Umdibaniso weLusu lweGut oluchaphazela i-Acne

intshayelelo

Umzimba uhlala utyhubela izinto ezininzi ezihlala zivavanya ukuqina okunokuchaphazela yonke i-microbiome ngokwayo. I lungile inceda i-homeostasis yomzimba ngokumetaboliza izondlo ezibonelela ngamandla okusebenza. I Inkqubo yamathumbu likhaya leetriliyoni zemicroorganisms ezinxibelelana ne inkqubo yobuchopho, inkqubo ye endocrine, inkqubo yomzimba, kunye nolusu ukuqinisekisa ukuba lusempilweni. Xa izinto eziphazamisayo zingena kwinkqubo yamathumbu, zinokubangela imiba eyahlukeneyo enokwenza umzimba ongasebenzi kakuhle ngelixa uchaphazela unxibelelwano lwawo kunye ne-axis yomzimba. Inqaku lanamhlanje ligxile kwimeko yolusu ethe wonke umntu wabandezeleka ebomini bakhe eyaziwa ngokuba yi-acne kunye nendlela i-axis yesikhumba esichaphazela ngayo. Ukubhekisa izigulana kubaboneleli abaqinisekisiweyo, abanezakhono abaziingcali kunyango lwe-gastroenterology. Sinikezela ngesikhokelo kwizigulana zethu ngokubhekisa kubaboneleli bethu bezonyango abanxulumeneyo ngokusekelwe kuvavanyo lwabo xa kufanelekile. Sifumanisa ukuba imfundo ibalulekile ekubuzeni imibuzo eqondayo kubaboneleli bethu. UDkt Alex Jimenez DC unikezela ngolu lwazi njengenkonzo yemfundo kuphela. isikhanyeli

 

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Yintoni i-Acne Vulgaris?

 

Ngaba ukhe wawaqaphela amaqhuma ebusweni bakho, ngakumbi empumlweni, ebunzi, nasezidleleni? Kuthekani malunga nokudumba okuchaphazela ulusu lwakho? Ngaba imiba efana neGERD, IBS, amathumbu avuzayo, okanye i-SIBO iyawachaphazela amathumbu akho? Uninzi lwale miba lubangelwa zizinto eziphazamisayo ezichaphazela unxibelelwano lwesikhumba kwaye lubangele imeko yolusu eyaziwa ngokuba yi-acne vulgaris. Wonke umntu unengxaki ye-acne xa bebancinci, kwaye yimeko eqhelekileyo kunye ne-follicular papules okanye i-comedones kunye neepapules ezivuthayo kunye ne-pustules. Izifundo zophando zibonisile ukuba i-acne vulgaris sisifo sokudumba esibangelwa yimiba emininzi enokubangela ukuba ibe mandundu kwaye idumbe. Ezinye zezinto ezinegalelo ezinokubangela ukuba i-acne vulgaris yenze ngenxa yoku kulandelayo:

• Usulelo (Propionibacterium acnes)
• Ukudumba kwezicubu
• Ukuxhunywa kweenwele ngenxa ye-epidermal hyperproliferation
• Ukungalingani kweHormone
• Ukuphazamiseka kwe-Endocrine
• Ukugqatswa lilanga ngokugqithisileyo

Ezinye izifundo zophando zibonisile ukuba ezinye izinto ezifana nokuphazamiseka kwamathumbu zinokuchaphazela ukukhula kwe-acne vulgaris. I-acne vulgaris inokunxulunyaniswa nezinto zeemvakalelo ezichaphazela ingqondo kunye nemiba yokudumba yamathumbu njengoko ihamba kunye. Xa umntu esiba noxinzelelo okanye exhalabile, ulusu lwabo luya kugqabhuka kwaye luphuhlise amaqhakuva kwiindawo ezithile zolusu. Izifundo ezongezelelweyo zikhankanyiwe ukuba imiba yeemvakalelo efana noxinzelelo kunye nokuxhalaba inokutshintsha i-gut microbiota kwaye yonyuse ukugcwala kwamathumbu. Xa ukuphazamiseka kwamathumbu kuqala ukufaka isandla ekudumbeni kolusu, kunokuwenza mandundu amaqhakuva aphuhle kwaye enze eluswini.

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Impilo yamathumbu kunye ne-Acne-Ividiyo

Ngaba ukhe waneengxaki zamathumbu ezibonakala zichaphazela umgangatho wobomi bakho? Ngaba uye waqaphela ukuba ukutya okuthile okutyayo akuhlali kakuhle kwinkqubo yakho yamathumbu? Kuthekani ngokuziva ucinezelekile kakhulu kwaye unexhala lokuba i-acne yenzeka ebusweni bakho? Ividiyo engentla ichaza indlela i-gut microbiome echaphazela ngayo umntu xa wenza utshintsho lokutya olunokubonelela ngeziphumo eziluncedo kwi-gut microbiota. Izifundo zophando zifumene ukuba i-intestinal microbiota ibalulekile ekwenzeni izilonda ze-acne ngelixa inoxanduva lokukhusela ngokufanelekileyo kunye nokukhusela i-microorganisms. Iphecana le-GI kunye nemeko ye-acne inxulumene ngokusondeleyo kuba ibonelela nge-neuroendocrine kunye nemisebenzi yokuzivikela emzimbeni. 

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I-Gut-Skin Axis kunye nendlela eyichaphazela ngayo i-Acne

 

Kuba ithumbu lisingisele kwiitriliyoni zeebhaktheriya, umsebenzi walo ophambili kukugcina unxibelelwano oluqhubekayo nolusu ukuthoba iimpawu zokukrala ezingeyomfuneko ezinokubangela ukuba ulusu luqhawuke. Izifundo zophando zifumene ukuba i-axis ye-gut-skin, xa ichaphazelekayo yi-acne, ivelisa i-metabolites ephezulu kakhulu eyenza i-ROS (iintlobo ze-oksijini esebenzayo) kwaye ibangele ukuvuvukala kumathumbu kunye nolusu. Uphando olongezelelweyo luye lwabonisa ukuba i-gut microbiome idlala indima ebalulekileyo kukuphazamiseka kwesikhumba kwaye ngokuphambeneyo. Xa utshintsho luchaphazela amathumbu okanye ulusu, lunokutshintsha kakhulu umphumo womntu ebomini. Yithi, umzekelo, imikhwa yokutya eyenza ukuvuvukala emathunjini. Oku kubangelwa kukutya okucutshungulweyo okubangela ukuba amathumbu avuthe kwaye enze ulusu luqale ukuphuhliswa kwamabala kwiindawo ezahlukeneyo zolusu. Uphando lubonisa ukuba i-gut microbiome inokuchaphazela kakhulu amajoni omzimba ngokuyilawula. Oku kwakha ukunyamezelwa kweenguqu zokutya emathunjini ukukhuthaza ulusu olungenamabala. Ke ukubandakanya ukutya okune-glycemic ephantsi kuye kwadityaniswa ne-acne ephuculweyo, mhlawumbi ngotshintsho lwamathumbu okanye ukuthomalalisa amanqanaba e-insulin.

 

isiphelo

Ngokubanzi, amathumbu adlala indima enkulu emzimbeni kwi-homeostasis yawo njengoko inceda umzimba ukuba udibanise izondlo ukuze uhlale usebenza kwaye uhamba. I-gut microbiota ikwanonxibelelwano lwe-bidirectional kunye nolusu njengoko ukuphazamiseka kwesikhumba okuqhelekileyo okufana ne-acne kudla ngokubonakala. I-acne ixhaphake kakhulu phakathi kwabantu, ngakumbi kubantu abancinci, njengoko inokuchaphazela iimvakalelo zabo kwaye ibangele utshintsho kwimpilo yabo yengqondo kunye nempilo yamathumbu abo. Ukubandakanya utshintsho oluncinci olufana nokutya ukutya okunempilo, ukugcina indawo engenaxinzelelo, kunye nokuzilolonga kunokuncedisa kungekuphela nje ukudumba kwamathumbu kodwa kucoce ulusu kwi-acne.

 

Ucaphulo

Bowe, Whitney P, kunye no-Alan C Logan. "I-Acne Vulgaris, iProbiotics kunye ne-Gut-Brain-Skin Axis-Buyela kwikamva?" IiPathogens zamathumbu, BioMed Central, 31 Jan. 2011, www.ncbi.nlm.nih.gov/pmc/articles/PMC3038963/.

Chilicka, Karolina, et al. "I-Microbiome kunye neeProbiotic kwi-Acne Vulgaris-Uphononongo oluBalisiweyo." Ubomi (eBasel, eSwitzerland), MDPI, 15 kuMatshi 2022, www.ncbi.nlm.nih.gov/pmc/articles/PMC8953587/.

De Pessemier, Britta, et al. "I-Gut-Skin Axis: Ulwazi lwangoku lokuNxibelelana phakathi kweMicrobial Dysbiosis kunye neeMeko zolusu." Iintsholongwane, MDPI, 11 Feb. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC7916842/.

Lee, Young Bok, et al. "Indima enokwenzeka yeMicrobiome kwi-Acne: Uphononongo oluBanzi." Ijenali yamayeza onyango, MDPI, 7 Julayi 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6678709/.

Salem, Iman, et al. "I-Gut Microbiome njengoMlawuli oMkhulu we-Gut-Skin Axis." Imida kwi Microbiology, Frontiers Media SA, 10 Julayi 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6048199/.

Sutaria, Amita H, et al. "I-Acne Vulgaris." Ku: StatPearls [Internet]. Isiqithi saseTreasure (FL), iStatPearls Publishing, 8 May 2022, www.ncbi.nlm.nih.gov/books/NBK459173/.

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