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Impilo Yesikhumba

Iqela laMayeza eliSebenzayo leKlinikhi yezeMpilo yoLusu. Ulusu lomntu lunokutyhila amabali ngobomi bakhe, ukusuka ekubengezeni kokukhulelwa ukuya kumabala avela kumonakalo welanga. Abantu beva ngokukhusela ulusu lwabo kwimitha yelanga, kodwa amanyathelo amaninzi alula ezempilo anokugcina ulusu lomntu lukwimo entle. Oku kungenxa yokuba ulusu lubonelela ngomqobo womzimba kunye neekhemikhali phakathi kokusingqongileyo ngaphandle kunye nezicubu zangaphakathi.

Lo mqobo usebenza ukukhusela izicubu eziphantsi kwi-pathogens, iikhemikhali, kunye nokuvezwa kokusingqongileyo. Ngokwesakhiwo, ulusu lunemigangatho emibini ephambili, i-epidermis, kunye nedermis. I-epidermis, okanye umaleko ongaphezulu, unoxanduva lwemisebenzi yokuthintela ulusu. I-dermis yinkxaso yesakhiwo kunye nesondlo phantsi kwe-epidermis. Umaleko ngamnye unesakhiwo kunye nomsebenzi wawo owahlukileyo, kwaye nganye ineemfuno zayo. Imiceli mngeni eyahlukeneyo yolusu olusempilweni ibandakanya:

  • Umonakalo wefoto okanye ukuvezwa kwi-ultraviolet (UV) ukukhanya. Ukutshiswa lilanga yeyona ndlela ixhaphakileyo.
  • Isikhumba esomileyo
  • Undintshwenyisile
  • Ukuphilisa Amanxeba
  • Ukuguga

Isimo sesondlo sidlala indima ebalulekileyo ekugcinweni kwesikhumba esinempilo. Isondlo solusu sinokwandiswa ngokuthe ngqo ngokusetyenziswa kwezihloko. Ukusetyenziswa okusemgangathweni kwe-micronutrients kunokuncedisa ukusetyenziswa kokutya, okukhokelela kumqobo onamandla, okhuselekileyo wokukhusela umzimba.

Ukutya okuphezulu kwe9 kukuKhusela kwiLanga El Paso, TX.

Ukutya okuphezulu kwe9 kukuKhusela kwiLanga El Paso, TX.

by | isondlo, Impilo Yesikhumba

Eyona nto ibalulekileyo ngehlobo kukutya. Iihotdog kunye neebhega ezikwi-grill kunye neziqhamo zamaxesha athile kunye nemifuno esele ivuthiwe ukuba ivunwe.� Njengokuba silithanda kakhulu ilanga lasehlotyeni, liseyingozi kwaye linokuba yingozi eluswini lwethu. Sisanxiba i-sun cream, sinxiba iminqwazi, kwaye sinxiba iimpahla zokuzikhusela elangeni, kodwa ubuyazi loo nto ukutya okuthile inokunceda ukuphilisa ulusu lwakho ekonakalisweni lilanga kwaye xa kunokwenzeka inokutyiwa ikrwada.

Kwinqaku elidlulileyo, sithethe ngezondlo ezili-9 ulusu lwakho olufuna ukukhuselwa kwimitha yelanga eyingozi. Nantsi i-9 yokutya ephezulu eya kukukhusela elangeni kwaye ilungele ihlobo.

IGuava:

Xa sicinga ngevithamin C, iingqondo zethu zicinga ngazo naziphi na iziqhamo zesitrasi ezifana neorenji, ilamuni, iikalika kunye negrapefruit. Kodwa ngaba ubusazi ukuba igwava inevithamin C nayo? Enyanisweni, igwava iqulethe malunga namaxesha ama-5 ngaphezulu kwevithamin C njengaso nasiphi na isiqhamo sesitrasi.

I-guava iqulethe malunga ne-228.3 mg yevithamin C kwaye ine-antioxidants ehlasela iiradicals zasimahla kwaye inceda ukomeleza amajoni akho omzimba. I-Vitamin C yaziwa ngokuba ukhwekhwe lwedabi. Ngaphezu koko igwava inokunceda phucula ulusu lwakho. Ngokutya isiqhamo okanye ukusebenzisa amagqabi e-guava, ulusu lwakho luya kuthotywa kwaye i-antioxidants evela kwisiqhamo inokugcina ulusu lwakho luvutha, ukulwa nemibimbi kunye nokunciphisa iimpawu zokuguga kwangaphambili.

Izambane eliswiti:

Ngubani ongathandi iitapile? Sizitya njengefries, zibhakiwe, zifakwe kwi-sautism, zicudiwe kwaye sizisebenzise njengokuzalisa iipayi. Ibhatata ayinjalo. Kukho iindidi ezininzi zeebhatata njengoko zifika zi-orenji, ezimhlophe, kunye nemfusa, kuxhomekeke ekubeni uzifumana phi kwaye ungowuphi ummandla.

Iibhatata esiziqhelileyo zine-orange hue ngenxa ye carotenoids; esinika loo mbala i-orenji ethandekayo kwaye ine-antioxidants ukukhusela ulusu lwethu kumonakalo welanga. Akunjalo kuphela kodwa; Iibhatata zinevithamin A eninzi kakhulu, elunge kakhulu xa ziphekiwe. Abanye abantu bathi iitapile zaziwa ngokuba zinestatshi kakhulu kwaye zinokusetyenziselwa ukuthomalalisa ukutshiswa lilanga ngokukhupha ubushushu esikhumbeni.

 

11860 Vista Del Sol, Ste. 128 Ukutya okuPhezulu oku-9 ukukukhusela kwiLanga El Paso, TX.

 

Amaqunube kunye namaqunube:

Omabini la maqunube mahle ngokwawo kodwa xa edibene, ayi-duo eguqukayo yokunceda imizimba yethu ilwe nelanga. Iiblueberries zizaliswe ngokutyebileyo antioxidants njengoko zilwa neeradicals zasimahla kwiinkqubo zethu kwaye zinokunciphisa amathuba okuba nomhlaza ubonakale.

Amaqunube mahle ngenene njengoko abizwa �indalo”sisithintelo selanga sendalo.� Aqulathe malunga ne-108% yevithamin C kunye ne-elagic acid, ecoca iiradicals zasimahla kwaye yehlise ukujika kwebala okonakaliswe lilanga.� Ijenali yeKhemistri yoKutya kweZolimo yatsho ukuba amaqunube aneanthocyanins, enika isiqhamo umbala waso obomvu othandekayo ukukhusela iiseli zethu.

Iti eluhlaza:

Ngubani ongathandi uhlaza iti? Ayiqulathanga kuphela L-theanine, kodwa ineengenelo ezininzi ezimangalisayo zempilo ezimangalisayo nezikhusela imizimba yethu. Iti eluhlaza inokuselwa okanye isetyenziswe njengekhrimu yesihloko ukuthomalalisa kunye nokuthambisa ulusu lwakho kwimitha yelanga erhabaxa. Iti eluhlaza ipakishiwe kunye neevithamini B2 kunye ne-E, kunye nezixa ezikhulu ze-polyphenol ezibandakanya, i-EGCG (Epigallocatechin Gallate).

Ezi polyphenols zinceda inkqubo yethu yokuvuvukala ilungise iDNA yethu kuyo nayiphi na into embi emizimbeni yethu. Plus iti eluhlaza kuye kwaziwa ukunciphisa umngcipheko iintlobo ezahlukeneyo zomhlaza.

Oatmeal:

I-oatmeal yenye yezokutya esikutyayo sonke ngesidlo sakusasa. Nangona kunjalo, ubuyazi loo nto i-oatmeal ingasetyenziswa ukuthomalalisa ukutshiswa lilanga nokukhupha ulusu olonakaliswe lilanga? Ayisiyiyo loo nto kuphela kodwa xa i-oatmeal igayiwe kakuhle yaziwa ngokuba I-colloidal oatmeal

Usenokuba ulubonile olu hlobo lwe-oatmeal kwicandelo lezempilo/lezonyango kwiivenkile zakho zengingqi kwaye ingabizwa ngokuba, �Aveeno.� �I-oatmeal e-Colloidal yamkelwe yi-FDA ukususela ngo-2003 kwaye isetyenziswe njenge-ointment ye-topical kuye nabani na onayo. eczema. Nabani na onomkhuhlane we-eczema uba nentaphane yokurhawuzelelwa xa evezwe kakhulu yimitha yelanga okanye ngenxa yobushushu basehlotyeni ukwazi kakuhle oku.

Nge-colloidal oatmeal, inceda ukuthomalalisa iimpawu ze-eczema ngokugalelwa ngamanzi kunye nokumbambazela ngobunono umxholo we-eczema ukuthoba ulusu oludumbileyo, ngaloo ndlela luthomalalisa.

Netyhukhamba:

Iikhukhamba zisetyenziselwa nayiphi na into esinokuyicinga ngayo. Kwi-spa, kwiisaladi zethu, okanye njenge-snack emangalisayo. Le mifuno eluhlaza igcwele iivithamini C kunye no-K kunye ne, i-caffeic acid kunye ne-potassium. Akunjalo kuphela kodwa iikomkomere zenziwe ngama-96% amanzi, ahlaziya kakhulu kwaye alungele ulusu. Ekubeni imizimba yethu ilahlekelwa ngamanzi xa sibila kwaye iikomkomere zizalisa zethu amanzi Ukuthatha ukutya kwaye kuyanceda ukupholisa imizimba yethu xa sitshiswe lilanga.

Utamatisi:

Kanye njengamaqunube, iitumato zinelycopene, enika iitumato umbala obomvu oqaqambileyo kwaye inevithamini C. K1, kunye neB9 kunye nepotassium. Iitumato zinokutyiwa zikrwada kwaye zizityebi ngee-antioxidants ezinceda ukulungelelanisa imizimba yethu ye-pH. Njengo, ukukhusela ulusu lwethu elangeni.

Ujodo:

Owu, ivatala � ayisiyiyo kuphela isiqhamo esisetyenziswa kakhulu kwi4th kaJulayi kodwa usesinye sezona ziqhamo zilungileyo zasehlotyeni ezinokutyiwa. Iivatala aziqukethe kuphela iivithamini A, B6 kunye noC; kodwa nabo baphethe I-lycopene njengeetumato. Inceda ulusu lwethu ekufotweni elangeni kodwa lukwindawo ephezulu engama-30 yokutya okuninzi okuthambisa amanzi, ecaleni kweekhukhamba ezine-92% zamanzi kwiipropathi ezigqwesileyo zokugalela ulusu lwethu.

Iikherothi:

Iminqathe ayilunganga nje emehlweni ethu kodwa ubusazi na ukuba iminqathe ilungile ipakethe exineneyo kunye ne-beta-carotene, ejika ibe yivithamin A xa siyitya. Ngaphezu koko ukugqatswa lilanga kunika iminqathe ivithamin C ukuze isincede sikhusele ulusu lwethu. Iminqathe inomthombo omangalisayo we-carotenoids ukuvelisa ukhuseleko lwefoto kwimpilo yethu yolusu.

Apha ekliniki, sizama ukwazisa izigulana zethu malunga nezakhamzimba ezifumaneka kukutya emizimbeni yethu. Kananjalo, ukwenza izigulana zethu zizive zilungile ngokugqibeleleyo, ukhetho olunesondlo. Nokuba kunge uhlengahlengiso okanye ubakhokelela kwiinketho zokutya ezahlukeneyo zobomi obunempilo, oku kutya kuphezulu kwe-9 akuncedi nje ukukhusela ulusu lwakho elangeni kodwa kumnandi kakhulu. Ke zonwabele iinyanga zasehlotyeni kodwa khumbula ukutya ukutya kwakho kwefotoprotective.

 

Izibonelelo zeNCBI

Ukutya okusempilweni sisiseko sempilo entle.�Kufuneka ugcine isondlo�oko kuquka inyama ebhityileyo, iziqhamo nemifuno esandul’ ukutyiwa, nokutya okuziinkozo. Undoqo kukukhetha ukutya okutsha, kwamaxesha athile onyaka akwindawo yakho. Ukutya okukhuliswe ngexesha labo kuneevithamini ezithile kunye neeminerali ezidingwa ngumzimba ngexesha lonyaka apho zivuthiwe kwaye zilungile.

 

 

Chaza

I-14 leeNzuzo zeMpilo ezinamandla zeGuava: www.organicfacts.net/health-benefits/fruit/health-benefits-of-guava.html

Imbono yabaBhali: Yintoni eyona nto iFakelwe iVithamin C ebantwini?: www.tandfonline.com/doi/abs/10.1080/10408398.2011.649149scroll=top&needAccess=true&journalCode=bfsn20&

I-10 eqinisekisiweyo yeeNzuzo zeMpilo zeBlueberries: www.healthline.com/nutrition/10-proven-benefits-of-blueberries

Isicatshulwa seStrawberry sikhusela kwimitha ye-UVA: www.eurekalert.org/pub_releases/2012-08/f-sf-sep080312.php

Tholisa iSistim yeNervous esembindini nge-L-Theanine: blog.bioticsresearch.com/soothe-the-central-nervous-system-with-l-theanine

I-10 leeNzuzo eziqinisekisiweyo zeTea eluhlaza: www.healthline.com/nutrition/top-10-evidence-based-health-benefits-of-green-tea

Imisebenzi echasene nokudumba kwe-oatmeal ye-colloidal (i-Avena sativa) inegalelo ekusebenzeni kwe-oats kunyango lwe-itch ehambelana nolusu olomileyo, olunomsindo: www.ncbi.nlm.nih.gov/pubmed/25607907

Igalelo laManzi asuka kuKutya kunye neeFluids ukuya kuMthelo opheleleyo waManzi: Uhlalutyo lwamaFrentshi kunye ne-UK Population Surveys: www.ncbi.nlm.nih.gov/pmc/articles/PMC5084017/

Iitumato zikhusela ekuphuhliseni i-UV-induced keratinocyte carcinoma ngokuguqulwa kwe-metabolomic: www.ncbi.nlm.nih.gov/pmc/articles/PMC5506060/

I-Watermelon lycopene kunye namabango ezempilo adibeneyo: www.ncbi.nlm.nih.gov/pmc/articles/PMC4464475/

Ukukhuselwa kwefoto yi-carotenoids yokutya: ingcamango, iindlela, ubungqina kunye nophuhliso lwexesha elizayo: www.ncbi.nlm.nih.gov/pubmed/21953695

I-9 iNutrients Nutrients for Healthy Skin El Paso, TX.

I-9 iNutrients Nutrients for Healthy Skin El Paso, TX.

by | Impilo Yesikhumba, nezongezo

Wonke umntu ehlabathini ufuna ulusu olusempilweni. Siyibona ipapashwa kumabonwakude kunye nezinto zokuthambisa kunye nezongezelelo zevithamini. Xa sizilolonga kwaye sitshintsha indlela esitya ngayo, sibona ulusu lwethu luqina ngokutya esikutyayo. Nangona kunjalo, nanini na sikhona gxi niniswa, ukuxhalaba, ukutya ukutya okungenamsoco, okanye ukuhlala elangeni ixesha elide; ulusu lwethu luthatha umthwalo omkhulu kumzimba wethu. Ulusu lwethu lelona lungu likhulu esigquma ukwakheka kwethu sonke kwamathambo. Xa sibeka ulusu lwethu kwiindawo ezibuhlungu okanye sinesifo solusu esiye safumana ngexesha lokuzalwa kwethu, ulusu lwethu luphelelwa izondlo ezithile ezifunwa lusu lwethu.

 

11860 Vista Del Sol, Ste. I-128 9 iZondlo eziBalulekileyo kwi-Healthy Skin El Paso, TX.

Glutathione:

IGlutathione yaziwa ngokuba yi �iyeza elimangalisayo� lokukhanyisa ulusu. Kwabanye abantu abanetoni emnyama, iya kukhanyisa i-melanin yabo yendalo. Eli bala liye laziwa kakhulu ziimpembelelo zemidiya ukuze abantu babe �ulusu lweporcelain. � Nangona kunjalo, eneneni iglutathione yenziwe ziiamino acids ezintathu:

  • Glutamine
  • Glycine
  • cysteine
11860 Vista Del Sol, Ste. I-128 9 iZondlo eziBalulekileyo kwi-Healthy Skin El Paso, TX.

IMelanin

le antioxidant enamandla ukulwa nama-radicals amahhala kwi-immune system yethu kwaye iyahambelana ne-Vitamin E kunye ne-C. Indlela yendalo yokuqinisekisa ukuba umzimba wakho ugcina izondlo ze-glutathione xa uneminyaka yobudala, nantsi imifuno eyotyiswa nge-glutathione:

  • Garlic
  • Anyanisi
  • Iponyoponyo
  • Ikhaphetshu
  • Okra
  • Ispinatshi
  • Kale
  • Icauliflower

Omega-3:

I-Omega-3s yenye yezona zixhaso zixhaphakileyo ezaziwa ngolusu olusempilweni. Esi songezo sigcina umzimba usempilweni kunye nokuthintela ukudumba. I-Omega-3s ikakhulu iku:

  • Intlanzi
  • Imifuno
  • IWalnuts
  • kuvuthwa
  • amaqanda
  • Ispinatshi

Kodwa, kukho imida ethile ekuthatheni izongezo ze-Omega-3 ukuba unokwaliwa kukutya kwaselwandle okanye ukwalana neqanda. Abantu abanezi ntlobo zokutya banokuthetha nogqirha wabo malunga nokuthatha izongezo ze-omega-3 kwifomu yepilisi kwiidosi eziphantsi okanye batye ukutya okutyetyisiweyo kwe-omega-3.

Ezinye izigulana ezinokusilela kwe-omega-3 zaziwa ngokuba nazo Psoriasis, Ngaloo ndlela kusetyenziswa i-lotion ye-topical efakwe kwi-omega-3s ziye zaziwa ngokuzola ukukrala.

Vitamin E:

Vitamin E yenye ezona zongezo zindala nezithembekileyo esele isetyenziswe iminyaka engama-50 nangaphezulu kwi-dermatology. Esi songezo sisebenza kunye neVithamin C ukuya ukulwa nelanga; eyingozi eluswini lwethu.

Amaqela okutya athile eziqulathe iVithamin E kunye neVithamin C ziyimithombo ebalaseleyo kwimpilo yakho iyonke.

Iglucosamine:

Esi songezo sidibene ne-chondroitin ibe yi-combo duo yokuphucula ukuhanjiswa kolusu kunye nokunciphisa imibimbi kunye ephilisa amanxeba eluswini lwethu.

Biotin:

I-Biotin zezona zongezo ezintathu-nye ezijolise iinzipho, iinwele kunye nolusu lwakho. Esi songezelelo sinokufumaneka kwiipilisi zevithamini kwiivenkile zakho zendawo kwaye zinconywa kakhulu ngabadermatologists. Nangona kunjalo, abanye abantu banokunqongophala kwe-biotin kunye ne-zinc enokuthi inyanyaniswe nokungahambi kakuhle kwesikhumba, ngoko, I-biotin idlala indima ebalulekileyo kwimpilo yethu yolusu.

Unokuthatha ipilisi yevithamini okanye bandakanya amaqela okutya athile njengamaqanda, amandongomane, ukutya okuziinkozo, ezinye iimveliso zobisi, kunye nemifuno ethile ekutyeni kwakho ukuze ufumane izondlo zabaxhamli ukugcina ulusu lwakho lusempilweni.

niacin:

Ikwabizwa ngokuba yi-vitamin B3, yaziwa ngokuxhasa impilo yolusu. Esi sondlo sinaso iziphumo ezininzi eziluncedo ukukhuthaza impilo entle yolusu. Sesinye sezona zondlo zibalulekileyo esizisebenzisayo kuba imizimba yethu ayinako ukuzivelisa ngokwayo. Amanye amaqela okutya akwisebe lenyama kunye necandelo lemifuno:

  • Amakhowe
  • Iipatata
  • Imifuno
  • Amazimba
  • Inyama
  • Intlanzi
  • amaqanda
  • Ubisi

IVithamini A:

I-Vitamin A igcwele izondlo njengoko iqulethe i-beta-carotene, ngoko ke ininzi iziqhamo kunye nemifuno equlethe le ncediso. Esi songezelelo sidlala indima ebalulekileyo njengoko inceda ukulungisa naziphi na iintsilelo zesikhumba kunye nempilo yamehlo. Okunye ukutya okonyusa ivithamin A zezi:

  • IiKaroti
  • Ibrokholi
  • Icantaloupe
  • I-squash

Vitamin C:

IVithamin C yenye yezona ndawo ziphezulu zokuphucula impilo yolusu kwaye inezinto ezininzi eziluncedo kuthi inkqubo yomzimba. Ezinye izigulana ziba nescurvy xa zingenayo ivithamin C eyaneleyo kwinkqubo yazo. Ifumaneka kakhulu kwisiqhamo se-citrus, enye yeendlela ezilungileyo zokusebenzisa ivithamini kwinkqubo yakho.

Kodwa, kukho ukubamba xa uthatha i-vitamin C. I-Vitamin C xa ibonakaliswe ekukhanyeni, i-oxidize kwaye ingazinzi. Ke ukuba uthatha isongezelelo, kufuneka sigcinwe kwindawo emnyama kwaye I-PH kufuneka ibe ku-3.5.

Izinki:

I-Zinc yenye yezongezo ezo ukuxhasa ulusu olusempilweni. Le micronutrient inokukhusela ulusu lwethu elangeni kwaye ixhasa inkqubo yethu yokuvuvukala. Okunye kokutya okunokusinceda sithintele umonakalo welanga kwaye kusinike ukongezwa kwe-zinc kubandakanya imbewu, inyama, i-shellfish, ubisi kunye netshokholethi emnyama.

Xa ulusu lwethu ludinga ezi zondlo ze-9, bayasibulela ngokuthatha ixesha lokufumana izongezo eziyimfuneko ukuze siqinisekise ukuba imizimba yethu isasebenza kwaye siphila ubomi obude obunempilo. Kuyavunywa ukuba amajelo eendaba aye asasaza iindlela ezininzi zokukhuthaza impilo yolusu, kodwa eneneni aqala ngokutya ukutya okufanelekileyo okufunwa yimizimba yethu. Xa sitya ukutya okucutshungulweyo kunye nokugalela iiswekile ezenziweyo emizimbeni yethu, siziva sisonqena, ulusu lwethu luthatha umthwalo wokunqongophala kwezondlo esingazinikiyo kunye neengxaki ezininzi zempilo esiya kujongana nazo.

Ewe, sinokuthatha iikhrimu kunye neloshini ukondla ulusu lwethu kwaye silwe nokoma olujongene nolusu lwethu. Kodwa oko kunokuhamba ixesha elide ngaphandle kokuba sitshintshe iindlela zethu zokutya. Abanye abantu basenokothuka ngenxa yokuba besiva ilizwi, ‘ukutya’ yaye baphelele kwizinto abanokukutya. Nangona kunjalo, xa ingumba wezempilo kunye noogqirha bethu besixelela ukuba kufuneka sitye ukutya okunempilo, siyayiyeka. Ngoko ke, ukutya okulungileyo kuyindlela yokuphila kwaye iqala ngezi zondlo ze-9 ukuqinisekisa ukuba ilungu lethu elikhulu liyakhathalelwa kunye nenkqubo yethu yomzimba wonke. Xa sinciphisa ukutya okubi kwaye sigxile ekutyeni okulungileyo, imizimba yethu ivakalelwa ngcono kakhulu.

 

Izibonelelo zeNCBI

Ukuphila impilo enempilo nokutya amaqela akho okutya okusisiseko; nokuba isekelwe kwisityalo okanye i-omnivorous, kunye, nokusebenzisa amaxesha ambalwa ngaphandle konyaka. Indlela yokuphila enempilo embi kukutya ukutya okucutshungulweyo kunye nokungazilolongi, okukhokelela ekutyebeni nasekubanjweni kwentliziyo. Ngokuxhomekeke kumntu kunye nemizamo abazimisele ngayo ukugcina impilo enempilo, banokufikelela ixesha elide ngokunyamekela amathumbu abo kuqala.

 

 

 

Chaza

Ukuncipha kwe-detoxification yolusu kunegalelo kuxinzelelo lwe-oxidative kunye nokumelana ne-insulin: www.ncbi.nlm.nih.gov/pmc/articles/PMC3415238/

I-Glutathione yokukhanyisa ulusu: intsomi ehlaziyiweyo okanye ubungqina obusekwe kubungqina?: www.ncbi.nlm.nih.gov/pmc/articles/PMC5808366/

Uphononongo malunga nokusetyenziswa kwe-omega-3 fatty acids njengesongezelelo sonyango kunyango lwe-psoriasis: www.ncbi.nlm.nih.gov/pmc/articles/PMC3133503/

Impembelelo yokukhusela ekutshisweni lilanga edityanisiweyo ye-ascorbic acid (i-vitamin C) kunye ne-d-alpha-tocopherol (i-vitamin E): www.ncbi.nlm.nih.gov/pubmed/9448204/

Ukutya okungama-20 okuPhezulu kwiVithamin E: www.healthline.com/nutrition/foods-high-in-vitamin-e

IGlucosamine: isithako esilusu kunye nezinye izibonelelo: www.ncbi.nlm.nih.gov/pubmed/17716251

Ukubonakaliswa kolusu lokusilela kwe-biotin: www.ncbi.nlm.nih.gov/pubmed/1764357

I-9 yokutya okutyebileyo kwe-biotin ukongezwa kwisidlo sakho: www.medicalnewstoday.com/articles/320222.php

I-Nicotinic acid/niacinamide kunye nolusu: www.ncbi.nlm.nih.gov/pubmed/17147561

Ukutya okungama-20 okuPhezulu kwiVithamin A: www.healthline.com/nutrition/foods-high-in-vitamin-a

I-Topical L-ascorbic acid: izifundo zokufunxa nge-percutaneous: www.ncbi.nlm.nih.gov/pubmed/11207686

Ukusetyenziswa okutsha kwe-zinc kwidermatology: www.ncbi.nlm.nih.gov/pubmed/20510767

 

I-Psoriasis: Eqhelekileyo kunye noNyango eYodwa

I-Psoriasis: Eqhelekileyo kunye noNyango eYodwa

by | LweMpilo, Impilo Yesikhumba

Psoriasis Abstract

I-Psoriasis sisifo esixhaphakileyo se-T-cell-mediated immune disorder esibonakaliswa ngamacwecwe asokiweyo, abomvu, ajiyile anomlinganiselo ogqithisileyo wesilivere-mhlophe. Kwenzeka kwihlabathi jikelele, nangona iziganeko zisezantsi kwiindawo ezifudumeleyo, ezinelanga. Unobangela ophambili we-psoriasis awaziwa. Ngexesha lesi sifo esisebenzayo, inkqubo yokuvuvukala ephantsi ihlala ibandakanyeka. Uninzi lwezonyango eziqhelekileyo zijolise ekucinezeleni iimpawu ezinxulumene ne-psoriasis kwaye zineziphumo ezibi ezibalulekileyo. Eli nqaku liphonononga uninzi lweendlela eziphandiweyo zendalo kunyango lwe-psoriasis, ngelixa lijongana nonobangela walo. (Altern Med Rev 2007;12(4):319-330)

intshayelelo

Inkqubela phambili yamva nje yemfuza kunye ne-immunological iye yandisa kakhulu ukuqonda kwe-pathogenesis ye-psoriasis njengesifo esingapheliyo, esibangelwa yi-immune-mediated disorder disorder. Isiphako sokuqala somzimba kwi-psoriasis sibonakala sinyuka kwi-cell signing nge-chemokines kunye ne-cytokines esebenza kwi-gene expression ephakanyisiweyo kwaye ibangele i-hyper-proliferation ye-keratinocytes. Ukuqonda okutsha kwesi sifo sintsokothileyo kubangele uphuhliso lonyango lwebhayoloji ekujoliswe kulo. Olu nyango lwenguquko alukho ngaphandle komngcipheko onokwenzeka, nangona kunjalo. Uphononongo lolunye unyango lwendalo lubonelela ngeendlela ezithile zokwandisa ukhuseleko kunye nokusebenza kakuhle kulawulo lwe-psoriasis. I-Psoriasis � I-Pathophysiology, iSiqhelo, kunye neendlela ezizezinye zoNyango uMichael Traub, ND, kunye noKeri Marshall MS, ND

Epidemiology

Ukuxhaphaka kwe-psoriasis kuyahluka ngokubanzi ngokuxhomekeke kubuhlanga. I-Psoriasis ixhaphake kakhulu kwiCaucasus, kunye neemeko eziqikelelwayo ze-60 kwi-100,000 / ngonyaka kule ndawo. Ukuxhaphaka kwayo e-United States yi-2-4 yeepesenti, nangona inqabile okanye ingekho kwi-Native American kunye nabemi abathile base-Afrika-baseMelika. Nangona ixhaphakile eJapan, ayixhaphakanga kangako eTshayina, kuqikelelwa ukuba kukho i-0.3 ekhulwini. Ukuxhaphaka kwabemi ngokubanzi kuMntla Yurophu kunye neScandinavia yi-1.5-3 ekhulwini. Abasetyhini kunye namadoda bachaphazeleka ngokulinganayo kule meko. Ukuqwalasela ukuba i-latitude ichaphazela ukuxhaphaka kunokwenzeka ukuba inxulumene nomphumo onenzuzo wokukhanya kwelanga kwisifo.1 Nangona i-psoriasis ingenzeka nakweyiphi na iminyaka, iminyaka yobudala bokuqala kwi-plaque engapheliyo iqikelelwa kwiminyaka eyi-33, kunye neepesenti ze-75 zamatyala aqaliswe. phambi kweminyaka yobudala engama-46.2 Iminyaka yobudala ibonakala ihamba kancinci kwabasetyhini kunamadoda. Uphononongo lwexesha elide lubonisa ukuxolelwa ngokuzenzekelayo kunokwenzeka malunga nesinye kwisithathu sezigulane ezine-psoriasis.3

Pathophysiology

Kuze kube kutshanje i-psoriasis yayithathwa njengengxaki ye-epidermal keratinocytes; nangona kunjalo, ngoku yaziwa ngokuyintloko njengengxaki yokukhusela umzimba. Ukuze uqonde kakuhle ukungasebenzi kakuhle kwamajoni omzimba okukhoyo kwi-psoriasis, kunyanzelekile ukuba uqonde impendulo eqhelekileyo yolusu. Ulusu lilungu eliphambili le-lymphoid elinenkqubo esebenzayo yokujonga i-immunology exhotyiswe ngeeseli ezibonisa i-antigen, i-cytokine synthesizing keratinocytes, iiseli ze-epidermotropic T, iiseli ze-dermal capillary endothelial, i-draining nodes, iiseli zemast, i-tissue macrophages, i-granulocytes, i-fibroLanger, iiseli ze-fibroblasts, iiseli ze-fibroblasts kunye neeseli ze-fibroblasts. Ulusu lukwanalo ne-lymph nodes kunye ne-T lymphocytes ejikelezayo. Xa zidibene ezi seli zinxibelelana nge-cytokine secretion kwaye ziphendule ngokufanelekileyo ngokuvuselelwa yibhaktheriya, iikhemikhali, ukukhanya kwe-ultraviolet (UV) kunye nezinye izinto ezicaphukisayo. I-cytokine ephambili ekhutshwe ekuphenduleni umboniso we-antigen yi-tumor necrosis factor-alpha (TNF-?). Ngokuqhelekileyo, le yinkqubo elawulwayo ngaphandle kokuba ukuhlambalaza kwesikhumba kuthatha ixesha elide, apho ukuveliswa kokungalingani kwe-cytokine kukhokelela kwimeko ye-pathological efana ne-psoriasis.

Ingxoxo iyaqhubeka nokuba ngaba i-psoriasis yi-autoimmune disorder okanye i-T-helper 1 (Th1) i-immune dysfunction. I-T-cell activation, i-TNF-?, kunye neeseli ze-dendritic zizinto ze-pathogenic ezivuselelwe ekuphenduleni into ebangela ukuba ibangele, njengokulimala komzimba, ukuvuvukala, ibhaktheriya, intsholongwane, okanye ukuhoxiswa kwamayeza e-corticosteroid. Ekuqaleni, iiseli ze-dendritic ezingekabikho kwi-epidermis zivuselela iiseli ze-T ezivela kwi-lymph nodes ekuphenduleni ukuvuselelwa kwe-antigen engaziwa. I-lymphocytic ingena kwi-psoriasis ikakhulu i-CD4 kunye neeseli ze-CD8 T. Iimolekyuli zokubambelela ezikhuthaza ukunamathela kwe-leukocyte zibonakaliswe kakhulu kwizilonda ze-psoriatic.4 Emva kokuba iiseli ze-T zifumana ukuvuselela okuphambili kunye nokusebenza, ukuveliswa kwe-mRNA ye-interleukin-2 (IL-2) kwenzeka, okubangelwa ukwanda okulandelayo kwe-IL-2 receptors. I-Psoriasis ithathwa njengesifo se-Th1 ngenxa yokwanda kwee-cytokines zendlela ye-Th1 � interferon gamma (IFN-?), IL-2, kunye ne-interleukin 12 (IL-12) � efumaneka kwiiplagi ze-psoriatic.

Ukonyuka kwe-IL-2 ukusuka kwiiseli ze-T ezisebenzayo kunye ne-IL-12 kwiiseli zeLangerhans ekugqibeleni zilawula iijene zekhowudi yokubhalwa kwee-cytokines ezifana ne-IFN-?, TNF-?, kunye ne-IL-2, ejongene nokwahlula, ukuvuthwa, kunye nokwanda kwe T iiseli kwimemori effector cells. Ekugqibeleni, iiseli ze-T zifudukela eluswini, apho ziqokelelana kufutshane nemithambo yegazi yedermal. Ezi ziyokuqala kuluhlu lweenguqu ze-immunologic ezibangela ukubunjwa kwezilonda ezibukhali ze-psoriatic. Ngenxa yokuba impendulo ye-immune echazwe ngasentla iyimpendulo ethile eqhelekileyo ekuvuseleleni i-antigen, ihlala ingacacanga ukuba kutheni i-T-cell activation eyenzekayo, ilandelwa yimfuduko elandelayo ye-leukocytes kwi-epidermis kunye ne-dermis, idala ukwanda kweselula ngokukhawuleza. Ukulawulwa kwemfuza okusemgangathweni kunokuba ngunobangela. I-Vascular endothelial growth factor (VEGF) kunye ne-interleukin-8 ekhutshwe kwi-keratinocytes inokufaka isandla kwi-vascularization ebonwe kwi-psoriasis.5

Iiseli ze-dendritic zibonakala zibandakanyeka kwi-pathogenesis ye-psoriasis. Olunye uhlobo lweeseli ze-dendritic ezibandakanyekayo ziiseli zeLangerhans, oyena mlindi wenkqubo yokhuselo lomzimba ebonayo kwaye ibambe ii-antigens, ifudukele kwii-lymph nodes zalapha, ize izinikeze kwiiseli ze-T. Ukusetyenziswa kwe-T lymphocytes kukhulula i-cytokines e-pro-inflammatory efana ne-TNF-? oku kukhokelela ekwandeni kwekeratinocyte. Le mpendulo ye-hyperproliferative iyancipha ixesha lokuhamba kwe-epidermal (ixesha elichanekileyo elithathayo ukuvuthwa okuqhelekileyo kweeseli zesikhumba) ukusuka kwiintsuku ze-28 ukuya kwiintsuku ze-2-4 kwaye ivelise i-scaly plaques ye-psoriasis ye-erythematous. Oku kuqonda kweendlela ze-pathogenic kuye kwakhokelela ekuphuhlisweni kunye nokusetyenziswa kwezonyango kwe-TNF-? i-blocking agents.

Malunga neepesenti ezingama-30 zabantu abane-psoriasis banembali yosapho yesi sifo kwisihlobo sokuqala okanye sesibini. Ubuncinci iiloci ezisithoba zokuchaphazeleka kwekhromosomal ziye zacaciswa (PSORS1-9). I-HLA-Cw6 yeyona nto iphambili kwi-phenotypic expression. Umbutho kunye ne-PSORS ifunyenwe kunye ne-polymorphisms esebenzayo kwi-modifier genes eyenza ukuvuvukala (umzekelo, i-TNF-?) kunye nokukhula kwe-vascular (umzekelo, i-VEGF) .6

Kuyaziwa ukuba i-psoriasis ikhula kwi-bone marrow abamkeli abasuka kubaxhasi abane-psoriasis, icoca kubamkeli kubaxhasi ngaphandle kwe-psoriasis, kwaye iziyobisi ze-immunosuppressive ziyasebenza ekunciphiseni i-psoriasis.7,8 Ngenxa yofuzo lwesi sifo, yintoni enokwenziwa ukuze ukunciphisa ukubonakaliswa kwemfuza ngaphandle kokubhenela kunyango lwe-immunosuppressive? Indlela ye-naturopathic ibandakanya ukuguqulwa kokutya,�ukuzila ukutya, ukongezwa kwe-omega-3, amayeza endalo endalo, amayeza esintu, kunye nolawulo loxinzelelo.

UPizzorno noMurray bacebisa ukuba ezi zikhankanywe ngasentla �ii-antigens ezingachazwanga� ziphuma kwiprotein engaphelelanga, ukunyuka kwamathumbu emathunjini, kunye nokutya okutyayo; isilonda i-toxemia (i-endotoxins); ukukhutshwa kwesibindi okungasebenzi kakuhle; ukusilela kwe-bile acid; ukusetyenziswa kotywala; ukusetyenziswa ngokugqithiseleyo kwamafutha ezilwanyana; ukusilela kwezondlo (iivithamini A kunye ne-E, i-zinc, kunye ne-selenium); kunye noxinzelelo.9 Ezi ngcamango, nangona zikholeleka, azizange zivavanywe ngokwaneleyo.

I-Co-Morbidities

I-Psoriasis inxulunyaniswa ne-co-morbidities ezininzi, kubandakanya ukuhla komgangatho wobomi, ukudakumba, ukwanda komngcipheko we-cardiovascular, uhlobo lwe-2 yeswekile, isifo se-metabolic, umhlaza, isifo sikaCrohn, kunye nesifo samathambo. Kuhlala kungacacanga ukuba umhlaza, ngakumbi umhlaza wolusu kunye ne-lymphoma, zinxulumene ne-psoriasis okanye kunyango lwayo. I-Phototherapy kunye ne-immunosuppressive therapy inokunyusa umngcipheko we-non-melanoma yomhlaza wesikhumba, umzekelo.10

Eyona nto ixhalabisayo likhonkco elijongwayo phakathi kwe-psoriasis kunye nesifo senhliziyo. Ubungqina bubonisa ukuba i-psoriasis yinto ezimeleyo yengozi yesifo se-cardiovascular disease.11 Dyslipidemia, i-coronary calcification, i-protein ye-C-reactive (CRP), iyancipha i-folate, kunye ne-hyperhomocysteinemia ifumaneka ngokuphindaphindiweyo kwizigulane ze-psoriasis.12 Ukuvuvukala ngumxholo oqhelekileyo. phantsi kweemeko zombini, ezibonakaliswe kubukho be-cytokines e-pro-inflammatory kunye ne-activation endothelial.

Iinkqubo ezivuthayo eziphantsi kwe-psoriasis nazo ziphakamisa ukuba kunokwenzeka ukuba i-omega-3 fatty acid, i-folate, kunye ne-vitamin B12 ingabikho, ekwafumaneka rhoqo kwisifo senhliziyo. Isantya esikhawulezayo sokuguqulwa kweeseli zesikhumba kwi-psoriasis sinokubangela ukwanda kokusetyenziswa kwe-folate kunye nokusilela okulandelayo. folate kunye nezinto ezongezelelekileyo zengozi yentliziyo.�13

I-Psoriatic arthritis yimeko yeklinikhi eyenzeka kwiipesenti ze-25 zabantu abane-psoriasis. I-Psoriatic arthritis ihlala ibonakalisa njenge-seronegative arthritis yokukrala, kunye nomboniso weklasikhi obandakanya i-oligoarthritis, ukubandakanyeka kwe-distal interphalangeal joint, i-dactylitis (ukudumba kwamanani), kunye nokudumba kwe-calcaneal.

Iimbono ziphikisana nokuba imeko yesikhumba kunye ne-arthritis ibonisa ukubonakaliswa okwahlukileyo kwesifo esifanayo. Ubungqina be-Genetic, izifundo ze-immunological, kunye nokuguquguquka kwempendulo yonyango zicebisa ukuba zinokuba neemeko ezimbini ezahlukeneyo, mhlawumbi kunye nokuvuvukala okuphantsi okufanayo kunye nokungahambi kakuhle kwe-immune.17,18.

Nangona i-palmoplantar pustulosis (PP) idla ngokuchazwa njenge-subtype ye-psoriasis, i-demographics eyahlukeneyo kunye nohlalutyo lwezofuzo lubonisa i-etiology eyahlukileyo kune-psoriasis. Kwinkangeleko, i-PP ine-yellowbrown sterile pustules evela ezintendeni nasezintweni. Kuphela iipesenti ezingama-25 zalabo bachaphazelekayo babika i-plaque psoriasis engapheliyo. I-PP iyenzeka rhoqo kubasetyhini (i-9: 1 / ibhinqa: indoda) kunye neepesenti ze-95 zabantu abachaphazelekayo banembali yangoku okanye yangaphambili yokutshaya. Ngenxa yoko, i-PP inokuthathwa njengemeko ye-co-morbid kunokuba uhlobo oluhlukileyo lwe-psoriasis.19

Iimpawu zokuxilonga

I-Psoriasis ihlelwa ngokweendidi ezininzi, kunye ne-plaque engapheliyo (i-psoriasis vulgaris) ifomu equka malunga neepesenti ze-90 zamatyala. Iipleyiti ezibukhali ze-erythematous silvery scaling plaques zenzeka kakhulu kumphezulu we-elbows, amadolo, isikhumba, i-sacral kunye ne-groin. Eminye imimandla ebandakanyekayo ibandakanya iindlebe, i-glans penis, indawo yeperinaal, kunye neendawo zokwenzakala okuphindaphindiweyo. Imeko esebenzayo yokuvuvukala kwe-psoriasis ingabonisa i-Koebner phenomenon apho izilonda ezintsha zenza kwindawo yokulimala okanye uxinzelelo.

Kwixesha elizayo, i-Plaque Psoriasis engapheliyo inokufunyanwa ineemeko ezininzi ezinxulumeneyo kunye neempawu ezicacileyo ze-phenotypical kunye ne-genotypical, inika inkcazo yempendulo yayo eguquguqukayo kunyango, ngakumbi ngeearhente zebhayoloji.

I-psoriasis eguquguqukayo yenzeka kwiindawo ezidibeneyo kunye nokugotywa kwesikhumba kwaye ibomvu, iyabengezela, kwaye ihlala ingenasikali. I-Sebopsoriasis, edla ngokubhidaniswa ne-seborrheic dermatitis, ibonakala ngamaxolo anamafutha.kumashiya, i-nasolabial folds, kunye neendawo ze-postauricular kunye ne-presternal.

I-Acute guttate psoriasis ivela kubantwana, abafikisayo, kunye nabantu abadala abancinci malunga neeveki ezimbini emva kosulelo olubukhali lwe-beta-hemolytic streptococcal, olufana ne-tonsillitis okanye i-pharyngitis, okanye usulelo lwentsholongwane. Ibonakalisa njenge-erythematous, i-papular eruption kunye nezilonda ezingaphantsi kwe-1 cm ububanzi kwi-trunk kunye neziphelo. I-Acute guttate psoriasis idla ngokuzibekela umda, isonjululwe kwiinyanga ezi-3-4. Olunye uphando lubonise isinye kwisithathu kuphela sabantu abane-guttate psoriasis bahlakulela i-classic plaque psoriasis.20

I-Pustular psoriasis (von Zumbusch) ikwayi-acute psoriatic eruption. Isigulana sibonisa umkhuhlane kunye nencinci, i-monomorphic, ibuhlungu, i-pustules eyinyumba, ehlala iqhutywe yintsholongwane ye-intercurrent okanye ukuhoxiswa ngokukhawuleza kwe-systemic okanye i-superpotent topical steroids. Inokuthi ibekwe kwindawo yesundu kunye ne-soles (i-palmar-plantar psoriasis) okanye ingenziwa ngokubanzi kwaye inokubeka ubomi esichengeni.

I-Erythrodermic psoriasis, ekwasongela ubomi, ibandakanya yonke indawo yomzimba kwaye inokubangela i-hypothermia, i-hypoalbuminemia, i-anemia, usulelo, kunye nokungaphumeleli kwentliziyo ephezulu.

Isifo sezikhonkwane se-Psoriatic senzeke malunga neepesenti ze-50 zezigulane ze-psoriasis kwaye zidla ngokubonakala njenge-pitting. Olunye utshintsho lwezikhonkwane lungabandakanya i-onycholysis, i-discoloration, ukuqina, kunye ne-dystrophy.

Izinto zobungozi

Ukuphuhliswa kwe-psoriasis kubandakanya ukusebenzisana kwezinto ezininzi zomngcipheko wemfuza kunye nezinto ezisingqongileyo, ezifana ne-beta-hemolytic streptococcal infection, i-HIV, uxinzelelo, kunye namayeza (umzekelo, i-beta-blockers kunye ne-lithium). Njengoko bekutshiwo ngaphambili, ukunqongophala kwe-folate kunye ne-vitamin B12 nako kunokukhokelela. Ukongezelela, kukho ubungqina bokuba utywala, ukutshaya icuba, ukutyeba, uhlobo lwe-2 yeswekile, kunye nesifo se-metabolic kwandisa umngcipheko wokuphuhlisa i-psoriasis.

Ngaphandle kweVEGF, akukho biomarkers zifunyenwe njengeziqikelelo ezithembekileyo zomsebenzi we-psoriasis. I-CRP, i-adhesion molecules e-soluble, kunye ne-soluble cytokine receptors ziye zaphandwa kodwa azihambelani nobunzima.21

Unyango oluqhelekileyo

Unyango oluqhelekileyo lwe-psoriasis lusekelwe kwinqanaba lobunzima. Unyango lwe-psoriasis oluncinci kunye noluncinci lubandakanya i-corticosteroids ye-topical, i-tars, i-anthralin, i-calcipotriene (i-vitamin D3 analog), i-tazarotene (i-retinoid), kunye ne-phototherapy. Oogqirha banokubeka izinto ezilindelekileyo zonyango, ukunika isigulane ukulawula kwesi sifo ngaphandle kokulindela unyango olupheleleyo. I-scalp psoriasis idla ngokuphendula kwiishampu ze-salicylic acid.

I-UVB ekwi-Narrow-band ayisebenzi kangako kodwa ikhuselekile kune-psoralen kunye ne-ultraviolet A (PUVA), enomngcipheko owongeziweyo womhlaza wolusu. Ukutshatyalaliswa kwelanga lolunye uhlobo lwe-phototherapy. Ukubonakaliswa kwe-UV kunciphisa ukubonakaliswa kwe-antigen kwaye kuchaphazela ukubonakaliswa kweeseli, ukuthanda uphuhliso lwe-T-helper 2 (Th2) iimpendulo zomzimba. Iiseli zeLangerhans ezibonisa i-Antigen ziyancipha kuzo zombini inani kunye nomsebenzi.22

Inhlanganisela ye-calcipotriene kunye ne-betamethasone (i-Taclonex) ibonise ukuphumelela okukhulu kwi-psoriasis enzima kune-monotherapy kunye nokuba yodwa.23

Ukuthotyelwa kwesigulane kufuneka kuthathelwe ingqalelo xa kuphuhliswa isicwangciso sonyango. Ukusetyenziswa kwesisombululo esincinci se-topical kunye nokulungiswa kwe-foam ye-corticosteroids ye-topical kunye ne-calcipotriene (xa kuthelekiswa namafutha kunye nama-creams) kunokuphucula ukuthotyelwa.

Unyango olucwangcisiweyo lwe-psoriasis enzima lubandakanya ukusetyenziswa kwe-retinoids yomlomo, i-methotrexate, i-cyclosporine, kunye ne-biological agents ezinokuchaphazela kakhulu ezinye iinkqubo zomzimba.

I-retinoid acitretin yomlomo i-teratogenic kwaye iguqulwa ibe yi-etretinate kunye nokusela utywala obuhambelanayo. I-Etretinate inobomi obude kwaye ine-teratogenic ngaphezu kwe-acitretin. Izigulana ezingamabhinqa kufuneka zisebenzise iindlela ezimbini zolawulo-nzala kwaye akufuneki zikhulelwe ubuncinci iminyaka emithathu emva konyango. Ngenxa yokusebenzisana okunokwenzeka kunye nezithinteli zokukhulelwa ngomlomo, iSt. John's wort (Hypericum perfoliatum) kufuneka iphetshwe. Eminye imiphumo emibi ibandakanya imiphumo ye-mucocutaneous, i-triglycerides ephakamileyo, i-alopecia, kunye ne-hepatitis. Unyango nge-acitretin lufuna ukubekwa esweni rhoqo kobalo lwegazi, iiprofayili zemetabolism ezibanzi, kunye nohlalutyo lokuchama. Amaqhinga okunciphisa i-acitretin toxicity ibandakanya ukusetyenziswa kwe-intermittent, ukunciphisa umthamo wesondlo kuyo yonke enye imini okanye yonke imihla yesithathu, unyango oludibeneyo kunye ne-PUVA okanye i-calcipotriene ye-topical, ukutya okunamafutha aphantsi, ukuzivocavoca kwe-aerobic, ukongezwa kweoli yeentlanzi, kwaye njengoko kuchazwe ngasentla, ukuphepha utywala.

I-Methotrexate (i-MTX) yi-agent ye-systemic esetyenziswa ngokuqhelekileyo kwi-psoriasis kwaye, ngenxa yokuba ikhona iminyaka eyi-35, ininzi yedermatologists ikhululekile ngokusetyenziswa kwayo. I-Methotrexate inqanda i-dihydrofolate reductase (ebangela ukusilela kwe-folic acid esebenzayo) kwaye yenza i-adenosine A1, i-agonist enamandla yokulwa nokuvuvukala. Indlela yokusebenza kwayo inokuba nzima ngakumbi, ibonakaliswe kukuba i-caffeine inqanda i-MTX's anti-inflammatory effects kwi-rheumatoid arthritis kodwa kungekhona kwi-psoriasis okanye i-psoriatic arthritis.24 Iziphumo ezibi kakhulu eziqhelekileyo ze-MTX yi-myelosuppression kunye ne-fibrosis yesibindi. Nangona i-myelosuppression ingenzeki rhoqo, izigulane ezisebenzisa i-MTX zihlala zichaza iimpawu zentloko, ukukhathala, kunye nesicaphucaphu. Ukuxhaswa kwe-folate kunciphisa iziganeko ze-megaloblastic anemia, i-hepatotoxicity, kunye nokunyanzeliswa kwesisu. Nangona i-folic acid kunye ne-folinic acid zibonakala zisebenza ngokulinganayo, i-folic acid ixabisa ngakumbi. . Izigulane zabelwa ngokungaqhelekanga ukufumana i-25 mg / imini ye-folic acid okanye i-placebo kwiiveki ze-22. I-PASI ephakathi kwenyuka (imbi kakhulu) kwiqela le-folic acid, ukusuka kwi-5 kwisiseko ukuya kwi-12 kwiiveki ze-6.4. Kwiqela le-placebo, i-PASI ye-PASI yawa ukusuka kwi-10.8 kwisiseko ukuya kwi-12 kwiiveki ze-9.8 (p <9.2 ngenxa yokwahlukana kwenguqu phakathi kwamaqela) .12

I-Cyclosporine, ichiza elinamandla kunye netyhefu, ngamanye amaxesha liqwalaselwa kwiimeko ezingalawulwayo nge-acitretin, i-PUVA, okanye i-MTX, kodwa ichasene nezigulane ezinomsebenzi ongaqhelekanga wezintso, uxinzelelo lwegazi oluphantsi, ukungasebenzi kakuhle kwesibindi, okanye ukugonywa kwe-immunosuppression. Ukusetyenziswa ixesha elide ngokuqinisekileyo kubangela umonakalo wezintso. Uxinzelelo lwegazi kunye nokujongwa kwe-creatinine kubalulekile.

Ii-Biological agents zivimba ukusebenza kwe-T-cell kunye ne-TNF-? I-Alefacept (Amevive�) iphazamisa ukusebenza kwe-T-cell kwaye inciphisa ukujikeleza kweeseli ze-CD 45 RO+ T. Eli chiza liyiprotheni edibeneyo ye-Fc receptor ye-IgG1 yabantu kunye ne-LFA3, i-co-stimulatory ligand, esebenzisana ne-CD2 kumphezulu we-T-cell. Iiseli ze-CD4 kufuneka zibekwe esweni qho ngeveki ngexesha lonyango ngale arhente.

I-Efalizumab (i-Raptiva�) li-antibody eyenzelwe umntu kwi-CD11 ephazamisana nokurhweba nge-T-cell kwizicubu ezivuthayo kwaye inqanda ukusebenza kwe-T-cell. Nangona isebenza ngokukhawuleza, inokwenzeka kwakhona.

TNF-? i-blockers yehlisa i-proinflammatory gene expression kunye nokubuyisela umva i-phenotype ye-psoriatic. I-Etanercept (Enbrel�) yiprotheni edityanisiweyo ejoliswe ngokuchasene ne-TNF-? I-Infliximab (i-Remicade�) yi-mouse/i-chimeric yomntu i-monoclonal antibody ngokuchasene ne-TNF-? Ezi TNF-? i-inhibitors ilawulwa nge-injection kwaye idibaniswe nokungeniswa kwezinto ezahlukeneyo ze-autoimmune phenomena. Njenge TNF-? ngokwayo, TNF-? i-inhibitors ingaba nemisebenzi ye-proinflammatory kunye ne-anti-inflammatory. Kungenxa yokuba i-arhente ethile ivimbela i-TNF-?, ayincedi nge-psoriasis. Ukuba isigulane sine-genetically predisposed to overproducing TNF- ?, Ukuyinqanda akunakukwanela ukuvelisa inzuzo.27 Iingozi ezinokwenzeka ze-TNF-? izithinteli ziquka ukuvuselelwa kwesifo sephepha esifihlakeleyo, i-hepatotoxicity, i-lymphoma, kunye nokungaphumeleli kwentliziyo.

Imingeni eseleyo kwi-biologics ye-psoriasis ibandakanya: (1) ukuqonda eyona ndlela iphambili kwi-psoriasis kunye ne-psoriatic arthritis; (2) ukuqonda iimpendulo zezigulane ezahlukeneyo kunyango; (3) ukuxela kwangaphambili impendulo yeklinikhi ngaphambi okanye ekuqaleni kwonyango; (4) ukuphuhlisa imixube yomlomo, yokuphefumlelwa kunye neyezihloko; kunye (5) nokugqiba ukuba ngaba unyango luguqula umphumo wexesha elide.

I-Fumaric acid lolona nyango luphambili lwe-psoriasis eJamani. Inciphisa ii-cytokines ezixhomekeke kwi-T-cell, kodwa ayisebenzi njengolunye unyango oluqhelekileyo, kwaye inomngcipheko ophezulu wetyhefu kunye nokunganyangeki kwesisu.

Ukubonelela ngonyango olujikelezayo kunye nokudibanisa kwandisa ukusebenza kunye nokunciphisa ubutyhefu bonyango. Ikamva lisenokuzisa unyango lwe-stem-cell kunye nonyango olusekwe kumfuza, kubandakanywa nonyango lwe-antisense olunqanda ngokuthe ngqo uhlobo oluthile lwe-psoriasis. Nangona kunjalo, iziphumo ezibi kunye netyhefu yonyango oluqhelekileyo lwe-psoriasis lufuna unyango lwendalo olukhuselekileyo nolusebenzayo olunokuthi lusetyenziswe njengezinye iindlela okanye ngendlela edibeneyo.

Unyango lweNdalo Kuba Psoriasis

idayethi

Indlela esekelwe kubungqina ibonisa i-psoriasis, eyona nto i-disorder disorder, kufuneka izuze kwi-anti-inflammatory diet, ukuchonga, ukupheliswa kunye / okanye ukujikeleza kokutya kwe-allergenic, kunye nokuzila ukutya. , izigulane ezininzi ze-psoriasis zibonisa ukunyuka kwe-gluten kunye neempawu zabo ze-psoriasis ziphucula kwi-gluten-free diet.28 Umlinganiselo we-antibodies kwi-tissue transglutaminase kunye ne-gliadin inokunceda ukuchonga eli qela. Ubungqina buphinda bucebise ukugcina ubunzima obunempilo kwizigulane ze-psoriasis, ekubeni i-psoriasis ihambelana ngokufanelekileyo kunye nokwanda kwe-index mass body.30

Ulungelelwaniso phakathi kwe-eicosanoids ye-proinflammatory kunye ne-anti-inflammatory eicosanoids ichaphazeleka kakhulu luhlobo lwe-fatty acids edliwayo. Ukutya okuchasene nokudumba kukugxininisa kumafutha alungileyo (iintlanzi zamanzi abandayo, iindongomane, imbewu, ioli yomnquma, ezinye ioyile ezikumgangatho ophezulu), iinkozo ezipheleleyo, iimbotyi, imifuno, kunye neziqhamo kunye nokuphepha "amafutha amabi" (ahluthisiweyo). amafutha ezilwanyana, amafutha atshintshiweyo, ukutya okuqhotsiweyo kunye nokucutshungulwayo, i-oyile ekumgangatho ophantsi) kunye neecarbohydrates ezisulungekileyo. Ukongezelela, ubuninzi be-omega-6 fatty acids ekutyeni bunokuba negalelo kwimpendulo yokuvuvukala.33 Imithombo ephambili ye-omega-6 yokutya ioli yemifuno efana nengqolowa, i-soy, i-safflower, kunye ne-sunflower, ngelixa imithombo ephambili. ze arachidonic acid yinyama, amaqanda, kunye nobisi.

I-Prostaglandin E2 (PGE2) yi-eicosanoid evelele ephuma kwi-omega-6 fatty acid arachidonic acid. Isenzo esiphezulu se-PGE2 njenge-molecule yesithunywa kukuphucula ukuvakalelwa kwiintlungu ze-neurons, ukwandisa ukuvuvukala, kunye nokunciphisa imithwalo yegazi. Ukusetyenziswa ngokugqithiseleyo kweoli ye-omega-6 kunika i-substrate engaphezulu kwe-synthesis ye-PGE2, eqhuba impendulo enobudlova kunye neqhubekayo yokuvuvukala. I-Prostaglandin E3 (PGE3) yi�evela kwi-omega-3 fatty acid, i-eicosapentaenoic acid (EPA). Amanqanaba aphezulu e-PGE3 anciphisa uvakalelo kwiintlungu, ukukhulula imithambo yegazi, ukwandisa ukuhamba kwegazi, kunye nokuxhasa impendulo yomzimba yendalo yokuchasana nokudumba (Umfanekiso 1).

Psoriasis umfanekiso

Ngelixa zombini i-PGE2 kunye ne-PGE3 ziyimfuneko kwi-homeostasis efanelekileyo, izixa ezihambelanayo zezi molekyuli zezithunywa ezikhuphisanayo zinokuba negalelo okanye zinciphise ii-syndromes ezingapheliyo ezivuthayo. I-EPA icingelwa ukuba isebenze ngokukhuphisana ne-arachidonic acid kwiindawo zokubopha kwi-cyclooxygenase-2 (COX-2), ukuvelisa umlamli ovuthayo ongenamandla, ngoko ke ukunciphisa ukuvuvukala.34

Ngaphambi kwe-Industrial Revolution, kwakungekho mithombo ebalulekileyo ye-omega-6 yeoli yemifuno ekutyeni. Uninzi lweenkcubeko zitya ukutya okuphantsi kwezi oyile kunye nentlanzi ephezulu okanye inyama yenkomo etyiswe kuluhlu okanye inyathi ephezulu kwi-omega-3s, idala umlinganiselo we-omega-6: i-omega-3 eyayimalunga ne-3: 1. I-Industrial Revolution yeza nolwazi kunye nezixhobo zokusulungekisa i-oyile yemifuno, okukhokelela ekutshintsheni ngokukhawuleza kwindlela yokutya kwiinkcubeko ezininzi zaseNtshona. Umlinganiselo we-omega-6: i-omega-3 yatyhalelwa ngokukhawuleza ukuya kuqikelelo lwangoku oluphezulu njenge-11: 1 i-omega-6: i-omega-3.35 Umzimba womntu awukwazanga ukuziqhelanisa nofuzo kolu tshintsho oluphawulekayo ekusebenziseni i-asidi enamafutha.

Iinkcubeko ezininzi zanamhlanje zisebenzisa izixa ezininzi zeoyile yemifuno, ubukhulu becala ekutyeni okucutshungulweyo. Ngokomzekelo, ukuveliswa kweoli ye-soy yokusetyenziswa kokutya kunyuke i-1,000-fold phakathi kwe-1909 kunye ne-1999.36 Ukongeza, imfuyo, iinkukhu, kunye neentlanzi ezifuywayo zondliwa i-cornmeal kunye ne-soy-based feed, ephakamisa umxholo we-omega-6 wenyama kunye nentlanzi. Xa izilwanyana zasefama ziphakanyiswe ngotshani, iintshulube, okanye ezinye izidlo zendalo, izicubu ziphezulu ngokwemvelo kwi-omega-3 fatty acids.37

Ishishini lenyama yenkomo lincoma �ukurhweba� kwimveliso yenkomo egqityiweyo, ngenxa yombona kunye nokutya kwesoya. Iinkomo ezityiswa umbona kunye nesoya zine-omega-6 fatty content ephezulu xa kuthelekiswa neenkomo ezondliwe ingca. Ngelixa iinkomo ezitya ingca zinokuqulatha ukuya kuthi ga kwi-4-pesenti ye-omega-3 fatty acids, iinkomo ezondliwa ngombona ziqukethe i-0.5-pesenti ye-omega-3s.37

Ukutya okuqhelekileyo kwaseMelika kunika umndilili we-omega-6:omega-3 umlinganiselo omalunga ne-11:1. Ukutya okusekelwe kwimifuno kunokubeka umntu emngciphekweni woku�ukutya izixa eziphakamileyo zeoyile yemifuno kunye neemveliso zesoya, kunye nezixa ezisezantsi zeentlanzi, ezinokuthi ziphelise ibhalansi ukuya kwimeko yokudumba. Ukunciphisa ioli yemifuno yokutya kunye nokwandisa i-omega-3 i-EPA kunye ne-docosahexaenoic acid (DHA) ngokutya iintlanzi ezinamafutha afana ne-cod, i-salmon, i-mackerel, kunye ne-sardines inokunceda abantu abajongene nezimo ezingapheliyo ezivuthayo.33

Izityalo ezininzi ezisetyenziselwa i-seasonings, kubandakanywa i-turmeric, i-pepper ebomvu, i-cloves, i-ginger, i-cumin, i-anise, i-fennel, i-basil, i-rosemary, i-garlic, i-pomegranate, inokuthintela i-nuclear factor-kappaB (NF?B) ukusebenza kwe-cytokines evuthayo.38

Izindlela zokutya eziguqula i-fatty acid intake zinokuchaphazela iprofayili ye-eicosanoid ngendlela yokuba iinkqubo ezivuthayo ezifana ne-arachidonic acid kunye ne-T-cell activation ziyancipha, ngelixa i-cytokines ezifana ne-interleukin-4 (i-cytokine ephambili ejongene nokuvuselela impendulo ye-immune ye-Th2. ) zilawulwa.34

Ukongezwa kweZondlo

I-Acids Fatty Acids

Amafutha abalulekileyo (EFAs) anempembelelo kwi-pathophysiology ye-psoriasis ngeendlela ezintathu: okokuqala, ii-EFA zichaphazela i-kinetics yeembrane zeseli; okwesibini, ii-EFA zichaphazela ukuhamba kwegazi kwi-dermal kunye ne-epidermal ngokuphuculwa komsebenzi we-endothelial; kwaye okwesithathu, ii-EFAs zisebenza njenge-agent ye-immunomodulating ngempembelelo yazo kwi-eicosanoids. Ii-EFAs zisetyenziswa njengeziseko ezisisiseko ekuphuhliseni i-phospholipid bi-layer phantse kuzo zonke iiseli ezisemzimbeni womntu, kubandakanya nedermis kunye ne-epidermis. Badala imfezeko yesakhiwo elawula ukuguquguquka, okuchaphazela ukuthuthwa kweeseli, ukubophelela kwezithunywa, kunye nonxibelelwano lweeseli. I-Omega-3 fatty acids inokwenza zombini ngokuthe ngqo na ngokungathanga ngqo kumsebenzi we-endothelial ngokunciphisa i-cytokines yeseli ye-mononuclear ezifana ne-IL-1 kunye ne-TNF?, I-39 iyancipha ukubunjwa kwe-chemo-ekhangayo kwiprotheni ye-platelet-derived growth factor (PDGF), ukwandisa i-bioavailability ye-nitric oxide , kunye nokunciphisa ukubonakaliswa kweemolekyuli zokubambelela. Isiphumo esongezelekayo sokumodareyitha aba balamli be-bioactive kukuthintela i-vascularization, okanye ukukhula komtya omtsha wegazi ngaphakathi kweplaque ye-psoriatic, ngelixa kwangaxeshanye ivumela ukuphuculwa kwe-perfusion ye-dermal tissue.

Izixhobo zombini zendalo kunye nokuzikhusela komzimba, kubandakanywa nokuveliswa kweemodyuli eziphambili ze-immune, kunokuchaphazeleka kwi-omega-3 kunye ne-6 fatty acid intake, njengoko kuxoxwe ngasentla. Iziphumo ze-Immunomodulatory ze-omega-3 fatty acids ziquka ukunyanzeliswa kwe-lymphoproliferation, iiseli ze-CD4 +, i-antigen presentation, i-adhesion molecule presentation, i-Th1 kunye ne-Th2 iimpendulo, kunye nokuveliswa kwe-cytokine e-pro-inflammatory.34

Izifundo ezininzi zibonise inzuzo ye-intravenous okanye yomlomo yokuncedisa ioli yeentlanzi kwi-psoriasis.40-42 Kuphando olwenziwa nguMayser et al, i-intravenous infusions ye-omega-3 fatty acids ikhokelela ekunyuseni kwe-anti-inflammatory leukotriene B5 (LTB5) phakathi kweentsuku ze-4-7 zokuqalisa unyango, xa kuthelekiswa nezigulane zokulawula. Akukho ziphumo bezingalindelekanga ziye zaqatshelwa.

I-EPA ikhuphisana ne-arachidonic acid (AA) ye-5-lipoxygenase kwaye ivelise i-LTB5, enye kuphela yeshumi njengeyona nto inamandla njenge-leukotriene B4 (LTB4) yokuvuvukala. Amanqanaba e-LTB4 abonakaliswe ukuba aphakanyiswe kwiiplagi ze-psoriatic kwaye abonise iimpawu ze-chemotactic eziyimfuneko ekungeneni kwe-leukocyte kunye ne-keratinocyte ukwanda.43

Inqaku lophononongo likaZiboh malunga ne-omega-3s kunye neereferensi ze-psoriasis izifundo ezintandathu ezenziwe kusetyenziswa isongezo se-oyile yentlanzi yomlomo eneziphumo ezixubeneyo. Ngelishwa, iireferensi zoqobo azifumaneki. Izifundo ezibini zaziyimfama kabini kwaye zilawulwa yi-placebo, zisebenzisa i-1.8 g EPA kunye ne-DHA kwiikhosi zeeveki ezisibhozo kunye neeveki ze-12. Uphononongo lweeveki ezisibhozo lubonise inzuzo kwi-itching, scaling, and erythema, ngelixa uphando lweeveki ze-12 lubonisa ukuba akukho nzuzo.44

Izifundo ezintathu ezivulekileyo zenziwe, zibonelela nge-10-18 g EPA kunye ne-DHA yonke imihla kwiiveki ezisibhozo. Zonke izifundo zibonise ukuphucuka, kunye nezifundo ezibini ezibonisa ubulali ukuya kumodareyitha kunye nophononongo olunye olubonisa ukuphucuka okuphakathi ukuya kokugqwesileyo ekunyuseni, ukurhawuzelelwa, kunye nobukhulu bezilonda. Olunye uphando oluvulekileyo oludityaniswe nokutya okunamafutha aphantsi lubonise ukunciphisa kakhulu iimpawu ze-psoriatic.44,45

Uphononongo oluninzi luphonononge ukusetyenziswa kweoyile yentlanzi esentloko kwiindawo ezahlukeneyo ze-EPA. Olunye uphando luchaze izibonelelo, kubandakanywa ukucutha ubukhulu be-plaque kunye nokulinganisa.izilonda ze-psoriatic, kunye nokunciphisa okuphawulweyo kwi-erythema.48 Eyona nto ibaluleke kakhulu i-drawback kwi-topical oil oil application kukuthotyelwa ngenxa yevumba.

Ioli yeentlanzi ibonise ukuba inenzuzo kwiimeko ezihlangeneyo ezizimeleyo ezifana ne-rheumatoid arthritis (RA) .49 Nangona ukuxhaswa kweoli yeentlanzi akuzange kusetyenziswe kwiimvavanyo zeklinikhi zonyango lwe-psoriatic arthritis, kunokuba luncedo ekuphatheni le meko, enokuthi isetyenziswe. ezininzi ezifanayo kwi-RA, kuquka indlela eqhelekileyo yokuvuvukala ephantsi kunye omzimba ukungasebenzi.

Ifayile

Unyango lwe-Methotrexate lubangela ukunqongophala kwe-folate. Njengoko kukhankanyiwe ngasentla, kwizigulane ezifumana i-MTX ye-psoriasis, i-folate supplementation yanciphisa iziganeko ze-hepatotoxicity kunye nokunyamezela kwamathumbu kodwa kunokuphazamisa ukusebenza kwe-MTX.24 Xa ukongeza i-folic acid okanye iifom ezisebenzayo, i-folinic acid okanye i-5-methyltetrahydrofolate, i-dose ephakanyisiweyo. yi-1-5 mg / ngosuku.

I-Bioactive Whey Protein Isolate

I-XP-828L iyinveli yezondlo zokutya ezenziwe ngesicatshulwa seprotheyini ephuma kwi-bovine whey esandul 'ukubonisa ukuba inenzuzo kwi-psoriasis.50,51 Iprofayili ye-bioactive ye-XP-828L inokwenzeka ngenxa yobukho bezinto zokukhula, i-immunoglobulins, kunye neepeptides ezisebenzayo ezifunyenwe kule sicatshulwa sithile se-whey. Uphononongo lwe-in vitro lubonise i-XP-828L ineempembelelo zokulawula i-immune, kubandakanywa nokuvimbela ukuveliswa kwe-cytokines ye-Th1 efana ne-IFN-g kunye ne-IL-2, enokuthi isebenze ekuphatheni izifo ezinxulumene ne-T-helper 1, ezifana ne-psoriasis. 52

Uphononongo oluvulekileyo lweleyibhile lwenziwa kwizigulane zabantu abadala be-11 abane-plaque psoriasis engapheliyo, ezinzileyo kwiipesenti ezimbini okanye ngaphezulu kwendawo yonke yomzimba. Abathathi-nxaxheba kuphononongo bafumana i-5 g kabini imihla ngemihla ye-XP-828L kwiintsuku ezingama-56. Uvavanyo olusebenzisa iPASI kunye neGlobal Assessment (PGA) amanqaku enziwe ngosuku lokuqala lokuhlola kwaye kwakhona ngeentsuku ze-1, i-28, kunye ne-56. Ekupheleni kophando, izifundo ezisixhenxe ze-11 zinezinga elincitshisiweyo le-PASI eliphakathi. ukusuka kwi-9.5 ukuya kwi-81.3 yeepesenti. 50 Iziphumo ze-double-blind enkulu,Uphononongo olulawulwa yi-placebo lwabantu be-84 abane-psoriasis e-mildto-moderate babonisa i-XP-828L (i-5 g / imini yeentsuku ze-56) yanciphisa kakhulu amanqaku e-PGA xa kuthelekiswa ne-placebo (p <0.05). Akukho zimpembelelo ezimbi eziye zaqatshelwa kuzo naziphi na abathathi-nxaxheba bophando kuyo nayiphi na isifundo.50,51

Vitamin D

Kuye kwaqinisekiswa ukuba izigulane ezine-psoriasis ezisasazwayo ziye zanciphisa kakhulu amanqanaba e-serum yefom ye-biologically esebenzayo ye-vitamin D, i-1-alpha, i-25-dihydroxyvitamin D3 (1-?, 25 (OH) 2D3; i-calcitriol) xa kuthelekiswa nobudala kunye nesondo. Ukulawulwa okuhambelanayo kunye nokuthelekiswa nezigulane ezine-psoriasis ephakathi.53 Ingaba le nto inegalelo kwi-psoriasis okanye umphumo we-disorder awukacaciswanga.

I-Keratinocytes kwi-epidermis iguqula i-7-dehydrocholesterol kwi-vitamin D3 phambi kwe-UVB. Ukukhanya kwelanga, i-UVB phototherapy, i-calcitriol yomlomo, kunye ne-topical vitamin D analogs lunyango olusebenzayo lwe-psoriasis ngenxa ye-vitamin D ye-anti-proliferative kunye ne-pro-differentiating action kwi-keratinocytes.54-56

I-Calcitriol-ibophelela kwi-vitamin D receptors (VDR) elukhumbeni imodareyitha ukubonakaliswa kwenani elikhulu leejeni ezibandakanya abalawuli be-cell cycle, izinto zokukhula, kunye nabamkeli babo. Iipolymorphisms ze-VDR gene zidibene ne-psoriasis kwaye zinokuthi zilungele ukuphuhliswa kwe-psoriasis kunye nokuchasana nonyango lwe-calcipotriol, kunye negalelo ekungasebenzi kakuhle kwesibindi kwizigulane ezine-psoriasis.57

Ngenxa yokubaluleka kwe-vitamin D kwi-psoriasis, umhlaza, izifo ezivuthayo, kunye nezinye iimeko, kuye kwacetyiswa ngabaphandi ukuba iingcebiso zokukhuselwa kwelanga kunye nokukhusela umhlaza wolusu kunokufuneka ukuba zihlolwe kwakhona ukuze zivumele isimo esaneleyo se-vitamin D. Uphononongo olutshanje lubonise ubuninzi belanga kwisampulu yabantu abadala baseHawaii abazange baqinisekise ukwanela kwe-vitamin D, ebonisa isidingo sokuxhaswa kwe-vitamin D ukufezekisa amanqanaba aphezulu egazi.58

Uphononongo lubonise ukuba i-vitamin D yomlomo inokuthatyathwa ngokukhuselekileyo kwiidosi zemihla ngemihla ukuya kwi-5,000 IU, ezinye iingcali zincoma ukuya kwi-10,000 IU imihla ngemihla ukulungisa ukusilela.59-61 I-Oral kunye ne-topical vitamin D, ukukhanya kwelanga kunye ne-UVB phototherapy ibonise ukusebenza kakuhle kunyango lwe-psoriasis.56

Imixholo yoNyango lwePsoriasis

Unyango oluninzi lwe-psoriasis lunokubonelela ngenzuzo, kuquka i-calcipotriene (iDovonex�; i-analogue ye-vitamin D3 yokwenziwa), i-Berberis aquifolium cream (10%) 62 (Psoriaflora�; Relieva�), i-curcumin gel (1%), i-Aloe vera, kunye ne-aloe vera. isalve etyebileyo yeflavonoid (Flavsalve�).

Ijeli ye-Curcumin yanikezela isisombululo se-90-pesenti yeeplagi kwiipesenti ze-50 zezigulane kwiiveki ze-2-6; intsalela yezifundo zophononongo ibonise i-50- kwi-85-ipesenti yokuphucula. I-Curcumin yafunyanwa iphindwe kabini njenge-calcipotriol cream (ehlala ithatha iinyanga ezintathu ukwenza umphumo wayo opheleleyo). Indlela ye-curcumin injenge-phosphorylase kinase inhibitor ekhethiweyo, ngaloo ndlela inciphisa ukuvuvukala ngokuvinjelwa kwe-NF?B.63

Uvavanyo olulawulwayo lwe-Aloe vera extract cream (0.5%) kwizigulane ze-60 kwiinyanga ezi-4-12 zibonise ukucocwa okuphawulekayo kwamacwecwe e-psoriatic (82.8%) xa kuthelekiswa ne-placebo (7.7%) (p<0.001). Ukongezelela, i-PASI iyancipha ibe yintsingiselo ye-2.2.64

Ubukhulu be-psoriasis buxhamla ekusebenziseni i-emollients. I-lipids ye-intercellular efana ne-ceramides (i-lipid molecules ezenziwe ngamafutha acids kunye ne-sphingosine) zidlala indima ebalulekileyo ekulawuleni i-homeostasis yesithintelo samanzi kunye nomthamo wamanzi. Kuye kwaboniswa ukuba i-ceramide iyancipha kwi-epidermis ye-psoriatic. I-emollients entsha equkethe i-ceramide (umzekelo, i-CeraVe�, i-Mimyx�, i-Aveeno Eczema Care) ibonise inzuzo kwi-psoriasis kwaye inokuphucula umsebenzi wokuthintela ulusu kunye nokunciphisa ukulahlekelwa kwamanzi.65

Iimpembelelo zeBotanical

I-Chinese herbal formula (Herose� Psoria Capsule) ibonise ukhuseleko kunye nokusebenza kakuhle kunyango lwe-plaque psoriasis enzima.66 I-Herose iqukethe i-rhizoma Zingiberis, i-radix Salviae miltiorrhizae, i-radix Astragali, i-ramulus Cinnamomi, i-radix Paeoniae alba, i-radix Codonopsis pilosula. Coicis. Kwilingo le-openlabel, izifundo ze-15 zathatha ii-capsules ezine ze-Herose (450 mg nganye) kathathu imihla ngemihla kwiinyanga ze-10. Umphandi uvavanye iPASI kunye nempendulo yonyango kwiHerose kwisigulane ngasinye. Ifomula yenzelwe ukufudumala i-yang kunye nokukhuthaza ukujikeleza kwegazi.

Ukungenelela kwindlela yokuphila

Izinto zokuphila ezifana nokutshaya icuba kunye nokusela utywala zihambelana nobunzima be-psoriasis.67 Umsebenzi owenziwe ngokomzimba kunye nemisebenzi yangaphandle (ukuthatha izilumkiso zokutshisa ilanga) kunenzuzo.68 Ukuhlamba kunye nokutshisa ilanga kuLwandle Olufileyo kwiiveki ezine kubangele ukuhla kwePASI ye Ipesenti ze-81.5, i-78-pesenti iyancipha kwi-keratinocyte hyperplasia, kwaye phantse ukupheliswa ngokupheleleyo kwe-T lymphocytes kwi-epidermis, kunye nenani eliphantsi eliseleyo kwi-dermis.69

Ulawulo loxinzelelo lunokunceda abantu abane-psoriasis. Izifundo eziphulaphule i-tape yokucamngca ekhokelwayo ngelixa i-phototherapy ihlanjululwa ngokuphindwe kane ngokukhawuleza kunabo bafumana i-phototherapy kuphela, njengoko kugwetywa ngabadermatologists ababini abazimeleyo. Isimo se-Psoriasis savavanywa ngeendlela ezintathu: ukuhlolwa ngokuthe ngqo ngabahlengikazi bekliniki; ukuhlolwa ngokuthe ngqo ngoogqirha abamfamekileyo kwimeko yokufunda yesigulana (iteyiphu okanye akukho tape); kunye novavanyo logqirha olumfamekileyo lweefoto zezilonda ze-psoriasis. Iimpawu ezine ezilandelelanayo zesimo solusu zibekwe iliso ngexesha lokufunda: iNdawo yokuPhendula yokuQala, iNdawo yokuTshintsha, iHalfway Point, kunye neClearing Point. Izifundo kumaqela e-tape zifikelele kwi-Halfway Point (p = 0.013) kunye ne-Clearing Point (p = 0.033) ngokukhawuleza kakhulu kunezo zingekho kwimeko ye-tape, kuzo zombini unyango lwe-UVB kunye ne-PUVA.70 Ekugqibeleni, i-psychotherapy ingaba yinto ebalulekileyo. iadjunct kubantu abanemiba yengqondo ethe gqolo engasonjululwanga enje ngoxinzelelo, uxinzelelo, kunye noxinzelelo lwengqondo kwesi sifo solusu singapheliyo.

ingxoxo

I-Psoriasis ibonakaliswe yi-T-cell activation ekhupha i-cytokines e-pro-inflammatory efana ne-TNF-?, ekhokelela ekwandeni kwe-keratinocyte kunye nezilonda zesikhumba eziqhelekileyo ze-psoriasis.

Indlela yesiqhelo yokunyanga i-psoriasis ibandakanya ukusebenzisa i-topical kunye/okanye i-corticosteroids yomlomo, amanye amachiza akhusela umzimba, i-retinoids yomlomo, ukukhanya kwe-UV, kunye nezininzi (ezingeyiyo inoveli, esele isetyenziswe ngaphambili kwi-Crohn's kunye ne-RA) i-biological agents. Nangona olu nyango lunokusebenza kakhulu ekulawuleni isifo, alukho olukhuselekileyo nolusebenzayo jikelele, kwaye ngalinye linomngcipheko omkhulu.

Kukho ubungqina bokusetyenziswa kokuguqulwa kokutya kunye neoli yeentlanzi ukunciphisa ukuvuvukala kwi-psoriasis. Uphando olongezelelekileyo lugunyaziswe ukucacisa ukusetyenziswa�kwezi kunye neendlela ezahlukeneyo zonyango lwebhotani kunye neendlela zokuphila zokuphucula iimpawu zeklinikhi, ukunciphisa ukubonakaliswa kwe-phenotypic ye-psoriasis, kunye nokubonelela ngonyango olukhuselekileyo nolusebenzayo.

 

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ukusebenza. J Am Acad Dermatol 2003;49:451-457.
70. Kabat-Zinn J, Wheeler E, Light T, et al. Impembelelo
yokunciphisa uxinzelelo olusekelwe kukucamngca kwengqondo
ungenelelo kumazinga okucoca ulusu kwizigulane
kunye ne-psoriasis ephakathi ukuya kobunzima
i-phototherapy (UVB) kunye ne-photochemotherapy
(PUVA). I-Psychosom Medicine 1998; 60: 625-632.

Vala i-Accordion
Izilwanyana zasekhaya ze-10 ezithatha izidumbu ze-Skin for Sunburn

Izilwanyana zasekhaya ze-10 ezithatha izidumbu ze-Skin for Sunburn

by | LweMpilo, WeMpilo yeNdalo, ulungiso, Impilo Yesikhumba, Ukuphila

Ihlobo laseburhulumenteni kuphela nje ngeveki, kwaye izigidi zabantu baseMelika zijongene neemeko eziphezulu zokubandezeleka kwelanga kwiinyanga ezizayo.

Ukuba ubamba imibala emininzi kunye nomoya ukhangeleka njenge-lobster, yintloko ngqo ekhitshini lakho. Akukho kudlala. Nazi ezinye izilwanyana zasemakhaya ezothusayo zokunciphisa ukutshiswa okulungileyo-okanye okungcono kunokuba - i-creams yesikhumba ekhoyo kunye nentengiso:

Iikotyi: Ezi mifuno zizityebi kwi-vitamin C kunye ne-acffe caffeic, ezo zombini zikunceda ukukhupha isikhumba esicasulayo nokunciphisa ukuvuvukala. IiCukes nazo zidibanisa neempawu ezibuhlungu ukuya kwintlungu. Unokukrazula iikomkom ezibandayo uze uzisebenzise kwiindawo ezitshisiweyo. Kulungile nokho, yenza unobumba ngokumisa okanye ukudibanisa iikomkhamba ezimbalwa uze uyisebenzise.

Ilethasi: Imifuno ine-compound ye-painkilling engathatha ukuphuma kwelanga. Ubilise amaqabunga emanzini, uze udibanise kwaye udibanise umbane. Faka isicelo se-fluid ngeebhola zekotoni.

Iipatata: Ezi zilimo eziyizigulane ziye zasetyenziselwa yonke imbali ukucima ukutshisa, ukubetha, i-scrapes, kunye nezinye iingxaki zesikhumba. LweXRender omnye okanye emibini de ukufumana pasty - kusenokufuneka ukongeza yegadi amanzi - ngoko obandayo i Cola kwaye isicelo nge iibhola cotton.

Ubusi: Eli phephelo lokutshisa libuyela kumaxesha amandulo aseYiputa. Ubusi buyanciphisa ukuvuvukala, kunika izondlo kwiimpawu ezinobungozi kunye neempawu zokunyusa. Kwakhona iipropati ze-antiseptic. Sasabalalisa ezinye zezinto ezintle apho zibuhlungu khona.

I-Apple cider viniga: Isisombululo samakhaya esisodwa kwiintlobo zeengxaki ezinobuthi be-ivy ukuya kwi-asidi zixhomekeka kwi-allergies, i-cider iphinda isebenze ngokushisa kwelanga. Unokufuna ukuwuhlutha okufutshane ukususela kwesinye sezithako ezisebenzayo, i-acetic acid, inokuthi igwebe xa isetyenziswe. Sebenzisa iibhola zepotton okanye udibanise indwangu yokuhlamba kwisisombululo sokufumana ingqalelo.

Ioconut oil: Ungayisebenzisa le nto yokukhuseleka - ine-factor protection block (SPF) kwindawo ethile phakathi kwe-5 kunye ne-10-kwaye uncedo xa uhlala ixesha elide ngaphandle kwesinye isikrini. Faka isicelo ngqo kwiindawo ezifudumeleyo kwaye unokuvakalelwa yimiphumo ephuculayo njengoko amafutha ayo adibeneyo anxiba esikhwameni sakho kwaye asebenze umlingo wokuphilisa.

Oatmeal: I-oats ehamba rhoqo iyakwenza kakuhle njengoko i-polataccharides ye-oatmeal iya kunceda ukuphilisa isikhumba sakho. Faka iikhompu ze-2 kwi-tube ye-tube ecocekileyo uze uyifake kwisibhakabhaka samanzi amanzi. Makhe zidibanise imizuzu embalwa, uze ugibele kuyo. Phunyeza i-sock yonke imizuzu embalwa, okuya kuguqula amanzi afufume. Xa usuphelile, umoya omile okanye uzibambe ngokucokisekileyo ngetayili elithambileyo.

Yogurt: I-yogurt iqukethe ama probiotics kunye neeprotheni eziya kunceda ukuphilisa isikhumba sakho. Qinisekisa ukuba i-yogurt icacile ngokungabi nambisi kunye nokuba iphile, iindawo ezisebenzayo. Yisasaze kwiindawo ezitshisiweyo, zivumele ukuba zihlale malunga nemizuzu emihlanu, uze uwuhluthe ngamanzi amnandi.

Witch hazel: Amathinini avela kwinqwelo yamanzi yityalo isinciphisa ukuvuvukala, ukubulala ibhaktheriya nokulungisa isikhumba esonakele. Sebenzisa iibhola zepotton okanye i-cloth ecocekileyo ukuze uyibeke kwiindawo ezinzima. Phinda usebenzise kwakhona njengoko kufuneka.

Ialoe vera: I-gel ephuma kumagqabi anamahloni esi sityalo isisityebi kwi-glyconutrients esilula kunye nokuphilisa zonke iintlobo zeengxaki zesikhumba, kuquka ukutshisa. Slice uvula iqabunga kwaye i-gel iya kuphuma. Faka isicelo ngqo kwiindawo ezifudumeleyo.

Xa ubandezeleka ngokushisa ilanga, qiniseka ukuba uphuze amanzi amaninzi, ngenxa yokuba ungancibilikiswa. Kwaye bazame ukuphepha iisepha ezimaxongo iya kukuhlambulula amafutha endalo yesikhumba sakho kunye yome phandle.

Ngokuqinisekileyo, ukulungiswa kwelanga elifanelekileyo kukukhusela. Oko kuthetha ukuhlala ngaphandle kwelanga ngexesha leeyure eziphambili, ngokuqhelekileyo phakathi kwe-10 kunye ne-2 ntambama. Iidermatologists zincoma ngokugqithise ukugqithisa ingubo, ezigubungela indawo ezichaziweyo kunye nezokusebenzisa i-sunscreen nge-SPF ye-15 okanye ngaphezulu.

Khangela i-sunscreen ebhalwe igama elithi "full spectrum" ukuqinisekisa ukuba ikhupha ii-ray ze-UVA kunye ne-UVB. Kodwa qaphela ukuba ezininzi zelanga zineemichiza ezinobuthi. Ubhedu bakho obufanelekileyo kukujonga Iqela leKomiti yokuSebenza ngokusingqongileyo I-database ephezulu kwi-online ukufumana iimveliso ezikhuselekileyo.

Abadala bajongene neendleko ezininzi kwiiMveliso ezininzi zeClub

Abadala bajongene neendleko ezininzi kwiiMveliso ezininzi zeClub

by | Ukuguga, Abadala, Impilo Yesikhumba

Amaxabiso eegeneric topical steroids ukunyanga iimeko zolusu ezifana ne-eczema kunye ne-psoriasis aye enyuka, kwaye abantu abadala abaninzi banokuhlawula ngaphezulu kwamayeza enziwe afana nalawo aveliswe ngabenzi kuneenguqulelo zegama lebrand, uphando lwase-US lufumanisa.

Abaphandi bathelekisa iindleko eziphuma epokothweni zesigulana kunye nenkcitho yi-Medicare, inkqubo ye-inshurensi yezempilo yase-US yabantu abaneminyaka engama-65 nangaphezulu, kwii-corticosteroids ezininzi ezichazwe ngokuqhelekileyo eziye zasetyenziswa amashumi eminyaka ukunyanga iimeko ezahlukeneyo zolusu.

I-Medicare Part D, inkqubo yenzuzo yeziyobisi, ichithe i-2.3 yeebhiliyoni zeedola kwi-topical steroids phakathi kwe-2011 kunye ne-2015, uphando lufumene. Ebudeni belo xesha, inkcitho yanda ngama-227 ekhulwini ngelixa inani lemigqaliselo lenyuka nje ngama-37 ekhulwini.

Ukuba oogqirha babemisele inguqulelo ephantsi kakhulu xa kukho iindlela ezahlukeneyo ezisebenzayo ezifanayo, i-Medicare yayinokugcina i-944.8 yezigidi zeedola, abaphandi babala.

Izigulane bezinokonga kakhulu nazo; inkcitho yonyaka yangaphandle kwepokotho yabantu abadala kwi-topical steroids ikhule ukusuka kwi-41.4 yezigidi zeedola ukuya kwi-101.8 yezigidi zeedola, i-146 ekhulwini, ngexesha lokufunda.

"Izigulana zihlala zinzima ukuhlawula amayeza azo kwaye izigulane ezininzi kwi-Medicare zidla umhlalaphantsi kunye neengeniso ezisisigxina," watsho umbhali ophezulu wokufunda uDkt. Arash Mostaghimi, umphandi we-dermatology kwi-Harvard Medical School kunye ne-Brigham kunye neSibhedlele sabaseTyhini eBoston.

"Ukuhlawula imali eyongezelelweyo kumayeza abo kunokuthetha ukuhamba ngaphandle kwamanye amayeza okanye ngamanye amaxesha ukutya," kusho uMostaghimi nge-imeyile.

IiGenerics zibalelwa phantse iipesenti ezingama-98 zenkcitho iyonke kwi-topical steroids ngexesha lophononongo, abaphandi banika ingxelo. JAMA Dermatology.

Ngokwethiyori, amachiza enziwe afana nalawo aveliswe ngabenzi kufuneka eze emarikeni emva kokuba iinguqulelo zegama lebrendi ziphulukane nokhuseleko lwelungelo elilodwa lomenzi wechiza e-US kwaye zincede amaxabiso aphantsi ngokunyusa ukhuphiswano. Uphononongo lweendleko ze-topical steroid, nangona kunjalo, lubonelela ngokujonga enye into enzima kakhulu kwaye iyabhidisa.

Kuphononongo, abaphandi bavavanya iindleko zamachiza ahlanganiswe ngokwamandla, okanye angakanani na amayeza adityaniswe kwi-ointments kunye ne-creams. Bahlela iziyobisi kwiindidi ezintlanu, enye ibe yeyona inamandla kwaye ezintlanu zilelona gunya libuthathaka.

Iindleko zikhule ngeyona ndlela icothayo, ipesenti ye-23, kwi-steroids ebuthathaka kakhulu, uphando lufumene. Ngokwahlukileyo, iindleko zenyuka kakhulu, iipesenti ezingama-604 zizonke, kwiqela elinamandla kakhulu le-steroids.

Kwelo qela lezona steroids zinamandla, okona kunyuka kakhulu kweendleko zomndilili zomsebenzisi ibiyeye-clobetasol propionate (Temovate), esetyenziselwa ukunyanga ukurhawuzelelwa kunye nokudumba okuvela kwimiba yolusu ebangelwa kukwalana, i-eczema kunye ne-psoriasis. Ngexesha lophononongo, iindleko zabasebenzisi beli chiza zinyuke ngaphezu kwama-605 ekhulwini.

Imida yophononongo ibandakanya ukunqongophala kwedatha kwizaphulelo ezithile zomenzi weziyobisi ezinokuthi zincede iindleko eziphantsi, inqaku lababhali. Abaphandi bebengazi nokuba oogqirha banezizathu ezithile zeklinikhi zokukhetha iinguqulelo ezithile zamayeza afanayo.

Sekunjalo, uphando lubonisa into oogqirha abasele beyibona ngalo lonke ixesha: ukuba ezi ndleko zihlala zithatha izigulane, utshilo uDkt Joslyn Kirby, umbhali we-editorial ehamba kunye nomphandi we-dermatology kwi-Penn State Hershey Medical Centre.

Omnye umngeni koogqirha kukuba abanakusoloko bebona ukuba yiyiphi i-steroids eyahlukileyo yexabiso elifanayo lexabiso xa lichaza amachiza, kuba oko akukho kwiirekhodi zonyango lwe-elektroniki, uKirby uthe nge-imeyile.

“Ndicela izigulane zam ukuba ziqhagamshelane nam kwaye zindazise ukuba iyeza endilimiseleyo ngexesha lokuqeshwa libiza kakhulu xa besiya ekhemesti,” wongeze watsho uKirby. "Ndifuna izigulana zam zazi ukuba kulungile ukundixelela ukuba kukho into ebiza kakhulu, kuba ndinokusebenza nabasebenzi bethu ukufumana enye indlela okanye isisombululo."

7.

Izindlela ezilula zokuDetox Isikhumba sakho Siphezu

Izindlela ezilula zokuDetox Isikhumba sakho Siphezu

by | Ukuxutyushwa, LweMpilo, Impilo Yesikhumba

Iindlela ezilula zokuthoba ulusu lwakho eNtwasahlobo

Ngentwasahlobo apha, kunye nehlobo ejikeleze ikona, eli lixesha eligqibeleleyo lokuvuselela ukunyamekela kwakho ukuguga nokuguga kwesikhumba. Iingcebiso ezilandelayo zibonelela ngeendlela ezininzi zokuxhoma ukuqala utshintsho lwakho oluhle!

Ukutya ukutya okutyebileyo kwimifuno, iziqhamo, i-legumes, amantongomane, imbewu, kunye neenkozo ezipheleleyo ngelixa ukunciphisa ukutya okucutshungulwayo / okulungiselelwe ngaphambili kunokuphucula umbala wakho. Iyantlukwano phakathi kwezi ziphilileyo�

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