I-Biologics ye-Ankylosing Spondylitis: I-El Paso ye-Back Clinic

I-Ankylosing spondylitis yimeko yokuvuvukala ebangela intlungu kunye nokuqina kumalungu omqolo.. Ngokuhamba kwexesha, inokuqhubela phambili ekudibaniseni amathambo omqolo / i-vertebrae, ukunciphisa ukuhamba komgudu kunye nokukhokelela kwiimpawu ezingathandekiyo. Le meko ixhaphake kakhulu emadodeni kodwa ikwachaphazela nabasetyhini. Akukho sizathu saziwayo, esikwisinye, kodwa ngabantu abanesizathu esithile ufuzo, HLA-B27, banomngcipheko okhulayo wokuphuhlisa imeko. Nangona kunjalo, i-gene ngokwayo ayithethi ukuba umntu une-spondylitis e-ankylosing; imfuzo kunye nezinye izinto zangaphandle nezisingqongileyo nazo zinendima. iiDMARDs, or Izifo-Ukuguqula Amachiza eAntirheumatic, cinezela ukuvutha. Unyango olusakhulayo lwe-DMARD lusebenzisa i-biologics ejolise ngakumbi kwaye icinezela iikhompawundi ezithile ezivuthayo.

Biologics

Ngokungafaniyo namayeza aqhelekileyo, adibeneyo, ibhayoloji yenziwe kwimithombo ephilayo nangaphakathi.

• Zikhuliswa kwiinkcubeko okanye zivunwa egazini.
• Iibhayoloji zintsonkothile kwaye ziyabiza.
• I-Biologics ibonelela ngonyango olunamandla kwiimeko ezininzi.
• Iibhayoloji ezimbini eziqhelekileyo ezisetyenziselwa ukunyanga i-ankylosing spondylitis zezi:
• I-TNF inhibitors.
• I-IL-17 inhibitors.

I-TNF Inhibitors

• I-TNF - i-tumor necrosis factor, i-TNF inhibitors iyeza lebhayoloji elijolise kwaye licinezele i-TNF, ebandakanyeka kwiinkqubo ezivuthayo kuwo wonke umzimba.
• Ukuthintela okanye ukucinezela i-TNF kunciphisa ukuvuvukala kwaye kunokulibazisa ukuqhubela phambili kwe-ankylosing spondylitis.
• Inokulawulwa ngenaliti okanye ngokutofelwa ukunika iyeza.

Imiphumela

Iziphumo ebezingalindelekanga ezinxulumene neli yeza, kunye nezinye iimeko, zibandakanya:

• Ukukhathazeka kwesikhumba – irhashalala okanye usulelo
• Ukumelwa yintliziyo
• Lupus
• Lymphoma
• Iziphazamiso ezijolise kwinkqubo yemithambo-luvo aziwa njenge ukuphazamiseka kwengqondo. Oku kunokubandakanya iimeko ezifana nezi:
• Isifo sokugubhuka
• Isifo seGuillain-Barré

I-IL-17 Inhibitors

• IL - interleukin - I-IL-17 yiprotheni echaphazelekayo kwiinkqubo ezivuthayo kunye neemeko.
• I-IL-17 inhibitors icinezela ukudumba okungamayeza amatsha abonakaliswe ukuba anceda abo bane-ankylosing spondylitis.
• Oogqirha bahlala belawula i-IL-17 inhibitors ngenaliti.

Imiphumela

Iziphumo ebezingalindelekanga ezincinci ziquka:

• Intloko
• Impumlo enemifinya
• Ukucaphuka kwindawo yokutofa.

Iziphumo ezibi kakhulu ziquka:

• Eminye i cancer
• Usulelo oluqatha
• Igazi elonyukayo

Okunye ngonyango

Iinjongo zonyango lwe-ankylosing spondylitis ziquka:

• Ukunciphisa ukuqhubela phambili kokuphazamiseka.
• Ukunciphisa ukuvuvukala.
• Ukunciphisa intlungu.
• Ukuphucula okanye ukugcina uluhlu oludibeneyo kunye nomqolo wokuhamba.

I-Biologics ayilona unyango lokuqala lwe-spondylitis ye-ankylosing.

• Ababoneleli badla ngokunyanga uxilongo lokuqala ngamayeza achasene nokudumba, njengee-NSAID, ukunciphisa ukudumba kunye nokucothisa ukuqhubeka kwemeko.
• Ukunyamekela kwe-Chiropractic kunye nokunyangwa ngokomzimba kunconywa ukuba kugcinwe kunye / okanye ukuphucula ukuma, amandla omzimba kunye nokunyamezela.
• Indlela yokuphila ecetyiswayo kunye nohlengahlengiso lwesondlo.
• Uqeqesho lwesimo luzolula kunye nemithambo.
• Izicwangciso ezifanelekileyo zentshukumo zokugqiba ngokukhuselekileyo nangokuzithemba imisebenzi yemihla ngemihla.

Amayeza ebhayoloji

I-Biologics ye-spondylitis ye-ankylosing inokuba okanye ingafaneleki. La mayeza enzelwe ukunceda ukudambisa ukudumba okunxulunyaniswa nemeko kunye nokucothisa ukuqhubela phambili kwesi sifo. Iqela lakho lokhathalelo lwempilo liza kusebenza nawe ukumisela unyango/unyango olululo kwaye lichaze uncedo, imingcipheko, kunye neentlobo zonyango. Baya kubeka iliso kwimeko, balandele inkqubela phambili, kwaye balungise isicwangciso ngokufanelekileyo.

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Uvavanyo loNyango lweHormone

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Ucaphulo

Ankylosing spondylitis. (nd) Iziko leSizwe leArthritis kunye neMusculoskeletal and Skin Diseases. ISebe lezeMpilo lase-US kunye neeNkonzo zoLuntu. Ifumaneka e: www.niams.nih.gov/health-topics/ankylosing-spondylitis#:~:text=Ankylosing%20spondylitis%20is%20a%20type,the%20spine%20can%20cause%20stiffness (Kufikelelwe kwi: Okthobha 12, 2022).

I-Chen C, i-Zhang X, i-Xiao L, i-Zhang X, i-Ma X. Ukusebenza okuFaniswayo kwe-Biologic Therapy Regimens ye-Ankylosing Spondylitis: Ukuphononongwa ngokuchanekileyo kunye ne-Network Meta-Analysis. Iyeza (Baltimore). 2016 Mar;95(11):e3060. doi: 10.1097/MD.0000000000003060. PMID: 26986130; I-PMCID: PMC4839911.

Gerriets V, Goyal A, Khaddour K. Tumor Necrosis Factor Inhibitors. [Ihlaziywe ngo-2022 kaJulayi 4]. Ku: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Ifumaneka kwi: www.ncbi.nlm.nih.gov/books/NBK482425/

Lindström, U., Olofsson, T., Wedrén, S. et al. Unyango lwebhayoloji ye-ankylosing spondylitis: uphononongo lwelizwe lonke lweendlela zonyango kwinqanaba lesigulana ekusebenzeni kweklinikhi. I-Arthritis Res Ther 21, 128 (2019). doi.org/10.1186/s13075-019-1908-9

Yin, Y., Wang, M., Liu, M. et al. Ukusebenza kunye nokhuseleko lwe-IL-17 inhibitors kunyango lwe-ankylosing spondylitis: ukuphononongwa ngokuchanekileyo kunye nohlalutyo lwemeta. I-Arthritis Res Ther 22, 111 (2020). doi.org/10.1186/s13075-020-02208-w