Uvavanyo lweGazi lokuxilonga i-Ankylosing Spondylitis Back Clinic

Ukuxilongwa i-ankylosing spondylitis ngokuqhelekileyo kubandakanya iimvavanyo ezininzi. Xa oogqirha beyalela uvavanyo lwegazi ukufumanisa i-ankylosing spondylitis, umntu ufumana iimpawu eziya zisiba mandundu kumqolo kunye namalungu. Rhoqo, ukuxilongwa kovavanyo lwegazi kuthetha ukuba ugqirha ukhangela ubungqina bayo nayiphi na enye into enokubangela iimpawu. Nangona kunjalo, iimvavanyo zegazi ngokwazo azikwazi ukuxilonga ngokuqinisekileyo i-ankylosing spondylitis, kodwa xa idibene nemifanekiso kunye novavanyo, inokubonelela ngeempawu ezibalulekileyo ezikhomba iimpendulo.

Uvavanyo lwegazi lwe-Ankylosing Spondylitis

I-Ankylosing spondylitis sisifo samathambo ichaphazela ikakhulu umqolo kunye nezinqe. Kunokuba nzima ukuxilonga njengoko kungekho vavanyo olunye olunokubonelela ngolwazi olugqibeleleyo loxilongo oluqinisekileyo. Kusetyenziswa indibaniselwano yovavanyo lokuxilonga, kubandakanywa uvavanyo lomzimba, umfanekiso, kunye novavanyo lwegazi. Oogqirha abakhangeli kuphela iziphumo eziza kubhekisela kwi-spondylitis ye-ankylosing, kodwa bafuna nayiphi na imiphumo enokuthi ibhekiselele kwimiphumo ye-spondylitis enokubonelela ngengcaciso eyahlukileyo yeempawu.

Uviwo loMzimba

Inkqubo yokuxilongwa iya kuqala ngembali yonyango lomntu ngamnye, imbali yosapho, kunye novavanyo lomzimba. Ngexesha loviwo, ugqirha uya kubuza imibuzo ukunceda ukulawula ezinye iimeko:

• Zinexesha elingakanani iimpawu zibonakalisa?
• Ngaba iimpawu ziba ngcono xa uphumla okanye ujima?
• Ngaba iimpawu ziya ziba mandundu okanye zihlala zifana?
• Ngaba iimpawu zibi ngakumbi ngexesha elithile losuku?

Ugqirha uya kujonga imida ekuhambeni kunye neendawo zethenda ze-palpate. Abaninzi iimeko zingabangela iimpawu ezifanayo, ngoko ugqirha uya kukhangela ukuba intlungu okanye ukungabikho kokuhamba kuhambelana ne-ankylosing spondylitis. Uphawu olubonakalayo lwe-ankylosing spondylitis yintlungu kunye nokuqina kumalungu e-sacroiliac. Amalungu e-sacroiliac ahlala kumqolo osezantsi, apho isiseko somqolo kunye ne-pelvis sidibana khona. Ugqirha uya kujonga ezinye iimeko zomqolo kunye neempawu:

• Iimpawu zentlungu emva okubangelwa - ukulimala, iipatheni zokuma, kunye / okanye iindawo zokulala.
• I-lumbar spinal stenosis
• Irheumatoid arthritis
• Isifo samathambo
• Ukusasaza i-idiopathic skeletal hyperostosis

Imbali Yentsapho

• Imbali yosapho idlala indima ekuxilongeni ngenxa ye imfuza ye-spondylitis ye-ankylosing.
• I-HLA-B27 i-gene ihambelana ne-spondylitis e-ankylosing; ukuba umntu unayo, omnye wabazali bakhe unayo.

Ukucinga

• IiX-reyi zidla ngokuba linyathelo lokuqala lokuxilongwa.
• Njengoko isifo siqhubela phambili, amathambo amatsha amatsha enza phakathi kwe-vertebrae, ekugqibeleni adibanise.
• Ii-X-reyi zisebenza ngcono ekwenziweni kwemephu yokuqhubela phambili kwesifo kunoxilongo lokuqala.
• I-MRI inikeza imifanekiso ecacileyo kwiinqanaba zokuqala njengoko iinkcukacha ezincinci zibonakala.

Uvavanyo lweGazi

Uvavanyo lwegazi lunokunceda ukulawula ezinye iimeko kunye nokujonga iimpawu zokuvuvukala, ukubonelela ubungqina obuxhasayo kunye neziphumo zeemvavanyo zemifanekiso. Ngokuqhelekileyo kuthatha malunga nosuku okanye ezimbini ukufumana iziphumo. Ugqirha unokuodola olunye kolu vavanyo lwegazi lulandelayo:

I-HLA-B27

Uvavanyo lwe-HLA-B27.

• I-HLA-B27 gene ibonisa iflegi ebomvu ukuba i-ankylosing spondylitis ingaba khona.
• Abantu abanale mfuza banomngcipheko ophezulu kakhulu wokukhula kwesi sifo.
• Idityaniswe neempawu, ezinye iilebhu, kunye neemvavanyo, inokunceda ukuqinisekisa ukuxilongwa.

ESR

Isantya se-sedimentation or Uvavanyo lwe-ESRt.

• Uvavanyo lwe-ESR lulinganisa ukudumba emzimbeni ngokubala umlinganiselo okanye ukuba iiseli ezibomvu zegazi zikhawuleza kangakanani ukuzinza ezantsi kwisampulu yegazi.
• Ukuba bahlala ngokukhawuleza kunesiqhelo, isiphumo siphezulu se-ESR.
• Oko kuthetha ukuba umzimba ufumana ukudumba.
• Iziphumo zeESR zinokubuya ziphezulu, kodwa ezi zodwa aziyixilonga i-AS.

CRP

Iproteni esebenzayo - Uvavanyo lwe-CRP.

• Iitshekhi zovavanyo lwe-CRP Amanqanaba e-CRP, iprotheni ehambelana nokuvuvukala emzimbeni.
• Amanqanaba e-CRP aphakamileyo abonisa ukuvutha okanye ukusuleleka emzimbeni.
• Sisixhobo esiluncedo sokulinganisa ukuqhubela phambili kwesifo emva kokuxilongwa.
• Ihlala ihambelana notshintsho kumqolo oboniswe kwi-X-ray okanye i-MRI.
• Kuphela i-40-50% yabantu abane-spondylitis e-ankylosing bafumana ukwanda kwe-CRP.

ANA

Uvavanyo lwe-ANA

• Izilwa-buhlungu zeAnuclear, okanye i-ANA, ilandela iiproteni ezikwinucleus yeseli, ixelela umzimba ukuba iiseli zayo zilutshaba.
• Oku kuvula impendulo yokuzivikela komzimba ukuba umzimba ulwe ukuyiphelisa.
• Uphononongo lufumanise ukuba i-ANA ifunyenwe kwi-19% yabantu abane-ankylosing spondylitis kwaye iphezulu kwabasetyhini kunamadoda.
• Xa kudityaniswa nolunye uvavanyo, ubukho be-ANA bunika omnye umkhondo woxilongo.

Health Gut

• The gut microbiome idlala indima ebalulekileyo ekuqaliseni ukuphuhliswa kwe-spondylitis ye-ankylosing kunye nonyango lwayo.
• Uvavanyo lokujonga impilo yamathumbu anokunika ugqirha umfanekiso opheleleyo wento eyenzekayo ngaphakathi emzimbeni.
• Uxilongo lovavanyo lwegazi lwe-ankylosing spondylitis kunye nezinye iimeko ezivuthayo zixhomekeke kakhulu ekudibaniseni iimvavanyo ezahlukeneyo ecaleni kweemviwo zeklinikhi kunye nokucinga.

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Oonobangela, Iimpawu, Uxilongo, kunye noNyango

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Ucaphulo

Cardoneanu, Anca, et al. "Iimpawu ze-intestinal microbiome kwi-ankylosing spondylitis." Iyeza lovavanyo kunye nonyango vol. 22,1 (2021): 676. doi:10.3892/etm.2021.10108

Prohaska, Et al. “Antinukleäre Antikörper bei Spondylitis ankylosans (Morbus Bechterew)” [Amasosha omzimba akwi-ankylosing spondylitis (inguqulelo yombhali)]. Wiener klinische Wochenschrift vol. 92,24 (1980): 876-9.

Sheehan, Nicholas J. "Iimpembelelo ze-HLA-B27." Ijenali yeRoyal Society of Medicine vol. 97,1 (2004): 10-4. doi:10.1177/014107680409700102

Wenker KJ, Quint JM. Ankylosing Spondylitis. [Ihlaziywe ngo-2022 ku-Epreli 9]. Ku: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Ifumaneka kwi: www.ncbi.nlm.nih.gov/books/NBK470173/

Xu, Yong-Yue, et al. "Indima ye-gut microbiome kwi-ankylosing spondylitis: uhlalutyo lwezifundo kuncwadi." Ukufunyanwa kweyeza vol. 22,123 (2016): 361-370.