I-Fiber Neuropathy encinci: Yintoni ekufuneka uyazi

Abantu abafunyaniswa benesifo se-peripheral neuropathy, okanye abane-fiber neuropathy encinci, banokuqonda iimpawu kwaye babangele uncedo ngonyango olunokubakho?

IFayibha encinci Neuropathy

I-fiber neuropathy encinci yi-classification ethile ye-neuropathy, njengoko kukho iintlobo ezahlukeneyo, ezinobungozi be-nerve, umonakalo, izifo, kunye / okanye ukungasebenzi. Iimpawu zinokubangela intlungu, ukulahlekelwa yimvakalelo, kunye neempawu zokugaya kunye nomchamo. Uninzi lweziganeko ze-neuropathy ezifana ne-peripheral neuropathy zibandakanya iintsinga ezincinci nezinkulu. Izizathu eziqhelekileyo ziquka isifo seswekile sexesha elide, ukunqongophala kwesondlo, ukusetyenziswa kotywala, kunye ne-chemotherapy.

• I-fiber neuropathy encinci ifunyaniswa emva kovavanyo lokuxilonga olubonisa kucacile ukuba i-nerve fibers encinci ibandakanyeka.
• Imicu encinci ye-nerve ibona ukuvakalelwa, ubushushu, kunye nentlungu kwaye inceda ukulawula imisebenzi engabonakaliyo.
• I-neuropathy ye-fiber encinci ekwanti inqabile, kodwa uphando luyaqhuba kuhlobo lomonakalo wemithambo-luvo kunye nonyango olunokubakho. (UStephen A. Johnson, et al., 2021)
• I-fiber neuropathy encinci ayiyongozi ngokukodwa kodwa luphawu/uphawu lonobangela/imeko eyonakalisa imithambo-luvo yomzimba.

iimpawu

Iimpawu ziquka: (UHeidrun H. Krämer, et al., 2023)

• Ubuhlungu - iimpawu zinokuthi zisuse ekuphatheni okuncinci okanye okuphakathi ukuya kwiintlungu ezinzima kwaye zingenzeka nanini na.
• Ukuphulukana nemvakalelo.
• Ngenxa yokuba imicu encinci ye-nerve inceda ekutyeni, uxinzelelo lwegazi, kunye nolawulo lwesinyi-impawu zokungasebenzi kakuhle kwe-autonomic zinokwahluka kwaye zinokubandakanya:
• Ukuqunjelwa, isifo sohudo, ukungahambi kakuhle, ukugcinwa komchamo - ukungakwazi ukukhupha ngokupheleleyo i-bladder.
• Ukuba kukho umonakalo oqhubekayo we-nerve, ubuninzi beentlungu buya kuncipha, kodwa ukulahlekelwa kwemvakalelo eqhelekileyo kunye neempawu zokuzimela kunokuba nzima. (UJosef Finsterer, uFulvio A. Scorza. 2022)
• I-Hypersensitivity ekuthinteni kunye neentlungu zentlungu zingabangela intlungu ngaphandle kwe-trigger.
• Ukulahlekelwa kwemvakalelo kungenza abantu bangakwazi ukubona ngokuchanekileyo ukuvakalelwa, ukushisa, kunye nentlungu kwiindawo ezichaphazelekayo, ezinokuthi zikhokelela kwiintlobo ezahlukeneyo zokulimala.
• Nangona uphando olongezelelweyo lufunekayo, ukuphazamiseka okuthile okungazange kuthathwe njenge-neuropathies kunokuba neenxalenye ezincinci ze-fiber neuropathy ezibandakanyekayo.
• Uphononongo lucebise ukuba i-neurogenic rosacea, imeko yesikhumba, inokuba nezinto ezithile ze-fiber neuropathy encinci. (UMin Li, et al., 2023)

IiFayibha zeNerve ezincinci

• Kukho iindidi ezininzi ze-nerve fibers ezincinci; ezimbini kwi-fiber neuropathy ezincinci ziquka i-A-delta kunye ne-C.UJosef Finsterer, uFulvio A. Scorza. 2022)
• Le micu encinci ye-nerve isasazwa kuwo wonke umzimba kubandakanywa phezulu kweminwe kunye neenzwane, i-trunk, kunye nezitho zangaphakathi.
• Le micu idla ngokufumaneka kwiindawo ezingaphaya komzimba, njengakumphezulu wolusu. (Mohammad A. Khoshnoodi, et al., 2016)
• Imicu emincinci ye-nerve eyonakaliswayo ibandakanyeka ekudluliseleni iintlungu kunye neemvakalelo zobushushu.
• Uninzi lwemithambo-luvo inohlobo olukhethekileyo lokugquma olubizwa ngokuba yi-myelin oluyikhuselayo nokwandisa isantya semithambo-luvo.
• Imicu emincinci yemithambo-luvo inokuba ne-sheath ebhityileyo, ibenze babe sesichengeni sokwenzakala kunye nomonakalo kumanqanaba angaphambili eemeko kunye nezifo. (UHeidrun H. Krämer, et al., 2023)

Abantu Abasemngciphekweni

Uninzi lweentlobo ze-peripheral neuropathy zibangela umonakalo kwi-peripheral nerve fibers ezincinci kunye ezinkulu. Ngenxa yoku, uninzi lwe-neuropathies luxube lwe-fiber encinci kunye ne-fiber neuropathy enkulu. Imiba eqhelekileyo yomngcipheko we-fiber neuropathy edibeneyo ibandakanya: (UStephen A. Johnson, et al., 2021)

• Diabetes
• Ukunqongophala kwezondlo
• Ukusela utywala ngokugqithisileyo
• Izifo ezizenzekelayo
• Ubuthi beyeza

I-neuropathy ye-fiber encinci ekwanti inqabile, kodwa kukho iimeko ezaziwa ngokuba negalelo kunobangela kwaye ziquka: (UStephen A. Johnson, et al., 2021)

Sjogren Syndrome

• Le ngxaki ye-autoimmune ibangela amehlo omile kunye nomlomo, iingxaki zamazinyo, kunye neentlungu ezidibeneyo.
• Isenokubangela umonakalo wemithambo-luvo kuwo wonke umzimba.

Isifo sikaFabry

• Le meko ibangela ukwakhiwa kwamafutha / lipids athile emzimbeni onokukhokelela kwimiphumo ye-neurological.

Amyloidosis

• Esi sisigulo esingaqhelekanga esibangela ukwakheka kweeprotheyini emzimbeni.
• Iiprotheni zingonakalisa izicubu ezinjengentliziyo okanye imithambo-luvo.

Lewy Body Disease

• Esi sisiphazamiso semithambo-luvo esibangela ukuphambana kwengqondo kunye nokuphazamiseka kokuhamba kwaye kunokukhokelela kumonakalo wemithambo-luvo.

Lupus

• Esi sisifo se-autoimmune esichaphazela amalungu, ulusu, kwaye ngamanye amaxesha izicubu zemithambo-luvo.

Ukosuleleka yintsholongwane

• Olu sulelo ludla ngokubangela ukubanda okanye ukucaphuka kwesisu/i-GI.
• Kancinci kaninzi zinokubangela ezinye iziphumo ezifana ne-fiber neuropathy encinci.

Ezi meko ziye zabonwa zibangela ukuba i-neuropathy encinci ye-fiber okanye iqale njenge-neuropathy ye-fiber encinci ngaphambi kokuba iqhubele phambili kwi-nerve fibers. Basenokuqala njenge-neuropathy edibeneyo, kunye neentsinga ezincinci nezinkulu.

Inkqubela

Ngokufuthi umonakalo uhambela phambili ngesantya esilinganiselweyo, nto leyo ekhokelela kwiimpawu ezongezelelekileyo kwiinyanga okanye iminyaka. Imithambo-luvo yefiber echatshazelwa yimeko esisiseko idla ngokuwohloka ngokuthe ngcembe, kungakhathaliseki ukuba ibekwe phi na. (Mohammad A. Khoshnoodi, et al., 2016) Amayeza anokunceda ukunciphisa umonakalo kwiimbilini ze-peripheral. Kubantu abafunyanwe kwisigaba sokuqala, kunokwenzeka ukuyeka ukuqhubela phambili, kwaye kunokuthintela ukubandakanyeka kwemicu emikhulu.

Unyango

Unyango olubhekiselele ekuthinteleni ukuqhubela phambili lufuna ukulawula imeko yonyango esisiseko ngeendlela zonyango ngokuxhomekeke kunobangela. Unyango olunokuthi luthintele ukuqhubela phambili lubandakanya:

• Ulawulo lweswekile yegazi kubantu abanesifo seswekile.
• Ukongezwa kwezondlo kunyango lokunqongophala kwevithamini.
• Ukuyeka ukusetyenziswa kotywala.
• Uxinzelelo lwamajoni omzimba ukulawula izifo ezizimelayo.
• I-Plasmapheresis - igazi lithathwa kwaye i-plasma iphathwa kwaye ibuyiselwe okanye itshintshelwe unyango lwezifo ezizimele.

Unyango lweempawu

Abantu ngabanye banokufumana unyango lweempawu ezingayi kubuyisela umva okanye ukunyanga imeko kodwa ezinokunceda kwisiqabu sexeshana. Unyango lweempawu lungabandakanya: (UJosef Finsterer, uFulvio A. Scorza. 2022)

• Ukulawulwa kweentlungu kunokubandakanya amayeza kunye / okanye i-analgesics ye-topical.
• Unyango lomzimba - ukuzolula, ukuthambisa, ukuthoba, kunye nohlengahlengiso ukugcina umzimba ukhululekile kwaye ubhetyebhetye.
• Ukubuyisela kwimeko yokunceda ukuphucula ukulungelelaniswa, okunokuthi kuphazamiseke ngokulahlekelwa yimvakalelo.
• Amayeza okunciphisa iimpawu ze-GI.
• Ukunxiba iimpahla ezikhethekileyo ezifana neekawusi ze-neuropathy ukunceda kwiimpawu zentlungu yonyawo.

Unyango kunye nolawulo lwezonyango lwe-neuropathies ludla ngokubandakanya i-neurologist. I-neurologist inokumisela amayeza okunceda ukunciphisa iimpawu zentlungu kunye nokubonelela ngongenelelo lwezonyango olufana ne-immunotherapy ukuba kukho inkxalabo yokuba inkqubo ye-autoimmune ingaba yimbangela. Ukongezelela, unyango lunokubandakanya ukunyamekelwa kweyeza lomzimba kunye nogqirha wokubuyisela okanye iqela lonyango lomzimba ukubonelela ngezolula kunye nokuzivocavoca ukunceda ukuqinisa umzimba kunye nokugcina ukuhamba kunye nokuguquguquka.

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I-Peripheral Neuropathy iintsomi kunye neenyaniso

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Ucaphulo

Johnson, SA, Shouman, K., Shelly, S., Sandroni, P., Berini, SE, Dyck, PJB, Hoffman, EM, Mandrekar, J., Niu, Z., Lamb, CJ, Low, PA, Singer , W., Mauermann, ML, Mills, J., Dubey, D., Staff, NP, & Klein, CJ (2021). Isehlo se-Fiber Neuropathy encinci, ukuxhaphaka, ukukhubazeka kwexesha elide, kunye nokukhubazeka. I-Neurology, i-97 (22), e2236-e2247. doi.org/10.1212/WNL.0000000000012894

Finsterer, J., & Scorza, FA (2022). I-fiber neuropathy encinci. I-Acta neurologica Scandinavica, i-145 (5), i-493-503. doi.org/10.1111/ane.13591

Krämer, HH, Bücker, P., Jeibmann, A., Richter, H., Rosenbohm, A., Jeske, J., Baka, P., Geber, C., Wassenberg, M., Fangerau, T., Karst , U., Schänzer, A., & van Thriel, C. (2023). I-Gadolinium i-agent echaseneyo: i-dermal deposits kunye nemiphumo enokubakho kwi-epidermal encinci ye-nerve fibers. Ijenali ye-neurology, i-270 (8), i-3981-3991. doi.org/10.1007/s00415-023-11740-z

Li, M., Tao, M., Zhang, Y., Pan, R., Gu, D., & Xu, Y. (2023). I-neurogenic rosacea inokuba yi-fiber neuropathy encinci. Imida yophando lwentlungu (Lausanne, Switzerland), 4, 1122134. doi.org/10.3389/fpain.2023.1122134

Khoshnoodi, MA, Truelove, S., Burakgazi, A., Hoke, A., Mammen, AL, & Polydefkis, M. (2016). Uvavanyo lweLongitudinal ye-Fiber Neuropathy encinci: Ubungqina be-Distal Axonopathy engaxhomekekanga kubude. I-JAMA ye-neurology, i-73 (6), i-684-690. doi.org/10.1001/jamaneurol.2016.0057