Ukuphonononga unyango lwe-Thyroid Regenerative

Njengoko uphando lusanda kumayeza okuvuselela amandla okukwazi ukukhulisa izicubu ze-thyroid, ngaba unyango lokuhlaziya lunokuphelisa imfuno yokuba izigulana zithathe iihomoni ze-thyroid?

UNyango lwe-Thyroid Regenerative

Ithemba elikhulu lonyango lokuvuselela amandla okukhula enempilo amalungu. Elinye lamalungu ajongwayo lidlala lengqula. Injongo kukukhulisa kwakhona izicubu ze-thyroid ku:

• Abantu abaye kwafuneka basuswe idlala ngenxa yomhlaza wegilo.
• Abantu abazalwa bengenalo idlala elikhule ngokupheleleyo.

Njengoko ukuqhubela phambili kwesayensi kunye nophando luye lwanda ukusuka kwibhubhoratri kunye novavanyo lwezilwanyana ukuvavanya izifundo zeeseli ze-thyroid zabantu, ukusetyenziswa kwe-stem cell therapy kule njongo akukabikho, njengoko uphando olubanzi lufunekayo ukuze kuqwalaselwe abantu.

UPhando loLuntu

Uphando malunga nokusetyenziswa kwe-thyroid regenerative therapy kwisifo se-thyroid aluzange lupapashe izifundo apho unyango lwe-stem cell luye lwazama kwizigulane ze-thyroid.

• Uphononongo olwenziweyo lwenziwa kwiimpuku, kwaye naziphi na iziphumo zolu phando azinakusetyenziswa ngokuzenzekelayo ebantwini. (HP Gaide Chevronnay, et al., 2016)
• Kwizicubu ze-thyroid zabantu kwizifundo zetyhubhu yokuvavanya, ukukhuthazwa kweeseli kwaphunyezwa ngendlela eyaphakamisa umbuzo wokwenza utshintsho lomhlaza ngakumbi ukuba luza kuzanywa ebantwini. (UDavies TF, et al., 2011)

Izifundo zakutsha nje

• Uphando lwangoku lubandakanya inkqubela phambili kwi i-embryonic stem cell – ESC kwaye i-pluripotent stem cell - iPSC. (Ngaba uSewell, uReigh-Yi Lin. 2014)
• Ii-ESC, ezaziwa ngokuba ziiseli ze-pluripotent stem, zinokunyusa naluphi na uhlobo lweseli emzimbeni.
• Zivunwa kwiimbumba eziveliswe, kodwa zingafakwanga, ngexesha leenkqubo ze-IVF.
• Ii-iPSC ziiseli ze-pluripotent eziye zaphuhliswa kusetyenziswa inkqubo yokuhlaziya iiseli zabantu abadala.

1. Iiseli ze-Follicular ziiseli ze-thyroid ezenza i-hormone ye-thyroid - i-T4 kunye ne-T3 kwaye ziye zaveliswa kwiiseli ze-embryonic stem zeempuku.
2. Kuphononongo olupapashwe kwijenali yeCell Stem Cell ngo-2015, ezi seli zikwazi ukukhula kwaye zikwazile ukuqalisa ukwenza ihomoni yegilo kwiiveki ezimbini. (Anita A. Kurmann, et al., 2015)
3. Emva kweeveki ezisibhozo, iiseli ezafakelwa kwiimpuku ezazingenawo amadlala edlala lengqula zazinemilinganiselo eqhelekileyo yedlala lengqula.

Idlala leNdlala eNtsha

• Abaphandi kwiSibhedlele saseMount Sinai bafake iiseli ze-embryonic stem kwiiseli zedlala lengqula.
• Babejonge ukuba kunokwenzeka ukwenza i-thyroid gland entsha kubantu abaye basuswa ngotyando lwabo lwegilo.
• Bachaza iziphumo zabo kwintlanganiso ye-84 yonyaka ye-American Thyroid Association. (R. Michael Tuttle, uFredric E. Wondisford. 2014)

Ikamva libukeka lithembisa ukukwazi ukukhulisa izicubu ze-thyroid kunye nokuphelisa ihomoni ye-thyroid. Nangona kunjalo, uphando oluninzi luyafuneka ukuze oku kuthathelwe ingqalelo njengento enokwenzeka.

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Ukuqhekezwa kweSikhokelo soVavanyo lweKhowudi yeThyroid ePhantsi

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Ucaphulo

Gaide Chevronnay, HP, Janssens, V., Van Der Smissen, P., Rocca, CJ, Liao, XH, Refetoff, S., Pierreux, CE, Cherqui, S., & Courtoy, PJ (2016). I-Hematopoietic Stem Cells Transplantation inokuQinisa umsebenzi we-Thyroid kwiMouse ye-cystinosis. I-Endocrinology, i-157 (4), i-1363-1371. doi.org/10.1210/en.2015-1762

UDavies, TF, Latif, R., Minsky, NC, & Ma, R. (2011). Uphononongo lweklinikhi: I-biology yeseli evelayo yeeseli ze-thyroid stem. Ijenali ye-endocrinology yeklinikhi kunye ne-metabolism, i-96 (9), i-2692-2702. doi.org/10.1210/jc.2011-1047

Sewell, W., & Lin, RY (2014). Ukuveliswa kweeseli ze-thyroid follicular ezivela kwiiseli ze-pluripotent stem: amandla okubuyisela iyeza. Imida kwi-endocrinology, i-5, i-96. doi.org/10.3389/fendo.2014.00096

Kurmann, AA, Serra, M., Hawkins, F., Rankin, SA, Mori, M., Astapova, I., Ullas, S., Lin, S., Bilodeau, M., Rossant, J., Jean, JC, Ikonomou, L., Deterding, RR, Shannon, JM, Zorn, AM, Hollenberg, AN, & Kotton, DN (2015). Ukuhlaziywa koMsebenzi we-Thyroid ngokuTshintshwa kweeSeli zeStem ze-Pluripotent ezahlukeneyo. I-cell stem cell, i-17 (5), 527-542. doi.org/10.1016/j.stem.2015.09.004

Tuttle, RM, & Wondisford, FE (2014). Wamkelekile kwintlanganiso yonyaka ye-84 ye-American Thyroid Association. I-Thyroid : ijenali esemthethweni ye-American Thyroid Association, i-24 (10), i-1439-1440. doi.org/10.1089/thy.2014.0429