I-bakteria ye-Gut ibambe iqhosha lokuThengisa, ukuPhatha ukunyamekela okungapheliyo

Isifo esinganyangekiyo esinganyangekiyo, isifo esixhalabisayo esichaphazela abantu abali-1 baseMelika, sinxibelelene ngokungalinganiyo namathumbu egciwane kwisifundo esitsha esivela kwiYunivesithi yaseMailman yezeMpilo kaRhulumente.

Abaphandi bafumene amanqanaba angaqhelekanga amabhakteria athile afunyanwa kubantu abanale meko- eyaziwa njenge-myalgic encephalomyelitis / chronic fatigue syndrome (ME / CFS), ngokophando olupapashwe kwiphephancwadi iMicrobiome.

Iziphumo zinikeza ithemba elitsha ngendlela entsha yokufumana i-ME / CFS, isifo esiyinkimbinkimbi, esinokudityaniswa ngezinye izihlandlo esinokuphazamisa imisebenzi yokuphila kwansuku zonke.

Iimpawu zibandakanya ukukhathala okukhulu emva kokunyamezela, iintlungu zomzimba kunye nentsebenziswano, ubunzima bokuqonda, ukuphazamiseka kokulala kunye nokunyamezela komzimba (ukukhanya okukhanyayo, ukuzondla, okanye ukuphazamiseka xa umile ngokuthe tye).

Ukufikelela kwiipesenti ze-90 ze-ME / CFS izigulane nazo zineengxaki zesifo sengqondo se-IBS, uphando oludlulileyo lubonise. Kodwa isifundo seYunivesithi yaseColumbia siphakathi kweyokuqala ukuphazamisa ukungalingani kwe-microbiome kubantu abane-ME / CFS kunye ne-IBS.

"Abantu abane-ME / CFS banomxube owahlukileyo wamathumbu ebacteria kunye nokuphazamiseka okunxulumene nemetabolic okunokuchaphazela ubungqongqo besifo sabo," utshilo umphenyi okhokelayo uGqirha Dorottya Nagy-Szakal.

Iziphumo zibonisa ukuba abantu abanesifo banokukwazi ukunciphisa iimpawu zabo ngokubandakanya ezinye iiprobiotic- ibacteria esempilweni kwizidlo zabo, ukulinganisa amathumbu ebacteria.

Ukufikelela kwizigqibo, abaphandi balanda izigulana ezingama-50 ze-ME / CFS kunye nezinye ezingama-50 ngaphandle kwale meko. Bavavanya iisampulu zelindle lezifundo kwiintlobo zebacteria, kunye neesampulu zegazi kwiimolekyuli zomzimba.

Iziphumo eziphambili zophando zibonisa ukuba:

• Amanqanaba eentlobo zebacteria zamathumbu ezahlukileyo-iFaecalibacterium, iRoseburia, iDorea, iCoprococcus, iClostridium, iRuminococcus, iCoprobacillus-inxulunyaniswa kakhulu ne-ME / CFS.
• Ubuninzi beentlobo ezibonakalayo bubonakala kwangaphambili kwe-ME / CFS ukuxilongwa.
• Ubuninzi bee-Alistipes kunye namazinga aphantsi aseFaecalibacterium awona maqhosha aphezulu eM ME / CFS nge-IBS. Ukwandiswa kwe-Bacteroides ininzi kunye nokunciphisa iBacteroides vulgatus yizona zixhobo eziphezulu ze-ME / CFS ngaphandle kwe-IBS.

Abaphandi baphinde baqaphela ubukrakra beempawu zezigulana- ezinjengeentlungu kunye nokudinwa-ezinxulumene nobuninzi beentlobo zebacteria.

Uhlalutyo lwethu lubonisa ukuba singanakho ukucoca izigulana nge-ME / CFS ngokuhlalutya i-fecal microbiome yazo, utshilo umphenyi okhokelayo uGqirha Brent L. Williams, Ph.D. "Ukuzithoba kunokubonelela ngeendlela zokuqonda umahluko kwizifo."

Uphononongo lubonisa kwakhona indlela engenzeka ngayo emva kokuphuhliswa kwe-ME / CFS.

UMBHALI omkhulu uGqr. W. Ian Lipkin ucacisa esithi: “I-ME / CFS isenokubandakanya ukusilela konxibelelwano phakathi kwamacala amabini nengqondo namathumbu adityaniswe ziibhaktheriya, iimetabolites, kunye neemolekyuli abaziphembelelayo.

"Ngokuchonga iibhaktheriya ezithile ezichaphazelekayo, sisondele ngakumbi ekuchongeni ngokuchanekileyo kunye nonyango ekujoliswe kulo."

Kuze kube ngoku, abaphandi abazange bachonge imbangela ye-ME / CFS. Akunakho naziphi na iimvavanyo zeprogram yokuxilonga okanye izibonelelo ezivunyiweyo ngokusemthethweni kwimeko. Ngenxa yezizathu ezingacacileyo, abafazi banamanye amaxesha angaphezu kwamane amane ngaphezu kwamadoda ukuba abe ne-ME / CFS.

Ngenxa yokuba i-MD / CFS iyahluka, unyango lujolise ekulawuleni izibonakaliso ngabanye. Iindlela eziqhelekileyo ziquka imithi yonyango yokuphatha uxhalaba, ukuxinezeleka nokulala; ukuqeqeshwa ngokunyanga, ukunyanga okwenyama, kunye nokucebisa ngengqondo kubandakanya ukunyangwa kwengqondo-yokuziphatha (CBT).

Iinkqubo zokwenza izinto ezikunceda ukulawula intlungu kunye nokukhathala ziquka:

• Ukwenza i-Acupuncture.
• Biofeedback.
• Ukuphefumula okujulile.
• Hypnosis.
• Ukuhlawula.
• Ukucamngca.
• Iindlela zokuphucula izihlunu.
• Yoga okanye tai chi.
• Uphando oluphambili kodwa olungagqibekanga lucacisa ukuba ezinye izilwanyana zendalo zinganceda kwi-ME / CFS, ngokweMayo Clinic. Ezi ziquka:
• I-Magnesium injected into imisipha yabantu abane-red magnesium cell cell.
• I-supplement supplement equkethe ioli yeentlanzi kunye neoli ye-primrose yamafutha.
• Melatonin.
• Nicotinamide.
• Adenine dinucleotide hydrate (NADH).
• Coenzyme Q10.
• Propionyl-L-carnitine.
• D-ribose.

Nangona uphando olutsha lweYunivesithi yase Columbia lubonisa ukuba i-probiotics supplement ingaba luncedo kuM ME / CFS, uphando oluthe lufunekayo, iingcali zithi.

Uvavanyo lwe-2009 lwezigulane ze-39 ME / CFS, nangona kunjalo, lwabonisa ukuba i-Lactobacillus casei i-Shirota (LcS) yayinxulumene neempawu ezixinzelelekileyo ezinxinxisiwe kunye ne-placebo.