Ngaba unengxaki yemicimbi yezempilo engapheliyo? Izifundo zophando zifumanise ukuba isifo sikaParkinson (PD) sinokunxulunyaniswa noqhagamshelo lobuchopho. Ubungqina kwiqela leempuku bubonise ukuba i-PD inokuqalisa ngenene emathunjini, nto leyo enokuchaza ukuba kutheni abaguli abane-PD benokuqhinwa kunye neminye imiba yempilo yamathumbu. Izazinzulu ziye zafumanisa ukuba abaguli abanesifo sikaParkinson baxela ukuba baneengxaki zempilo yamathumbu ukuya kuthi ga kwiminyaka eli-10 ngaphambi kokuba babe nokungcangcazela kunye nezinye iimpawu. Ngokwamanye amaphononongo ophando, izigulana ezine-PD zinokuba neentlobo ngeentlobo zebhaktiriya zamathumbu kunabanye abantu abadala abasempilweni. �
Imilinganiselo yesiphumo kwiqela leempuku ibonise ukuba i-alpha-synuclein fibers "eyingozi" eyakhayo kwi-nerve cell endings yezigulane ezine-Parkinson's disease inokuchaphazela ngokukhawuleza i-neurons engqondweni. Iingcali zenzululwazi zifumene oku ngokuchonga ukusasazeka kwe-alpha-synuclein fibers kwi-nerve cell endings ye-neurons echaphazelekayo kwingqondo yezigulane ezine-PD. I-Alpha-synuclein yinto e-fat-soluble, efumaneka ngokubanzi kwii-neurons eziphilileyo, nangona kunjalo, iimolekyuli ze-alpha-synuclein zinokudibanisa kwaye zonakalise iiseli zengqondo. Iingcali zenzululwazi zikwafumanise ukuba izigulana zinokuba ne-alpha-synuclein fibers emathunjini azo. �
Contents
Unxibelelwano lwe-Gut-Brain
Ingqokelela yeentsinga, ezaziwa ngokuba yi-vagus nerve, eqala kwisiqu sobuchopho kwaye idlulele kumalungu amakhulu, kubandakanya namathumbu, kukholelwa ukuba ngowona mthombo wePD onxulunyaniswa nonxibelelwano lwe-gut-brain. Uphononongo lwakutsha nje lwezigulane ze-vagotomy lubonise umngcipheko oncitshisiweyo wokuphuhlisa isifo sikaParkinson. Iingcali zenzululwazi ziye zafumanisa ukuba i-alpha-synuclein fibers efakwe kwinkqubo yokugaya yeqela leempuku inokufikelela kwingqondo nge-vagus nerve. Ukuba iimolekyuli ze-alpha-synuclein zinokufikelela kwingqondo ukusuka emathunjini, kutheni le nto i-fat-soluble substance yakha emathunjini kwasekuqaleni? �
Iingcali zenzululwazi zikholelwa ukuba i-alpha-synuclein ikhula kwi-gastrointestinal (GI) tract ukunceda ukulwa ne-pathogens kunye nezinye izinto "eziyingozi". UMichael Zasloff, unjingalwazi kwiYunivesithi yaseGeorgetown, kunye noogxa bakhe baxela ukuba iimolekyuli ze-alpha-synuclein eziphuhliswe kubantwana abasempilweni emva kokuba usulelo kunye ne-alpha-synuclein ibonakala ngathi ibangela iiseli zomzimba. Iingcali zenzululwazi zikholelwa ukuba i-alpha-synuclein inokwakheka kwiphecana le-GI ngenxa ye-gut microbiome ngokwayo. Ubungqina kwiqela leempuku bubonise ukuba iibhaktheriya zinokuthi ekugqibeleni zisebenze uphuhliso lwe-alpha-synuclein emathunjini nasengqondweni. �
Izifundo zophando sele ziqalisile ukuqonda ukuba i-gut microbiome inokunxulunyaniswa njani nesifo sikaParkinson. Izazinzulu zifumanise ukuba izigulana ezinesifo sikaParkinson zineentlobo ngeentlobo zezinto eziphilayo zebhaktiriya zamathumbu kwaye izazinzulu ziye zafumanisa ukuba ukutshintshwa kwe-fecal microbe ukusuka kwizigulana ukuya kwiqela leempuku kunokonyusa i-alpha-synuclein ebuchotsheni kwaye zibe mandundu iimpawu kwizigulana ezinePD. Olunye uphando lophando luye lwabonisa ukuba iimolekyuli ze-alpha-synuclein zibonakala ngathi zibangela iiseli ze-microglial. Le nto inokuthumela umqondiso nge-vagus nerve okanye ingene kuyo ngokupheleleyo ngomjelo wegazi. �
Ukuvuvukala kunye nesifo seParkinson
Ngokwezifundo ezininzi zophando, ukudumba okubangelwa sisigulo esingaqhelekanga se-gut microbiome nako kunokubangela ukukhula kwesifo sikaParkinson. Kwisifundo sophando, u-Inga Peter, i-genetic epidemiologist kwi-Icahn School of Medicine eNtabeni yeSinayi, kunye noogxa bakhe bahlalutya ubudlelwane phakathi kwe-inflammation bowel syndrome (IBS) kunye nesifo sikaParkinson. Uhlalutyo luthelekisa abathathi-nxaxheba be-144,018 abane-ulcerative colitis okanye isifo sikaCrohn kunye ne-720,090 yokulawula okunempilo apho i-PD yayiyi-28 yeepesenti ephezulu kubantu abane-IBS kunabo bakwiqela lolawulo, elixhasa iziphumo zophando lwangaphambili. �
Ukudumba kukholelwa ukuba kwandisa umngcipheko wokuphuhlisa isifo sikaParkinson kuba kunokunyusa i-alpha-synuclein kunye nokwandisa intestinal kunye ne-blood-brain barrier (BBB) ukungena. Ukuvuvukala kunokwandisa ii-cytokines, iimolekyuli ezinokunyusa ukuvuvukala emzimbeni. Ngaphezu koko, i-microbiome ye-gut engaqhelekanga inokubangela ukuvuvukala. Nangona kunjalo, ngenxa yokuba ayizizo zonke izigulana ezinesifo sika-Parkinson eziya kuba nesifo sokukrala kwamathumbu okanye nayiphi na eminye imiba yezempilo yamathumbu, ubungqina obongezelelweyo buyafuneka ukuze kubonwe ukuba unxibelelwano lwengqondo lwamathumbu lunokuthi ludityaniswe njani nePD. �
Ukuba oku kuyinyani ngokwenene, nangona kunjalo, kuya kuvumela izazinzulu ukuba ziphuhlise ungenelelo olutsha kunyango lwesifo sikaParkinson esijolise emathunjini endaweni yengqondo. Izifundo zophando ezininzi sele ziqalisile ukuhlalutya iziphumo zolu ngenelelo lutsha. Ngo-2015, uMichael Zasloff kunye noogxa bakhe baqala inkampani, eyaziwa ngokuba yi-Enterin, ngoku ivavanya into enciphisa uphuhliso lweemolekyuli ze-alpha-synuclein kwiphecana lesisu (GI). Nangona unyango lwenzelwe ukunciphisa ukuqunjelwa, izazinzulu zinethemba lokuba ziya kukwazi ukuthintela okanye zibuyisele iziphumo zePD. �
Nangona izifundo ezininzi zophando kunye nobungqina buxhasa i-hypothesis yokuba isifo sikaParkinson sinokunxulunyaniswa kakhulu ne-axis ye-gut-brain kunokuba besicinga, umbuzo wokuba utshintsho lwenkqubo yokugaya lunokwenzeka njani awukaziwa. Ngapha koko, ezinye izazinzulu zisacebisa ukuba iPD ingaqala kwenye indawo emzimbeni. �Ndiyakholelwa ekubeni kusenokwenzeka ukuba kukho iindawo ezahlukeneyo zemvelaphi yesifo sikaParkinson, utshilo uViviane Labrie, isazi ngemithambo-luvo kwiVan Andel Research Institute eMichigan. �Kubantu abaninzi, isenokuba sisibilini ngelixa kubantu abaninzi, inokuba yinto nje eyenzekayo engqondweni.
Isifo sikaParkinson (PD) sisifo sokunyakaza esichaphazela inkqubo ye-nervous central. I-PD inokubangela ezahlukeneyo, iimpawu ezaziwayo-kakuhle, kubandakanywa ukungcangcazela, ukunyakaza okucothayo, ukuqina, kunye nokulahleka kokulingana, phakathi kwabanye. Uphononongo lophando lubonise ukuba ukonakala kweeseli zemithambo-luvo engqondweni kunokunciphisa i-dopamine, i-neurotransmitter kunye/okanye ihomoni, enokubangela isifo sikaParkinson. Nangona kunjalo, izazinzulu ziye zafumanisa ukuba unxibelelwano lwe-gut-brain lunokuthi ekugqibeleni ludityaniswe nePD. Ukudumba okubangelwa yi-microbiome yamathumbu engaqhelekanga kunye nemiba yempilo yamathumbu njenge-irritable bowel syndrome (IBS) ikwakholelwa ukuba yenye yezinto eziphambili zePD ezinxulumene noqhagamshelo lwe-gut-brain. �- UGqr. Alex Jimenez DC, CCST Insight
Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic, musculoskeletal, kunye nemicimbi yezempilo yovalo okanye amanqaku amayeza asebenzayo, izihloko kunye neengxoxo. Sisebenzisa iiprothokholi zempilo ezisebenzayo ukunyanga ukwenzakala okanye ukuphazamiseka kwenkqubo yemusculoskeletal. Iofisi yethu yenze umzamo oqinisekileyo wokubonelela ngezikhokelo ezixhasayo kwaye ichonge isifundo sophononongo esifanelekileyo okanye izifundo ezixhasa izithuba zethu. Sikwenza iikopi zezifundo zophando ezixhasayo ziya kufumaneka ebhodini okanye kuluntu xa luceliwe. Ukuqhubeka nokuxoxa ngomxholo ongentla, nceda ukhululeke ukubuza uGqirha Alex Jimenez okanye unxibelelane nathi apha 915-850-0900.
Ikhethwe nguGqirha Alex Jimenez
Iingxelo:
- IYunivesithi yaseJohns Hopkins yeSikolo sezoNyango. Uphando olutsha lubonisa imvelaphi yesifo sikaParkinson emathunjini. � Unyango lwe-Xpress yoNyango-ukuPhambili koPhando ngezoNyango kunye neeNdaba zezeMpilo, Unyango lwe-Xpress, nge-26 kaJuni ngo-2019, Medicalxpress.com/news/2019-06-parkinson-disease-gut.html.
- CureParkinsonsTrust. �Ubungqina obutsha bucebisa ukuba uParkinson angaqali eBuchotsheni.� I-Cure Parkinson's Trust, Ngomhla wamashumi amabini anesibhozo ku-Novemba ngo-28, www.cureparkinsons.org.uk/news/parkinsons-starts-in-gut.
- Kwon, Diana. Ngaba iParkinson iqala emathunjini?� Scientific American, Inzululwazi yaseMelika, nge-8 kaMeyi 2018, www.sci scienceamerican.com/article/does-parkinsons-begin-in-the-gut/.
Ifom yoVavanyo lweNeototransmitter
Le fom ilandelayo yoVavanyo lweNeurotransmitter inokugcwaliswa ize ingeniswe kuGqirha Alex Jimenez. Ezi mpawu zilandelayo zidweliswe kule fomu azenzelwanga ukuba zisetyenziswe ekuchongeni nasiphi na isifo, imeko, okanye naluphi na uhlobo lomcimbi wezempilo.
Isihloko esongezelelweyo seNgxoxo: kubuhlungu obungapheliyo
Intlungu engxamisekileyo yindlela yokuphendula yendalo kwinkqubo yovalo eyanceda ukubonisa ukwenzakala okunokwenzeka. Ngokomzekelo, imiqondiso yentlungu ihamba ukusuka kwindawo eyenzakeleyo ngokuhamba ngeemvakalelo kunye nentambo yomgogodla ukuya kwingqondo. Ubuhlungu buhlala bungaphantsi kakhulu njengobaphilisayo, nangona kunjalo, iintlungu ezingapheliyo zahlukile kunoluhlobo lweentlungu eziphakathi. Ngeentlungu ezingapheliyo, umzimba womntu uya kuqhubeka nokuthumela imiqondiso yentlungu ebuchotsheni, nokuba wenzakele. Intlungu engapheliyo inokuhlala iiveki ezininzi ukuya kwiminyaka eliqela. Ubuhlungu obungapheliyo bunokuchaphazela kakhulu ukuhamba kwesigulana kwaye bunokunciphisa ukuguquguquka, amandla kunye nokunyamezela.
I-Neural Zoomer Plus yesifo seNeological
Ugqirha Alex Jimenez usebenzisa uthotho lovavanyo ukunceda ukuvavanya izifo ze-neurological. I-Neural ZoomerTM Ukudibana kuluhlu lwee autoantibodies ze-neurological ezinikezela ukwamkelwa okuthile kwe-anti-to-antigen. I-Vulrant Neural ZoomerTM Ukudibanisa kuyilelwe ukuvavanya ukwenziwa kwakhona kwe-antigen ye-48 ye-neurological antigens ngokudibana nezifo ezahlukeneyo ezinxulumene nonyango. IVibrant Neural ZoomerTM Kwaye kujolise ekunciphiseni iimeko zemithambo-luvo ngokuxhobisa abaguli kunye noogqirha ngesixhobo esibalulekileyo sokufumana umngcipheko kwangoko kunye nokugxininiswa okuphuculweyo kuthintelo olusisiseko lomntu.
Ubuntununtunu bokutya kwiMpendulo ye-IgG kunye ne-IgA ye-immune
Ugqirha Alex Jimenez usebenzisa uthotho lovavanyo ukunceda ukuvavanya imiba yezempilo ehambelana neemvakalelo zokutya. I-Zoenser yokutyaTM luluhlu lwe-180 iantianti zokutya ezisetyenziswa ngokuxhaphakileyo ezibonelela ngokubonakalayo kwe-anti-to-antigen. Eli phaneli lilinganisela ubuntununtunu bomntu ngamnye be-IgG kunye ne-IgA kwiimvakalelo zokutya. Ukukwazi ukuvavanya ii-antibodies ze-IgA kubonelela ngolwazi olongezelelekileyo kukutya okunokubangela ukonakala kwe-mucosal. Ukongeza, olu vavanyo lulungile kwizigulana ezinokuthi zihlupheke ngenxa yokulibaziseka kokuphendula kukutya okuthile. Sebenzisa uvavanyo lokuvavanywa kokutya okusekwe kwi-antibody kunokunceda ekubekeni phambili ukutya okuyimfuneko ukuphelisa kunye nokwenza isicwangciso sokutya esenziwe ngokwezifiso kwiimfuno ezithile zesigulana.
I-Gut Zoomer ye-Intestinal encinci ye-bacterial overgrowth (SIBO)
Ugqirha Alex Jimenez usebenzisa uthotho lweemvavanyo ukunceda ekuvavanyeni impilo ye-gut enxulunyaniswa nokugcwala kwamathumbu esibeleko (SIBO). I-Vulrant Gut ZoomerTM inikeza ingxelo equka iingcebiso zokutya kunye nezinye izongezo zendalo ezifana ne-prebiotics, iprobiotics kunye neepolphenhen. I-gut microbiome ifunyenwe ikakhulu emathunjini amakhulu kwaye ineentlobo ezingaphezu kwe-1000 zeebhaktheriya ezidlala indima ebalulekileyo emzimbeni womntu, ekubumbeni amajoni omzimba kunye nokuchaphazela imetabolism yezakha mzimba ukomeleza isithintelo samathumbu emathunjini (isithintelo samathumbu) ). Kubalulekile ukuba uqonde ukuba inani leebhaktiriya ezihlala kwisisu somntu (GI) lichaphazela njani impilo yezisu kuba ukungalingani emathunjini e-microbiome kunokukhokelela kwisifo se-gastrointestinal (GI), imeko zolusu, ukuphazamiseka komzimba, ukungalingani kwamasosha omzimba. , kunye nokuphazamiseka okuninzi kokudumba.
Iifomu zeNkxaso yeMethylation
XYMOGEN's Iifomula zeeNgqungquthela zodwa zifumaneka ngokukhetha abaqeqeshi bezempilo abanemvume. Intengiso ye-intanethi kunye nokuhlaziywa kwamafomula e-XYMOGEN ayinqatshelwe.
Ngebhongo, UDkt. Alexander Jimenez yenza i-XYMOGEN ifomula ifumaneka kuphela kwizigulane ezingaphantsi kwethu.
Nceda ufonele iofisi yethu ukuze sikwazi ukudlulisela udokotela ngokubonisana nokufikelela ngokukhawuleza.
Ukuba uyigulane Unyango lwezoNyango kunye neChiropractic Klinikhi, unokubuza malunga ne-XYMOGEN ngokubiza 915-850-0900.
Ukuze ube lula kwaye uhlaziywe XYMOGEN iimveliso nceda uphonononge ikhonkco elilandelayo. *I-XYMOGEN-Inkcazo-umxokozelo
* Zonke iinkqubo ze-XYMOGEN ezingentla zihlala zisebenza ngokuthe ngqo.
Unyango oluDityanisiweyo lwale mihla
IYunivesithi yeSizwe yeSayensi yezeMpilo liziko elibonelela ngeendidi ngeendidi zemisebenzi enomvuzo kwabo bazileyo. Abafundi banokuziqhelanisa nokuthanda kwabo ukunceda abanye abantu ukuba bafezekise impilo kunye nokuba sempilweni ngokubanzi ngothumo lweziko. IYunivesithi yeSizwe yeSayensi yezeMpilo ilungiselela abafundi ukuba babe ziinkokeli eziphambili kwiyeza ezidibeneyo zanamhlanje, kubandakanywa nokunakekelwa kwe-chiropractic. Abafundi banethuba lokufumana amava angenakulinganiswa kwiYunivesithi yeSizwe yeSayensi yezeMpilo ukuze bakwazi ukunceda ukubuyisela ingqibelelo yendalo yesigulane kwaye bachaze ikamva leyeza elidibeneyo langoku. �
Umgangatho wobuchule wokuSebenza *
Ulwazi olulapha ku "Umsebenzi we-Neurology: UQhagamshelo lwe-Gut-Brain kwiZifo zikaParkinson"Akujoliswanga ukuthatha indawo yobudlelwane obubodwa kunye nomntu oqeqeshiweyo wezempilo okanye ugqirha onelayisensi kwaye akusiyo isiluleko sonyango. Sikhuthaza ukuba wenze izigqibo zezempilo ngokusekelwe kuphando lwakho kunye nentsebenziswano kunye nochwepheshe bezempilo abaqeqeshiweyo.
Ulwazi lweBlog kunye neengxoxo zoMda
Umda wethu wolwazi ilinganiselwe kwiChiropractic, i-musculoskeletal, amayeza omzimba, impilo, igalelo le-etiological ukuphazamiseka kwe-viscerosomatic ngaphakathi kweentetho zeklinikhi, ezinxulumene ne-somatovisceral reflex clinical dynamics, i-subluxation complexes, imiba yezempilo ebuthathaka, kunye / okanye amanqaku amayeza asebenzayo, izihloko kunye neengxoxo.
Sibonelela kwaye sibonise intsebenziswano yeklinikhi neengcaphephe kumacandelo ahlukeneyo. Ingcali nganye ilawulwa ngumsebenzi wabo wobugcisa kunye negunya labo lokufumana iphepha-mvume. Sisebenzisa iiprothokholi ezisebenzayo zempilo kunye nempilo entle ukunyanga nokuxhasa ukhathalelo lokwenzakala okanye ukuphazamiseka kwenkqubo ye-musculoskeletal.
Iividiyo zethu, izithuba, izihloko, imixholo, kunye nokuqonda zibandakanya imiba yezonyango, imiba, kunye nezihloko eziyelelene kwaye zixhase ngokuthe ngqo okanye ngokungathanga ngqo umda wokuziqhelanisa wethu.
I-ofisi yethu izamile ngokufanelekileyo ukubonelela ngeengcaphulo ezixhasayo kwaye ichonge uphando olufanelekileyo lophando okanye izifundo ezixhasa izithuba zethu. Sinikezela ngeekopi zophando ezixhasayo ezifumanekayo kwiibhodi ezilawulayo nakuluntu ngesicelo.
Siyaqonda ukuba sigubungela imicimbi efuna inkcazo eyongezelelweyo yokuba inganceda njani kwisicwangciso esithile sokhathalelo okanye inkqubo yonyango; ke, ukuqhubeka nokuxoxa ngombandela ongentla, nceda ukhululeke ukubuza UDkt Alex Jimenez, DC, okanye qha ga mshelana nathi 915-850-0900.
Silapha ukunceda wena kunye nosapho lwakho.
Iintsikelelo
UDkt Alex Jimenez D.C., I-MSACP, RN*, I-CCST, IFMCP*, I-CIFM*, I-ATN*
email: qeqeshi@elpasofunctionalmedicine.com
Ilayisenisi njengoGqirha weChiropractic (DC) kwi Texas & New Mexico*
Texas DC Ilayisensi # TX5807, New Mexico DC Ilayisensi # I-NM-DC2182
Unikwe Ilayisensi njengoMongikazi oBhalisiweyo (RN*) in Florida
Florida License RN Ilayisensi # I-RN9617241 (Nombolo yolawulo. 3558029)
Ubume obubambeneyo: ILayisensi yeeNkcazo ezininzi: Ugunyaziswe Ukuziqhelanisa I-40 States*
UGqr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
Ikhadi lam loShishino lweDijithali
