UGqr. Alex Jimenez Unikezela: Usetyenziso loNyango lwe-Anti-Inflammatory Botanicals

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intshayelelo

UDkt Alex Jimenez, DC, ubonisa indlela i-botanicals echasayo kunye ne-phytochemicals enokunciphisa i-cytokines evuthayo enokubangela imiba efana nentlungu emzimbeni. Singena kwindlela amayeza ahlukeneyo anokuchaphazela ngayo i-NF-kappaB kunye nendlela iimeko ezingapheliyo ezinokuchaphazela ngayo ukuvuvukala. Sithumela izigulana zethu kubaboneleli abaqinisekisiweyo ababandakanya ubuchule kunye nonyango oluninzi kubantu abaninzi abaphethwe kukudumba, kwaye iimpawu zayo ezihambelanayo zinokuchaphazela inkqubo ye-musculoskeletal. Sikhuthaza kwaye siyasixabisa isigulana ngasinye ngokusithumela kubaboneleli bezonyango abanxulumeneyo ngokusekwe kuxilongo lwaso xa kufanelekile. Siyaqonda ukuba imfundo yeyona ndlela imangalisayo xa ubuza ababoneleli bethu imibuzo entsonkothileyo ngokwesicelo sesigulana kunye nokuqonda kwakhe. UDkt Jimenez, DC, usebenzisa le ngcaciso kuphela njengenkonzo yemfundo. isikhanyeli

 

Ingaba Umzimba Ujongana Njani Nokudumba

UGqr. Alex Jimenez, DC, unikezela: Iinjongo zethu kukujonga ubungqina bokusebenzisa i-phytochemicals ekhethiweyo kunye ne-botanicals njenge-anti-inflammatory and analgesic agents. Izifundo ezilawulwayo ziye zakhula zibe ngamanani amaninzi kule minyaka idlulileyo, kwaye sinokuziva sizithemba ngakumbi kwezinye iziphumo zabo kuba uninzi lwezi zifundo zenziwe ngabaphandi abasemgangathweni kunye nezifundo eziyilwe kakuhle. Kwaye nangona sizifumana ezi zifundo zipapashwa, ingxaki kukuba asifane sive ngazo. Amajelo eendaba kufuneka awathathe, kwaye aqhelekanga ukungena kwindawo yezonyango ngaphandle kwezifundo zabo. Ukuba uthelekisa oko xa uphando lwamachiza lwenziwa, uyazi ukuba luhlala lusenza iintloko kunye neendaba. Makhe sijonge ezinye zezi botanicals kunye phytochemicals namhlanje.

 

Kwiimeko ze-autoimmune, iintlungu ngumcimbi omkhulu emzimbeni, kwaye sifuna ukusebenzisa iipropathi zayo ze-analgesic. Kwaye ke, kufuneka sichonge ezona phytochemicals ezifanelekileyo kakhulu kunye ne-botanicals kwiimeko ezithile zokuvuvukala kunye neentlungu. Ke, ngaphambi kokuba sitsibe kuloo nto, sifuna ukuphonononga ezinye zeendlela zoxubo mayeza ezidla ngokumiselwa kwiimeko zokukrala kunye ne-autoimmune. Kwanezinye zezinto ezintsha zebhayoloji esibhekisele kuzo kancinci, sifuna ukujonga kuzo kwaye, kwaye sijonge indlela ezisebenza ngayo kunye nezinye iingxaki zazo, kwaye emva koko siya kuphonononga kwezi zityalo zikhoyo kuthi. Ke kubalulekile ukukhumbuza nabani na ukuba zonke izifo eziwohlokayo zinesimo sokudumba okanye ukudumba njengenxalenye yeengcamango zabo ze-biochemical. Kwaye ukudumba yindlela yokugqibela eqhelekileyo yazo zonke ezi zinto zahlukeneyo. Isifo seswekile, i-Alzheimer's, i-atherosclerosis, umhlaza, kunye nezinye izifo zengqondo ezifana ne-schizophrenia kunye nokudakumba zonke zinokudumba njengenye yezizathu zazo. Ngoku kule modyuli, sigxile kwabo bakwizangqa kunye nezi.

 

Njengoko uyazi, ezininzi izifo ezingapheliyo zidibene nokugqithisa, ukuvuvukala okuqhubekayo. Siyibethe kakuhle loo ngongoma ekhaya ngokwaneleyo, njengoko ukudumba okungapheliyo kwenzeka xa ukwenzakala kuqhubeka okanye xa amajoni omzimba angavaleki. Iyasilela kwi-counter-regulation kunye nokuvuvukala okunamandla, okunenzuzo; nangona kunjalo, inokujika ibe kukudumba okungapheliyo ukuba ayiphathwanga. Izifo ezininzi ezingapheliyo ziye zadibaniswa nokuvuvukala okugqithisileyo okanye okuqhubekayo. Xa kuziwa kukuvuvukala okungapheliyo kukhula xa ukwenzakala okanye isiganeko esibuhlungu siqhubeka, sibangela ukuba izihlunu zibe nzima okanye xa amajoni omzimba eqala ukuhlasela umzimba xa kungekho pathogens echaphazela umzimba. Kwaye ukuba unyango oluqhelekileyo lwe-pharmacological lugxininise kwiindlela ezithile ezihlala zisezantsi ngokwenene kuloo nkqubo yokuvuvukala, kwaye kwimbono yeyeza elisebenzayo, sifuna ukujonga kancinci phezulu ukuze sifumanise ukuba yintoni unobangela wokudumba okungapheliyo okubangela oku kuninzi. imiba kulo mntu kunye nendlela i-botanicals echasene nokuvuvukala kunye ne-phytochemicals inokunciphisa le miphumo yokuvuvukala emzimbeni.

 

Ingaba amayeza awenza njani uMzimba?

UGqr. Alex Jimenez, DC, unikezela: Enye yezinto ezinokuthi zongeze iimpawu zokudumba ngamachiza axuba amayeza. Ngoko, umzekelo, ulawulo lwe-pharmacologic njenge-NSAID lunokuthintela i-COX enzyme, ngelixa i-leukotriene inhibitors inhibit i-enzyme ye-LOX. I-DMARD inokuchaphazela iindlela ezahlukeneyo zokuzivikela ezinokuthi ziphembelele ukuphuhliswa kokuvuvukala okungapheliyo. I-Biologics inokuthintela i-cytokines ezininzi emzimbeni, kuquka i-TNF-alpha kunye ne-steroids, enokuchaphazela i-NF-kappaB kunye ne-phospholipase-A2. Ngoko kukho iindlela ezininzi zokuphembelela indlela yokuvuvukala kwaye ibangele imiba yeentlungu kunye nezihlunu.

 

I-Pharmaceuticals ayizona kuphela izinto ezinokubangela ukuba izinto ezivuthayo zichaphazele umzimba; ingaba kukutya esikutyayo okanye indawo esihlala kuyo enokubangela i-NF-kappaB, edibanisa kwi-I-kappaB ngelixa ingena kwi-nucleus kwaye ibophe kwi-DNA. Loo ngongoma ikhokelela ekukhutshelweni kwemizila yemfuza emininzi eyahlukeneyo. Imizila yemfuza yomzimba ayenzi nje kuphela iDNA kodwa inokwenza iRNA. Xa umzimba usenza i-RNA, emva koko i-biotransformed ibe yi-DNA, ekhokelela ekujikweni kweendlela ezahlukeneyo zokudumba. Ngoko xa i-pharmaceutical iqala ukungena emzimbeni, inokuthintela ezinye i-cytokines kunye ne-enzymes ukuba zivule kwaye zibangele ukuvuvukala okungapheliyo, ngaloo ndlela kubangela ukuba iimpawu ezichasene nokuvuvukala zinciphise kwaye zibangele ukuba i-immune system igxininise kwi-NF-kappaB.

 

NSAID

UGqr. Alex Jimenez, DC, unikezela: Ngoko ke makhe siqale ukujonga ii-non-steroidal anti-inflammatories okanye ii-NSAID, ezifumaneka kuyo yonke indawo njengoko zixhaphake kakhulu ukuba abantu abaninzi bafikelele xa besezintlungwini. Kwaye isizathu sokuba bayisebenzise kukuba bayasebenza. I-NSAID inqanda i-cyclooxygenase enzymes kwaye ikhusela ezo prostaglandin ezivuthayo, ezibangela ukuvuvukala kunye nentlungu kwimisipha okanye kumalungu. Ngoku i-paracetamol ilapha, okanye i-acetaminophen ayisiyo-NSAID ngokobuchwephesha, kodwa siya kujonga oko ngokwahlukeneyo.

 

Kodwa ezi NSAID, uyazi, azikho ngaphandle kwemiba, njengoko i-70 yezigidi zemimiselo ye-NSAID ibhalwe e-US ngonyaka. Kwaye ukusetyenziswa kwe-over-the-counter kubandakanya i-30 yeebhiliyoni zeedosi ze-NSAID. Leyo yimali eninzi kakhulu, kwaye akumangalisi ukuba uninzi lwethu luyithathile; siyinxalenye yaloo 30 billion. Nangona kunjalo, eso sixa sinokukhokelela kumathumbu avuzayo kwinkqubo yethu yomzimba. Siyazi unxulumano lwabo kunye nezilonda ze-peptic kunye ne-GI ukopha ngelixa livimbela loo ndlela yokusombulula, okubalulekileyo ukuvala impendulo yokuvuvukala. Ngoko ke makhe sijonge kwii-DMARD okanye ii-anti-rheumatic agents eziguqula izifo. Lunyango lomgca wokuqala kwi-rheumatoid arthritis. Kwaye esinye sezizathu zokuba babelunyango lokuqala kukuba alubizi kakhulu kodwa lusebenza kade kwaye luyancipha ukudumba, kodwa alusebenzi kakuhle ukuthomalalisa iintlungu ngokuthe ngqo.

 

Ke i-methotrexate yi-hydroxychloroquine, okanye i-Plaquenil yaziwa kakhulu ngoku, ngakumbi ngokusetyenziswa kwayo namhlanje. Sekunjalo, i-methotrexate inqanda i-RNA kunye ne-DNA synthesis, esetyenziswe njenge-agent ye-chemotherapy kumhlaza. Kwaye xa inqanda, ichaphazela i-dihydrofolate reductase, efunekayo ukwenza i-DNA kunye ne-RNA; nangona kunjalo, iphinda icinezele ukusebenza kwe-T kunye ne-B-cell ngelixa inqanda i-IL1 beta ekubopheni i-receptors yayo. Ke, ngelishwa, nangona ilunyango lodidi lokuqala, beza neziphumo ebezingalindelekanga ezininzi eziqatha. Kodwa sihlala sithetha ngale ngcamango yeziphumo ebezingalindelekanga; akukho ziphumo ebezingalindelekanga. Ziiziphumo ezithe ngqo zeyeza.

 

Iziphumo Zamachiza

UGqr. Alex Jimenez, DC, unikezela: Uyazi, zinokuba yimiphumo engafunekiyo efana ne-rashes, isisu esibuhlungu, isibindi, umongo wethambo, ubuthi, ukukhubazeka kokuzalwa, kwaye, ngokuqinisekileyo, siya kuyibona ngokuphindaphindiweyo. Naliphi na ixesha xa uvala amajoni akho omzimba, uzivulela usulelo. Ngoko ke uba sesichengeni ngakumbi kusulelo. Ke, jonga ezi DMARD zebhayoloji, ezisebenza njenge TNF-alpha blockers. Ezi DMARD zebhayoloji zisebenza ngokunqanda ukusebenza kwe-T-cell okanye ukuthintela i-TNF, eyona nto ixhaphakileyo, kodwa ziyakwazi nokumisa izinto ezifana ne-IL-six, i-T-cells echithayo, kwaye isebenze ngezinye iindlela. Ezi bhayoloji zibizwa ngokuba zii-biologics kuba ziyi-monoclonal antibodies. Kwaye ke ezi zilwa-buhlungu ze-monoclonal, njengoko zisenza izilwa-buhlungu, zinee-affinities ezibophelelayo ezinamandla kakhulu.

 

Kwaye ke, ukusebenzisa izilwa-buhlungu njengamayeza kube yinkqubela phambili enkulu. Ngoku, njengoko siza kubona, basenokungabi sesona sisombululo sigqibeleleyo sokunyanga isifo esizisebenzelayo, kodwa banesithembiso esikhulu, ngakumbi xa sifuna ukucaciswa kwabo. Ngoko kukho iimeko ezininzi ezingapheliyo ukuba i-NSAIDs DMARDs okanye i-Biologic DMARDs inokufihla ukuvuvukala kwaye ibangele intlungu kwimisipha kunye namalungu. Ezinye zezigulo ezingapheliyo ziquka:

• Ankylosing-spondylitis
• Arthritis
• Isifo sikaCrohn
• Endometriosis
• Psoriasis
• Irheumatoid arthritis
• Osteoarthritis
• Fibromyalgia
• Lupus

 

isiphelo

UGqr. Alex Jimenez, DC, unikezela: La mayeza anokuzinciphisa iintlungu azivayo umntu ngezi meko, kodwa zezokwexeshana kwaye ziyawuvala lo mbandela de umntu aye kunyango. Xa umntu ene-autoimmune okanye isifo esingapheliyo esinxulumene nokudumba, ixabiso lalo naliphi na iyeza liphezulu. Nangona amayeza alungileyo abalulekile, kufuneka sijonge unyango olunokuthi luhlolisise iimeko ezingaziwayo okanye ezinqabileyo ezinokunciphisa iziphumo ezivuthayo ezibangela intlungu kunye nemisipha.  Ukubandakanya i-botanicals echasene nokudumba kunye nezongezelelo ezifana:

• Ioli yeentlanzi
• Curcumin
• Ukukhupha ijinja
• I-Tea eluhlaza
• Resveratrol

Zonke zinezixhobo ezichasayo ezinokunciphisa i-cytokines ezivuthayo ezivela kwi-muscle kunye namalungu kwaye zidibanise nonyango lomzimba. Unyango lomzimba lunokuvumela umzimba ukuba uziphilise kwaye uya kwenza ukuba umntu angabi nazintlungu ngokwemvelo.

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