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intshayelelo
UDkt Alex Jimenez, DC, ubonisa ngokubanzi ukungasebenzi kwe-hormonal kunokuchaphazela amahomoni ahlukeneyo emzimbeni onokunyusa amanqanaba e-cortisol kule nxalenye ye-3. Le ntetho ibonelela ngolwazi olubalulekileyo kubantu abaninzi abajongene nokungasebenzi kakuhle kwehomoni kunye nendlela yokwazi iimpawu kunye nokusetyenziswa kweendlela ezipheleleyo kwimpilo yabo. Icandelo 1 iya kujonga isishwankathelo ukungasebenzi kakuhle kwehomoni. Icandelo lesi-3 liza kujonga unyango olupheleleyo olukhoyo lokungasebenzi kakuhle kwehomoni. Sithumela izigulane kubaboneleli abaqinisekisiweyo ababandakanya iindlela ezahlukeneyo zonyango ze-hormone ukuqinisekisa impilo efanelekileyo. Sikhuthaza kwaye siyasixabisa isigulana ngasinye ngokusithumela kubaboneleli bezonyango abanxulumeneyo ngokusekwe kuxilongo lwaso xa kufanelekile. Siyaqonda ukuba imfundo yeyona ndlela ibalaseleyo xa ubuza ababoneleli bethu imibuzo entsonkothileyo ngokwesicelo sesigulana kunye nokuqonda kwakhe. UDkt Alex Jimenez, DC, usebenzisa le ngcaciso kuphela njengenkonzo yemfundo. isikhanyeli
Isishwankathelo seHormonal Expression
UGqr. Alex Jimenez, DC, unikezela: Ke imfundiso yakudala malunga neehomoni kukuba ziveliswa kwidlala le-endocrine kwaye emva koko zithuthelwe kwiiseli apho umzimba uya kuzisebenzisa. Kodwa izinto zinzima kancinci. Ke yonke iseli iqulethe imfuza eyimfuneko yokubonakaliswa kwehomoni kunye nokusebenza komzimba.
Kwaye siyayazi le nto kuba xa i-de-yahluka ukusuka kwinqanaba lokugqibela, ngelishwa, iiseli zomhlaza zityhila imbonakalo yemfuza. Ezo seli zenza iihomoni kwiindawo ezingafanelekanga nangamaxesha anzima. Ke oko kuthetha ukuba nayiphi na iseli inokwenza nayiphi na ihomoni emzimbeni. Sekunjalo, ukubonakaliswa kwehomoni yemfuza ethile kubonisa ubukho bee-enzyme ezithile, ezimisela ukuba yiyiphi i-hormone eya kuzala. Ngoko, umzekelo, kufuneka ube ne-precursors efanelekileyo kunye ne-enzymes. Ke kumfazi ozalayo, iiseli zegranulosa, iluteinize, kunye necorpus luteum ziveliswa emzimbeni. Iiseli zegranulosa ziifollicles, ngelixa i-corpus odium isemva kwe-ovulation. Kwaye ezi seli ziqala ukubunjwa kweehomoni ze-steroid ekuphenduleni i-FSH kunye ne-LH. Ngoko ke i-FSH kunye ne-LH zivela kwi-pituitary gland kwaye zivuselela iiseli ze-granulosa ukuba ziqalise ukwenza i-estrogen. Ukuveliswa kweSteroid kuya kuqalisa ukuba umyalezo osuka kwi-FSH kunye ne-LH ufika kwindawo yeseli eyenza i-estrogen. Oku kuvumela umzimba ukuba ulawule ukuveliswa kwehomoni kwaye uyigcine isebenza. Xa imiba iphazamisa ukulawulwa kwehomoni, umzimba unokugqithisa okanye uvelise imveliso yehomoni, ekhokelela kwimiba ye-metabolic ehambelana nentlungu kunye nentlungu edibeneyo.
Ke le yinkqubo entsonkothileyo, kwaye zininzi iindawo apho oku kungahamba kakubi. Ke unokuba nezixa ezifanelekileyo zehomoni, kodwa awufumani mveliso yehomoni. Ke imiyalezo kufuneka ingene kwiseli kuqala, kwaye i-FSH kunye ne-LH zikhulu kakhulu ukuba zingene kwisakhiwo seselula. Ke, kuya kufuneka basebenzise i-enzyme esekwe kwi-membrane ebizwa ngokuba yi-adenylate cyclase ukuvelisa i-AMP ye-cyclic yokungena kwinethiwekhi yeselula kwaye iqalise ukwakheka kwehomoni emzimbeni. Le yiP, okanye ukuveliswa kweehomoni. Ngoko ngokucinga ngempilo ye-membrane yeselula, ukuba ugqirha wenza uhlalutyo oluyimfuneko lwe-fatty acid, izigulane zinokuba ziphantsi kakhulu kwi-omega-3s; Ngoko ke, iiseli zabo ziqinile kwaye zichaphazela inkqubo yehomoni yomzimba. Xa izigulana zingayithathi i-omega-3s yazo, inokubangela ukuba ii-cytokines ezivuthayo zibangele imiba yeentlungu ezidibeneyo xa izinto ezahlukeneyo zichaphazela umzimba ngaphakathi. Ekubeni ukuvuvukala kunokuba kuhle okanye kubi emzimbeni, kunokubangela ukungasebenzi kakuhle kwehomoni xa zihlasela izakhiwo zeselula ezinempilo. Oko kuya kuchaphazela le nkqubo yokuveliswa kwehomoni.
Inkqubo yokuveliswa kweHormonal kuMzimba
UGqr. Alex Jimenez, DC, unikezela: Nje ukuba yenziwe, i-estradiol iya ngqo egazini kwaye ayigcinwa, kodwa ibotshelelwe kwi-SHBG kunye ne-albumin. Kwaye i-SHBG iguqulwa kukutyeba kunye ne-insulin ehambelana ne-hypothyroidism. Ke xa abasetyhini betyebe kakhulu okanye be-hyperinsulinemic baya kuba ne-SHBG encinci okanye i-hypothyroidism yokuhambisa i-estrogen kwiiseli. Oku kuxelela umzimba ukuba iihomoni azisekho i-FSH okanye i-LH kunye ne-cyclic AMP, kodwa le yi-estrogen. Kwaye ke, i-estradiol inovelwano kuba i-estradiol kufuneka ingene kwaye ibe ne-cytoplasmic receptor. Ngoko i-estrogen receptor ikwicytoplasm. Emva kokuba ibophe kwi-receptor, ingena kwi-nucleus, kwaye ibhalwe kwaye iphinde ibuyele ngaphandle kwaye iguqulelwe ukuvumela umzimba ukuba wenze iiprotheni ezibangela ukwanda kweeseli. I-Estrogen yi-hormone ekhulayo. Kwaye yakuba isebenze kwiseli emva kokwanda, ithotywa kwisisele kunye neeproteni zokothuka ubushushu okanye ikhutshwe ibuyele kumjikelezo kwinkqubo yomzimba.
Makhe sithethe ngezinye izinto ezisisiseko ze-biochemistry kuba indlela ye-steroidogenic n umzimba uneendlela ezahlukeneyo zokunciphisa iikhabhoni emzimbeni. Inkqubo yomzimba inokuguqula ibe yi-estrone okanye i-estriol, kunye ne-estrogen encinci ejikelezayo. Kwaye ke i-estradiol, i-estrone, i-estriol, yonke into iyacinywa ngeendlela zokuchithwa kwe-detoxification. Ke kwi-Living Matrix, i-detoxification enempilo kunye neendlela ze-estrogen metabolism zinceda umzimba uhlale usebenza. Xa umzimba uhamba nge-detoxification, inceda ukunciphisa imiba ngokufumanisa oko kubangela iingxaki ezichaphazela inkqubo yomzimba kunye nokucotha ukwazisa okanye ukususa intlungu enokuvumela ukulawulwa kwehomoni eqhelekileyo. Xa umzimba unciphisa i-carbon eninzi, unokunciphisa i-cholesterol ekufikeleleni kumanqanaba ayingozi.
ICholesterol kunye neeHormones
UGqr. Alex Jimenez, DC, unikezela: Ngoko yonke into iqala nge-cholesterol, kwaye umzimba awukwazi ukwenza i-cholesterol eyaneleyo, ngoko sidla ukutya ukuze sivumele ukuba singene emzimbeni kwaye siqalise i-biotransform kwi-LDL (i-low-density lipoprotein) ukuqalisa i-hormone synthesis ye-steroid. Ke sidinga i-LDL emzimbeni ukunciphisa iikhabhoni kuba isalathiso somanyano. Xa kufikwa kwiimeko zokunqongophala kwehomoni, ngamanye amaxesha abasetyhini banokuza bene-LDL ephantsi kakhulu kuba bekwi-statins, benobunzima obungaphantsi, okanye bakwi-athletic egqithisileyo; ezi ziqhagamshelo kunye nokuqatshelwa kwepateni. Kumzimba wesetyhini, ii-ovari kwicala lasekhohlo nasekunene lenkqubo yokuzala kwabasetyhini zivelisa zontathu ii-steroids zesini: i-estrogens, i-progesterones, kunye ne-androgens, ukuze usebenze ngokufanelekileyo komzimba. Zahlukile kunenkqubo yokuzala kwendoda, equka amasende, ngenxa yezinye ii-enzymes. Ziyahluka kwii-testes ngeendlela ezininzi ngenxa yemveliso eyongezelelweyo yehomoni emzimbeni, eyahlukileyo kuneehomoni ze-adrenal. Umzekelo, ukuba umzimba awukwazi ukwenza i-aldosterone okanye i-cortisol kumadlala e-endocrine, aya kukhutshwa ukuze enze iihomoni zesini. Kwaye ekubeni umzimba ngamnye uhlukene, indoda okanye ibhinqa, ezinye iihomoni azikwazi ukwenza iglucocorticoids okanye i-mineral corticoids.
Ke kufuneka sicinge ngempilo ye-mitochondrial yokuveliswa kwehomoni, ebaluleke kakhulu ekuveliseni iihomoni. Koomama abalindelekileyo, ivumela ukubunjwa kokukhulelwa yedwa kwi-mitochondria. Ngoko amandla ezempilo e-mitochondrial anxulumene nempilo yehomoni, ebangela ukufunyanwa kwe-cholesterol yi-mitochondria kwi-adrenal glands kunye nama-ovari anokuvuselela i-ACTH. Ngoko i-mitochondria inokwenza amahomoni njengoko sihamba ngelixa sivumela i-enzymes kumzimba wesetyhini ukuba yenze i-pregnenolone formation. Nangona kunjalo, ukufumana i-cholesterol kwi-membrane yangaphakathi kunye ne-LDL kwi-membrane yangaphakathi kwi-mitochondria linyathelo lokunciphisa izinga kuyo yonke i-hormone ye-steroid synthesis. Ngoku inokuphuhlisa kwaye ingene kwiindlela ezimbini ezahlukeneyo emzimbeni. Iyakwazi ukudala i-DHEA, okanye inokubandakanya i-progesterone xa i-cholesterol isenza i-pregnenolone kwaye inokukhangela umzobo kwiziphumo zovavanyo.
I-DHEA kunye neeHormones
UGqr. Alex Jimenez, DC, unikezela: Ke ukuba i-mitochondria inokwenza ukuba i-pregnenolone yomzimba yenze i-DHEA okanye iprogesterone, masiqale ngokuhamba ngezinto ngokuphuhlisa iprogesterone kuba i-hydroxylated. Idala i-enzyme ebizwa ngokuba yi-17 hydroxy progesterone, i-precursor yangoko ye-androgens kunye ne-estrogens. Ke i-17 hydroxy progesterone ekugqibeleni iya kwenza i-androgens okanye i-estrogens, kwaye i-androstenedione inokuphuhlisa i-testosterone, kwaye zombini ingaba yi-estrogens ngokuvumba. Kuthetha ukuthini ke oku? Kuthetha ukuba kufuneka ube nexhala malunga nee-androgens ezininzi ezijikeleze kuba zinokuba yi-estrogen. Indlela efanelekileyo yokukhumbula oku kukuba i-androstenedione ingaba yi-estrone, kwaye i-testosterone ingaba yi-estradiol. Oku kunokubangela ukuba iprogesterone ibe ngumanduleli we-cortisol emzimbeni kwaye inokuhamba ngeendlela ezimbini ezahlukeneyo.
Ke iprogesterone ikwangumphambili we-aldosterone, ebuza ukuba kuya kwenzeka ntoni xa umzimba udinga i-cortisol okanye i-aldosterone. Umzimba uya kuthi emva koko uvelise iprogesterone encinci ebangela ukuba ithintelwe kwimveliso yehomoni kwaye ibangele ukuba i-cortisol ivelise kakhulu. Oku kwaziwa ngokuba yi-cortisol steal, kwaye ukuba ayiphathwa okwangoku, inokubangela ukudumba kwemisipha kunye nokudibanisa emzimbeni, okukhokelela kwimibandela eyahlukeneyo umntu ajongene nayo.
Ukunciphisa ukubunjwa kwe-androgens kunye ne-estrogens kunokuthintela indlela ye-DHEA. Ke xa umzimba usenza i-cortisol eninzi, kunokubangela ukuba iihomoni ziphuhlise imilo elawula i-estrogen ebangela ukuba ihomoni ye-cortisol ivuselele i-aromatase. Ukuza kuthi ga ngoku, kunokukhokelela kumhlaza webele, i-fibroids, kunye ne-endometriosis kwixesha elide. Abasetyhini banokufumana uxinzelelo, ukukhanya okushushu, kunye nokuncipha kwe-libido ngenxa yokuncipha kwehomoni emizimbeni yabo.
isiphelo
Eminye imiba efana noxinzelelo inokubangela ukwanda kokwakheka kwe-cortisol, ukuxhalaba, ukudumba, i-carbohydrates elula, kunye ne-cetera kumzimba ohambelana nentlungu edibeneyo kunye nemisipha. Bangakwazi nokuthintela ukuveliswa kwe-hormone yesini kunye nesondo ngokuthe ngqo nangokungathanga ngqo. Ke kulapho abantu kufuneka baxhalabe ukuba banika iDHEA kuba iDHEA inokuziguqula ibe ziihomoni zesini. Ke loo nto inokuba yinto entle ukuba ujongene nokusilela kwehomoni. Kodwa ukuba unika iDHEA eninzi kakhulu, unokuvelisa ngokugqithisileyo umsebenzi wehomoni.
isikhanyeli
Umgangatho wobuchule wokuSebenza *
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Iividiyo zethu, izithuba, izihloko, imixholo, kunye nokuqonda zibandakanya imiba yezonyango, imiba, kunye nezihloko eziyelelene kwaye zixhase ngokuthe ngqo okanye ngokungathanga ngqo umda wokuziqhelanisa wethu.
I-ofisi yethu izamile ngokufanelekileyo ukubonelela ngeengcaphulo ezixhasayo kwaye ichonge uphando olufanelekileyo lophando okanye izifundo ezixhasa izithuba zethu. Sinikezela ngeekopi zophando ezixhasayo ezifumanekayo kwiibhodi ezilawulayo nakuluntu ngesicelo.
Siyaqonda ukuba sigubungela imicimbi efuna inkcazo eyongezelelweyo yokuba inganceda njani kwisicwangciso esithile sokhathalelo okanye inkqubo yonyango; ke, ukuqhubeka nokuxoxa ngombandela ongentla, nceda ukhululeke ukubuza UDkt Alex Jimenez, DC, okanye qha ga mshelana nathi 915-850-0900.
Silapha ukunceda wena kunye nosapho lwakho.
Iintsikelelo
UDkt Alex Jimenez D.C., I-MSACP, RN*, I-CCST, IFMCP*, I-CIFM*, I-ATN*
email: qeqeshi@elpasofunctionalmedicine.com
Ilayisenisi njengoGqirha weChiropractic (DC) kwi Texas & New Mexico*
Texas DC Ilayisensi # TX5807, New Mexico DC Ilayisensi # I-NM-DC2182
Unikwe Ilayisensi njengoMongikazi oBhalisiweyo (RN*) in Florida
Florida License RN Ilayisensi # I-RN9617241 (Nombolo yolawulo. 3558029)
Ubume obubambeneyo: ILayisensi yeeNkcazo ezininzi: Ugunyaziswe Ukuziqhelanisa I-40 States*
UGqr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
Ikhadi lam loShishino lweDijithali
