Ufuna Ulusu olucacileyo? Unakekele Amathumbu Akho

intshayelelo

Njengoko wonke umntu esazi, amathumbu anceda umzimba ukuba udibanise izondlo kunye neevithamini ekufuneka zisebenze ngokuchanekileyo. I Inkqubo yamathumbu kwakhona ivumela umzimba ku khusela ukwenza ngelixa uhlala unxibelelana ne ngengqondo. Amathumbu anceda ukuthumela imiqondiso emva naphambili ukulawula iihomoni zomzimba imiqondiso kunye nezinye izinto eziluncedo ezifunwa ngumzimba. Amathumbu nawo anxibelelana nelona lungu likhulu emzimbeni, elulusu. Xa izinto ezinganyamezelekiyo ziqala ukonakalisa amathumbu kwaye zibangele isiphithiphithi ngaphakathi kwinkqubo yamathumbu, iphazamisa imiqondiso yobuchopho kwinkqubo ye-nervous kwaye inokuthatha umonakalo eluswini. Inqaku lanamhlanje liza kugxila kwimeko yolusu eyaziwa ngokuba yi-rosacea, ukuba iyichaphazela njani inkqubo yamathumbu, kwaye yintoni unxibelelwano lwesikhumba. Ukubhekisa izigulana kubaboneleli abaqinisekisiweyo, abanezakhono abaziingcali kunyango lwe-gastroenterology. Sinikezela ngesikhokelo kwizigulana zethu ngokubhekisa kubaboneleli bethu bezonyango abanxulumeneyo ngokusekelwe kuvavanyo lwabo xa kufanelekile. Sifumanisa ukuba imfundo ibalulekile ekubuzeni imibuzo eqondayo kubaboneleli bethu. UDkt Alex Jimenez DC unikezela ngolu lwazi njengenkonzo yemfundo kuphela. isikhanyeli

 

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Yintoni iRosacea?

 

Ngaba ukhe waziva nakuphi na ukuphazamiseka kwamathumbu okufana ne-IBS, amathumbu avuzayo, okanye iGERD echaphazela icandelo lakho eliphakathi? Kuthekani ngobubomvu obujikeleze ubuso bakho, ngakumbi iimpumlo nezidlele? Ngaba ulusu lwakho lubonakala luthambile kwindawo ethile? Uninzi lwezi mpawu zinxulumene nesifo esingapheliyo sokudumba esaziwa ngokuba yi-rosacea. Ngokuqhelekileyo kuboniswa ngamacandelo ofuzo kunye nokusingqongileyo okunokubangela ukuqaliswa kwe-rosacea eluswini. I-Rosacea ngokuqhelekileyo yenziwa mandundu kukunganyangeki kakuhle kwenkqubo yomzimba yokulwa izifo ezizalwa nayo. Uphando lophando lukhankanyile ukuba i-rosacea idla ngokuphuhliswa yi-lymphatic dilation kunye nemithambo yegazi evezwe kumaqondo obushushu agqithisileyo, iziqholo, okanye utywala obubangela ukuba i-rosacea ichaphazele izidlele kunye neempumlo. Akunjalo kuphela, kodwa i-genetics, i-immune reaction, i-microorganisms, kunye nezinto ezisingqongileyo zikhokelela kubalamli abahlukeneyo njenge-keratinocytes, iiseli ze-endothelial, iiseli ze-mast, i-macrophages, uhlobo lomncedisi we-T 1 (TH1), kunye neeseli ze-TH17.

 

Ichaphazela Njani Inkqubo Yamathumbu?

Ekubeni i-rosacea iphuhliswa ngokuvezwa kwamaqondo aphezulu, iziqholo, okanye utywala, izifundo zophando zibonisile oko kutya kunye neziselo ezithile kubangela ukuba i-cytokines evuthayo iqalise ebusweni. Ukongezelela, izinto ezininzi ezibangela ukuba zikwazi ukunxibelelana ngokuthe ngqo kwinkqubo ye-nervous cutaneous; I-neurovascular and neuro-immune neuropeptides esebenzayo ikhokelela ekubonakalisweni kwezilonda ze-rosacea. Ezinye zezinto ezibangela ukuba i-rosacea ikhule yinkqubo yamathumbu engenampilo. A uphononongo lubonisiwe ukuba ngaphezu kwe-50% ine-asidi yesisu ephantsi phakathi kwezigulane ezine-rosacea kunye ne-dyspepsia. Ibhaktheriya i-H.pylori ihlala esiswini kwaye iye yaqatshelwa ukuba iqalise ukuvutha kunye nokugungxula okubangelwa yi-gastrin, oko kubangela i-rosacea. Izifundo ezongezelelweyo zikhankanyiwe ukuba abantu be-rosacea baya kufumana ukuphazamiseka kwamathumbu ukuba kwenzeke. Kuba inkqubo yamathumbu inokunikezela kwizinto ezahlukeneyo, inokuchaphazela ukubunjwa kwamathumbu kwaye ibangele i-rosacea. Kuba i-gut microbiota inefuthe kwi-homeostasis yomzimba, inokuchaphazela ulusu. Xa kukho izinto ezibangela umqobo wamathumbu emathunjini, unokuchaphazela ulusu, okubangela ukuba i-cytokines evuthayo iqhubeke nokuphuhliswa kwe-rosacea.

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Ukutyhila uQhagamshelwano lweGut-Skin-Video

 

Ngaba ulusu lwakho luziva lugungxulwe ngenxa yobushushu obugqithisileyo okanye ukutya okuneziqholo? Ngaba ukhe wafumana ukuphazamiseka kwamathumbu okufana ne-SIBO, i-GERD, okanye amathumbu avuzayo? Ngaba ulusu lwakho lubonakala lugqabhuka ngakumbi kunokuba lufanele? Ulusu lwakho lunokuchatshazelwa yi-gut microbiota yakho, njengoko le vidiyo ingasentla ibonisa ukuba yintoni unxibelelwano lwesikhumba samathumbu kunye nendlela abasebenza ngayo omnye komnye. Izifundo zophando zibonisile kuba i-microbiome yamathumbu ingumlawuli ophambili wokhuselo lomzimba, idlala indima ebalulekileyo kwiziphazamiso ezahlukeneyo zolusu. Oku kuthetha ukuba xa izinto zokusingqongileyo zichaphazela i-microbiome yamathumbu, ichaphazela ulusu nge-dysbiosis. 

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Yintoni uQhagamshelwano lweGut-Skin?

 

Njengoko bekutshiwo ngaphambili, inkqubo yamathumbu ilikhaya leetriliyoni zemicroorganisms ezinceda ukuhlaziya i-homeostasis yomzimba, kubandakanya nelona lungu likhulu, ulusu. Izifundo zophando zifumene ukuba xa amathumbu microbial kunye nolusu ukunxibelelana omnye komnye. Yenza uxhulumaniso lweendlela ezimbini. I-gut microbiome ikwangumlamli obalulekileyo wokudumba emathunjini kwaye ichaphazela ulusu. Xa kukho izinto ezinje ngokumelana ne-insulin, ukungalingani kwiihomoni zesini, ukudumba kwamathumbu, kunye ne-microbial dysbiosis eyonakalisayo inkqubo yamathumbu, iziphumo zinokubangela i-pathology yokuphazamiseka kokudumba okuchaphazela ulusu. Naluphi na utshintsho emathunjini lunokuchaphazela ulusu njengoko amathumbu etya ukutya ukuze kuguqulwe i-biotransform ibe izondlo ezifunwa ngumzimba. Kodwa xa ukutya kunye nobuthathaka kuchaphazela amathumbu, ulusu nalo luyabandakanyeka, lubangela ukuphazamiseka kolusu njengerosacea.

 

isiphelo

Ngokubanzi amathumbu aqinisekisa ukuba umzimba usebenza ngokuchanekileyo ngokugalela izondlo kukutya okusetyenzisiweyo. Inkqubo yamathumbu inonxibelelwano kungekuphela nje kwingqondo kunye ne-immune system kodwa kunye nolusu. Uqhagamshelo lolusu luhamba kunye njengoko izinto ezichaphazela amathumbu zinokuchaphazela ulusu ekuphuhliseni ukuphazamiseka kwesikhumba njengerosacea. Xa umntu enengxaki yokuphazamiseka kwamathumbu, ulusu lwakhe lonakaliswa zizinto ezifana noxinzelelo, ubuthathaka bokutya, kunye nokuphazamiseka kolusu olunokuba yinkathazo. Oku kunokuncitshiswa ngotshintsho oluncinci olunjengokunciphisa uxinzelelo, ukutya ukutya okunempilo, kunye nokwenza umthambo, okuluncedo ekuthomalaliseni amathumbu kunye nokuphazamiseka kolusu kubantu abafuna ukubuyisela impilo yabo.

 

Ucaphulo

Daou, Hala, et al. "IRosacea kunye neMicrobiome: Uphononongo olucwangcisiweyo." I-Dermatology kunye noNyango, Springer Healthcare, Feb. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC7859152/.

De Pessemier, Britta, et al. "I-Gut-Skin Axis: Ulwazi lwangoku lokuNxibelelana phakathi kweMicrobial Dysbiosis kunye neeMeko zolusu." Iintsholongwane, MDPI, 11 Feb. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC7916842/.

Farshchian, uMehdi, kunye noSteven Daveluy. "Rosacea." Ku: StatPearls [Internet]. Isiqithi saseTreasure (FL), StatPearls Publishing, 30 Dec. 2021, www.ncbi.nlm.nih.gov/books/NBK557574/.

Kim, Hei Sung. "I-Microbiota eRosacea." Ijenali yaseMelika yeClinical Dermatology, iSpringer International Publishing, ngoSeptemba 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7584533/.

Mikkelsen, Carsten Sauer, et al. "IRosacea: Uphononongo lweKlinikhi." Iingxelo zeDermatology, IPHEPHAPress Publications, Pavia, Italy, 23 Juni 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5134688/.

Salem, Iman, et al. "I-Gut Microbiome njengoMlawuli oMkhulu we-Gut-Skin Axis." Imida kwi Microbiology, Frontiers Media SA, 10 Julayi 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6048199/.

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