UDkt Alex Jimenez Unikezela: Ukuvavanya iiHormones

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UDkt Alex Jimenez, DC, ubonisa indlela yokuvavanya amahomoni ahlukeneyo emzimbeni kunye nendlela iimvavanyo ezahlukeneyo zehomoni ezingasetyenziselwa ukumisela izinga emzimbeni. Le ntetho ivumela abantu abaninzi ukuba bazi ukuba balindele ntoni xa befunyaniswa ngoogqirha babo bokuqala. Sithumela izigulane kubaboneleli abaqinisekisiweyo ababandakanya iindlela ezahlukeneyo zonyango ze-hormone ukuqinisekisa impilo efanelekileyo kunye nokuphila kakuhle. Sikhuthaza kwaye siyasixabisa isigulana ngasinye ngokusithumela kubaboneleli bezonyango abanxulumeneyo ngokusekwe kuxilongo lwaso xa kufanelekile. Siyaqonda ukuba imfundo yeyona ndlela ibalaseleyo xa ubuza ababoneleli bethu imibuzo entsonkothileyo ngokwesicelo sesigulana kunye nokuqonda kwakhe. UDkt Alex Jimenez, DC, usebenzisa le ngcaciso kuphela njengenkonzo yemfundo. isikhanyeli

Ukuvavanya iiHormones

UGqr. Alex Jimenez, DC, unikezela: Wamkelekile kuyo yonke into odinga ukuyazi malunga novavanyo lweehomoni kunye nendlela yokwenza uvavanyo. Sithathe isigqibo sokwenza oku njenge-webinar kuba sinexesha elincinci lokuyenza ngexesha lemodyuli. Ngapha koko, oko kuya kwenza ubomi bakho bube lula. Kuya kufuneka ukuba olu lwazi lube phantsi kwebhanti yakho kuba nantsi eyona nto ibalulekileyo ekufuneka uyazi. Unyango lweHormone bubugcisa, hayi inzululwazi. Ukuba ufumana abasebenzi abahlanu okanye abathandathu abenza unyango lwehomoni, uya kufumana iindlela ezintlanu okanye ezintandathu ezahlukeneyo zokwenza umyalelo kunye neendlela ezingaphezulu kunoko zokwenza uvavanyo lokuwubeka iliso.

UGqr. Alex Jimenez, DC, unikezela: Into ebalulekileyo kukuba ugcine engqondweni into esiyaziyo ngokwesayensi yindlela engcono okanye engeyiyo-yokukhathalela izigulane malunga novavanyo. Emva koko fumana oko kusebenza kuwe kwaye ube yingcali kuloo nto. Kuba ukuba awuguquguquki ekuhambeni kwexesha, ungasebenza malunga neenzuzo kunye nokubi kuzo zonke iindlela zovavanyo kwaye ufumanise into ekufuneka uyenzile, nokuba loluphi uhlobo lovavanyo ogqiba ukulwenza. Kulungile, kufuneka sizikhathaze ngantoni? Zininzi iingxaki ezinokubakho ekulinganiseni amanqanaba ehomoni kuba amanqanaba amaninzi ehomoni ayaguquguquka kakhulu. Ukuze kuhlolwe iihomoni emzimbeni, oogqirha kufuneka bazi ukuba yintoni, nini, kwaye ngubani oza kuvavanya. Ke siza kuthetha ngayo yonke loo nto.

Ukuxilongwa kweeHormones kwisigulane

UGqr. Alex Jimenez, DC, unikezela: Ezinye ziyahluka emini, ezinye ziyahluka ngexesha lomjikelo, kwaye ezinye iihomoni azihlukanga kwaphela. Ke kufuneka ukhumbule ukuba zeziphi ekufuneka uzikhathaze malunga nokuguquguquka. Uphononongo olwenziweyo aluwalinganisi amanqanaba ehomoni. Ke, ukufumana amanqanaba ehomoni aqhelekileyo ngamanye amaxesha kuyingxaki. Isenokwahluka kwinto esetyenziswa ziilebhu ngoku. Kwaye kwizifundo apho beze namanqanaba ehomoni aqhelekileyo, uninzi lwazo zizifundo ezindala kakhulu, kwaye indlela yokusebenza ibingathembekanga ngakumbi kunesi siyisebenzisayo ngoku. Ke ngokugcina loo nto engqondweni malunga nento abantu abayibiza ngokuba ngamanqanaba ehomoni aqhelekileyo, uninzi lwezi zifundo zinokwenza umyinge wamaqela angathelekisekiyo. Ithetha ukuthini le nto kukuba baya kuthelekisa, masithi, iqela lama-apile, iiorenji, neediliya kwaye bazidibanise zonke bathi, ewe, ke lo mndilili uza kusebenza.

UGqr. Alex Jimenez, DC, unikezela: Ngoko kufana nokwenza uhlalutyo lwe-meta, kwaye ukuba uthatha iqela leedatha ezahlukeneyo, awukwazi ukutsho ukuba lo mndilili uyavakala. Mhlawumbi sele uyayazi into yokuba ezinye iilebhu zigcina ziphuhlisa uluhlu olwahlukileyo lwereferensi. Kwaye ke ukuba usebenzisa iilebhu ezininzi ezahlukeneyo, awunakuthelekisa iziphumo zovavanyo ozifumanayo kuba uluhlu lwereferensi lwahlukile. Kwaye, ngamanye amaxesha, nangaphakathi kwelebhu enikiweyo, ngokuxhomekeke kwikhithi yovavanyo esetyenziswa zizigulane, njengovavanyo olusuka kuQuest, ngenye imini bangasebenzisa ikhithi yovavanyo enye. Ke uluhlu lwereferensi luya kuba yi-XYZ, kwaye baya kwilebhu enye ngolunye usuku, kodwa basebenzisa ikhithi yovavanyo eyahlukileyo kwaye banoluhlu olwahluke ngokupheleleyo lwereferensi. Kwaye ke kufuneka ufikelele kwinqanaba lokuba kwizigulane. Ukuba unesigulana esikrelekrele esizama ukulandelela ukuba kwenzeka ntoni na ngokwaso, banokuba noluvo olungalunganga ngexesha lovavanyo.

I-Estrogen kunye neProgesterone

UGqr. Alex Jimenez, DC, unikezela: Ukuba unoluhlu olwahlukileyo lwereferensi olubonisa kwiziphumo zovavanyo lwakho, kungcono ukugcina umkhondo waloo nto xa ufuna ukukhumbula. Ngoku kukho iiyantlukwano ezinkulu phakathi kwabantu ngabanye nangaphakathi kumntu omnye. Ugxininiso lweserum yazo zombini ii-steroids zendalo kunye nezenziweyo zinokufuna ukucaciswa phakathi kwabanye abantu. Kukho umahluko omkhulu kungakhathaliseki ingcambu yolawulo lweehomoni. Into oyilindeleyo kumntu omnye inokwahluka komnye umntu olandelayo. Kwaye, ewe, kuye nawuphi na umntu, uya kufumana amanqanaba okuguquguquka imini yonke ngokusekwe kwizinto ezininzi ezahlukeneyo. Yonke into evela kuxinzelelo olubonwayo okanye lokwenyani oluya kutshintsha amanqanaba ehomoni kukutya ababekutya ngalo mini kunokwenza umahluko. Ubume be-hydration bunokwenza umahluko. Ngoko ke ezinye iinguqulelo ozibonayo ngaphakathi komntu, kodwa ngokutsalwa kwegazi okwahlukileyo, zinokusekelwe kwinto eyayisenzeka ngaloo mini.

UGqr. Alex Jimenez, DC, unikezela: Ke zama ukubethelela izigulana zakho njengoko usenza uvavanyo ukuze ugcine iintsuku zokutsalwa kwegazi zifana. Ngoku ukulinganisa ngolwelo olwahlukileyo lomzimba olunje ngeserum, umchamo, okanye amathe akusixeleli ngokuxinana kwezinye izihlunu, kwaye oogqirha kufuneka bayigcine le nto engqondweni kuba isigulana sinokufumana imvakalelo yobuxoki yokhuseleko, kwaye ayizukuba njalo. banento yokwenza nethishu abazama ukuyinyanga. Ngoku, oogqirha abaninzi kufuneka bakhumbule zonke iintlobo ezahlukeneyo ze-estrogens abanokuthi bafune ukuzigcina ngexesha lovavanyo. Ke, xa beqaphela i-estrogen, kukho ichibi le-estrogen. Kukho i-estrogen ekhululekile kwaye eboshiweyo emzimbeni kunye nokuveliswa kwe-estrogen kumfazi okanye kwindoda ngokwabo. Kukho ii-estrogens zangaphandle onokuthi uzinike. Kukho i-estrogens egciniweyo, i-metabolites, kwaye zonke ezi estrogens zahlukeneyo oogqirha kufuneka balandele umkhondo. Ke lo ngumzekelo nje omnye wokuba namanqanaba amaninzi e-estrogen emzimbeni, kwaye isigulana siyazibuza, ingaba ugqirha ujonge ntoni? Ngaba uvavanyo olunye lungandinika lonke olu lwazi lwahlukileyo? Kwaye oku kuphela estrogen. Kuyinyaniso into efanayo, nangona ingenzima kangako. Kukwanjalo nangamanye amahomoni asemzimbeni.

UGqr. Alex Jimenez, DC, unikezela: Ngoku kwiprogesterone, iyinto efanayo. Ezinye iziphumo zijongeka ngolu hlobo kwi-estrogens kunye ne-testosterone, kwaye oku kukusikhumbuza konke ukuhlukahluka okukhoyo. Ngokubonisa umahluko phakathi kwabantu abahlukeneyo kwizigaba zabo zebhayoloji, umzekelo, i-premenopausal kunye ne-postmenopausal. Iziphumo eziboniswa ngugqirha kwisigulane ziseka umthunzi okhanyayo oluhlaza ngaphandle kokuhluka kwe-intercycle ukusuka ngaphakathi komfazi onikiweyo. Kwaye ke umbala omthubi kukwahluka phakathi kwabasetyhini, okuthetha ukuba umfazi omnye komnye. Kwaye ke laa mgca uzuba embindini ngumndilili; oku kubonelela ngolwazi abanokuthi balufune ukuxilonga.

Ukuvavanya amanqanaba eHormone

UGqr. Alex Jimenez, DC, unikezela: Kulungile, ke makhe sijonge kuvavanyo kunye nokuvavanya amahomoni njengoko sijonga zonke iintlobo zehomoni, iindlela ezahlukeneyo zokuzivavanya, kunye neenzuzo kunye nezibi. Kukho amashumi eminyaka yophando oluqinisekisiweyo kumanqanaba e-serum hormone. Ke i-estrogens, i-estrone, i-estradiol, kunye ne-estriol, kunye ne-estrogen metabolites kwi-serum, iindaba ezilungileyo kukuba zilinganisa ukuveliswa kwehomoni engapheliyo. Ke ukuba ufumana inqanaba lehomoni yeserum, siyazi ukuba zithetha ukuthini ezo ziphumo.

UGqr. Alex Jimenez, DC, unikezela: Iindaba ezimbi zezi ziphumo zikunika ihomoni ekhululekile kwaye eboshiweyo. Ikubonisa ii-estrogens zizonke. Nangona kunjalo, awukwazi uku-odola i-estradiol epheleleyo kunye novavanyo lwe-estradiol lwamahhala njengoko benganikeli. Kukho idatha elinganiselweyo malunga namanqanaba e-serum ezi metabolites ngokwengqikelelo yengozi yempilo. Kwaye kunokuba nzima kwezinye iilebhu ukufumana ubungakanani obuchanekileyo kubasetyhini abasemva kokuya exesheni kuba amanqanaba e-estrogen asezantsi kakhulu. Ke, ukugcina loo nto engqondweni ngumbandela wokwazi ilebhu yakho kunye nokuba ichane kangakanani na. Ngoku xa kufikwa kumathe, iindaba ezimnandi aziphazamisi. Izigulana zinokukwenza oku ekhaya, okwenza kube lula ukuba oogqirha bazama ukwenza umlinganiselo wesiriyali we-estradiol kumjikelo wonke kwi-premenopausal woman. Kuba akukho mntu unengqondo ephilileyo uya kuya elebhu kwaye atsalwe igazi yonke imihla.

UGqr. Alex Jimenez, DC, unikezela: Ukwazi ukuba i-estradiol ye-salivary idibanisa kakuhle kwi-estradiol yamahhala kwi-serum ivumela oogqirha ukuba babone into esematheni kunye noko bafuna ukukubona kwi-serum. Iindaba ezimbi malunga namathe kukuba kukho izifundo ezimbalwa zokuqinisekisa kuneserum. Kusekho ezimbalwa, ngoko ke yindlela yokuvavanya esebenzayo. Yinto nje yokuba ayiqinisekiswanga kakuhle njengeserum kuba kusafuneka yenziwe. Kwakhona, kunokuba ngumngeni kakhulu kwezinye iilebhu kuba amanqanaba e-estrogen ematheni asezantsi kakhulu kuneserum. Ke oogqirha kufuneka baqinisekise ukuba ilebhu yenza umsebenzi olungileyo ngokwaneleyo ukuhlola la manqanaba asezantsi kakhulu. Lonke uvavanyo lwamathe lunokungcoliswa ligazi eliphuma kumlomo womlomo.

Uvavanyo lwamathe

UGqr. Alex Jimenez, DC, unikezela: Ngoko ukuba isigulana sine periodontitis okanye into ehambisana naloo migca, oogqirha abafuni ukuba kumanqanaba amathe; kubalulekile ukubaxelela ukuba bakwenze oko phambi kokuba bahlambe amazinyo, hayi emva koko, xa benokopha xa bexukuxa. Kodwa oko kuyinyaniso kulo naluphi na uvavanyo lwamathe; awukwazi ukufumana i-estrogen metabolites eyenziwa ngamathe. Kwaye ingxaki enkulu kwi-postmenopausal yowesifazane kukuba abaninzi bafumana umlomo owomileyo emva kokuyeka ukuya exesheni. Kwaye ke, kunokuba nzima ngokwenene ukwenza uvavanyo kuba kufuneka bavelise amathe amaninzi ukuze bafumane umfuziselo owaneleyo. Ngoku, ukuba oko kuyenzeka, banokuya kuvavanyo lomchamo olungamashumi amabini anesine. Uvavanyo lomchamo lweeyure ezingama-24 lwe-estrogen kunye ne-estrogen metabolites lunokuba luncedo ukuba uzama ukufumana imveliso yemihla ngemihla yehomoni. Unokufumana imilinganiselo ye-estrogen metabolites, ezinzile ixesha elide.

UGqr. Alex Jimenez, DC, unikezela: Unexesha elininzi lokucutshungulwa kwaye ufumane imilinganiselo ye-estrogen yasimahla kunye nedibeneyo. Ngoko ke luncedo. Iindaba ezimbi, eziyinyani kulo naluphi na uvavanyo lomchamo lweeyure ezingama-24, luxhomekeke kwimilinganiselo echanekileyo yomthamo kunye nokuqokelelwa okupheleleyo kwezigulane. Izigulana ezininzi ziya kuyijika loo nto. Xa benosuku oluxakekileyo, baya kuchama kwaye kufuneka bakhumbule into abafanele bayenze, enokuba yingxaki. Ke, ukuqinisekisa ukuba isigulana siyasiqonda kunokuncedisa kwiziphumo zovavanyo. Awunakuyisebenzisa le nto kubantu abanokungasebenzi kakuhle kwezintso kuba isekwe kulungiso lwe-creatinine. Ke ukuba i-creatinine yabo ayiqhelekanga, kuya kufuneka bakwazi ukukunika inqanaba elaneleyo, elifanelekileyo kwaye ngamanye amaxesha bakunike ezinye zezi mvavanyo ezenza imichamo yeeyure ezingama-24 ziya kukubonelela ngeemetabolites ezininzi ezinokuba luncedo ngakumbi ngokwezonyango kodwa zingekho. .

UGqr. Alex Jimenez, DC, unikezela: Ngoku kwindawo eyomileyo, uvavanya, kwaye unokufumana i-estrogen metabolites, okulungileyo kuba i-metabolites izinzile ixesha elide, ngoko akukho ngxaki. Kwaye unokulinganisa zombini ii-estrogens zasimahla kunye ne-conjugated kula mabala kuvavanyo lomchamo. Eyona ngxaki inkulu apha kukuba inezona zifundo zincinci zokuqinisekiswa kwezonyango. Ke, yindlela entsha yovavanyo. Iyathandwa kwaye ilula kwizigulana, kodwa akukho nkxalabo encinci ngenxa yezifundo ezimbalwa zokuqinisekiswa kwezonyango abazenzileyo. Ngoku, imingeni eyongezelelweyo iyakhankanywa: ukucinga malunga nento ekufuneka yenziwe ilebhu; imilinganiselo abayifunayo ukuze bakwazi ukuyibonelela inokwahluka kakhulu kuba kukho amanqanaba asezantsi kakhulu e-estrogen kwabasetyhini abadala, hayi kunyango lokubuyisela ihomoni.

UGqr. Alex Jimenez, DC, unikezela: Kwaye ke ukuya kufikelela kumlinganiselo la mayeza aphezulu aphezulu kwabasetyhini abalungiselela i-IVF. Kwaye, uyazi, amanqanaba anokwahluka nge-10,000. Ngaba kusengqiqweni ukucinga ukuba naluphi na uvavanyo luya kuchaneka kuzo zonke ezo meko? Kukwanzima ukuvavanya amanqanaba e-estrogen kwabasetyhini abaphathwa nge-aromatase inhibitors kuba banokuba ne-estrogen esezantsi kakhulu. Ke loo nto isenokungafunyanwa ngokuchanekileyo ngovavanyo olusemgangathweni. Kwaye ke ukuchaneka kuyingxaki kuba sithetha malunga nendlela i-estradiology ejolise ngayo ikakhulu kwindlela eyaphulwa ngayo kwi-estrone kwaye emva koko i-estrones iyaphulwa njani. Kodwa inyaniso kukuba i-estradiols iguqula ibe ngaphezu kwekhulu le-metabolites eyahlukeneyo, enokuphazamisa ubungakanani obuchanekileyo.

Uvavanyo lweSerum

 UGqr. Alex Jimenez, DC, unikezela: Ke, iilebhu kufuneka ziyigcine engqondweni loo nto kwaye ziqinisekise ukuba zifumana iinkcukacha ezaneleyo kuwe. Enye i-tidbit enomdla kukuba imithombo yangaphandle ye-S-trial ingakhokelela kumanqanaba aphakamileyo e-estradiol. Ke gcina loo nto engqondweni ukuba unesiphumo sovavanyo esihlekisayo esingenangqondo.

UGqr. Alex Jimenez, DC, unikezela: I-progesterone kunye ne-progesterone metabolites kwi-serum; zininzi iincwadi zokuxhasa ukusetyenziswa kwenqanaba leprogesterone elizotywe ngethemba ngomhla wama-21 womjikelo weentsuku ezingama-28 ukuqinisekisa ukuvuthwa kweqanda. Iprogesterone ineengxaki njengoko ihluke kwi-estradiol. Ngoko ke kwamkelekile ukusebenzisa amanqanaba e-serum progesterone kuloo nto, njengoko ukuveliswa kwakhona kwamanqanaba e-serum kulinganiselwe ukuba amanqanaba e-serum aphantsi. Ke ukuba oko kuthetha ukuthini ukuba ubunokuthatha umntu kwisiqingatha sokuqala somjikelo wakhe kwaye uzobe inqanaba leprogesterone iintsuku ezintathu zilandelelana ekuqaleni kwenkqubo kwaye iprogesterone kufuneka ibe phantsi, awunakufumana amanani afanayo. ngenxa yokuba amanqanaba e-hormone aphantsi.

UGqr. Alex Jimenez, DC, unikezela: Ke ukuveliswa kwakhona kwenza oogqirha baphambane kancinci, kodwa yiloo nto ekufuneka bayigcine engqondweni ngeserum. Kwakhona, ukuvavanywa kwamathe akuhlaseli; kulungele ukuba ufuna ukulandela umjikelo wonke kwi-premenopausal woman. Kwakhona, uphando lubonisa ukuba inqanaba le-salivary ye-17 alpha hydroxyprogesterone yamkelekile nje ngenqanaba leserum yokuxilonga i-congenital adrenal hyperplasia. Ngoku i-downside ye-progesterone's metabolites amanqanaba amathe eprogesterone kwi-metabolites yayo kukuba unokuguquguquka okukhawulezileyo kwamanqanaba eprogesterone ematheni. Ke, ukuba unomntu ongafuniyo ukutsalwa igazi kwaye akanangxaki nokutshicela kumbhobho, ungasebenzisa oku endaweni yoko.

UGqr. Alex Jimenez, DC, unikezela: Ke kufuneka usebenzise iziphumo zovavanyo ezingaphezu kwesinye ukwenza isigqibo; unokufuna isampulu yothotho ukufumana ukuva umndilili. Kukwakho ingxaki ngokuphambana kwe-reactivity enokuphazamisa i-immunoassays kwaye ichaphazele iziphumo. Kwaye kwakhona, ingxaki efanayo inamanqanaba asezantsi kakhulu eprogesterone kumathe kuneserum. Ke kwezinye iilebhu, oko kunokuba lucelomngeni ukufumana uhlalutyo lokuqala kunye nengxaki efanayo malunga nokungcoliswa kwegazi; kunjalo, oko kuyinyaniso kuzo zonke iimvavanyo zeselula. Umchamo weeyure ezingama-24 kunye novavanyo lomchamo owomileyo we-progesterone unengxaki efanayo kuba i-progesterone metabolites iya kuhambelana neempawu. Ngoko baye bafunda, umzekelo, i-allopregnanolone kumchamo. Inqanaba lalonto linxibelelana nomgangatho wokulala kwabasetyhini abakwi-perimenopausal.

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Iimpembelelo ezahlukeneyo zoVavanyo lweHormone

UGqr. Alex Jimenez, DC, unikezela: Intsingiselo yeyokuba ukuba iyahambelana, mhlawumbi inqanaba elichanekileyo; nangona kunjalo, iprogesterone kunzima ukuyilinganisa kumchamo. Kwaye ke, basebenzisa i-metabolites yokuvavanya kwaye banqume inqanaba leprogesterone esekelwe kwi-metabolites. Kulungile, ngaphandle kokuba akukho ncwadi ichaza ukusetyenziswa kweklinikhi ye-progesterone metabolites. Ke iprogesterone kumchamo iyingxaki malunga nokuchaneka kunye nento oyifumanayo. Ingxenye yomcimbi kunye ne-progesterone ye-serum kukuba incinci kakhulu ikhoyo, kunye nomhlaba ongeyena iprotheni, ininzi ibophelelwe kuzo zonke kunye nezinye iiprotheni; yiprogesterone yasimahla ekhoyo kwiithishu ekujoliswe kuzo nakwizinkcwe. Ke iprogesterone oyimetayo kwiserum ubukhulu becala yiprogesterone ebotshelelweyo, hayi eyona nto ibalulekileyo ekliniki.

UGqr. Alex Jimenez, DC, unikezela: I-progesterone ye-Transdermal kunzima kakhulu ukuyilinganisa kuba nabani na ufumana i-metabolism nge-alpha reductases ezintlanu eluswini. Ifunxwa ngokukhawuleza ziinwebu zeseli ebomvu zegazi kwaye isiwe kwithishu. Kwaye ngenene, kuya kuthi emva kokuba isigulana sisebenzise ukhilimu weprogesterone okanye ijeli yangaphandle, bafumana la manqanaba aphezulu eprogesterone ematheni nakwiibhedi zecapillary, kodwa hayi kwiserum. Kwaye ke kungakho indlela engcono yokulinganisa okwenzekayo kwisigulana. Ngoko i-progesterone ye-transdermal, ukuzama ukulandela ukuba naluphi na uvavanyo kunzima.

UGqr. Alex Jimenez, DC, unikezela: Kukho amashumi eminyaka yophando kumanqanaba e-serum hormone. Ekuvavanyeni kwe-serum, i-testosterone, kunye ne-metabolites yayo, unokufumana zombini i-total and free level test level, kwaye unokufumana inqanaba le-DHT, eliluncedo. Kukho uluhlu lwe-serum olusekiweyo lokuxilongwa kokungabikho kwe-androgen. Ke amanqanaba e-serum e-testosterone alungile ngokubanzi. Kunokuba nzima ukuncedisa i-serum xa amanqanaba asezantsi, njengakwabasetyhini nasebantwaneni nakumadoda angaphantsi. Ke, kuya kufuneka uyazi ilebhu yakho kunye nendlela yayo. Masithi uvavanya i-testosterone kubasetyhini, amadoda angama-hypogeal, okanye abantwana kuba kufuneka baqinisekise ukuba benza uvavanyo lwe-serum olufanelekileyo ukufumana la manqanaba asezantsi ngokuchanekileyo.

UGqr. Alex Jimenez, DC, unikezela: Kuvavanyo lwamathe, kulula kakhulu ukufumana isampuli. Kukho uluhlu olusekiweyo lokuxilongwa kokungoneli kwe-antigen, kwaye kulula ukusebenzisa olu vavanyo lokwahlula phakathi kwe-gonadal kunye ne-hypogonadal amadoda. Kwaye unokufumana inqanaba lehomoni yasimahla njengophando oluninzi olupapashwe malunga nokusetyenziswa kwamanqanaba amathe okuvavanya i-testosterone. Noko ke, le ngxaki ifana neprogesterone; ufumana oku kuguquguquka ngokukhawuleza kwamathe. Unokufuna ngaphezu kwesinye iziphumo zovavanyo lwamathe ukuze ufumane ulwazi oluthembekileyo. Ke awufuni ukwenza isigqibo ngokusekwe kwisiphumo esinye. Kwaye kwakhona, kufuneka uyazi ilebhu yakho kuba amanqanaba asezantsi kakhulu kuneserum. Ngoko kulucelomngeni ukufumana ibali elichanileyo kwaye ulumkele ukosulela kwegazi. Kuvavanyo lomchamo, iiyure ezingama-24 kunye nomchamo webala unemiba eyahlukileyo kancinci.

UGqr. Alex Jimenez, DC, unikezela: Uvavanyo lweyure ye-24 yomchamo we-testosterone ingasetyenziselwa ukufumana imveliso ye-testosterone yemihla ngemihla. Izigulane ziya kufumana inqanaba le-hormone yamahhala kunye ne-metabolites, into enhle. Bangasebenzisa olo lwazi ukuvavanya ngokungangqalanga imisebenzi emihlanu ye-alpha-reductase kunye ne-aromatase ngokusekelwe ekubeni zingaphi iimetabolites ezahlukeneyo abazifumanayo. Zimbalwa kuphela iinkcukacha ezixhasa ukusetyenziswa kweklinikhi yazo zonke i-metabolites ezilinganisiweyo. Kukho i-polymorphism ye-UGT ukuya kwi-B17; ukuba isigulana sinayo loo nto, inqanaba labo le testosterone yomchamo liya kubuyela ku-zero, ke gcina loo nto engqondweni ukuba ukhe wafumana iziphumo zovavanyo. Ngapha koko, iphantsi kakhulu kuba kusenokwenzeka ukuba isigulane sakho sinalo mbandela. Ngoku umchamo webala uya kukunika ezinye zeendlela ezifanayo njengoko uya kufumana amanqanaba ehomoni asimahla kunye neemetabolites. Oku kukuvumela ukuba usebenzise olo lwazi ukuvavanya imisebenzi emihlanu ye-alpha-reductase aromatase; nangona kunjalo, ingxaki ikhona; njengamanye amahomoni esixoxe ngawo, olu vavanyo lunezifundo ezimbalwa zokuqinisekiswa kwezonyango kuba luhlobo olutsha lovavanyo, ke yigcine engqondweni loo nto.

Cortisol

UGqr. Alex Jimenez, DC, unikezela: ICortisol kunye neemetabolites zayo kwiserum ziyafana nezinye iihomoni ezikhankanyiweyo, njengoko kukho uluhlu oluqinisekisiweyo lwereferensi ye-cortisol. Uninzi lweencwadi zokuphononongwa koontanga ezichaza ukusetyenziswa kolu vavanyo, kwaye izigulana zinokuziva zikhululekile ukufumana ezi ziphumo. Iya kubaxelela nje i-cortisol epheleleyo, hayi i-cortisol yabo yasimahla. Ke ngokugcina loo nto engqondweni, baya kufumana ipateni ye-diurnal. Banokufumana kuphela uvavanyo lwamanqaku amane njengoko benokwenza ngamathe ngenxa yokuba abanalo uluhlu oluqhelekileyo lwamaxesha amane ahlukeneyo ngosuku. Kwaye izigulana ezininzi zixela koogqirha bazo njengoko zifumana i-serum cortisol, ziye zithi, “Yima, awuqondi. Ndiyoyika kakhulu ukutsalwa kwegazi lam kangangokuba ikhuphe i-cortisol yam, kwaye andifane ndibukeke kakubi ngale ndlela.

UGqr. Alex Jimenez, DC, unikezela: Gcina ukhumbula ukuba kwiserum, banoluhlu lwezalathiso oluqhelekileyo kuphela amaxesha amabini emini, 7 ukuya 9:00 AM kunye 3 ukuya 5:00 PM. Ke kufuneka uqinisekise ukuba usebenzisa i-serum cortisol, bangena ngokuzila ukutya ngaphambi kwentsimbi yethoba, okanye banokuhamba kamva emini. Yaye ukuba bahamba emva kwemini, akuyomfuneko ukuba bazile ukutya. Ke ukuba ufumana i-cortisol nge-10 okanye i-11 kusasa, ayiloncedo kakhulu kwiziphumo. Ngoku uvavanyo lwamathe, abantu abaninzi bayaqhelana noku.

UGqr. Alex Jimenez, DC, unikezela: Ungayifumana ipateni yakho yemini kuba iinkampani ezininzi zineekiti apho uneesampulu ezine okanye ezintlanu imini yonke. Kukho uncwadi oluninzi oluphononongwa ngoontanga oluchaza ukusetyenziswa koku. Kwaye oku yeye-cortisol, hayi eye-cortisol metabolic. Ibonakalisa i-plasma concentration engabotshwanga, engeyiyo le nto siyibonayo ngeserum. Ingxaki kukuba i-11 beta hydroxy steroid dehydrogenase yi-enzayimi kumadlala amathe eguqula ngokubonakalayo i-cortisol ibe yicortisone. Ke kukho imibuzo malunga neziphumo oogqirha abazifumanayo kwi-cortisol ye-salivary kwaye kwenzeka ntoni okanye ingaba iguqulelwe kwi-cortisone, kwaye awuyicholi loo nto kuvavanyo?

UGqr. Alex Jimenez, DC, unikezela: Ke xa ujonga i-cortisol metabolites ematheni, ezinye iinkampani ezizenzayo kwaye ezinye zingenzi, i-cortisone yamathe ihambelana nokuvezwa kwe-cortisol ngaphezulu kweeyure ezingama-24. Kukho inqanaba eliphakathi loncwadi olusebenzisa olu vavanyo kodwa ngokwaneleyo ukuba kufuneka uzive ukhululekile. Kukho imiba xa i-serum cortisol iphantsi ngokwenene, isenza ukuba kubonakale ngathi isigulana siyantlithwa okanye siphantsi konyango lwe-hydrocortisone. Loo nto yenza i-salivary cortisone ibe yi-serum marker ephezulu xa kuthelekiswa ne-salivary cortisol. Phantsi kwezi meko, ngenxa yendlela oku kusetyenzwa ngayo, ziinkampani ezimbalwa kuphela ezijonga i-cortisone ngqo ematheni. Ke ngeli xesha, kuba ngakumbi kwinqanaba eliphakathi loncwadi, uya kube usenza amanqanaba e-cortisol ematheni.

Uvavanyo lomchamo kwiiHormones

UGqr. Alex Jimenez, DC, unikezela: Ngoko masiqhubele phambili kuvavanyo lomchamo. Ngoku, kuvavanyo lomchamo lweeyure ezingama-24, unokuvavanya umlinganiselo we-cortisol, onokuba luncedo xa uxilonga. Kwaye i-cortisol yasimahla yeeyure ezingama-24 ihambelana nenqanaba le-cortisol engenaserum; nangona kunjalo, ingxaki kuphela kukho izifundo eziqinisekisiweyo zeklinikhi zoku. Kwaye, kuvavanyo lomchamo lweeyure ezingama-24, awufumani ipatheni ye-diurnal cortisol. Kwaye, kumchamo wendawo, unokufumana umlinganiselo we-cortisol, onokuba luncedo. Unokucela isigulana ukuba senze uvavanyo lomchamo kwindawo izihlandlo ezininzi ngemini ukuze ufumane utshintsho lwemini njengoko ubuya kwenza ngamathe. Kodwa ngelishwa, indawo ovavanyayo inezona zifundo zincinci zokuqinisekiswa kwezonyango. Ngoko kufuneka ugcine loo nto engqondweni. Ke ngoku, ngokuyintloko, abantu baziva bekhululekile ukusebenzisa nokuba ngamanqanaba e-serum enziwe ngexesha elifanelekileyo losuku, ukuqonda ukuba awuyifumani i-cortisol engafakwanga, okanye benza uvavanyo lwamathe olunamanqaku amane.

UGqr. Alex Jimenez, DC, unikezela: Uvavanyo lwe-salivary olunamanqaku amane lunokubona ipateni phakathi kwento isigulana esixelele ngayo oogqirha babo malunga nenqanaba lamandla abo imini yonke kunye nendlela abaziva ngayo kwaye bathelekise oko kunye nesiphumo esibuyileyo. Oogqirha abaninzi baqaphela ukuba bebelindele ukuba iziphumo zovavanyo zibe yintoni na phambi kokuba iilebhu zesizwe zibe nazo.

Uvavanyo lweDHEA

UGqr. Alex Jimenez, DC, unikezela: Siza kuxoxa nge-DHEA kunye ne-DHEA sulfates ngokwahlukeneyo ekubeni i-DHEA kwiserum inezifundo ezininzi zokuqinisekiswa kwekliniki ezinokukwenza uzive ukhululekile ukufumana iziphumo ezifanelekileyo. Ngoku, i-DHEA inepateni ye-diurnal. Ke kuya kufuneka uqinisekise ukuba bayenza ngexesha elifanelekileyo losuku kuba oku kuzila ukutya phambi kwentsimbi yethoba kusasa, kanye njenge-cortisol. I-DHEA eyenziwe kamva emini ayithethi nto; nangona kunjalo, i-DHEA sulfate kwi-serum ayilandeli ipateni ye-circadian, ngoko ke uvavanyo olulodwa olwenziwe nangaliphi na ixesha lulungile.

UGqr. Alex Jimenez, DC, unikezela: Kukho izifundo ezininzi zokuqinisekiswa kweklinikhi malunga ne-DHEA; ngelishwa, kukho ingxaki nge-DHEA sulfate kuba inepateni encinci ye-circadian. Ungaphuthelwa ukuhluka okuncinci kwi-DHEA ngokuhamba kwexesha kumntu ngokusekelwe kwindlela abaziva ngayo kunye noxinzelelo. Ke ngamaxesha athile, kumnandi ukujonga iDHEA kwisigulana logama nje sele yenziwe ekuseni kuba ke uya kuziva ngotshintsho ekuhambeni kwexesha kumntu ofanayo ongayi kumbona nge-DHEA sulfate.

UGqr. Alex Jimenez, DC, unikezela: Uvavanyo lwe-salivary ye-DHEA kulapho ulinganisa khona i-DHEA yasimahla emzimbeni, into entle. Kukho ulungelelwaniso kunye namanqanaba e-serum, kwaye ayichaphazeli. Ingxaki kukuba ugxininiso lunxulumene ngokungafaniyo nesantya sokuhamba kwamathe kwaye lukwachatshazelwa yi-pH yamathe. Umzekelo inokuba ngumntu ohamba ngaphaya kwendawo yokubhaka, eqala ukugalela amathe kakhulu ngokusekelwe kwinto ebeyiva nje. Oku kunokutshintsha iziphumo zabo zesantya sokutya xa besenza uvavanyo lwabo lweDHEA. I-DHEA sulfate inengxaki efanayo esisiseko kumathe, enxulumene nesantya sokuhamba kwamathe kunye ne-pH yamathe. Ke gcina loo nto engqondweni ukuba ujonge amanqanaba amathe kumchamo, nokuba yiyure ezingama-24 okanye umchamo wamabala; akukho zifundo zoqinisekiso lwezonyango malunga nokujonga nokuba yi-DHEA okanye i-DHEA sulfate emchameni. Ke, gcina loo nto engqondweni ukuba uvavanya umchamo kwaye bakunika iphaneli epheleleyo ebandakanya i-DHEA okanye i-DHEA sulfate, unokufuna ukwazi ukuba zithetha ntoni ezo ziphumo.

UGqr. Alex Jimenez, DC, unikezela: Kwiihomoni zepituitary, uvavanyo olukhethwayo yiFSH, LH, kunye neprolactin serum. Ayilungelanga imilinganiselo yesiriyali imini yonke ukubona utyando lwe-LH, umzekelo, kodwa iziphumo zichanekile kakhulu. Kwaye ematheni, kukho uncwadi olujongwe ngoontanga olulinganiselweyo oluchaza iihomoni ze-salivary pituitary nokuba zanele na okanye hayi. Izixhobo zokufumanisa i-LH ekhaya zilungele uvavanyo lomchamo kuba zisetyenziswa kakhulu kwaye kudala zikhona. Utyando lwe-LH lunxulumana nomchamo kwaye lusebenza kakuhle kunye neserum yotyando lwe-LH. Ke ukuba uzama ukunceda abantu baqonde ukuba baphi na kumjikelo wabo kwaye nokuba bakhuphile na okanye hayi, olu vavanyo yindlela yokuhamba. Ayenzi umsebenzi olungileyo wokuyilinganisa; ikuxelela nje ukuba kukho utyando kuba ezi zihomoni ezinkulu, ngoko ke azingeni emchameni ngokulula.

UGqr. Alex Jimenez, DC, unikezela: Ke uya kwazi ukuba ngaba ulufumene okanye awulufumani utyando, awuzukwazi ukuba leliphi inqanaba lokwenyani, kwaye kulungile kuba ixesha elininzi, akukhathaliseki nokuba leliphi inqanaba lehomoni. Ngokusisiseko, ngaphandle kokuba uzama ukufumanisa ukuba banalo na utyando lwe-LH, ufuna ukusebenzisa i-serum nokuba yi-FSH, LH, okanye iprolactin. Kwi-globulin ebopha i-hormone yesini, uninzi lwezifundo zokuqinisekiswa kweklinikhi zikwiserum; awukwazi ukuyilinganisa ngamathe okanye umchamo, ngoko kulula ukuyikhumbula. Ke sele sithethile ngemiba eneendlela ezahlukeneyo zovavanyo, kwaye kukho iindlela ezimbalwa zovavanyo eziya kukunika yonke into oyifunayo ukuyazi malunga nehomoni nganye ekufuneka uyazi.

Leliphi elona xesha lilungileyo leHormones?

UGqr. Alex Jimenez, DC, unikezela: Ke ngoku, leliphi ixesha elifanelekileyo lokuvavanya iihomoni? Kwakusasa kuxa iihomoni ziya kuba zezona ziphakamileyo kwiihomoni ezininzi. Ke, eyona ndlela ilungileyo yokuhamba kwaye uvavanye amanqanaba ehomoni afana ne-cortisol kunye neehomoni ze-gonadal yinto yokuqala kusasa kuba kufuneka ungaguquguquki kwaye ukhawuleze kuba into oyityileyo inokutshintsha amanqanaba ehomoni. Ke ukuba uhlala uzila ukutya, ubuncinci uya kufumana ukuhambelana phakathi kwesampulu kunye nomntu omnye. Kufuneka kwakhona wazi apho bebekho kumjikelo wabo kwiimvavanyo ezithile. Ke, abaguli ababhinqileyo abasahamba ngebhayisekile kufuneka babhale usuku lokuqala lwexesha labo elilandelayo ukuze bazi ukuba loluphi usuku olwenze ngalo uvavanyo lwazo. Ngaphandle koko, kuya kufuneka basebenzise iikiti ze-ovulation ukuze bazi ukuba ziphi na.

UGqr. Alex Jimenez, DC, unikezela: Kwaye kunjalo, into embi apha kukuba, ukuba uzama, umzekelo, ukufumana i-progesterone yosuku-21, kwaye uhlala enomjikelo weentsuku ezingama-28, ke umxelela ukuba ahambe ngomhla wama-21, kodwa ngaloo nyanga. unomjikelo weentsuku ezingama-35, awuzange ulifumane izinga obulifuna. Ke inokuba yingxaki encinci, kodwa bakhumbuze ukuba bayilandelele ukuze ungabinakho ukujonga ngasemva kwaye wazi ukuba bebephi xa besenza iimvavanyo zabo. Ke, silufuna nini olu mvavanyo kubafazi bangaphambi kunye nabe-perimenopausal? Masithi ufuna iprogesterone ngosuku lwe-21. Unokwenza i-globulin ye-hormone-binding globulin ngaloo mini. Abasetyhini abasexesheni badubula malunga nosuku lwesithathu lwe-estradiol, i-estrone, i-FSH, i-testosterone, okanye i-globulin ebopha i-hormone yesini.

UGqr. Alex Jimenez, DC, unikezela: Ngoku, nangona ezi zifanelekile, ungazifumana ngezinye iintsuku zomjikelo wazo? Ewe, kodwa ziya kuba nokuchaneka okwahlukileyo. Kwaye, ewe, inokuba lusuku olongezelelweyo kunosuku lwesithathu kuba kuthekani ukuba usuku lwesithathu lwenzeka emhlabeni ngempelaveki kwaye ilebhu ayivulwanga? Ke, nceda uqwalasele ukuba le nto uyifunayo apha kukuvavanya amanqanaba ehomoni xa ekwelona nqanaba liphezulu. Yiyo loo nto sidubula isithathu kunye ne-21. Ke, uyazi, nanku umhla wesithathu nowesine. Kwaye ke iFSH izakuba linqanaba elihle apha. I-estradiol ijikeleza kakhulu ngeli xesha, ngoko ukuzama ukuyifumana kule nxalenye yomjikelezo kuya kuba luncedo kakhulu. Kwaye, ngeprogesterone, uya kufumana incopho yakho apha, yiyo loo nto ufuna ukuzama ukudubula kangangeentsuku ezingama-21 kuba uyazi ukuba iya kuba yeyona ndlela ilula yokuqinisekisa ukuba uyayifumana. Kwaye kwakhona, kuya kukunceda ukuba ungaguquguquki ukusuka kumjikelo ukuya kumjikelo ukuba uhlala uzama ukuyifumana ngexesha elinye lenkqubo.

Unyango lweHormone Replacement

UGqr. Alex Jimenez, DC, unikezela: Ngoku nantsi apho ifika ikhohlisayo kuba yinto enye ukufumanisa ukuba umntu uphi phambi kokuba umfake kulo naluphi na unyango lokubuyisela ihomoni; nangona kunjalo, ukubeka iliso kunyango lokubuyisela ihomoni kuba yingxaki ngakumbi. Ukuba usebenzisa i-estrogen yomlomo, kuyacetyiswa ukuba ufumane isiseko seserum phambi kwe-HRT kwaye ujonge ngexesha lonyango; ukuba wenza i-estrogen yomlomo, amanqanaba e-salivary awabonisi ukusetyenziswa kwe-estrogen yangaphandle konke konke, ngoko ke abaloncedo kakhulu.

UGqr. Alex Jimenez, DC, unikezela: Yaye i<em>oral estrogen okanye naziphi na iincindi zamadlala ezivavanywayo kufuneka zibonise ngokuchanekileyo inkqubo yemetabolism yesibindi kunye namanqanaba omchamo. Ke ukuba wenza unyango lonyango lokubuyisela i-estrogen yomlomo, ekuphela kwendlela yokuyivavanya kukusebenzisa i-serum kuba oogqirha baya kuqinisekisa isigulana ngemodyuli, ngoko awufuni kusebenzisa i-estrogen yomlomo nakanjani na. Ukuba usebenzisa i-estrogen yolwimi olungaphantsi, amanqanaba aya kunyuka kwaye ehle ngokukhawuleza kwiiyure ezimbalwa. Kwaye ke i-serum ayisebenzi ngokumalunga nokulinganisa. Amathe awasayi kwenza ngqiqo ukuba wenza i-sublingual kuba une-estrogen yakho apho. Ngoko ke ithetha ukuthini? Kuthetha ukuba umchamo weyure ezingama-24 kunye novavanyo lomchamo kunye neehomoni ezingaphantsi kweelwimi azikhuthazwa kuba kusoloko kukho umbuzo wokuba uginya kangakanani kwaye ufunxa malini ngokungekho lwimi.

UGqr. Alex Jimenez, DC, unikezela: Ngoku, ukuba uyaqaphela ukuba ithi ngolwimi olungaphantsi, kunokubakho iindlela ezingcono zovavanyo. Kuba ungayazi ukuba yimalini eginyiweyo kwaye yafumana isiphumo sokuqala semetabolism, isiphumo seyure ezingama-24 okanye umchamo wamabala owomileyo unokufuna ukucaciswa. Yingxaki ke leyo. Usenokwenza unyango lwe-estrogen yolwimi olungaphantsi; kuthetha nje ukuba akukho ndlela ibalaseleyo yokuyivavanya. Ukuba usebenzisa iikhrimu ze-estrogen, uvavanyo lweserum lunokusebenza, kwaye siyazi ukuba iiparamitha zeklinikhi zihambelana namanqanaba e-serum xa usebenzisa iikhrimu ze-estrogen, singayenza loo nto. Kwi-saliva, i-estradiol kunye ne-estriol zihanjiswa ngenkuthalo kwi-saliva; amanqanaba aphezulu kunokuba ubuyakubona kwiserum kwaye aguquguquka kakhulu. Ke amanqanaba amathe eekhrimu awenzi ngqiqweni, kwaye akukho zifundo zijongiwe ntanga zinika iinkcukacha ngekrimu ye-estrogen esebenzayo kumanqanaba omchamo.

Ukusebenzisa iHormone Creams & Patches

UGqr. Alex Jimenez, DC, unikezela: Mhlawumbi ayingombono ulungileyo ukusebenzisa amanqanaba omchamo kumntu osebenzisa iikhrimu ze-estrogen ngelo xesha. Ukuba usebenzisa i-labial okanye i-estrogen ye-vaginal, uvavanyo lwe-serum lubonakala lolona khetho lungcono lokujonga ukufunxa. Amanqanaba amathe akabonisi naluphi na utshintsho lwethamo. Ngoko ke ngokwesiseko, mhlawumbi yinkcitha xesha ukufumana inqanaba amathe uzama ukwenza uvavanyo lomchamo; Ukusebenzisa i-estrogen ye-labial okanye i-estrogen ye-labial inokuba yingxaki kuba wazi njani ukuba awuwungcolisanga umzekeliso womchamo. Kwaye ukuba usebenzisa isiziba, amaxabiso e-serum ayakunyuka ngokuxhomekeke kwidosi kwaye anqabe ngokukhawuleza oku kususwa kulandelayo. Kunokuba luncedo, siyazi ukuba amaxabiso e-serum atshintsha ngokusekelwe xa ubeka isiqwenga kwaye xa usikhupha, kodwa kuseyingxaki.

UGqr. Alex Jimenez, DC, unikezela: Akukho bungqina bujongwe ngontanga obubonisa ukuba i-estrogen yamathe ingasetyenziselwa ukubeka esweni isiqwenga se-estrogen. Kwaye xa kuziwa kuvavanyo lomchamo kunye ne-estrogen patch, kubonakala ngathi amaxabiso kumchamo aya kunyuka ngokuxhomekeke kwidosi. Isenokuba ichanekile ngokwentelekiso, kodwa ayilona vavanyo lugqwesileyo lwezonyango lwe-estrogen patch. Umyalezo wokuya ekhaya apha kukuba akukho vavanyo lugqibeleleyo kwaye uninzi lwethu luhlengahlengisa ithamo kwixabiso eliphantsi, elona nqanaba lisezantsi esinokulifumana, kwaye iimpawu zethu zilawulwa. Oko akuthethi ukuba abavavanyi; kufuneka uzame ukuqinisekisa ukuba awugqithisi idosi kulo mntu. Kodwa khumbula ukuba kukho imida emininzi malunga novavanyo olunokuba luncedo kuxhomekeke kuhlobo lwe-estrogen oyisebenzisayo.

UGqr. Alex Jimenez, DC, unikezela: Ngoku, iprogesterone kunye neprogesterone yomlomo, ukuba usebenzisa loo nto, amanqanaba aphakama kwaye awela ngokukhawuleza. Awunakukwazi ukubamba inqanaba le-serum enengqiqo ukuba uthatha i-progesterone yakho ngokuhlwa kwaye ulinganise ekuseni. Ngenxa yokuba abaninzi abafazi, ukuba bathatha i-progesterone yomlomo, baya kuyithatha ngokuhlwa kuba ibanceda balale. Kukwakho ingxaki ngokuphambana kwe-metabolites kunye ne-immunoassays. Ngoko unyango lokubuyisela iprogesterone, ukuba ngomlomo, kufuneka uthathe amanqanaba e-serum ngengqolowa yetyuwa. Into efanayo ngamathe kunye nokuvavanya umchamo weeyure ezingama-24. Sathetha ngendlela ongayifumani ngayo iprogesterone; ufumana i-progesterone metabolites, ngoko ke kunokuba luncedo. Kodwa kukho ingxaki yendlela esemthethweni yokusetyenziswa kwe-progesterone metabolites. Ke ukusetyenziswa ngomlomo kweprogesterone, ukufumana inqanaba, kwaye ukuyilandela kuyinkohliso encinci.

UGqr. Alex Jimenez, DC, unikezela: Ngoku kunye ne-creams kunye ne-progesterone ye-transdermal, akukho nanye yeemvavanyo eyenza nayiphi na ingqiqo kuba ufumana amanqanaba okwandisa ngokwasengqondweni kwi-serum engavuki ngayo nayiphi na indlela ecacileyo. Njengazo zonke iihomoni ze-steroid, ezi zi-soluble-fat-soluble, ngoko ke ukuba zihamba kwaye zihlale kwi-adipose kunokuba zingene egazini, ayibonakalisi inqanaba le-serum. Ayibonakalisi amanqanaba eethishu esibelekweni nasebeleni, kulapho sikhathala khona. Ngoko inqanaba le-serum ye-progesterone cream yingxaki. Amanqanaba esalivary emva kokuba i-progesterone cream inyuka kwaye ayihambelani neempawu kuzo zonke. Ngoko ungakhathazeki ngokufumana inqanaba le-salivary emva kwekhilimu yeprogesterone. Kukho ubungqina bokuvavanya umchamo ukuba unokufumana ukunyuka okuncinci kwi-dial ekhulelweyo i-glucosides ukuba usebenzisa i-progesterone cream. Kwaye ke kunokuvela ukuba sinokusebenzisa oko njengomlinganiselo wento eyenziwa yiprogesterone yakho.

UGqr. Alex Jimenez, DC, unikezela: Kodwa oku kusafuna uvavanyo oluthile. Ngoko kuya kuba kuhle ukuba ukhumbule ukuba kufuneka kubekho indlela ethembekileyo yokulandelela okwenzekayo xa umntu esebenzisa i-progesterone cream. Ke nceda uthathe ixesha lakho ngokufumana inqanaba kwaye wenze isigqibo esisekwe kuyo. Ngoku, i-progesterone suppositories yangasese inengxaki efanayo. Ufumana amanqanaba amancinci anyuswe kwi-serum, engayi kukunika umphumo owaneleyo. Iprogesterone iyanyibilika okanye ibuhlungu; ungasebenzisa amanqanaba e-serum kwi-troche kuba ufumana inqanaba elichanekileyo kwi-serum kunokuba ubuyithathe ngomlomo. Kukho ukunqongophala kophando oluphononongwe ngoontanga kumanqanaba amathe emva kweesuppositories zeprogesterone yelungu lobufazi. Kwaye kufuneka ulumke xa uzama ukwenza uvavanyo lomchamo kuba wazi njani ukuba awuzange ungcolise isampulu?

UGqr. Alex Jimenez, DC, unikezela: Awukwazi ukusebenzisa inqanaba le-salivary ngenxa yokuba une-troche okanye inyibilika emlonyeni womntu. Kwaye ke, kukho ubuncinci ingxaki enokubakho ngokufumana inqanaba lomchamo we-troche okanye unyibilike ngenxa yokuba, njengolwimi olungaphantsi, ingakanani lento oyiginyayo? Abantu ngabanye banokutya enye yayo kwaye baxhomekeke kwimetabolism yokuqala, okuthetha ukuba awuyi kukwazi ukuyichola kumchamo. Inxalenye enkulu iya kufakwa kwigazi le-capillary kwaye mhlawumbi ichanekile kwiiyure ezingama-24 okanye uvavanyo lomchamo owomileyo. Kodwa oko kufuneka kufundwe ngokwaneleyo, ngoko gcina loo nto engqondweni ukuba usebenzisa kakubi okanye inyibilika. Kwaye olu luphononongo olubonise ukuba emva kokufaka i-progesterone ye-topical, amathe kunye namanqanaba egazi le-capillary ahluke kakhulu xa kuthelekiswa nalawo abonwa kwi-serum okanye igazi elipheleleyo.

Kubalulekile Ukwenza Uphando

UGqr. Alex Jimenez, DC, unikezela: Ke esi sisifundo nje esibalulekileyo sophando ukukukhumbuza ngokuthembela kumanqanaba e-serum yeprogesterone. Ukuba ubeka iliso, idosi ye-topical inokukhokelela kumanqanaba ezicubu ezingaphantsi, ke uya kunika ngaphezulu kunokufunayo. Ke, lumka ngokuthembela kumanqanaba e-serum kwi-progesterone ye-topical kuba uya kubagqithisa abantu abanjengokuphambana. Kwaye khumbula, ukuba ugqithise i-progesterone, iphezulu kwindlela ye-hormone ye-steroid, kwaye awukwazi ukuba umzimba walo mntu uya kwenza ntoni ngayo; basenokuyijika ibe yiyo nantoni na eyenye. Ngoku, iikhrimu okanye iijeli zonyango zokutshintsha i-testosterone zinokubangela amanqanaba egazi, kwaye inqanaba leserum liyenyuka ngokukhawuleza kunye nesicelo kwaye alibonakalisi ngokuthembekileyo ukutshintsha kwedosi, naluphi na utshintsho lwedosi. Ngoko i-serum kunye namanqanaba egazi mhlawumbi ayikho indlela efanelekileyo yokuhamba. Kwi-saliva, amanqanaba aphezulu kakhulu kuneserum kwaye aguquguquka kakhulu kuba anokunika isibonakaliso sobuxoki sokugqithisa.

UGqr. Alex Jimenez, DC, unikezela: Kuvavanyo lomchamo, akukho nto ilungileyo kumchamo weyure ezingama-24. Mhlawumbi ufuna ukusebenzisa enye into ngaphandle komchamo weeyure ezingama-24. Iindaba ezimnandi ngumchamo owomileyo. Ngoku kumchamo owomileyo, i-epitestosterone inokulinganiswa ukuba kuya kubakho ukucinezelwa ngenxa yokuveliswa kwe testosterone yangaphandle ukuba yiloo nto ucinga ukuba iyaqhubeka. Unokulinganisa i-epitestosterone kuvavanyo lomchamo owomileyo, oya kukuxelela ukuba okanye hayi, ucinezele imveliso yalo mntu ye testosterone ngokubanika okuthile. Ngoku, ukusetyenziswa kwe-vaginal okanye i-labial ye testosterone, akukho ndlela ilungileyo yokufumana inqanaba legazi elinengqiqo. Amanqanaba amathe, njengayo nayiphi na enye ikhrimu okanye usetyenziso esinokuba nalo ezandleni zakho, kufuneka ulumke kuba ukuba uphethe iibhotile zesampulu, ukufumana amathe, ungayifumana kwindawo yovavanyo.

UGqr. Alex Jimenez, DC, unikezela: Kwaye ke, njengawo nasiphi na isicelo selungu lobufazi okanye i-labial, ukuba uzama ukufumana imizekelo yomchamo, kufuneka uqaphele ukuba awungcolisi umchamo kwaye ufumane inqanaba eliphakamileyo ngobuxoki. Amanqanaba egazi alungile ukuba wenza inaliti ye testosterone, nokuba inaliti okanye i-pellet. Fumana isiseko sesinye kwisithathu, kwaye uzisebenzisele ukubeka iliso. Ikunika amanqanaba afanelekileyo. Uya kufumana ukuphakama okubalulekileyo kumathe emva kokutofa kwe-IM, kodwa kukho ukuhluka okubanzi ukusuka kumntu ukuya komnye. Ke kuya kufuneka uyithathe ngengqolowa yetyuwa malunga nokuba ichaneka kangakanani isiphumo sakho. Kwenzeka into efanayo kumzekelo womchamo weeyure ezingama-24. Uza kufumana ukuphakama emva kwesitofu se-IM, kodwa ke, kukho ukuguquguquka okukhulu, ngubani owaziyo ukuba ichanekile kangakanani?

UGqr. Alex Jimenez, DC, unikezela: Ngenqanaba le-salivary, kukho ulungelelwaniso oluthile kuphela kwi-testosterone ye-bioavailable. Ukuba usebenzisa i-patch testosterone, unokufumana amanqanaba afanelekileyo, kwaye kukho izifundo ezilungileyo zokubonisa ukuba izinga legazi liya kulungile. Ukuba usebenzisa i-testosterone patch, amanqanaba omchamo, zombini kumchamo weeyure ezingama-24 kunye namanqanaba omchamo owomileyo, aya kubonisa iidosi ezikhulayo. Ufumana inqanaba elilungileyo ngokusebenzisa oko. Ngoku, ukuba usebenzisa unyango lwe-DHEA okanye i-DHEA yomlomo, uya kufumana ukwanda okukhawulezayo kumanqanaba egazi kanye emva kokuba usongezo ngomlomo njengoko ufumana kunye namathe. Uyifumana loo nto nakumathe nasemchameni. Ke uthatha into yokuba uluthathe uvavanyo lweDHEA.

isiphelo

UGqr. Alex Jimenez, DC, unikezela: Ingxaki kukuguquguquka kwegazi, amathe, kunye neziphumo zomchamo. Abaninzi abayithandi ngokukhethekileyo ukusebenzisa i-DHEA yomlomo eninzi ngenxa yokuba, njengawo onke amahomoni e-steroid, umzimba wakho uya kuwuthatha usiwe esibindi, kwaye isibindi sinethuba lokuyitshintsha ibe enye into ngaphambi kokuba ingene egazini. yenza umsebenzi wayo. Ezinye izicelo zinokuba luncedo ngakumbi, njenge-transdermal DHEA okanye i-DHEA yezihloko; kuya kufuneka ubone indlela isigulana esiziva ngayo ngokweempawu kuba ukuba usebenzisa i-DHEA yangaphakathi, amanqanaba egazi uya kufumana ukunyuka okukhulu kanye emva kokufakwa kwesicelo sokuqala.

UGqr. Alex Jimenez, DC, unikezela: Ke ithetha ukuthini loo nto kuba iwa kwangoko? Emva koko, kwi-saliva emva kokusetyenziswa kwe-transdermal ye-DHEA, amanqanaba aya kwanda, kodwa kungekhona ngokulandelelana. Ngoko ke loo nto ayinangqondo. Kwaye akukho phando luphononongwe ngontanga oluchaza okwenzekayo kumanqanaba e-DHEA kumchamo emva kokusetyenziswa kwe-transdermal. Umcimbi omkhulu ke unokuba ufuna ukubeka iliso kwinto eyenziwa yimveliso yokudiliza ezantsi kuba ukuba awukwazi ukufumana inqanaba elihle le-DHEA, unokufuna ubuncinci ukujonga i-testosterone kunye ne-estradiol. Kwaye oko kuya kukunika isibaso ukuba uye wasebenzisa kakhulu okanye wasebenzisa ngaphantsi kwe-DHEA. Ngoku, ngokusetyenziswa kwelungu lobufazi okanye kwilebhu, amanqanaba egazini awapheli kwaphela.

UGqr. Alex Jimenez, DC, unikezela: Alukho uphando oluchaza amanqanaba emva kokufakwa kwelungu lobufazi kujonge kumanqanaba amathe okanye womchamo. Ngoko awukwazi ukusebenzisa oko njengendlela yokuyibeka esweni. Ke kwakhona, oku kuya kuba ngumcimbi nje wokulandela umntu kunye nendlela abaziva ngayo emva kokuyisebenzisa. Awuyi kufuna ukuba nexhala malunga nokufumana nayiphi na imilinganiselo emva koko. Yinto nje yeklinikhi. Uvavanyo olukhethayo luxhomekeke kwinto omnika yona umntu, ifom oyinikayo, kwaye ke yintoni ozama ukuyifumanisa. Ngokufumana uxwebhu lonyango oluthandayo kwaye uziva ukhululekile ngalo, qonda ukuba ungalufumana na uvavanyo ngokuxhomekeke kulwakhiwo kunye notshintsho olisebenzisayo. Kwaye ke, qiniseka ukuba ufumana ulwazi oluluncedo kwaye hayi ulwazi olulahlekisayo.