I-GI enempilo inokukhulula i-Atopic Dermatitis

intshayelelo

Ulusu lelona lungu likhulu emzimbeni kwaye lidibana nezinto ezininzi ezinokuthi zincede okanye ziwonakalisa umzimba. Ulusu lunceda ukukhusela amalungu kunye namathumbu kwindawo Inkqubo yamathumbu, igcina i inkqubo yemisipha ulwakhiwo olusebenzayo, kwaye lunceda i luvo thumela imiqondiso yemisebenzi ye-motor-sensory kuwo wonke umzimba. Ulusu lunxulunyaniswa nenkqubo yamathumbu njengoko i-gut microbiota ibamba iitriliyoni zezityalo eziluncedo zamathumbu ezithumela izondlo ezinceda ukukhuthaza ukukhula kwezicubu, ukuphucula ukhuseleko lomzimba, kunye nokutyhala impilo yolusu ngokuyikhusela kwiintsholongwane eziphazamisayo. Xa ezi ntsholongwane zibangela imiba yokuvuvukala kwinkqubo yamathumbu, inokuchaphazela ulusu lomzimba, ingqondo, kunye nempilo yokhuselo lomzimba ngokubenza bangasebenzi kakuhle. Inqaku lanamhlanje liza kujonga imeko yolusu eyaziwa ngokuba yi-atopic dermatitis, ukuba iyichaphazela njani inkqubo yesikhumba, kwaye loluphi unyango olukhoyo lokuphelisa imiba yamathumbu kunye ne-atopic dermatitis kubantu. Ukubhekisa izigulana kubaboneleli abaqinisekisiweyo, abanezakhono abaziingcali kunyango lwe-gastroenterology. Sinikezela ngesikhokelo kwizigulana zethu ngokubhekisa kubaboneleli bethu bezonyango abanxulumeneyo ngokusekelwe kuvavanyo lwabo xa kufanelekile. Sifumanisa ukuba imfundo ibalulekile ekubuzeni imibuzo eqondayo kubaboneleli bethu. UDkt Alex Jimenez DC unikezela ngolu lwazi njengenkonzo yemfundo kuphela. isikhanyeli

 

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Yintoni iAtopic Dermatitis?

 

Ngaba uye wafumana ukudumba okujikeleze amathumbu akho okanye kwiindawo ezithile zolusu lwakho? Ngaba imiba efana ne-SIBO, i-IBD, amathumbu avuzayo, okanye ukuqunjelwa iye rhoqo? Ngaba ukutya okuthile kubangela iimpawu ezivuthayo kulusu lwakho kunye namathumbu? Iimpawu ezininzi kunye neempawu zibangelwa yingxaki yolusu ebizwa ngokuba yi-atopic dermatitis. I-atopic dermatitis okanye i-eczema yi-pruritic, i-hereditary skin disorder. Ubuninzi bexesha lokuphila luyi-10% ukuya kwi-20%, kunye namatyala amaninzi aqala njengomntwana kwaye anyuke ukuya kwi-20% ukuya kwi-40% njengoko abantu abadala baqhubeka bene-atopic dermatitis. Izifundo zophando ziye zachaza i-atopic dermatitis njengenye yezifo zesikhumba eziqhelekileyo ezibangela ukuvutha okungapheliyo kwesikhumba. I-pathophysiology ye-atopic dermatitis iyinkimbinkimbi kwaye i-multifactorial. Ibandakanya izinto zokungasebenzi kakuhle komqobo, utshintsho kwiimpendulo zokuzikhusela kwiseli, i-IgE-mediated hypersensitivity, kunye nezinto zokusingqongileyo ezibangela ukudangala. Izifundo zophando ezongezelelweyo zikhankanyiwe ukuba i-pathology ye-atopic dermatitis ijongwa njengolusu olungaqhelekanga lwesakhiwo kunye nokukhubazeka komzimba kudlala indima yabo njengoko le meko iqhubela phambili. Ezinye iinguqu zofuzo nazo zichongiwe, ukuguqula umsebenzi womqobo wolusu, okukhokelela kwi-atopic dermatitis phenotype. Ukungalingani kwe-Th2 ukuya kwi-cytokines ye-Th1 kubonwa njengoko iguqula iimpendulo ze-immune zeseli. I-atopic dermatitis inokukhuthaza i-IgE-mediated hypersensitivity esikhumbeni njengenxalenye yophuhliso lwayo. Oku kunokuba ngenxa yeemeko zokusingqongileyo ezibangela ukuphuhliswa kwe-atopic dermatitis.

 

Ichaphazela Njani uQhagamshelwano lweGut-Skin?

Ekubeni i-atopic dermatitis sisifo esingapheliyo solusu, zininzi izinto eziza kudlala ekuphuhliseni kwayo. Ngokomzekelo, ukutya okutyayo kubangela i-atopic dermatitis kwi-25% ukuya kwi-50% yabantwana. Ezinye zezinto ezixubayo zokutya ezidla ngokudityaniswa ne-atopic dermatitis ziquka:

• amaqanda
• Ndikhoyo
• Ubisi
• Ngqolowa
• Intlanzi
• yesilwanyana saselwandle esineqokobhe
• Amanqatha

Enye yezinto ezinokubangela ukuphuhliswa kwe-atopic dermatitis yimiba yamathumbu. Izifundo zophando zibonisile ukuba naluphi na utshintsho kwi-gut microbiome ngenxa ye-atopic dermatitis ichaphazela ibhalansi ye-immune system emzimbeni. Xa i-gut microbiome iguqulwa, ichaphazela imveliso ye-metabolite kwaye inciphisa amajoni omzimba. Xa iibhaktheriya zikhula kwipheshana le-GI, kuye kwacetyiswa njengento ebangela izifo ezibangelwa yi-allergic, kuquka i-atopic dermatitis. Omnye umba kuxa abantu besebenzisa amafutha e-trans, anyusa ukukhula kwe-atopic dermatitis kuba ephazamisana nemetabolism kunye nokusetyenziswa kwe-fatty acids ebalulekileyo.

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IMicrobiome yeAtopic Dermatitis-Ividiyo

Ngaba uye wafumana ukuvuvukala kwindlela yakho yokugaya okanye iindawo ezithile zolusu lwakho? Ngaba umzimba wakho uziva udiniwe rhoqo? Ngaba unayo nayiphi na imiba yamathumbu okanye ukuphazamiseka okuchaphazela impilo yakho? Uninzi lwezi mpawu zizibonakaliso zokuba ufumana i-atopic dermatitis ebangelwa yimiba yamathumbu. Uphononongo lophando lufumene ukuba izinto ezahlukeneyo zinokubangela i-atopic dermatitis, ichaphazele amajoni omzimba, kwaye iphazamise i-gut microbiota. Ividiyo engentla ichaza i-microbiome kwi-atopic dermatitis kunye nendlela echaphazela ngayo amathumbu, ulusu kunye nomzimba wonke. Ngethamsanqa kukho unyango olukhoyo lokunyanga i-atopic dermatitis kunye nokuphazamiseka kwamathumbu ekwenzakalise umzimba.

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Unyango lokuthomalalisa i-Atopic Dermatitis kunye namathumbu

 

Xa umntu eqala ukufumana unyango lokuphelisa i-atopic dermatitis ngokuqhelekileyo kubandakanya:

• Ukuxilongwa kwangoko.
• Ukuxhaswa komsebenzi wokuthintelwa kwesikhumba.
• Ukunciphisa ukudumba kwesikhumba.
• I-stratification yomngcipheko ehambelanayo

Enye indlela abantu abaninzi abanokunciphisa ngayo i-atopic dermatitis ngephecana le-GI enempilo. Oku kuya kunceda abantu abaninzi abanengxaki yokutya, isifuba, i-rhinitis ye-allergies, kunye nokwaliwa kwendalo ukuthomalalisa i-atopic dermatitis ekuqhubeleni phambili. A uphononongo lubonisiwe ukuba iiprobiotics kunye ne-prebiotics zibalulekile ekukhuseleni ukutya kunye ne-eczema. Iiprobiotics kunye ne-prebiotics zinceda ukuzalisa ibhaktheriya enenzuzo emathunjini kunye nokulawula amajoni omzimba. Oku kuthintela i-atopic dermatitis ekuyekeni ukuqhubela phambili kunye nokubuyisela umzimba emva.

 

isiphelo

Izinto ezininzi ezibangela ukuba i-atopic dermatitis iqhubele phambili ibe nzima, njengoko kubalulekile ukufumana oyena nobangela wokugqabhuka kwaye unciphise kumthombo. Ngokubanzi ukuba nemiba yamathumbu enxulumene ne-atopic dermatitis ayiyonto ihlekayo. Xa i-gut microbiome ichaphazeleka kukuphazamiseka kokudumba, inokuphazamisa amajoni omzimba kwaye ibangele ukuba i-atopic dermatitis ikhule eluswini. Ukubandakanya i-probiotics kunye ne-prebiotics kunokunceda ukugcwalisa iibhaktheriya zamathumbu kwaye ufumanise ukuba yintoni ebangela ukuba iimpawu zokukrala ziphume ekutyeni okuthile kuya kunceda amathumbu kunye nolusu ukuba lube sempilweni.

 

Ucaphulo

UFang, uZhifeng, et al. "I-Gut Microbiota, iiProbiotic, kunye nokuSebenzisana kwabo kuThintelo kunye noNyango lwe-Atopic Dermatitis: Uphononongo." Imida e-Immunology, Frontiers Media SA, 14 Julayi 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8317022/.

Kapur, Sandeep, et al. "Atopic Dermatitis." Ukwalana, Umbefu, kunye neKlinikhi yokugonywa kwezifo : Ijenali esemthethweni yoMbutho waseKhanada weAllergy kunye neClinical Immunology, BioMed Central, 12 Septemba 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6157251/.

UKim, uJung Eun, kunye noHei Sung Kim. "I-Microbiome yeLusu kunye neGut kwi-Atopic Dermatitis (AD): Ukuqonda i-Pathophysiology kunye nokuFumana ubuCwangciso boLawulo lweNoveli." Ijenali yamayeza onyango, MDPI, 2 kuMatshi 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6518061/.

Kolb, Logan, kunye noSarah J Ferrer-Bruker. "I-Atopic Dermatitis-Statpearls-ishelufa yeencwadi ye-NCBI." Ku: StatPearls [Internet]. Isiqithi saseTreasure (FL), StatPearls Publishing, 13 Aug. 2021, www.ncbi.nlm.nih.gov/books/NBK448071/.

Lee, So Yeon, et al. "I-Microbiome kwi-Gut-Skin Axis kwi-Atopic Dermatitis." Ukwala, Umbefu kunye noPhando nge-Immunology, I-Academy yaseKorea ye-Asma, i-Allergy kunye ne-Clinical Immunology; I-Academy yaseKorea ye-Pediatric Alergy kunye neZifo zokuPhumla, ngoJulayi 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC6021588/.

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