomula zeeNgqungquthela zodwa zifumaneka ngokukhetha abaqeqeshi bezempilo abanemvume. Intengiso ye-intanethi kunye nokuhlaziywa kwamafomula e-XYMOGEN ayinqatshelwe.

Iqhayiya, UDkt. Alexander Jimenez yenza i-XYMOGEN ifomula ifumaneka kuphela kwizigulane ezingaphantsi kwethu.

Nceda ufonele iofisi yethu ukuze sikwazi ukudlulisela udokotela ngokubonisana nokufikelela ngokukhawuleza.

Ukuba uyigulane Iiklinikhi zoNyango kunye neKliniki yeChiropractic, unokubuza malunga ne-XYMOGEN ngokubiza 915-850-0900.

xymogen el paso, tx

Ukuze ube lula kwaye uhlaziywe XYMOGEN mveliso nceda uhlolisise le nxu lumene. *I-XYMOGEN-Inkcazo-umxokozelo

* Zonke iipolisi ze-XYMOGEN ezingentla zihlala zisebenza ngokuthe ngqo.

***