Ikhonkco phakathi kwe-Neuroinflammation & Neurodegenerative Diseases

intshayelelo

The ngengqondo ithumela imiqondiso ye-neuron emzimbeni ukuze isebenze iintshukumo zemihla ngemihla njengokuhamba, ukubaleka, okanye ukuphumla. Ezi zibonakaliso zihamba ukusuka kwi- umqolo ngeengcambu ezininzi zemithambo-luvo ezidityaniswe nezihlunu, izicubu, kunye nemigqaliselo exhasa amalungu kunye namalungu avela kwizinto ezininzi. Nangona kunjalo, ezi zinto ziyawuchaphazela umzimba ngokuhamba kwexesha, zibangela imiba ebangela intlungu kunye nokuphazamiseka emzimbeni. Xa oku kusenzeka, kuphazamisa imiqondiso ekuhambeni ukuya naphambili ebuchotsheni, kubangele ukungasebenzi kakuhle emzimbeni kwaye kukhokelela ekubeni ukuphazamiseka kwemithambo-luvo ezinxulumene neuroinflammation. Inqaku lanamhlanje lijonga i-neuroinflammation, ukuba iwuchaphazela njani umzimba, kwaye yintoni ikhonkco phakathi kwe-neuroinflammation kunye nezifo ze-neurodeergenerative. Sithumela izigulana kubaboneleli abaqinisekisiweyo abaziingcali kunyango lwe-neurological ukunceda abantu abaninzi abajongana ne-neuroinflammation ehambelana nezifo ze-neurodeergenerative. Sikwakhokela izigulana zethu ngokubhekisa kubaboneleli bethu bezonyango abanxulumeneyo ngokusekelwe kuvavanyo lwabo xa kufanelekile. Sifumanisa ukuba imfundo sisisombululo sokubuza ababoneleli bethu imibuzo ecacileyo. UDkt Alex Jimenez DC unikezela ngolu lwazi njengenkonzo yemfundo kuphela. isikhanyeli

Yintoni iNeuroinflammation?

 

Ngaba ufumana ukudinwa kwaye ulahlekelwe kukugxila kwingqondo yakho? Ngaba usoloko uziva uxinezelekile okanye usebenza kakhulu? Okanye kuthekani ngokuphuhlisa umngcipheko we-Alzheimer okanye ezinye izifo zemithambo-luvo? Uninzi lwezi mpawu zihambelana ne-neuroinflammation kwingqondo. Neuroinflammation ichazwa njengempendulo yokuvuvukala echaphazela ingqondo okanye intambo yomgogodla. Umzimba unothungelwano olubanzi olwaziwa ngokuba sisixokelelwano somzimba, esivelisa iicytokines, amajoni omzimba, iiseli ezimhlophe zegazi, kunye neminye imichiza ekhusela umzimba kubahlaseli bamanye amazwe. Ukuvelisa i-cytokines kubangela ukuvuvukala emzimbeni apho abahlaseli bangaphandle bapheliswa. Ingqondo ngokumangalisayo ine-immune system, ebonelela ngesondlo kunye neplastiki. Xa izinto ezibuhlungu ziqala ukuchaphazela i-immune system, i-nociceptors iba yi-hypersensitive kunye ne-excited ngenxa yeziphumo zokulimala kwezicubu kunye nokuvuvukala kwinkqubo ye-nervous peripheral. Uphando lutyhila ukuba ukudumba kwi-peripheral nervous system kuphuma ku-hyperactivity kwinkqubo ye-nervous, echaphazela nokuba sisiphumo esihle okanye esibi kwingqondo.

 

Ingaba iNeuroinflammation iwuchaphazela njani uMzimba?

Ekubeni i-neuroinflammation ineziphumo ezilungileyo okanye ezimbi kwinkqubo ye-nervous, inokuthi ibangele umzimba, uwenze ungasebenzi. Uphando lutyhila ukuba i-neuroinflammation idibene nokuveliswa kwee-cytokines, i-ROS (iintlobo ze-oksijini ezisebenzayo), kunye nezithunywa zesibini eziba yimiphumo yeempendulo ze-neuroinflammatory. Oku kuthetha ukuba iziphumo ezivuthayo zithathelwa ingqalelo ngokuxhomekeke kubukhulu kunye nobude beempawu zokuzivikela kwi-system ye-nervous, enokuthi ibe yinto engalunganga okanye efanelekileyo. Imiba emihle ye-neuroinflammation ibandakanya:

• Ukuhlengahlengiswa kwezinto eziphambili ngokubaluleka (unxibelelwano lwe-immune-brain)
• Ukulungiswa kwezicubu (ukunciphisa ukwenzakala)
• Ukhuseleko lwe-Neuro (ukhuselo lwe-pre-conditioning)
• Ukuphucula i-neuro-plasticity (uphuhliso, umsebenzi wememori)

Ngelixa imiba engalunganga ye-neuroinflammation ibandakanya:

• Ukuphazamiseka kwengqondo (ukuguga)
• Umonakalo wokuzibambisa (ukwenzakala okubuhlungu)
• Umonakalo we-neuronal (izifo ze-neurodeergenerative)
• Uxinzelelo oluphindaphindiweyo lokoyiswa kwentlalo (ixhala, ukudakumba)

 

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Ingcaciso eyenziwe lula kwi-Neuroinflammation-Video

Ngaba ukhe waziva unexhala okanye udandathekile? Ngaba sele ulibele ngoku? Ngaba ufumana iziphumo ezivuthayo kwingqondo yakho? Uninzi lwezi mpawu luphawu lokuba unokuchaphazeleka kwi-neuroinflammation ebuchosheni. Le vidiyo ingasentla ichaza i-neuroinflammation kunye nendlela edityaniswa ngayo kumajoni omzimba achaphazela umzimba. Kuba i-neuroinflammation inokubangela imiba eyahlukeneyo yezempilo efana nexhala, uxinzelelo, uxinzelelo kunye nezinye iimpawu ezaziwayo, izifundo zityhila ukuba neuroinflammation luphawu oluqhelekileyo lwezifo ze-neurodeergenerative. Ukuza kuthi ga ngelo xesha, ubudlelwane phakathi kwe-neuroinflammation kunye nezifo ze-neurodeergenerative zibonisa ukuba i-neuroinflammation iye yaba noxanduva lokukhuselwa okungaqhelekanga kwee-cytokines ze-proinflammatory ukuqalisa iindlela zokubonisa umqondiso kwingqondo, iyenze ingasebenzi. 

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Ikhonkco phakathi kwe-Neuroinflammation & Neurodegenerative Diseases

 

Kuba ingqondo lelona ziko lomyalelo womzimba, ikhonkco phakathi kwezifo ze-neurodeergenerative kunye ne-neuroinflammation ziyadibana kwaye zibangele isiphithiphithi emzimbeni. Uphando lutyhila ukuba abalamli abavuthayo kunye ne-neurotoxic bakhululwa kwingqondo, ngaloo ndlela bedala i-neuroinflammation kunye ne-neurodegeneration emzimbeni. Xa umzimba ujongene ne-neuroinflammation, enye yeempawu ezibalaseleyo emzimbeni luxinzelelo olungapheliyo lwe-oxidative. Izifundo zophando ziye zatyhila ukuba i-neuroinflammation inxulunyaniswe noxinzelelo olungapheliyo lwe-oxidative, uphawu olubalulekileyo lwazo zonke izifo ze-neurodeergenerative ezibangela ukuguqulwa kwezakhi zofuzo. Ukuza kuthi ga ngoku, kukhokelela kwi-neurodegeneration. Ngethamsanqa, kukho iindlela zokunciphisa i-neuroinflammation ehambelana nezifo ze-neurodeergenerative. Ezinye zeendlela abantu abaninzi abazisebenzisayo ukunciphisa i-neuroinflammation ziquka:

• Ukutya okuchasene nokudumba (iiavokhado, iintlanzi ezinamafutha, icocoo, iginseng, iGinkgo Biloba, njl.
• Ukulawula iswekile yegazi
• Ukusebenzisa
• Ukulawula uxinzelelo
• Ukulala ngokwaneleyo
• Ukhathalelo lweChiropractic

 Lonke olu tshintsho luncinci luyamangalisa ekunciphiseni i-neuroinflammation kunye nokulawula izifo ze-neurodeergenerative emzimbeni. Oku kuya kunceda abantu abaninzi abajongana ne-neuroinflammation ehambelana nezifo ze-neurodeergenerative kwaye banokuphinda bafumane impilo kunye nempilo yabo ngokuyilawula.

 

isiphelo

Ingqondo liziko lomyalelo eliphambili elithumela imiqondiso ye-neuron emzimbeni ukuze isebenze kwintshukumo yemihla ngemihla. Iimpawu ze-neuron zihamba zisuka ebuchotsheni ziye kwintambo yomgogodla ngokusebenzisa iingcambu ezininzi zemithambo-luvo eziqhagamshelwe kwizihlunu, izicubu, kunye nemigqaliselo yokuxhasa amalungu kunye namalungu. Xa izinto zokusingqongileyo zichaphazela umzimba ngokuhamba kwexesha, oko kusemngciphekweni wokukhula kwe-neuroinflammation ehambelana nezifo ze-neurodeergenerative. I-Neuroinflammation kuxa abalamli abavuthayo baqala ukuchaphazela ingqondo, inokwenza ingqondo iphazamise imiqondiso ye-neuron ukusuka ekuhambeni ukuya emzimbeni kwaye ibangele imiba ehambelana ne-neurodegeneration. Ngethamsanqa, ukudibanisa iindlela ezahlukeneyo zokunciphisa i-neuroinflammation kunokunceda ukulawula izifo ze-neurodeergenerative kwaye kuzuze umzimba.

 

Ucaphulo

Chen, Wei-Wei, et al. "Indima ye-Neuroinflammation kwi-Neurodeergenerative Diseases (Uphononongo)." Iingxelo zeMolekyuli yamayeza, DA Spandidos, Epreli 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4805095.

DiSabato, Damon J, et al. "I-Neuroinflammation: UMtyholi ukwiinkcukacha." Journal of Neurochemistry, Ilayibrari yeSizwe yaseMelika yoNyango, Okthobha 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5025335/.

UGuzman-Martinez, uLeonardo, kunye nabanye. "I-Neuroinflammation njengeNxibelelwano eqhelekileyo ye-Neurodeergenerative Disorders." Imida kwi-Pharmacology, Frontiers Media SA, 12 Septemba 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6751310/.

Kempuraj, D, et al. "I-Neuroinflammation yenza i-Neurodegeneration." Ijenali ye-Neurology, i-Neurosurgery kunye ne-Spine, ILayibrari yeSizwe ka-US yamayeza, 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC5260818/.

UMatsuda, uMegumi, et al. "Iindima zoKudumba, uKudumba kweNeurogenic, kunye neNeuroinflammation kwiintlungu." Ijenali ye-Anesthesia, ILayibrari yeSizwe yaMayeza yase-US, ngoFebruwari 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6813778/.

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