Amathumbu Ahlukeneyo YiMicrobiome esempilweni

intshayelelo

The Inkqubo yamathumbu likhaya kwiibhaktheriya ezininzi eziluncedo eziqinisekisa ukuba yonke into isebenza ngokuchanekileyo. Amalungu enza inkqubo yamathumbu ancedisa ukuthutha izondlo kunye negazi eline-oxygen kwimisipha, izicubu, iinqanawa kunye neengcambu zemithambo-luvo ezivumela umzimba ukuba usebenze. Amathumbu nawo anxibelelana ne ngengqondo kwaye i inkqubo yomzimba ukunika amandla ayimfuneko ukwenza umzimba uhambe ukusuka kwindawo ukuya kwenye. Xa izinto eziphazamisayo ziqala ukuphazamisana ne-gut microbiota, kunokubangela izinto ezivuthayo kunye neminye imiba enxulumene namathumbu ukutshabalalisa iindonga zamathumbu emathunjini kwaye zichaphazele impilo yonke yomntu. Inqaku lanamhlanje lizakugxila kwindima ye-gut microbiome emzimbeni, ukusebenza kwemetabolism yeebhaktheriya zamathumbu, kunye nendlela izinto ezahlukeneyo ezinokuchaphazela ngayo amathumbu ekusebenzeni ngokuchanekileyo. Ukubhekisa izigulana kubaboneleli abaqeqeshiweyo nabanezakhono abaziingcali kunyango lwe-gastroenterology. Sikhokela izigulana zethu ngokubhekisa kubaboneleli bethu bezonyango abanxulumeneyo ngokusekelwe kuvavanyo lwabo xa kufanelekile. Sifumanisa ukuba imfundo ibalulekile ekubuzeni imibuzo ecacileyo kubaboneleli bethu. UDkt Jimenez DC unikezela ngolu lwazi njengenkonzo yemfundo kuphela. isikhanyeli

 

Ngaba i-inshorensi yam ingayihlawula? Ewe, kunokwenzeka. Ukuba akuqinisekanga, nali ikhonkco kubo bonke ababoneleli beinshorensi esibakhuselayo. Ukuba unemibuzo okanye iinkxalabo, nceda ufowunele uDkt Jimenez kwi-915-850-0900.

Indima yeGut Microbiome eMzimbeni

 

Ngaba ubuziva ugula sisisu sakho? Ngaba uziva udumbile kumbindi wecandelo lomzimba wakho? Ngaba uziva unovelwano kukutya obukutyayo? Uninzi lwezi mpawu yimiba enxulumene namathumbu echaphazela i-gut microbiome. I-gut microbiota idlala indima ebalulekileyo ye-metabolic kwiinkqubo ezininzi ezinceda ukugcina umzimba usebenza ngokugcina ulungelelwano oluthambileyo kunye nokuthetha ngokunqamlezayo kunye ne-immune system. Izifundo zophando zibonisile ukuba i-gut microbiome ilikhaya kuluntu oluntsonkothileyo kwaye oluguquguqukayo lwezityalo zamathumbu eziphembelela umzimba. Kuba i-gut microbial ecosystem ithathwa njengelona lungu likhulu le-endocrine emzimbeni, inokuvelisa iikhompawundi ezahlukeneyo zebhayoloji ezisebenza ngokufanayo neehomoni. Ezi khompawundi zithwalwa ngokujikeleziswa kwaye zisasazwe kwiindawo ezikude ngaphakathi komkhosi, ziphembelela iinkqubo zebhayoloji ezibalulekileyo ezahlukeneyo. Ezinye izifundo zophando zikhankanyile ukuba i-intestinal tract in the body intestinal ecosystem ecosystem enokuphenjelelwa zizinto ezininzi ezichaphazela i-gut microbiome ekubunjweni kwayo kunye notshintsho. Olunye lolu tshintsho lunceda ukukhula kakuhle kwebhaktheriya kwi-gut microbiota.

 

Umsebenzi weMetabolic weBacteria emathunjini

Xa umntu esitya ukutya okunesondlo, uhamba emathunjini ukuze abe biotransformed zibe izondlo. Yenza indlela yayo emathunjini, apho igcinwa kwaye ilungele ukuhanjiswa kuwo wonke umzimba. Xa ukutya kokugaya kuhleli emathunjini, kulapho ibhaktheriya enenzuzo yamathumbu ingena kwaye inceda ukubumba i-gut microbiota. Izifundo zophando zibonisile ukuba iibhaktheriya eziluncedo emathunjini zidlala indima ebalulekileyo kwi-gut microbiome njengoko inceda ukugcina i-immune kunye ne-homeostasis ye-metabolic. Umsebenzi we-metabolism yebhaktheriya emathunjini emzimbeni inceda ukophula iifayibha zokutya ezithi emva koko zijike zibe zii-SCFAs (iiasidi ezinamafutha amafutshane). Eminye imisebenzi eyenziwa yintsholongwane yamathumbu kwi-gut microbiome ibandakanya:

• Ukuveliswa kweePhenols
• Ukuchithwa kwe-oligosaccharides
• Inceda ukulawula Amafutha, TG, kunye neCholesterol
• Ukufunxa iivithamini
• Ukuveliswa kwe-mucous
• Ukuxutyushwa

 

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Isishwankathelo sevidiyo ehlukeneyo yeGut

Ngaba ubuziva utyhafile imini yonke? Ngaba uziva uqhinile okanye udumbile? Ngaba uye wanovelwano ngokutya okuthandayo? Ukuba ubujongene nale miba kubomi bakho bonke, inokuba kungenxa ye-microbiome yakho yamathumbu ethetha nawe. Le vidiyo ingasentla icacisa indlela i-gut microbiome lelinye lamalungu abalulekileyo emzimbeni kuba inceda kwizinto ezahlukeneyo zebhayoloji kwinkqubo yamathumbu. Ukubaluleka kokwahlukahlukana okukhulu kweentsholongwane kunxulunyaniswa namandla omzimba okujongana noxinzelelo, njengeentsholongwane ezithatha amathuba okanye ukuphazamiseka kokutya okuchaphazela inkqubo yokwetyisa. Xa abantu benezifo ezinxulumene namathumbu, kunokwenzeka ukuba batshintshe i-microbiome yabo yamathumbu kunabantu abasempilweni. Ubudlelwane obuninzi phakathi kokuncipha kweyantlukwano ye-microbial kunye nokugula zirekhodwa kuncwadi ukuze abantu bafumanise ukuba kuqhubeka ntoni kwinkqubo yabo yamathumbu. Ukugcina amathumbu asempilweni kunokuthintela imingcipheko efana nezifo ze-metabolic ezifana nohlobo lwe-2 yeswekile, i-IBD (isifo samathumbu esivuthayo), i-SIBO, kunye nezinye izinto ezibeka ingozi emathunjini ekuchaphazeleni amathumbu.

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Izinto ezinokuchaphazela iThumbu

 

Xa kukho imeko yokungalingani kwe-microbial ecology enegalelo ekuchaphazeleni umlinganiselo weebhaktheriya zamathumbu, kunokubangela izifo ezininzi ezingapheliyo ezibangela ukuba umzimba ungasebenzi. Ukukhula okugqithisileyo kwezilwanyana ezincinci kwintsholongwane ephantsi ye-intrinsic virulence kubangela isifo ngokuguqula:

• Ubume besondlo
• Ukusabela komzimba
• Amandla okuphelisa umamkeli

Izifundo zophando zifumene ukuba izinto ezichaphazela i-gut microbiome zinokubangela iindlela zokukrala ezihlasela iindonga zamathumbu kwaye zivumele ibhaktheriya ukuba iphume. Ezinye izinto ezinje ngoxinzelelo okanye ukugqabhuka ngokweemvakalelo kunokubangela ukukhula kweebhaktheriya eziyingozi ukuba zigqithise iibhaktheriya ezilungileyo. Oku kubangela ukuba i-gut microbiome ingasebenzi kwaye iqhubele phambili kwimiba engapheliyo yamathumbu. Ezinye izifundo zophando zibonisile ukuba izinto zokusingqongileyo zikwadlala indima ekuguquleni i-gut microbiome. Ezi zinto zibangela utshintsho olungafunwayo olunokumenzakalisa umntu engazi nokwazi. Ukubonisa ukuba zeziphi izinto ezichaphazela amathumbu zinokuthintelwa xa umntu ebeka umsebenzi wokuphucula impilo yakhe. 

 

isiphelo

Njengoko bekutshiwo ngaphambili kwinqaku lanamhlanje, i-gut microbiome ithathwa njengelona lungu likhulu le-endocrine elinceda ukuqinisa amajoni omzimba kunye ne-homeostasis emzimbeni. Ke ngoko, ukuzalisa i-gut microbiome ngeebhaktheriya eziluncedo kunokunceda ukusombulula uninzi lwemiba engapheliyo echaphazela umzimba. Xa izinto zokusingqongileyo zibangela umonakalo kwinkqubo yamathumbu, inokuchaphazela wonke umzimba ukuba awuphathwa ngoko nangoko. Ukuphelisa izinto eziyingozi zokusingqongileyo kubomi bemihla ngemihla bomntu kunokubonelela ngesiqabu ebesisoloko besifuna.

 

Ucaphulo

Al Bander, Zahraa, et al. "I-Gut Microbiota kunye noKudumba: Isishwankathelo." Ijenali yehlabathi yoPhando lwezeNdalo kunye neMpilo yoLuntu, MDPI, 19 Okt. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7589951/.

UDurack, uJuliana, kunye noSusan V Lynch. "I-Gut Microbiome: Ubudlelwane Nezifo kunye namathuba oNyango." Ijenali yoMfuniselo woNyango, Rockefeller University Press, 7 Jan. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6314516/.

Ferraris, Cinzia, et al. "I-Gut Microbiota yeMpilo: Ukutya kunokusigcina njani iGut Microbiota esempilweni?" Amanzi, MDPI, 23 Nov. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7700621/.

ULobionda, uStefani, kunye nabanye. "Indima ye-Gut Microbiota kwi-Intestinal Inflammation ngokumalunga nokutya kunye neeStressors zangaphandle." Iintsholongwane, MDPI, 19 Agasti 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6722800/.

NgoLwesine, uElizabhete, kunye noNathalie Juge. "Intshayelelo kwiMicrobiota yaBantu." Ijenali ye-Biochemical, Portland Press Ltd., 16 May 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5433529/.

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