Ziziphi iinzuzo zeNrf2?

Uxinzelelo oluxhamlayo luyinxaxheba enkulu ekuphuhlisweni kwemiba yezempilo eyahlukeneyo, kuquka nomhlaza, isifo senhliziyo, isifo sikashukela, ukuguga ngokukhawuleza kunye ne-neurodegeneneration. Ukutya okucebileyo, iitrob kunye nezongezelelo zingasetyenziselwa ukukhusela umzimba womntu ukusuka kumanqanaba aphakamileyo oxinzelelo. Uphando olutsha luye lwabonisa ukuba Indlela yokuguqula i-Nrf2 unokunceda ukukhulisa imiphumo ye-antioxidants. I iinzuzo zeNrf2 zichazwe ngezantsi.

Ukhusela iBhunga malunga neTyxin

I-NRF2 yinto yangaphakathi enokukhusela iiseli kwizinto ezinobungozi, zangaphakathi nangaphandle. I-NRF2 inokunceda ekuphuculeni indlela umzimba womntu osabela ngayo kwiziyobisi / kumayeza kunye ne-toxins, ukuphucula ukuveliswa kweeprotheyini ezinceda ukuphelisa i-compounds kwiseli, eyaziwa ngokuba yi-multidrug resistance-associated proteins, okanye i-MRPs. Ukuphefumla umsi wecuba ukuvumela imiphunga ukuba ikhuphe ubutyhefu.

Ukongeza, kubalulekile ukuba imiphunga izikhusele ngokuchasene nezinto ezinokuthi zenzeke, izifo zentsholongwane, i-endotoxins yebhaktiriya, i-hyperoxia, kunye nezinto ezahlukeneyo ezingcolisa indalo. I-trigger eqhubekayo ye-Nrf2 nangona kunjalo, inokunciphisa amanqanaba ento eyaziwa ngokuba yi-glutathione kuwo wonke umzimba womntu. I-NRF2 inokukhusela isibindi kwityhefu kwaye inokukhusela isibindi kwi-arsenic hepatotoxicity. Ngaphezu koko, i-NRF2 ikhusela isibindi kunye nengqondo ekusetyenzisweni kotywala. Ngokomzekelo, i-Nrf2 inokukhusela ngokuchasene ne-acetaminophen toxicity.

Ukulwa nokuvuvukala kunye nokuxinezeleka koxinzelelo

Ukuqalisa ukusebenza kwe-NRF2 kunokunceda ukulwa nokuvuvukala ngokunciphisa ama-cytokines avuzayo, afana nalawo akhona kwi-psoriasis. I-NRF2 inokunciphisa ukutshaya okunxulumene neentlobo zempilo ezinjenge-arthritis kunye ne-fibrosis yesibindi, izintso kunye nemiphunga. I-NRF2 inokukunceda ukulawula i-allergies ngokunciphisa i-Th1 / iT17 cytokines nokuphakamisa i-cytokines ye-TH2. Oku kunokuba luncedo kwizifo ezinjenge-asthma.

I-NRF2 ikwakhusela kumonakalo weselula ukusuka ekukhanyeni okuluhlaza �kunye nakwi-UVA/UVB� efumaneka ekukhanyeni kwelanga. Ukusilela kwe-Nrf2 kunokwenza ukuba kube lula kakhulu ukufumana ukutshiswa lilanga. Enye ingqiqo emva koku kukuba i-NRF2 iyakwazi ukulawula i-collagen ekuphenduleni imisebe ye-UV. I-Advanced Glycation End-Products, okanye i-AGEs, igalelo ekuphuhliseni imiba emininzi yezempilo, kuquka isifo sikashukela kunye nezifo ze-neurodeergenerative. I-NRF2 inokunciphisa uxinzelelo lwe-oxidative ye-AGEs ngaphakathi komzimba. I-NRF2 inokukhusela umzimba womntu kumanqanaba aphezulu oxinzelelo olusekelwe kubushushu.

Uphucula iMitochondria kunye nokuSebenza koMsebenzi

I-NRF2 yi-booster ye-mitochondrial. Ukusebenza kwe-NRF2 kunegalelo ekunyukeni kwamandla e-ATP kwi-mitochondria, ngaphezu kokusetyenziswa okuphuculweyo kwe-oksijini, okanye i-citrate, kunye namafutha. Ngaphandle kwe-NRF2, i-mitochondria iya kuba namandla okusebenza kunye noshukela, okanye i-glucose, kunamafutha. I-NRF2 ikwabalulekile kwimitochondria ukuba iphuhle ngenkqubo eyaziwa ngokuba yi-biogenesis. Ukusebenza kwe-NRF2 kubalulekile ukuze �ukuxhamla kwiinzuzo zokuzilolonga.

Ngenxa yomsebenzi we-Nrf2, umthambo uphakamisa umsebenzi we-mitochondrial, apho esi siphumo sinokunyuswa nge-CoQ10, iCordyceps, kunye neCaloric Restriction. Ukuzivocavoca okuphakathi okanye ukuzivocavoca ngokukhawuleza kubangela i-mitochondrial biogenesis kunye ne-synthesis ephakamileyo ye-superoxide dismutase, okanye i-SOD, kunye ne-heme-oxygenase-1, okanye i-HO-1, ngokusebenzisa i-NRF2 activation. I-Alpha-Lipoic Acid, � okanye i-ALA, kunye noDan Shen banokunyusa i-NRF2 mediated mitochondrial biogenesis. Ngapha koko, i-NRF2 inokuphucula ukunyamezelana komthambo apho ukususwa kwe-NRF2 kwenza umthambo ube yingozi.

Khusela i Hypoxia

I-NRF2 inceda ekukhuseleni umzimba womntu kwi-cellular oxygen loss / dection, umcimbi wezempilo obizwa ngokuba yi-hypoxia. Abantu ngabanye abane-CIRS banciphise amazinga oksijeni ekubeni i-NRF2 yabo ivinjelwe, oku kuphumela kumanqanaba amancinci we-VEGF, i-HIF1 kunye ne-HO-1. Ngokuqhelekileyo, kubantu abanezempilo abane-hypoxia, i-miR-101, efunekayo ekudalweni kweeseli ze-stem, zixhalabele kwaye zikhulise inani lee-NRF2 / HO-1 kunye ne-VEGF / iNOS, ngoko ukukhusela umonakalo wengqondo, kodwa oko kungabonakali ukuba kwenzeke kwiiCIRS.

I-Hypoxia, ebonakaliswe yi-HIF1 ephantsi, kwii-CIRS nayo ingakhokelela ekukhuseleni kwegazi yengqondo ngenxa ye-NRF2 ukungalingani. I-Salidroside, e-Rhodiola, imisebenzi kwi-NRF2 isebenze kwaye incedisa nge-hypoxia ngokunyusa amazinga e-VEGF kunye ne-HIF1 ngaphakathi komzimba womntu. I-NRF2 nayo iyakhusela ekugqibeleni isakhiwo se-lactate entliziyweni. Ukusebenziswa kwe-NRF2 kunokumisa nokunyuka kwe-hypoxia-kukhutshwe kwi-Altitude Motion Ukugula, okanye i-AMS.

Uguqula Ukuguga Ukuguga

Iikhompawundi ezininzi ezinokubulala ngobuninzi obukhulu zinokwandisa ixesha elide kumanani amancinci ngenxa ye-xenohormesis nge-NRF2, i-PPAR-gamma, kunye ne-FOXO. Ubungakanani obuncinci beetyhefu bunyusa amandla eseli ukuze ixhotyiswe ngcono kwixesha elizayo xa icelwa umngeni nge-toxin, nangona kunjalo, oku ayisosiqinisekiso sokutya iikhemikhali ezinetyhefu.

Umzekeliso olungileyo wale nkqubo kukuthintelwa kwekhalori. I-NRF2 inokuphucula ubomi beeseli ngokuphakamisa amanqanaba e-mitochondria kunye ne-antioxidants kunye nokunciphisa amandla okufa kweeseli. I-NRF2 iyancipha ngokuguga kuba i-NRF2 ikhusela iiseli ze-stem ukuba zingafi kwaye zibancede ukuba bahlaziye. I-NRF2 idlala indima ekuphuculeni ukuphiliswa kwesilonda.

Ikhuthaza iNkqubo yeMascular

Ukwenziwe ngokuchanekileyo ngemveliso ye-sulforfane, ukusetyenziswa kwe-NRF2 kunokukhusela kwizifo zentliziyo ezifana nokunyuka kwengcinezelo yegazi, okanye uxinzelelo lwegazi, kunye nobunzima beetriyiti, okanye i-atherosclerosis. I-NRF2 inokuphucula u-Acetylcholine, okanye i-ACh, umsebenzi ophumayo kwisistim ye-vascular ngeli xesha ukunciphisa uxinzelelo lwe-cholesterol. Ukusebenza kwe-Nrf2 kunokuqinisa intliziyo, nangona kunjalo, i-Nrf2 ingaphumelelwanga inokuphakamisa amathuba okuba nesifo senhliziyo.

Iitatimins zinokuthintela okanye zikhokele kwisifo senhliziyo. I-NRF2 nayo inendima enkulu ekulinganiseni i-iron kunye ne-calcium enokukhusela umzimba womntu ekubeni unamanqanaba ensimbi ephakamileyo. Ngokomzekelo, i-Sirtuin 2, okanye i-SIRT2, inokulawula i-homeostasis yesinyithi kwiiseli ngokusebenza kwe-NRF2 ekholelwa ukuba iyafuneka kwimilinganiselo enempilo yesinyithi. I-NRF2 inokunceda kwakhona ngeSickle Cell Disease, okanye i-SCD. Ukungasebenzi kakubi kwe-NRF2 kusenokuba sisisemva kwe-endotoxemia efana ne-dysbiosis okanye i-lectins eyenze ingozi yomshukela. I-Nrf2 inokukhusela umzimba womntu ngokumelene ne-amphetamine eyonakalisa umonakalo kwinkqubo yesistim.

Ukulwa Neuroinflammation

I-NRF2 inokukhusela kunye nokuncedisa ukuvuvukala kwengqondo, ebizwa ngokuba yi-neuroinflammation. Ukongezelela, i-NRF2 inokukunceda ngeNkqubo yokuThuthukiswa kweNkqubo yeNervous Central, okanye i-CNS, ukuphazamiseka, kuquka:

• Izifo ze-Alzheimer (AD) - kunciphisa uxinzelelo lwe-betyloid beta kwi-mitochondria
• I-Amyotrophic Lateral Sclerosis (ALS)
• Izifo zeHuntington (HD)
• Multiple Sclerosis (MS)
• Ukuvuselelwa Kwamanzi
• Isifo se-Parkinson (PD) - sikhusela i-dopamine
• Ukulimala kweNtsholongwane yokuCala (SCI)
• I-stroke (ischemic and hemorrhagic) - inceda i-hypoxia
• Ukulimala kweBrain Injury

I-NRF2 ibonakalise ukuhla kwe-neuroinflammation kulutsha olune-Autism Spectrum Disorders okanye i-ASD. I-Idebenone idibanisa ngokufanelekileyo kunye ne-NRF2 activators ngokuchasene neuroinflammation. I-NRF2 inokuphucula i-Blood Brain Barrier, okanye i-BBB. Ngokomzekelo, ukusetyenziswa kwe-NRF2 kunye ne-carnosic acid efunyenwe kwi-rosemary kunye ne-sage inokuwela i-BBB kwaye ibangele i-neurogenesis. I-NRF2 iye yaboniswa ukuba iphakamise i-Brain Derived Neurotrophic Factor, okanye i-BDNF.

I-NRF2 iphinda imodareyithe amandla okutya okunesondlo ukuze kubangele iNerve Growth Factor, okanye i-NGF njengoko inokunceda kwakhona ngenkungu yengqondo kunye nemiba ebangelwa yi-glutamate ngokumodareyitha i-N-Methyl-D-Aspartate, okanye i-NMDA receptors. Inokunciphisa uxinzelelo lwe-oxidative kwi-quinolinic acid, ebizwa ngokuba yi-QUIN. Ukusebenza kwe-NRF2 kunokukhusela ekubanjweni kwaye iidosi ezinkulu zinokunciphisa umda wokubamba. Kwiidosi eziqhelekileyo zokuvuselela, i-NRF2 inokuphucula amandla okuqonda emva kokubanjwa ngokunciphisa i-glutamate ye-extracellular kwingqondo kunye nokukwazi ukutsala i-cysteine ​​​​kwi-glutamate kunye ne-glutathione.

Ukhulula uxinzelelo

Kwixinzelelo, kuqhelekile ukuqaphela ukuvuvukala kwengqondo, ingakumbi ukusuka kwi-prefrontal cortex kunye ne-hippocampus, kunye nokuhla kwe-BDNF. Kwezinye iinguqulelo zokudakumba, i-NRF2 inokuphucula iimpawu zokudandatheka ngokunciphisa ukuvuvukala ngaphakathi kwengqondo kunye nokwandisa amazinga e-BDNF. Ukwazi u-Agmatine ukunciphisa uxinzelelo ngokuphakamisa i-noradrenaline, i-dopamine, i-serotonin kunye ne-BDNF kwi-hippocampus incike kusebenziso lwe-NRF2.

Iqulethe iipropati zeNtsholongwane

I-NRF2 inokulingana nomxhasi we-tumor njengokuba umgqugquzeli we-tumor ukuba angayilawulwa ngokufanelekileyo. I-NRF2 inokukhusela kumdlavuza obangelwa yi-radicals yamahhala kunye noxinzelelo lwe-oxidative, nangona kunjalo, ukugqithiswa kwe-NRF2 kunokufumaneka kwiseli yomhlaza. Ukusebenza ngokubanzi kwe-NRF2 kunokunceda ngeendlela ezahlukeneyo zeekhensi. Ngokomzekelo, ukuncedisa i-Protandim kunokunciphisa umdlavuza wesikhumba ngo-activation NRF2.

Uxolela ubuhlungu

I-Gulf War Illness, okanye i-GWI, isifo esichaphazelekayo esichaphazela kwiMfazwe yeMfazwe yaseGulf, iqoqo leempawu ezingapheliyo, ezinokuthi zibandakanye ukhathala, iintloko, intlungu edibeneyo, ukunyanzelisa, ukulala, ukusila, ukugula, kunye nokukhunjulwa kwemiba. I-NRF2 inokuphucula iimpawu ze-GWI ngokunciphisa i-hippocampal kunye nokuvuvukala ngokubanzi, ngaphezu kokunciphisa intlungu. I-NRF2 inokunceda ukuncedisa intlungu ebuhlungu besifo somzimba kunye nokuphucula umonakalo weentambo kwi-neuropathy ye-diabetes.

Uphucula isifo sikashukela

Amanqanaba aphezulu e-glucose, okubhetele ngokubhekiselele kwi-hyperglycemia, ibangela umonakalo ochaphazelekayo kwiiseli ngenxa yokuphazamiseka komsebenzi we-mitochondrial. Ukuqalisa ukusebenza kwe-NRF2 kunokukhusela umzimba womntu ngokumalunga nokulimala kwe-hyperglycemia kwiseli, oko kukuthintela ukufa kwesisele. Ukusetyenziswa kwe-NRF2 kunokukhusela ngokuphindaphindiweyo, ukubuyisela, nokuphucula umsebenzi we-beta-cell we-pancreatic, ngelixa kunciphisa ukunyanzelwa kwe-insulin.

Ukhusela Umbono Nokuva

I-NRF2 iyakhusela ukulimala kwiso kwi-retinopathy yesifo sikashukela. Inokuthi iphinde iphephe ukubunjwa kwe-cataracts nokukhusela i-photoreceptors enxamnye nokufa okubangelwa kukukhanya. I-NRF2 yongeza ukhusela indlebe, okanye i-cochlea, kwi-stress kunye nokulahlekelwa kwindlebe.

Unokukunceda ukunyaniseka

I-NRF2 inokunceda ngokukhuluphala ngokuyinhloko ngenxa yokukwazi ukulawula ukuguqulwa kwezinto ezisebenzisayo kwi-fat accumulation emzimbeni womntu. Ukusebenza kwe-NRF2 kunye ne-sulforaphane kunokuphakamisa ukukhutshwa kwe-Acat Acid Synthesis, okanye i-FAS, kunye ne-Uncoupling Proteins, okanye i-UCP, okubangelwa ukuqokelela kwamafutha amaninzi kunye namafutha amaninzi amaninzi, ebonakala njengamafutha afaka i-mitochondria.

Ukhusela i-Gut

I-NRF2 inceda ukukhusela umthamo ngokukhusela i-intestine microbiome homeostasis. Ngokomzekelo, i-lactobacillus probiotics izokubangela iNRF2 ukulondoloza umthamo kwixinzelelo loxinzelelo. I-NRF2 inokukunceda ukunqanda i-Ulcerative Colitis, okanye i-UC.

Ukhusela amaLungu eSondo

I-NRF2 inokukhusela amasende kwaye igcine inani lamadlozi kwingozi kubantu abanesifo seswekile. Inokunceda kwakhona nge-Erectile Dysfunction, okanye i-ED. Ezinye izongezo zokunyusa i-libido njenge-Mucuna, i-Tribulus, kunye ne-Ashwaganda-zinokuphucula umsebenzi wesondo ngokuvula i-NRF2. Ezinye izinto eziphakamisa i-NRF2, ezifana nokukhanya kwelanga okanye i-broccoli ihluma, inokunceda ukuphucula i-libido.

Ulawula iiBones kunye neMiscle

Uxinzelelo lwe-oxidative lungabangela ukuxinwa kwethambo nokunciphisa amandla, okuqhelekileyo kwi-osteoporosis. Ukuqalisa ukusebenza kwe-NRF2 kunokukwazi ukuphucula ama-antioxidants amathambo nokukhusela ekugugeni kwethambo. I-NRF2 inokukhusela ukulahlekelwa kwemisipha kunye nokuphucula i-Duchenne Muscular Dystrophy, okanye i-DMD.

Iqulethe iipropati zeNtsholongwane

Okokugqibela kodwa kuncinci, ukusebenza kwe-NRF2 kunokunceda ekugqibeleni ukukhusela umzimba womntu kwiintsholongwane ezininzi. Kwizigulane ezine-virus ye-dengue, iimpawu zazingekho kakhulu kubantu ababenamanqanaba amakhulu e-NRF2 xa kuthelekiswa nabantu abanamadigri angaphantsi kwe-NRF2. I-NRF2 inokunceda abantu abane-Human Immunodeficiency-1 Virus,� okanye i-HIV. I-NRF2 inokukhusela uxinzelelo lwe-oxidative kwi-Adeno-Associated Virus, okanye i-AAV, kunye ne-H. Pylori. Ekugqibeleni, i-Lindera Root inokucinezela i-virus ye-Hepatitis C kunye nokusebenza kwe-NRF2.

I-Nrf2, okanye i-NF-E2 enxulumene ne-2, iyinto ebonakalayo ebhalweni kubantu abalawula ukuthetha kwetadi ethile ye-antioxidant kunye ne-detoxifying gene. Le ndlela yokubonisa iyasebenza ngenxa yoxinzelelo lwe-oxidative njengoko iphakamisa amaninzi e-antioxidant kunye nesigaba se-II se-detoxification detective enzymes yokubuyisela i-homeostasis emzimbeni womntu. Abantu bachitshiyelwa ukuba basebenze kuwo wonke umhlaba we-homeostasis okanye ibhalansi. Xa umzimba ubhekene noxinzelelo lwe-oxidative, i-Nrf2 isebenza ukulawula i-oxidation kunye nokulawula uxinzelelo. I-Nrf2 ibalulekile ekukhuseleni imiba yempilo enxulumene noxinzelelo lwe-oxidative. UDkt Alex Jimenez DC, i-CCST Insight

I-Sulforaphane kunye neZiphumo zayo kuMhlaza, ukusweleka, ukuGuga, uBongo kunye nokuziphatha, isifo sentliziyo kunye nokunye

I-Isothiocyanates zizinye zezona zibalulekileyo zityalo zezityalo onokuzifumana kwisondlo sakho. Kule vidiyo ndiyenzela iimeko ezinzulu kunazo zonke eziye zenziwa. Ukufutshane okufutshane? Dlulela kwisihloko ozithandayo ngokuchofoza enye yeengongoma zangezantsi. Umgca wexesha eliphantsi.

Amacandelo aphambili:

• 00: 01: 14 - I-cancer kunye nokufa
• 00: 19: 04 - Ukuguga
• 00: 26: 30 - Ubunono nokuziphatha
• I-00: I-38: 06 - I-recap yokugqibela
• 00: 40: 27 - Dose

Umgca wexesha elipheleleyo

• 00: 00: 34 - Ukuqaliswa kwe-sulforaphane, ingqwalasela ephambili yevidiyo.
• I-00: I-01: 14 - Ukusetyenziswa kwemifuno yeCruciferous kunye nokunciphisa kuzo zonke izizathu zokufa.
• I-00: 02: 12 - Umngcipheko womhlaza we-prostate.
• I-00: 02: 23 - Ingozi yomhlaza wesibeletho.
• I-00: 02: 34 - Umdlavuza womlenze kwingozi yokubhema.
• 00: 02: 48 - Ingozi yomhlaza wesifuba.
• I-00: 03: 13 - I-Hypothetical: kuthekani ukuba unomdlavuza? (ukungenelela)
• I-00: I-03: 35 - Indlela engabonakaliyo yokuqhuba umhlaza kunye nokufa kwedatha yokudibanisa.
• 00: 04: 38 - Sulforfane nomhlaza.
• I-00: 05: 32 - Ubungqina benkomo obonakalisa impembelelo enamandla ye-broccoli inhluma ehluthwayo ekuphuculweni kwe-tumor kwi-rats.
• I-00: I-06: 06 - Impembelelo yokuxhaswa ngokuthe ngqo kwe-sulforaphane kwizigulane zomhlaza wesibeletho.
• I-00: I-07: 09 - Ukuqokelela i-isothiocyanate i-metabolites kwimizimba yesisu.
• I-00: 08: 32 - Ukuvinjelwa kweeseli zomhlaza zesisu.
• 00: 08: 53 - Isifundo somlando: i-brassicas yasungulwa njengezakhiwo zezempilo nakwiRoma lasendulo.
• I-00: 09: 16 - I-Sulforfane ikhono lokuphucula ukwanda kwe-carcinogen (benzene, acrolein).
• I-00: 09: 51 - NRF2 njengenguqu yokuguqula izakhi nge-antioxidant response elements.
• I-00: 10: 10 - Indlela eyenziwa ngayo i-NRF2 isebenzise ukwanda kwe-carcinogen nge-glutathione-S-conjugates.
• I-00: I-10: I-34 - i-Brussels ihluma iyakhuphula i-glutathione-S-transferase kwaye iyanciphisa umonakalo we-DNA.
• I-00: 11: I-20 - i-Broccoli ihluma isiselo iphakamisa ibhenene ngaphandle kwe-61%.
• I-00: I-13: I-31 - I-Broccoli ihluma i-homogenate ikwandisa i-enzymes e-antioxidant ephezulu.
• I-00: I-15: 45 - Ukusetyenziswa kwemifuno yeCruciferous kunye nokufa kwesifo senhliziyo.
• I-00: I-16: I-55 - i-Broccoli ihluma i-powder iphucula i-lipids yegazi kunye nesifo sengqondo senhliziyo yesifo se-2.
• 00: 19: 04 - Ukuqala kwecandelo lokuguga.
• I-00: I-19: I-21 - I-Sulforaphane-ukutya okunomsoco kwandisa ubomi be-beetles ukusuka kwi-15 ukuya ku-30% (kwiimeko ezithile).
• I-00: 20: 34 - Ukubaluleka kokuvuvuka okuphantsi kwexesha elide.
• I-00: I-22: I-05 - Imifuno e-Cruciferous kunye ne-broccoli ihlumela i-powder ibonakala iyanciphisa iindidi ezahlukahlukeneyo zokumangalisa abantu.
• I-00: 23: 40 - Ukuhlaziywa kwe-mid-video: umdlavuza, izigulane eziguga
• I-00: I-24: I-14 - Iziphumo zemouse zibonisa ukuba i-sulfurephane inokuphucula ukusebenza kwe-immune ngexesha lokuguga.
• I-00: I-25: I-18 -Sulforaphane ithuthukise ukunyuka kweenwele kwimodeli ye-mouse yokukhangela. Umfanekiso kwi-00: 26: 10.
• 00: 26: 30 - Ukuqala kwecandelo lobuchopho kunye nokuziphatha.
• I-00: 27: 18 - Impembelelo ye-broccoli ihluma i-autism.
• 00: 27: 48 - Umphumo we-glucoraphanin kwi-schizophrenia.
• I-00: I-28: 17 - Ukuqala kwengxoxo yokudandatheka (iindlela kunye nezifundo).
• I-00: 31: 21 - Uvavanyo lweMouse usebenzisa i-10 imizekelo eyahlukeneyo yokuxinezeleka okubangelwa uxinzelelo kubonisa ukuba i-sulforaphane efana neyofana ne-fluoxetine (prozac).
• I-00: I-32: I-00 - Ukufundiswa kubonisa ukungena ngokuthe ngqo kwe-glucoraphanin kwiimicebe kusebenza ngokufanayo ekukhuseleni ukudandatheka kwindlela yokuxhatshazwa kwentlalo.
• I-00: I-33: 01 - Ukuqala kwecandelo lokuvelisa i-neurodegeneneration.
• 00: 33: 30 - Sulforaphane kunye nesifo se-Alzheimer.
• 00: 33: 44 - Sulforaphane kunye nesifo sikaParkinson.
• 00: 33: 51 - iSulforaphane nesifo sikaHongtington.
• I-00: 34: I-13 - I-Sulforfane iphakamisa ama-proteins.
• 00: 34: 43 - Ukuqala kwecandelo lokulimala kwengqondo elibuhlungu.
• I-00: I-35: I-01 - I-Sulforaphane injected ngokukhawuleza emva kwe-TBI iphucula imemori (isifundo se mouse).
• I-00: 35: 55 - iSulforaphane kunye ne-plastic neuronal.
• I-00: I-36: I-32 - I-Sulforfane iphucula ukufunda kwi-type II yesifo sikashukela kwiimiceba.
• I-00: 37: 19 - iSulforaphane kunye ne-duchenne i-dystrophy muscular.
• I-00: 37: 44 - I-Myostatin inhibition kwiiseli ze-satellite ze-muscle (in vitro).
• I-00: 38: 06 - Ukuhlaziywa kwexesha elide: i-mortality kunye nomhlaza, umonakalo we-DNA, uxinzelelo lwe-oxidative kunye nokuvuvukala, i-benzene excretion, isifo se-cardiovascular, uhlobo lwesi-2 seswekile, iimpembelelo kwingqondo (ukudandatheka, autism, schizophrenia, neurodegeneration), indlela ye-NRF2.
• I-00: I-40: 27 - Iingcamango zokuqikelela umthamo wamahlumela e-broccoli okanye i-sulforfane.
• I-00: I-41: I-01 - i-Anecdotes xa ihluma ekhaya.
• I-00: 43: 14 - Ekuphekeni kwamaqondo okushisa kunye nomsebenzi we-sulforaphane.
• I-00: 43: 45 - Gut bacteria ukuguqulwa kwe-sulforaphane kwi-glucoraphanin.
• I-00: I-44: I-24 - I-Supplements isebenza ngcono xa idibene ne-myrosinase esebenzayo kwimifuno.
• I-00: I-44: I-56 - Amasu okupheka kunye nemifuno e-cruciferous.
• 00: 46: 06 - Isothiocyanates njenge-goitrogens.

Xa umzimba womntu ujongene nezinto eziyingozi zangaphakathi nangaphandle njenge-toxin, iiseli kufuneka zikhawuleze zibangele amandla azo e-antioxidant ukulwa noxinzelelo lwe-oxidative. Ngenxa yokuba amanqanaba aphezulu oxinzelelo lwe-oxidative azimisele ukubangela imiba eyahlukeneyo yezempilo, kubalulekile ukusebenzisa i-Nrf2 isebenze ukuthatha inzuzo yayo. Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic kunye nemiba yempilo yomgogodla. Ukuxoxa ngalo mbandela, nceda uzive ukhululekile ukubuza uGqr. Jimenez okanye uqhagamshelane nathi apha915-850-0900 .

Ikhutshwe nguDkt. Alex Jimenez

Ingxoxo yesihloko esongezelelweyo: cBuhlungu obuBuhlungu

Umqolo obuhlunguSesinye sezona zizathu zixhaphakileyo zokukhubazeka kunye neentsuku eziphosiweyo emsebenzini kwihlabathi liphela. Iimpawu ezibuhlungu zangasemva kwisizathu sesibini esiqhelekileyo sokutyelelwa yi-ofisi kagqirha, ngaphezulu kwenani losulelo oluphezulu lokuphefumla. Phantse iipesenti ezingama-80 zabemi baya kufumana iintlungu zangasemva kube kanye ebomini babo. Umqolo sisakhiwo esintsonkothileyo esenziwe ngamathambo, amalungu, iigaments, kunye nezihlunu, phakathi kwezinye izicwili ezithambileyo. Ngenxa yoku, ukwenzakala kunye / okanye iimeko ezixineneyo, ezinje ngedisni, ekugqibeleni inokukhokelela kwiimpawu zentlungu emva. Ukulimala kwezemidlalo okanye ukulimala kwengozi yemoto kudla ngokuba yimbangela eqhelekileyo yeentlungu zangasemva, nangona kunjalo, ngamanye amaxesha ukunyakaza okulula kunokuba neziphumo ezibuhlungu. Ngethamsanqa, ukhetho olulolunye unyango, olufana nokunyamekela kwe-chiropractic, lunokunceda ukunciphisa intlungu emva kokusetyenziswa kohlengahlengiso lomqolo kunye nokunyanzeliswa kwezandla, ekugqibeleni kuphuculwe intlungu. �

I-EXTRA EXTRA | ISIHLOKO ESIBALULEKILEYO: Kunconywe i-El Paso, TX I-Chiropractor

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