Ngaba unokutshintsha i-Epigenetic Clock yakho?

Ukwaluphala yinxalenye yobomi yendalo kwaye ayinakuyekiswa. Okanye ubuncinci, yile nto besicinga. Abaphandi e-Intervene Immune, eStanford, kwiDyunivesithi yaseBritish Columbia, nakwi-UCLA bakholelwa ukuba iwotshi yethu ye-epigenetic inokutshintshwa, becebisa ukuba zisenokubakho iindlela zabantu zokuphila ixesha elide. Kwinqaku elilandelayo, siza kuthetha ngeziphumo ezihambelana ne-epigenetics kunye nokwaluphala.

 

Yintoni i-Epigenetic Clock?

 

Iwotshi ye-epigenetic ngumlinganiselo wobudala bebhayoloji onokuthi usetyenziselwe ukuqikelela ubudala bexesha lobomi babantu okanye ezinye izinto ngokuvavanya iipateni ezithile ze-methylation yeDNA. Nangona ubudala obuqikelelwa kwiwotshi ye-epigenetic rhoqo ihambelana nobudala beminyaka, akuqondwa ngokupheleleyo ukuba iiprofayili ze-methylation ze-DNA kwiwotshi ye-epigenetic inxulumene ngokuthe ngqo nokuguga.

 

Kwiminyaka emininzi, abaphandi baqwalasele utshintsho olunxulumene nobudala ekubonakalisweni kwesini kunye ne-DNA methylation. Nangona kunjalo, umbono wokusebenzisa "iwotshi ye-epigenetic" ukukwazi ukuqikelela ubalo lwexesha ngokuvavanya iipateni ezithile ze-methylation yeDNA yaqala yacetyiswa nguSteve Horvath apho yafumana ukuthandwa emva kophando luka-2013 kupapasho lwejenali yeGenome Biology.

 

Iiwotshi ze-Epigenetic zisetyenziswa kwizifundo zophando-nzulu ukumisela iminyaka yomntu ongaziwayo ngegazi okanye ezinye iisampuli zebhayoloji kwindawo yolwaphulo-mthetho nakwizikrini zokuxilonga ukumisela ingozi eyandisiweyo yezifo ezihambelana nokuguga, kubandakanya iintlobo ezahlukeneyo zomhlaza. Iiwotshi ze-Epigenetic zinokuqaqambisa nokuba ngaba indlela ethile yokuziphatha okanye unyango olunokuthi luchaphazele ubudala be-epigenetic.

 

Ngaba i-Epigenetic Age iyahambelana ne-Chronological Age?

 

Esona sizathu siphambili sokuba iiwotshi ze-epigenetic kunye ne-DNA methylation zisetyenziselwe ukuqikelela ubalo lwexesha loluntu okanye ezinye izinto kukuba zihambelana kakuhle nobudala bexesha kwizifundo ezivavanyiweyo. Isifundo sokuqala sophando kwiwotshi ye-epigenetic epapashwe ngu-Steve Horvath ngo-2013 ibandakanya amasayithi angama-353 e-CpG achongwe kwizifundo zophando zangaphambili.

 

Kwezi ndawo, i-193 iba yimetylated kakhulu ngobudala kwaye i-160 ibe ngaphantsi kwe-methylated, ekhokelela kuqikelelo lwe-methylation ye-DNA esetyenziselwa ukumisela ixesha lewotshi. Kuwo onke amanyathelo esiphumo, kubandakanya yonke iminyaka yezifundo, uHorvath wabona unxibelelaniso lwe-0.96 phakathi kweminyaka ye-epigenetic awayibalayo kunye nobudala bokwenyani ngokwexesha, ngenqanaba lempazamo kwiminyaka emi-3.6.

 

Iwotshi ye-epigenetic yangoku isavavanywa ukunceda ukuphucula ukubikezelwa kobudala kunye nokuqonda kunye / okanye ubuchule bokuqonda kwezi mvavanyo. Olunye uvavanyo olusebenzisa iindlela ze-NGS ekugqibeleni zinamandla okuphucula iiwotshi ze-epigenetic, zizenze zibanzi ngakumbi ngokwandiswa kovavanyo lweendawo ze-methylation ze-DNA kuzo zonke iisayithi zeCpG kwi-genome.

 

Ngaba singazitshintsha iiClocks zethu ze-Epigenetic?

 

Izifundo zophando zibonakalise ukuba umhlaza unokutshintsha iwashi ye-epigenetic. Oku kuqaphelekayo kuphakamisa ukuba iwotshi ye-epigenetic inokutshintsha phantsi kwemeko ezithile. Ke ngoko, kunokwenzeka ukuba iwashi ye-epigenetic ibe nokusetyenziswa ngokutshintsha kwendlela yokuziphatha okanye iindlela zonyango ukuyicothisa okanye inokuyibuyisela, ivumele abantu ukuba baphile ubomi obude kunye nokuba sempilweni.

 

 

Abaphandi bakholelwa ukuba iwotshi yethu ye-epigenetic inokutshintshwa. Kwinqaku elilandelayo, sixubushe ngoko kufunyanisiweyo nge-epigenetics kunye nokwaluphala. Iwotshi ye-epigenetic ngumlinganiselo weminyaka yezinto eziphilayo ezinokuthi zisetyenziswe ukuqikelela ixesha lokulandelelana kwabantu okanye ezinye izinto eziphilayo ngokuvavanya iipateni ezininzi ze-DNA methylation. Esona sizathu siphambili sokuba iiwotshi ze-epigenetic kunye ne-DNA methylation zisetyenziselwa ukuqikelela ixesha lokulandelelana kwabantu okanye ezinye izinto eziphilayo kukuba zihambelana kakuhle kunye nobudala bokulandelelana kwizifundo ezivavanyiweyo. Iiwotshi zangoku ze-epigenetic zikwavavanywa ukunceda ngakumbi ukuphucula ukuqikelelwa kweminyaka yobudala kunye nobuchule bokuxilonga kunye / okanye ukubikezela kolu vavanyo. Izifundo zophando zibonise ukuba umhlaza unokutshintsha iwotshi ye-epigenetic. Ngoko ke, kunokwenzeka ukuba iwotshi ye-epigenetic ingasetyenziswa ngotshintsho kwindlela yokuziphatha okanye kwizicwangciso zonyango ukuze icothise okanye ikwazi ukuyibuyisela umva, ukuvumela abantu ukuba baphile ubomi obude kunye nobomi obunempilo. Ngokutshintsha iiwotshi zethu ze-epigenetic, iingcali zempilo zinokuthi zikwazi ukulawula imiba yezempilo enxulumene nobudala, njengokudumba kunye neentlungu ezidibeneyo. Ezi zinokuba luncedo ekunyamekelweni kwe-chiropractic, enye inketho yonyango esebenzisa uhlengahlengiso lomqolo ukubuyisela ngokucophelela ukulungelelaniswa komqolo. - UDkt Alex Jimenez DC, CCST Insight

 

 

 

IJes Beet Juice

IiNkonzo: 1
Ixesha lokupheka: I-5-10 imizuzu

1 i-grapefruit, ixotyulwe yacolwa
Apple 1 i-apile, ihlanjwe yasikwa
1 i-beet iphelele, kunye namagqabi ukuba unayo, uhlanjiwe kwaye usikiwe
Ob I-1-intshi ye-ginger knob, ihlanjwe, ihlanjululwe kwaye ihlulwe

Ijusi zonke izithako kwijusi ephezulu. Kugqitywe kwangoko.

 

 

Ikhaphethi enye nje ikunika yonke i-Vitamin A yakho imihla ngemihla

 

Ewe, ukutya umnqathe oyi-80g (2�oz) enye ebilisiweyo kukunika i-beta carotene eyaneleyo ukuze umzimba wakho uvelise i-1,480 micrograms (mcg) yevithamin A (eyimfuneko kuhlaziyo lweseli yolusu). Oku kungaphezulu kokucetyiswa kwe-vitamin A yemihla ngemihla e-United States, malunga ne-900mcg. Kungcono ukutya iminqathe ephekiweyo, njengoko oku kuthambisa iindonga zeseli kuvumela ukuba i-beta carotene eninzi ifunxe. Ukongeza ukutya okunempilo kwisidlo sakho yindlela efanelekileyo yokuphucula impilo yakho yonke.

 

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Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic, musculoskeletal, amayeza omzimba, impilo, kunye nemicimbi yezempilo ebuthathaka kunye / okanye amanqaku amayeza asebenzayo, izihloko kunye neengxoxo. Sisebenzisa iinkqubo zempilo kunye nezempilo ukunyanga kunye nenkxaso yokhathalelo lokonzakala okanye ukuphazamiseka kwenkqubo yemisipha. Izithuba zethu, izihloko, izifundo, kunye nokuqonda kugubungela imicimbi yeklinikhi, imiba, kunye nezihloko ezinxulumene kwaye zixhasa ngokuthe ngqo okanye ngokungathanga ngqo indawo yethu yeklinikhi yokusebenza. Izifundo ezixhasa iiposti zethu. Senza ikopi yezifundo zophando ezixhasayo ukuba zifumaneke ebhodini nakuluntu xa kuceliwe. Siyaqonda ukuba sigubungela imicimbi efuna inkcazo eyongezelelweyo malunga nendlela enokunceda ngayo kwisicwangciso esithile sokhathalelo okanye kwinkqubo yonyango; Ke, ukuqhubeka nokuxoxa ngalo mbandela ungentla, nceda ukhululeke ukubuza uGqirha Alex Jimenez okanye unxibelelane nathi kwa 915-850-0900. Umboneleli (s) unelayisensi eTexas * naseNew Mexico *

 

Ikhutshwe nguGqr Alex Jimenez DC, CCST

 

Iingxelo:

 

• Abasebenzi beMotif esebenzayo. �Ngaba ungayibuyisela ngenene iXesha lakho le-Epigenetic?� Inkuthazo esebenzayo, 1 Oct. 2019, www.activemotif.com/blog-reversing-epigenetic-age#:~:text=Epigenetic%20clocks%20are%20a%20measure,certain%20patterns%20of%20DNA%20methylation.
• UPal, uSangita, kunye noJessica K Tyler. �I-Epigenetics kunye nokuguga.� Uphuhliso lwezesayensi, Umbutho waseMelika woPhuhliso lweSayensi, i-29 kaJulayi 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4966880/.
• Matloff, Ellen. �Isipili, isipili, eDongeni: I-Epigenetics yokuguga.� Forbes, Forbes Magazine, 25 Jan. 2020, www.forbes.com/sites/ellenmatloff/2020/01/24/mirror-mirror-on-the-wall-the-epigenetics-of-aging/#75af95734033.
• Dowden, u-Angela. �Ikofu siSiqhamo kunye nolunye uKutya kweNyaniso eNgakholelekiyo.� Indlela yokuphila yeMSN, 4 Juni 2020, www.msn.com/en-us/foodanddrink/did-you-know/coffee-is-a-fruit-and-other-unbelievably-true-true-facts/ss-BB152Q5q?li=BBnb7Kz&ocid =signout#umfanekiso=24.