Ziziphi izingozi ze-Nrf2 Exverendression?

The i-nyukliya erythroid I-2 enxulumene ne-2 yokubonisa indlela, eyaziwa ngokuba ngu-Nrf2, yindlela yokukhusela esebenza "njengomlawuli oyintloko" wempendulo yomzimba womntu olwa ne-antioxidant response. I-Nrf2 ivala amanqanaba okuxinwa kwe-oxidative ngaphakathi kweeseli kwaye ibangela iindlela ezikhuselayo zokukhusela i-antioxidant. Nangona i-Nrf2 isebenze inokufumana inzuzo eninzi, i-Nrf2 "ukugqithiseleka" inokuba nemingcipheko emininzi. Kubonakala ukuba i-NRF2 ibaluleke kakhulu ekuthintela ukuphuhliswa jikelele kwezifo ezahlukeneyo ngaphezu kokuphucula ngokubanzi le micimbi yezempilo. Nangona kunjalo, i-NRF2 inokubangela iingxaki. Isizathu esibangeleyo emva kwe-NRF2 "ukugqithisa kakhulu" ngenxa yokuguquka komzimba okanye ukuqhubela phambili okungapheliyo kwimizi yeciksi okanye ukuxinzezeleka kwengcinezelo, phakathi kwabanye. Ngezantsi, siza kuxubusha ukuhlaselwa kwe-Nrf2 ngokugqithiseleyo nokubonisa iindlela zayo zokusebenza ngaphakathi komzimba womntu.

Cancer

Izifundo zophando zifumanise ukuba iimpuku ezingachazi i-NRF2 zithambekele ngakumbi ekuphuhliseni umhlaza ekuphenduleni ukuvuselela komzimba kunye neekhemikhali. Izifundo ezifanayo zophando, nangona kunjalo, zibonise ukuba ukusebenza kwe-NRF2 ngaphezulu, okanye ukungasebenzi kwe-KEAP1, kunokubangela ukonyuka komhlaza othile, ngakumbi ukuba ezo ndlela ziphazamisekile. I-NRF2 egqithisileyo inokubakho ngokutshaya, apho ukusebenza okuqhubekayo kwe-NRF2 kukholelwa ukuba kungunobangela womhlaza wemiphunga kubantu abatshayayo. I-Nrf2 overexpression inokubangela ukuba iiseli ezinomhlaza zingazonakalisi, ngelixa ukusebenza kwe-NRF2 okwethutyana kunokuthintela iiseli ezinomhlaza ekuvuseleleni ukwenziwa kwe-toxin. Ukongeza, ngenxa yokuba i-NRF2 overexpression inyusa amandla e-antioxidant omzimba womntu okusebenza ngaphaya kwe-redox homeostasis, oku kukonyusa ukwahlulwa kweseli kwaye kuvelise ipateni engaqhelekanga ye-DNA kunye ne-histone methylation. Oku ekugqibeleni kunokwenza i -chemotherapy kunye ne-radiotherapy zingasebenzi kakuhle kumhlaza. Ke ngoko, ukunciphisa umda ekusebenzeni kwe-NRF2 ngezinto ezinjenge-DIM, iLuteolin, i-Zi Cao, okanye i-salinomycin inokuba zilungele izigulana ezinomhlaza nangona i-Nrf2 yokunyanzeliswa kokusebenza kungathathwa njengeyona nto ibangela umhlaza. Ukusilela kwesondlo kunokuchaphazela ii-genes, kubandakanya i-NRF2. Oku kunokuba yindlela enye yokuba ukusilela kunegalelo njani kwizidumbu.

Ibindi

Ukugqithiswa kwe-Nrf2, kunokuchaphazela nokusebenza kwamalungu athile emzimbeni womntu. Ukugqithiswa kwe-NRF2 kunokukhawulela ekugqibeleni ukuveliswa kwe-insulin-efana nokukhula kwe1, okanye i-IGF-1, esesibindi, esibalulekileyo ekuhlaziyweni kwesibindi.

intliziyo

Nangona i-Nrf2 ingenakuncedo, ukugqithisa okuqhubekayo kwe-NRF2 kunokudala iziphumo ezinobungozi kwixesha elide entliziyweni, njenge-cardiomyopathy. Inkulumo ye-NRF2 inganyuswa ngamazinga aphezulu e-cholesterol, okanye ukusetyenziswa kwe-HO-1. Oku kukholelwa ukuba yisona isizathu sokuba amazinga aphezulu angama-cholesterol angabangela iimeko zempilo yengqondo.

Vitiligo

Ukugqithiswa kwe-NRF2 kuye kwabonakaliswa ukuba kuvimbele ukukwazi ukuguqulwa kwi-vitiligo njengoko kunokuthintela iTyrosinase, okanye i-TYR, isenzo esibalulekileyo ekuguqulweni kwe-melaninogenesis. Ucwaningo luye lwabonisa ukuba le nkqubo ingaba esinye sezizathu eziphambili zokuba kutheni abantu abane-vitiligo bengabonakali ukuvuselela i-Nrf2 ngokufanelekileyo njengabantu abangenayo i-vitiligo.

Kutheni i-NRF2 ingaSebenzi kakuhle

EHormesis

I-NRF2 kufuneka ivulwe ngokwe-hormetically ukuze ikwazi ukuthatha inzuzo yayo. Ngamanye amazwi, i-Nrf2 akufuneki iqalise yonke imzuzu okanye yonke imihla, ngoko ke, luluvo olukhulu ukuthatha ikhefu kuyo, ngokomzekelo, iintsuku ezi-5 ngeentsuku ezi-5 zokuphumla okanye yonke enye imini. I-NRF2 kufuneka kwakhona ifezekise umda othile wokuqalisa impendulo yayo ye-hormetic, apho i-stressor encinci ingenako ngokwaneleyo ukuyiqalisa.

I-DJ-1 Oxidation

Iprotheni deglycase DJ-1, okanye nje i-DJ-1, ebizwa ngokuba yi-protein ye-Parkinson, okanye i-PARK7, ngumlawuli oyintloko kunye nomtshina we-redox kwisimo somzimba. I-DJ-1 ibalulekile ekulawuleni indlela i-NRF2 enokuyenza ngayo umsebenzi wayo kwaye ivelise impendulo ye-antioxidant. Kwimeko apho i-DJ-1 iba ngaphezulu, iiseli ziya kwenza iprotheni ye-DJ-1 ingafinyeleleki. Le nkqubo yenza ukuba ukusebenza kwe-NRF2 kuphelelwe ngokukhawuleza njengoko i-DJ-1 ibaluleke kakhulu ukugcina amanqanaba alinganiselayo we-NRF2 kwaye ikhusela ukuba iphulwe phantsi kwiseli. Ukuba ngaba iprotheni ye-DJ-1 ayikho okanye ingaphezulu, i-NRF2 ibonakaliso iya kuba yinto encinci, mhlawumbi isebenzise i-DIM okanye ezinye i-activation NRF2. I-DJ-1 ibonakaliso imele ukubuyisela isenzo se-NRF2 esingakwaziyo.

Ukugula okungapheliyo

Ukuba unesifo esingapheliyo, kuquka i-CIRS, izifo ezingapheliyo / i-dysbiosis / i-SIBO, okanye i-heavy metal build up, efana ne-mercury kunye / okanye ukusuka kwiingcambu zeengcambu, ezi zinokuthintela iinkqubo ze-NRF2 kunye nesigaba sesibini sokutshatyalaliswa. Kunokuba uxinzelelo lwe-oxidative luguqule i-NRF2 ibe yi-antioxidant, i-NRF2 ayiyi kubangela kwaye uxinzelelo lwe-oxidative lunokuhlala kwiseli kwaye lubangele umonakalo, oku kuthetha ukuba akukho mpendulo ye-antioxidant. Esi sisizathu esibalulekileyo sokuba kutheni abantu abaninzi abane-CIRS benovelwano oluninzi kwaye bafikelele kwizinto ezininzi. Abanye abantu bakholelwa ukuba banokuba nempendulo ye-herx, nangona kunjalo, le ndlela yokusabela inokuba yonakalisa iiseli kude. Ukunyanga izifo ezingapheliyo, nangona kunjalo, kuya kuvumela isibindi ukuba sikhuphe i-toxins kwi-bile, ngokuthe ngcembe siphuhlise impendulo ye-hormetic ye-activation ye-NRF2. Ukuba i-bile ihlala inetyhefu kwaye ayikhutshwanga emzimbeni womntu, iya kuphinda ivuselele uxinzelelo lwe-oxidative ye-NRF2 kwaye ibangele ukuba uzive ubi nakakhulu xa iphinda ihlanjululwe kwi-gastrointestinal, okanye i-GI, iphecana. Ngokomzekelo, i-ochratoxin A inokuvala i-NRF2. Ngaphandle kokunyanga ingxaki, i-histone deacetylase inhibitors inokuthintela ukusabela kwe-oxidative ukusuka kwizinto ezininzi ezibangela ukusebenza kwe-NRF2 kodwa kunokuthintela i-NRF2 ekubeni ibangele - ngokuqhelekileyo, enokuthi ekugqibeleni isilele ukukhonza injongo yayo.

I-Fish Oil Dysregulation

I-Cholinergics yizinto ezikhuthaza i-acetylcholine, okanye i-ACh, kwaye i-choline ebuchosheni ngokunyuka kwe-ACh, ngokukodwa xa ikhubaza ukuwa kwe-ACh. Izigulane ezine-CIRS zihlala zifumana iingxaki ngokuchithwa kwamanqanaba e-acetylcholine emzimbeni womntu, ingakumbi kwingqondo. Ioli yeentlanzi ivuselela i-NRF2, isebenzise indlela yayo yokukhusela i-antioxidant ngaphakathi kweeseli. Abantu abanezigulo ezinganyangekiyo banokuba neengxaki zoxinzelelo lwengqondo kunye ne-acetylcholine excitotoxicity, ukusuka ekuqokelelekeni kwe-organophosphate, enokubangela ukuba i-oyile yeentlanzi idale ukudumba emzimbeni womntu. Ukusilela kweCholine ukongeza ukusebenza kwe-NRF2. Kubandakanya i-choline kwisidlo sakho, (i-polyphenols, amaqanda, njl. Njl.) Inokunceda ekuphuculeni iimpembelelo ze-cholinergic dysregulation.

Yintoni eyehlisa i-NRF2?

Ukunciphisa i-NRF2 ukugqithisa kakhulu kukulungele abantu abanomhlaza, nangona kunokuba luncedo kwiintlobo zeminye imiba yempilo.

Ukutya, iziNcediso, kunye namayeza aqhelekileyo:

• Apigenin (amanani aphezulu)
• Brucea javanica
• Chestnuts
• I-EGCG (iindleko eziphezulu zanda iNRF2)
• Fenugreek (Trigonelline)
• UHiba (Hinokitiol / ?-thujaplicin)
• Isidlo seTyuwa esiphezulu
• I-Luteolin (i-Celery, i-pepper eluhlaza, i-parsley, i-perilla leaf, kunye ne-chamomile tea - i-dose ephezulu iyakwandisa i-NRF2-40 mg / kg luteolin kathathu ngeveki)
• I-Metformin (ukungadliyo okungapheliyo)
• I-N-Acetyl-L-Cysteine ​​(i-NAC, ngokuthintela impendulo ye-oxidative, i-doses ephezulu)
• I-Orange Peel (i-polymethoxylated flavonoids)
• I-Quercetin (amanani aphezulu anganyusa iNRF2 - 50 mg / kg / d quercetin)
• Salinomycin (iziyobisi)
• I-retinol (yonke i-ac retinoic acid)
• I-Vitamin C xa idibene neQuercetin
• I-Zi Cao (i-Purple Gromwel i-Shikonin / i-Alkannin)

Iindlela kunye nezinye:

• Bach1
• ukubheja
• Biofilms
• Brusatol
• Camptothecin
• DNMT
• DPP-23
• EZH2
• I-Glucocorticoid I-Receptor ukusayinwa (i-Dexamethasone ne-Betamethasone kunye)
• I-GSK-3? (ingxelo elawulayo)
• Kusebenze kwe-HDAC?
• Halofuginone
• I-Homocysteine ​​(i-ALCAR ingakwazi ukuguqula le homocysteine ​​yenza amazinga aphantsi a-NRF2)
• IL-24
• Keap1
• MDA-7
• I-NF? B.
• I-Ochratoxin A (i-aspergillus neepeniciclium species)
• Leprothemia ye-Promyelocytic
• p38
• p53
• p97
• I-alpha receptor alpha
• Selenite
• SYVN1 (Hrd1)
• STAT3 inhibition (njenge-Cryptotanshinone)
• I-Testosterone (kunye ne-Testosterone propionate, nangona i-TP intranasally inokunyusa iNRF2)
• Trecator (Ethionamide)
• I-Trx1 (ngokunciphisa iCys151 eKeep1 okanye kwiCys506 kwingingqi ye-NLS yeNrf2)
• Trolox
• Vorinostat
• Ukunqongophala kweZinc (kwenza kube nzima nakubungqondo)

Indlela ye-Nrf2 yeNtsebenzo

Uxinzelelo lwe-oxidative lubangela i-CUL3 apho i-NRF2 esuka ku-KEAP1, inhibitor engafanelekanga, ingena kwinucleus yale seli, ivuselela ukubhalwa kwe-ARE, ijika i-sulfuridi ibe yi-disulfide, ibe iguqula ibe yi-geneticidants genes, ekhokelela ekuphuculweni kwe-antioxidants, njenge-GSH, i-GPX, i-GST, i-SOD, njl. Ezinye ezinye ziyakubonwa kwiluhlu olungezantsi:

• Ukwandisa i-AKR
• U kwandisa
• Ukwandisa i-ATF4
• Ukwandisa iBcl-xL
• Ukwandisa iBcl-2
• Ukwandisa iBDNF
• Ukwandisa i-BRCA1
• Ukwandisa c-Juni
• Ukwandisa iCAT
• Ukwandisa iCGMP
• Ukwandisa i-CKIP-1
• Ukwandisa i-CYP450
• Ukwandisa iCul3
• Ukwandisa i-GCL
• Ukwandisa i-GCLC
• Ukwandisa i-GCLM
• Ukwandisa i-GCS
• Ukwandisa i-GPx
• Ukwandisa i-GR
• Ukwandisa i-GSH
• Ukwandisa i-GST
• Ukwandisa iHIF1
• Ukwandisa i-HO-1
• Ukwandisa iHQO1
• Ukwandisa i-HSP70
• Ukwandisa i-IL-4
• Ukwandisa i-IL-5
• Ukwandisa i-IL-10
• Ukwandisa i-IL-13
• Ukwandisa i-K6
• Ukwandisa i-K16
• Ukwandisa i-K17
• Ukwandisa iMEH
• Ukwandisa uMnup2-5
• Ukwandisa iNADPH
• Ukwandisa i-Notch 1
• Ukwandisa iNQO1
• Ukwandisa iPARAR-alpha
• Ukwandisa iPrx
• Ukwandisa i-p62
• Ukwandisa i-Sesn2
• Ukwandisa i-Slco1b2
• Ukwandisa i-sMafs
• Ukwandisa i-SOD
• Ukwandisa iTrx
• Ukwandisa iTxn (d)
• Ukwandisa UGT1 (A1 / 6)
• Ukwandisa iVEGF
• Iyanciphisa i-ADAMTS (4 / 5)
• Iyancipha i-alpha-SMA
• Iyancipha i-ALT
• Iyancipha i-AP1
• Iyanciphisa i-AST
• Iyanciphisa iBach1
• Iyancipha i-COX-2
• Iyanciphisa i-DNMT
• Iyancipha iFASN
• Iyancipha iFGF
• Iyanciphisa i-HDAC
• Yehlisa i-IFN-?
• Iyanciphisa i-IgE
• Iyanciphisa i-IGF-1
• Iyancipha i-IL-1b
• Iyancipha i-IL-2
• Iyancipha i-IL-6
• Iyancipha i-IL-8
• Iyancipha i-IL-25
• Iyancipha i-IL-33
• Iyancipha iNOS
• Iyancipha i-LT
• Iyanciphisa i-Keap1
• Iyanciphisa i-MCP-1
• Iyanciphisa iMIP-2
• Iyanciphisa i-MMP-1
• Iyanciphisa i-MMP-2
• Iyanciphisa i-MMP-3
• Iyanciphisa i-MMP-9
• Iyanciphisa i-MMP-13
• Iyanciphisa iNfkB
• Iyancipha NO
• Iyanciphisa i-SIRT1
• Iyanciphisa i-TGF-b1
• Iyanciphisa i-TNF-alpha
• Iyanciphisa iTyr
• Iyancipha i-VCAM-1

• I-encoded kwi-gene NFE2L2, i-NRF2, okanye i-2 enxulumene ne-2 yenkampani ye-nerythroid, iyinqobo ye-leucine, okanye i-bZIP, i-superfamily esebenzisa iKap'n'Collar, okanye i-CNC isakhiwo.
• Ikhuthaza ama-enzymes e-nitric, i-biotransformation enzymes, kunye ne-xenobiotic abathumeli bezithuthi.
• Ngumlawuli obalulekileyo xa kusenziwa isigaba sesibini se-antioxidant kunye ne-detoxification enzyme genes, ekhusela iiseli kumonakalo obangelwe yi-oxidative stress kunye ne-electrophilic attack.
• Ngeemeko ze-homeostatic, i-Nrf2 isetyenziswe kwi-cytosol ngokuqhotyoshelweyo komzimba we-N-terminal domain ye-Nrf2, okanye iprotheni ehlobene ne-Kelch-e-ECH okanye i-Keap1, ebizwa ngokuba yi-INrf2 okanye i-Inhibitor ye-Nrf2, yokuvimbela ukusetyenziswa kwe-Nrf2.
• Inokuphinda ilawulwe yi-mammalian selenoprotein thioredoxin ukunciphisa i-1, okanye i-TrxR1, esebenza njengomlawuli ongekho.
• Xa bexhatshazwa kwi-electrophilic stressors, i-Nrf2 idibanisa ne-Keap1, idlulisela kwinucleus, apho i-heterodidize idilesi yeprotheni elawulayo.
• Ukusebenzisana rhoqo kunokubandakanya kunye nalawo asemagunyeni okubhalwa kwirejista uJun noFos, ezinokuba ngamalungu eproduct yentsapho yeprotini yezinto ezibhaliweyo.
• Emva kokunciphisa, ezi zinkimbinkimbi zibophezela kwizinto eziphendulayo ze-antioxidant / electrophile / ARE / EPRE kwaye zisebenzise ukubhalwa kwephepha, njengoko kunjalo kwiinkomfa zakwaJun-Nrf2, okanye ukucima umbhalo, kufana ne-Fos-Nrf2.
• Ukumiswa kwe-ARE, ekhutshwe okanye evinjelwe, iya kugqiba ukuba yeyiphi i-gene elawulwa ngodluliselo ngolu hlobo.
• NINI ikhutshwa:

1. Ukusebenza kwe-thesynthesis ye-antioxidants iyakwazi ukukhupha i-ROS njenge-catalase, superoxide-dismutase, okanye i-SOD, GSH-peroxidases, GSH-reductase, GSH-transferase, NADPH-quinone oxidoreductase, okanye i-NQO1, inkqubo yeCytochrome P450 monooxygenase, thioredoxin, reductase, kunye ne-HSP70.
2. Ukusetyenziswa kwale synthase ye-GSH kuvumela ukukhula okuqaphelekayo kwenqanaba le-intracellular ye-GSH, ekhuselayo.
3. Ukongezwa kwale nxalenye kunye namazinga e-phase II enzymes efana ne-UDP-glucuronosyltransferase, i-N-acetyltransferases kunye ne-sulfotransferase.
4. Ukugqitywa kwe-HO-1, eyona mvume yokukhusela ekhuselekileyo yokukhula kwe CO, ngokubambisana ne-NO ivumela ukuba i-vasodilation yamaseli esicchem.
5. Ukunciphisa i-iron overload ngokusebenzisa i-ferritin ephakamileyo kunye ne-bilirubin njenge-lipophilic antioxidant. Zombili iiprotheni zesigaba II kunye ne-antioxidants ziyakwazi ukulungisa uxinzelelo olungapheliyo lwe-oxidative kunye nokuvuselela inkqubo eqhelekileyo ye-redox.

• I-GSK3? phantsi kolawulo lwe-AKT kunye ne-PI3K, i-phosphorylates Fyn ekhokelela kulwakhiwo lwenyukliya lwe-Fyn, ethi i-Fyn phosphorylates i-Nrf2Y568 ikhokelele kuthumelo lwenyukliya kunye nokonakaliswa kwe-Nrf2.
• I-NRF2 iphinda inciphise impendulo ye-TH1 / TH17 kwaye ivuselele impendulo ye-TH2.
• Ii-inhibitors ze-HDAC zenze indlela yokubonakalisa iNrf2 kwaye ilawulwa phezulu ukuba i-Nrf2 iinjongo eziphantsi kwe-HO-1, i-NQO1, kunye ne-glutamate-cysteine ​​ligase i-catalytic subunit, okanye i-GCLC, ngokukhupha i-Keap1 nokukhuthaza ukuhlukana kwe-Keap1 ukusuka kwi-Nrf2, i-Nrf2 i-transplant nuclear, ne-Nrf2 -AHA ebophayo.
• I-Nrf2 ibandakanya isigxina-ubomi malunga nemizuzu ye-20 phantsi kweemeko ezisisiseko.
• Ukunciphisa i-IKK? ichibi ngeKeap1 yokubopha kunciphisa I? B? Ukuthotywa isidima kwaye kunokuba yindlela engafunekiyo apho ukwenziwa kwe-Nrf2 kungqineke kuthintela ukwenziwa kwe-NF?
• I-Keap1 ayisoloko idityaniswe ukuba i-NRF2 isebenze, njenge-chlorophyllin, blueberry, ellagic acid, i-astaxanthin kunye ne-tea polyphenols inokukhuthaza i-NRF2 kunye ne-KEAP1 kwi-400 ipesenti.
• I-Nrf2 ilawula kakubi ngekota ye-stearoyl CoA desaturase, okanye i-SCD, ne-citrate lyase, okanye i-CL.

Genetics

KEAP1

Rs1048290

• I-C allele - ibonakalise umngcipheko omkhulu kunye nefuthe elikhuselekileyo lokulwa nesifo sokuxhatshazwa kwezilwanyana (DRE)

rs11085735 (Ndiyi-AC)

• idibene nenqanaba lokunciphisa ukusebenza komphunga kwi-LHS

MAPT

Rs242561

• I-Tlele - ukukhusela i-Parkinsonian disorders-yayinamandla ngakumbi kwi-NRF2 / sMAF yokubopha kwaye yahlanganiswa namazinga aphezulu e-MAPT mRNA kwimimandla eyahlukeneyo ye-MAPT, kubandakanya i-cerebellar cortex (CRBL), i-cortex ye-tempte (i-TTX), into ebomvu ye-intralobula (i-WHMT)

NFE2L2 (NRF2)

rs10183914 (Ndiyi-CT)

• T allele - ukwandiswa kwamanqanaba eprotheni ka-Nrf2 kunye nokulibazisa iminyaka yokuqalisa kweParkinson ngeminyaka emine

rs16865105 (Ndiyi-AC)

• I-C allele - yayinobungozi obukhulu beZifo ze-Parkinson

rs1806649 (Ndiyi-CT)

• I-C allele - sele ichongiwe kwaye ingaba ifanelekile kwi-etiology yomhlaza webele.
• edibene nomngcipheko ophezulu wokwamkelwa esibhedlele ngexesha lamazinga aphezulu e-PM10

rs1962142 (NdingumGG)

• I-allele - yayinxulumene nenqanaba eliphantsi le-cytoplasmic NRF2 ibinzana (P = 0.036) kunye ne-negative sulfiredoxin ibinzana (P = 0.042)
• I-protected-left-protected from blood circulation (FEV) yokunciphisa (ukunyanzeliswa komthamo wokuphefumula kwesibini) ngokumalunga nesimo sokubhema ugwayi (p = 0.004)

rs2001350 (ndingumTT)

• I-Tlele-protected-protected from FEV decline (ukunyanzeliswa komthamo wokuphefumula ngomzuzwana omnye) ngokumalunga nesimo sokubhema ugwayi (p = 0.004)

rs2364722 (NdingumAA)

• Ikhuseleke ngokukhawuleza ukusuka kwi-FEV yokunciphisa (ukunyanzeliswa kwevolumu yokuphefumula kwesibini) ngokumalunga nesimo sokubhema ugwayi (p = 0.004)

Rs2364723

• I-C iphela-inxulumene nokunciphisa kakhulu i-FEV kubantu baseJapan abanomdlavuza wamaphaphu

Rs2706110

• G allele - ubonise umngcipheko omkhulu kunye nesiphumo esikhuselekileyo sokulwa nesifo sokuxhatshazwa kwezidakamizwa (DRE)
• I-AA alleles - ibonise kakhulu incitshiso ye-KEAP1
• I-AA alleles - idibene nomngcipheko wokwanda komhlaza wesibeleko (P = 0.011)

rs2886161 (ndingumTT)

• I-allele - ehambelana neZifo ze-Parkinson

Rs2886162

• I-allele-yayinxulunyaniswa nentetho ephantsi ye-NRF2 (P = 0.011; OKANYE, 1.988; CI, 1.162-3.400) kunye ne-AA genotype yayinxulumene nokuphila okungalunganga (P = 0.032; HR, 1.687; CI, 1.047 2.748)

rs35652124 (ndingumTT)

• I-allele-ehambelana nephezulu ehambelana nobudala ekuqaleni kweSifo se-Parkinson vs G allele
• I-C allele - inyuse iprotheni ye-NRF2
• I-allele - yayineeprotheni ezingaphantsi kwe-NRF2 kunye nomngcipheko omkhulu wesifo senhliziyo kunye noxinzelelo lwegazi

rs6706649 (Ndiyi CC)

• I-C allele - yayineeprotheni ezisezantsi ze-NRF2 kwaye yandisa ingozi yeZifo ze-Parkinson

rs6721961 (NdingumGG)

• I-allele - yayineprotheni ephantsi yeNRF2
• I-TT ithobela - umbutho phakathi kokubhema ugwayi kwi-smoking smokers kunye nokunciphisa izinga lomzimba
• I-TT allele - yayinxulumene nomngcipheko wokwanda komhlaza webele [P = 0.008; OKANYE, 4.656; ixesha lokuzithemba (CI), 1.350�16.063] kunye ne-T allele idibaniswe nomlinganiselo ophantsi we-NRF2 inkcazo yeprotheni (P = 0.0003; OKANYE, 2.420; CI, 1.491�3.926) kunye ne-SRXN1 ibonakaliso (P = 0.047; 1.867; CI = 1.002�3.478)
• I-allele - allele yadibaniswa ngokuchanekileyo ne-ALI ehlobene ne-28-day-mortality emva kwe-syicrome
• I-Tlele-protected-protected from FEV decline (ukunyanzeliswa komthamo wokuphefumula ngomzuzwana omnye) ngokumalunga nesimo sokubhema ugwayi (p = 0.004)
• G allele - enxulumene nomngcipheko ophezulu we-ALI olandela ingxaki enkulu kwi-Yurophu nase-Afrika-yaseMelika (umlinganiselo we-OR, X ORUMX; 6.44%
• I-AA alleles - ehambelana nesifo sesifuba esisisifo
• I-AA alleles - ibonakaliswe kakhulu ekunciphiseni imbonakalo ye-NRF2 yesimo somzimba kwaye ngenxa yoko, ingozi enkulu yomdlavuza wamaphaphu, ngakumbi abo babesolo
• I-AA alleles - inomngcipheko ophezulu kakhulu wokuphuhlisa i-T2DM (OKANYE 1.77; 95% CI 1.26, 2.49; p = 0.011) ngokumalunga nalabo abane-CC genotype
• I-AA ixhomekeke-inxulumano oluqilileyo phakathi kokulungiswa kwelinxeba kunye nobutshanje obunokutsha kweemitha-mlilo (ezinxulumene nomngcipheko ophezulu kakhulu wokuphuhlisa imiphumo emfutshane kwi-Afrika-baseMerika ngokuhamba kwiCaucasians)
• ezinxulumene nomlomo we-estrogen unyango kunye nomngcipheko we-thromboembolism eneengqungquthela kubasetyhini abasemva

rs6726395 (Ndingum AG)

• Ukhuselo olukhuselekileyo ukusuka kwi-FEV1 ukwehla (ukunyanzela umthamo wokuphefumula kwesibini) ngokumalunga nesimo sokubhema ugwayi (p = 0.004)
• I-allele-ehambelana nokunciphisa kakhulu i-FEV1 kubantu baseJapan abanomdlavuza womphunga
• I-GG alleles - yayinezinga eliphezulu leNRF2 kwaye iyancipha umngcipheko wokuhlaselwa kwe-macular
• I-GG alleles - yayinomdla ophezulu kunye neCholangiocarcinoma

rs7557529 (Ndiyi-CT)

• I-C iphela-ehambelana nezifo ze-Parkinson

Uxinzelelo lwe-oxidative kunye nezinye izixinzelelo zingabangela umonakalo weseli ekugqibeleni ekukhokelela kwimibandela yezempilo. Uphando luye lwabonisa ukuba ukusebenza kwe-Nrf2 kunokukhuthaza umzimba wokhuselo lomzimba wokukhusela i-antioxidant, nangona kunjalo, abaphandi baye baxubusha ukuba i-Nrf2 ukugqithisa ingxaki inokuba neyona mngcipheko omkhulu kwimpilo kunye nokuphila kakuhle. Iindidi ezahlukahlukeneyo zomhlaza zingenzeka kwakhona nge-Nrf2 yokuqhekeza. UDkt Alex Jimenez DC, i-CCST Insight

I-Sulforaphane kunye neZiphumo zayo kuMhlaza, ukusweleka, ukuGuga, uBongo kunye nokuziphatha, isifo sentliziyo kunye nokunye

I-Isothiocyanates zizinye zezona zibalulekileyo zityalo zezityalo onokuzifumana kwisondlo sakho. Kule vidiyo ndiyenzela iimeko ezinzulu kunazo zonke eziye zenziwa. Ukufutshane okufutshane? Dlulela kwisihloko ozithandayo ngokuchofoza enye yeengongoma zangezantsi. Umgca wexesha eliphantsi. Amacandelo aphambili:

• 00: 01: 14 - I-cancer kunye nokufa
• 00: 19: 04 - Ukuguga
• 00: 26: 30 - Ubunono nokuziphatha
• I-00: I-38: 06 - I-recap yokugqibela
• 00: 40: 27 - Dose

Umgca wexesha elipheleleyo

• 00: 00: 34 - Ukuqaliswa kwe-sulforaphane, ingqwalasela ephambili yevidiyo.
• I-00: I-01: 14 - Ukusetyenziswa kwemifuno yeCruciferous kunye nokunciphisa kuzo zonke izizathu zokufa.
• I-00: 02: 12 - Umngcipheko womhlaza we-prostate.
• I-00: 02: 23 - Ingozi yomhlaza wesibeletho.
• I-00: 02: 34 - Umdlavuza womlenze kwingozi yokubhema.
• 00: 02: 48 - Ingozi yomhlaza wesifuba.
• I-00: 03: 13 - I-Hypothetical: kuthekani ukuba unomdlavuza? (ukungenelela)
• I-00: I-03: 35 - Indlela engabonakaliyo yokuqhuba umhlaza kunye nokufa kwedatha yokudibanisa.
• 00: 04: 38 - Sulforfane nomhlaza.
• I-00: 05: 32 - Ubungqina benkomo obonakalisa impembelelo enamandla ye-broccoli inhluma ehluthwayo ekuphuculweni kwe-tumor kwi-rats.
• I-00: I-06: 06 - Impembelelo yokuxhaswa ngokuthe ngqo kwe-sulforaphane kwizigulane zomhlaza wesibeletho.
• I-00: I-07: 09 - Ukuqokelela i-isothiocyanate i-metabolites kwimizimba yesisu.
• I-00: 08: 32 - Ukuvinjelwa kweeseli zomhlaza zesisu.
• 00: 08: 53 - Isifundo somlando: i-brassicas yasungulwa njengezakhiwo zezempilo nakwiRoma lasendulo.
• I-00: 09: 16 - I-Sulforfane ikhono lokuphucula ukwanda kwe-carcinogen (benzene, acrolein).
• I-00: 09: 51 - NRF2 njengenguqu yokuguqula izakhi nge-antioxidant response elements.
• I-00: 10: 10 - Indlela eyenziwa ngayo i-NRF2 isebenzise ukwanda kwe-carcinogen nge-glutathione-S-conjugates.
• I-00: I-10: I-34 - i-Brussels ihluma iyakhuphula i-glutathione-S-transferase kwaye iyanciphisa umonakalo we-DNA.
• I-00: 11: I-20 - i-Broccoli ihluma isiselo iphakamisa ibhenene ngaphandle kwe-61%.
• I-00: I-13: I-31 - I-Broccoli ihluma i-homogenate ikwandisa i-enzymes e-antioxidant ephezulu.
• I-00: I-15: 45 - Ukusetyenziswa kwemifuno yeCruciferous kunye nokufa kwesifo senhliziyo.
• I-00: I-16: I-55 - i-Broccoli ihluma i-powder iphucula i-lipids yegazi kunye nesifo sengqondo senhliziyo yesifo se-2.
• 00: 19: 04 - Ukuqala kwecandelo lokuguga.
• I-00: I-19: I-21 - I-Sulforaphane-ukutya okunomsoco kwandisa ubomi be-beetles ukusuka kwi-15 ukuya ku-30% (kwiimeko ezithile).
• I-00: 20: 34 - Ukubaluleka kokuvuvuka okuphantsi kwexesha elide.
• I-00: I-22: I-05 - Imifuno e-Cruciferous kunye ne-broccoli ihlumela i-powder ibonakala iyanciphisa iindidi ezahlukahlukeneyo zokumangalisa abantu.
• I-00: 23: 40 - Ukuhlaziywa kwe-mid-video: umdlavuza, izigulane eziguga
• I-00: I-24: I-14 - Iziphumo zemouse zibonisa ukuba i-sulfurephane inokuphucula ukusebenza kwe-immune ngexesha lokuguga.
• I-00: I-25: I-18 -Sulforaphane ithuthukise ukunyuka kweenwele kwimodeli ye-mouse yokukhangela. Umfanekiso kwi-00: 26: 10.
• 00: 26: 30 - Ukuqala kwecandelo lobuchopho kunye nokuziphatha.
• I-00: 27: 18 - Impembelelo ye-broccoli ihluma i-autism.
• 00: 27: 48 - Umphumo we-glucoraphanin kwi-schizophrenia.
• I-00: I-28: 17 - Ukuqala kwengxoxo yokudandatheka (iindlela kunye nezifundo).
• I-00: 31: 21 - Uvavanyo lweMouse usebenzisa i-10 imizekelo eyahlukeneyo yokuxinezeleka okubangelwa uxinzelelo kubonisa ukuba i-sulforaphane efana neyofana ne-fluoxetine (prozac).
• I-00: I-32: I-00 - Ukufundiswa kubonisa ukungena ngokuthe ngqo kwe-glucoraphanin kwiimicebe kusebenza ngokufanayo ekukhuseleni ukudandatheka kwindlela yokuxhatshazwa kwentlalo.
• I-00: I-33: 01 - Ukuqala kwecandelo lokuvelisa i-neurodegeneneration.
• 00: 33: 30 - Sulforaphane kunye nesifo se-Alzheimer.
• 00: 33: 44 - Sulforaphane kunye nesifo sikaParkinson.
• 00: 33: 51 - iSulforaphane nesifo sikaHongtington.
• I-00: 34: I-13 - I-Sulforfane iphakamisa ama-proteins.
• 00: 34: 43 - Ukuqala kwecandelo lokulimala kwengqondo elibuhlungu.
• I-00: I-35: I-01 - I-Sulforaphane injected ngokukhawuleza emva kwe-TBI iphucula imemori (isifundo se mouse).
• I-00: 35: 55 - iSulforaphane kunye ne-plastic neuronal.
• I-00: I-36: I-32 - I-Sulforfane iphucula ukufunda kwi-type II yesifo sikashukela kwiimiceba.
• I-00: 37: 19 - iSulforaphane kunye ne-duchenne i-dystrophy muscular.
• I-00: 37: 44 - I-Myostatin inhibition kwiiseli ze-satellite ze-muscle (in vitro).
• I-00: 38: 06 - Ukuhlaziywa kwexesha elide: i-mortality kunye nomhlaza, umonakalo we-DNA, uxinzelelo lwe-oxidative kunye nokuvuvukala, i-benzene excretion, isifo se-cardiovascular, uhlobo lwesi-2 seswekile, iimpembelelo kwingqondo (ukudandatheka, autism, schizophrenia, neurodegeneration), indlela ye-NRF2.
• I-00: I-40: 27 - Iingcamango zokuqikelela umthamo wamahlumela e-broccoli okanye i-sulforfane.
• I-00: I-41: I-01 - i-Anecdotes xa ihluma ekhaya.
• I-00: 43: 14 - Ekuphekeni kwamaqondo okushisa kunye nomsebenzi we-sulforaphane.
• I-00: 43: 45 - Gut bacteria ukuguqulwa kwe-sulforaphane kwi-glucoraphanin.
• I-00: I-44: I-24 - I-Supplements isebenza ngcono xa idibene ne-myrosinase esebenzayo kwimifuno.
• I-00: I-44: I-56 - Amasu okupheka kunye nemifuno e-cruciferous.
• 00: 46: 06 - Isothiocyanates njenge-goitrogens.

Ngokwezifundo zophando, i-Nrf2, yeyona nto ibalulekileyo ekhutshelweyo eyenza ukuba iiseli zikhusele iindlela zokulwa ne-antioxidant ukuze zikhuphe ubuthi emzimbeni womntu. Ukugqithiswa kwe-Nrf2, nangona kunjalo, kunokubangela imiba yezempilo. Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic kunye nemiba yempilo yomgogodla. Ukuxoxa ngalo mbandela, nceda uzive ukhululekile ukubuza uGqr. Jimenez okanye uqhagamshelane nathi apha915-850-0900 . Ikhutshwe nguDkt. Alex Jimenez

Ingxoxo yesihloko esongezelelweyo: cBuhlungu obuBuhlungu

Umqolo obuhlunguSesinye sezona zinto zixhaphakileyo zokukhubazeka kunye neentsuku eziphosiweyo emsebenzini kwihlabathi liphela. Iimpawu ezibuhlungu zangasemva kwisizathu sesibini esiqhelekileyo sokutyelelwa kweofisi kagqirha, ngaphezulu kwenani losulelo oluphezulu lokuphefumla. Ngokumalunga neepesenti ezingama-80 zabemi baya kuba neentlungu zentlungu emva kanye ebomini babo. Umqolo sisakhiwo esintsonkothileyo esenziwe ngamathambo, amalungu, iigaments, kunye nezihlunu, phakathi kwezinye izicwili ezithambileyo. Ukwenzakala kunye / okanye iimeko ezixhonyiweyo, ezinje ngedisni, ekugqibeleni unokukhokelela kwiimpawu zentlungu. Ukulimala kwezemidlalo okanye ukulimala kwengozi yeemoto ngokuqhelekileyo kubangelwa yintlungu yokubuhlungu, kodwa ngamanye amaxesha ukuhamba kwezinto ezilula kunokuba neziphumo ezibuhlungu. Ngethamsanqa, ezinye iindlela zokhathalela unyango, ezifana nokunyamekelwa kwe-chiropractic, kunokunceda ukubuyisela intlungu emva kokusetyenziswa kwemilenze kunye nokunyanzeliswa kwemigaqo, ekugqibeleni ukuphucula intlungu.  

I-EXTRA EXTRA | ISIHLOKO ESIBALULEKILEYO: Kunconywe i-El Paso, TX I-Chiropractor

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