Umsebenzi we-Endocrinology: Ukuyeka ukuya esikhathini kunye neOsteoporosis

Ngaba uziva:

• I-Perimenopausal?
• Ukuvuvukala kumalungu?
• Ukutshintsha ubude bomjikelezo wokuya esikhathini?
• Amadangatye ashushu?
• Ukungalingani kweHormonal?

Ukuba ufumana naziphi na kwezi meko, ke unokufumana ukuya esikhathini kunye neempawu zaso.

Xa umntu obhinqileyo ehlasela amashumi amane eminyaka angene kwaye engena kumashumi amahlanu okuqala, baya kwinkqubo yokuguga yendalo eyaziwa ngokuba kukuyeka ukuya exesheni. Ukuyeka ukuya exesheni kuxa umfazi engakhange aye exesheni malunga neenyanga ezilishumi elinambini ezilandelelanayo kwaye engasenakukhulelwa. Ukuyeka ukuya exesheni kuza neempawu ezingathandekiyo njengokutshisa, ukoma kwilungu lobufazi, kunye nokungalingani kwamahomoni. Kubafazi, ukungalingani kwehomoni kunokuhluka ekubeni neehomoni ezininzi kakhulu okanye ezincinci kwigazi lomzimba. Xa ukuya exesheni kwenzeka, ukuphulukana nomsebenzi we-ovari emzimbeni wabasetyhini kunokuba nefuthe kwimpilo yabo yamathambo, kubangele i-osteoporosis kumalungu.

I-Osteoporosis kunye nokuyeka ukuya esikhathini

Kuyamangalisa nangona kunjalo, i-estrogen ye-hormone inakho Dlala indima ekuphuhlisweni kwe-osteoarthritis kwaye xa umfazi ephantsi kwenqanaba lokuya esikhathini. Banokufumana ukuhla kwamanqanaba abo e-estrojen, kwaye isifo samathambo siya kuqala ukonakalisa amathambo kunye nokudibana, okubangela usulelo olungapheliyo. Izifundo zifumene Ukuba i-hormone ye-estrogen iqala ukutshintsha ngexesha lokutshintsha kokuya esikhathini, baya kuqalisa ukuguquguquka emva koko ngequbuliso. Batsho ukuba i-estrogen inceda ukukhusela amathambo ukuba angabi namandla ngokuwohloka kwendalo. Nawaphi na amaqhaqha avela kwiingozi ezinokubangela iintlungu, ukunciphisa ukuhamba, kunye nokusebenza okuqhelekileyo komzimba wesetyhini ngenxa yesifo samathambo.

Kukho nokuba ubungqina obungakumbi ukuba ukuguquguquka kwe-estradiol enokuthi ibe nokuchazwa ngakumbi kwi-perimenopause kwaye ayinakho ukulungelelanisa kakuhle nokuqina kwethambo kunye nokulahleka komzimba. Ke, ngeli xesha lokuya menopausal, ukuxinana kwamathambo kuya kuhla xa abantu basetyhini benesifo samathambo. Kubekho amarhe okuba isifo samathambo yinto umntu angafanele ukuba abe nexhala kuba iyenzeka kuphela xa kukho imbali yosapho ekuthiwa yi-osteoporosis. Okulusizi nangona kunjalo, isifo samathambo sisifo sethambo esiqhelekileyo, kwaye ukuba nembali yosapho yesifo kungonyusa amathuba. Nangona kunjalo, kukwakhona nezinye izinto ezinobungozi ezinokubangela isifo samathambo:

• Utywala obukhulu
• Ameorrhea
• ukutshaya
• Ubunzima bomzimba

Uphando lubonisa ukuba i-osteoporosis iqala xa umfazi ekwinqanaba lokuya kwinqanaba lokuya esikhathini uye wayeka ukuvumba i-ovulating, umjikelo wakhe wokuya esikhathini uyema. Amanqanaba akhe e-estrogen aya kuyeka ngokungummangaliso, ngokunjalo. Yachaza ukuba abantu basetyhini banokuphulukana nethambo elipheleleyo kwiminyaka elishumi elandela ukuya esikhathini. Xa kukho ukunqongophala kwe-estrogen emzimbeni ngenxa yokuphelisa ukuya esikhathini, ukuphulukana nokuxinana kwamathambo kubaluleke kakhulu kwaye kunokubangela ukwaphuka emzimbeni. Izifundo zifumene ukuba oochwephesha bezempilo bendawo bayakubabuza ababhinqileyo malunga nobungakanani bethambo elilahlekileyo ngexesha lokutshintsha kokuya esikhathini kunye nokuqala kwabo. Baye bafumanisa ukuba i-follicle-ivuselela i-hormone kubafazi itshintshile kanye ngexesha lokutshintsha kokuya esikhathini.

Ukuvuselelwa kwamathambo

Ngaphezu koko, Izifundo ezifunyenweyo Abantu abangaphezu kwama-20 baseMelika bachaphazeleka yi-osteoporosis, kwaye oku kungakhokelela kwizigidi ezingama-1.5 zamathambo aphulukene nokwaphuka minyaka le, ngaloo ndlela esenza ukuba isifo samathambo sibe yenye yeengxaki eziphambili zempilo yoluntu. Izifundo ezingaphezulu ziye zafumanisa ukuba abasetyhini banokuphulukana neepesenti ezingama-XNUMX zethambo labo eline-trabecular, kwaye malunga neepesenti ezingama-XNUMX zethambo labo lomzimba emzimbeni wabo baya kuthi baphulukane kwiminyaka eli-XNUMX yokuqala ngexesha labo lokuma. Abasetyhini kufuneka bathathe okungenani iivithamini D zokuqinisekisa ukuba amathambo abo asempilweni kwaye awotyekeli ekuphulukaneni namathambo.

Nantsi lapho ulwazi malunga kutheni ukulahleka kwethambo kubonakala kukhawuleza emva kokuba umjikelezo wesini womfazi uphelile kwaye kutheni ukulungiswa kwamathambo kunokunceda ukubuyisela amathambo amadala alahlekileyo ngenxa ye-osteoporosis okanye ngenxa yokuphuka. Okumangalisayo kukuba, ukulungiswa kwamathambo yinkqubo yokutshintsha amathambo amadala kunye namathambo amatsha omzimba, kwaye iquka izigaba ezintlanu. Bazi:

• UkusebenzaNgeli nqanaba lokuphinda kulungiswe amathambo, ii-osteoclasts ziqeshwa kumphezulu wethambo.
• Ukuphinda ubenamandla: Kweli nqanaba, i-osteoclast iveliswa kwi-acidic microenvironment kumphezulu wethambo, ngaloo ndlela inyibilika kwaye iphinda iphinde iphinde iphinde iphinde iphinde iphinde iphinde iphinde ifake i-mineral content.
• Ukuguquka: Kweli nqanaba, i-osteoclast emva koko idlula kwi-apoptosis kwaye emva koko igaywe kumphezulu wethambo.
• uqeqeshoEli linqanaba lokugqibela lokuvuselelwa kwamathambo njengoko i-osteoclast ifaka i-collagen kwaye emva koko kwenziwe amaminerali ukwenza ithambo elitsha emzimbeni.

isiphelo

Ukuyeka ukuya esikhathini yinxalenye yendalo yamanqanaba e-hormone ukuba ehlile, kwaye abafazi abasayi kuphinda bakhulelwe. Olona phawu luqhelekileyo ufunyenwe ngabafazi kubantu ababhinqileyo kukudumba kwamathambo. I-Osteoporosis kuxa amathambo eba brittle kwaye unokwaphuka ekuweni okanye ekonakaleni. Abasetyhini kufuneka bathathe izongezo zempilo yamathambo ukuze amathambo kunye nomzimba usebenze ngokuchanekileyo. Abanye iimveliso zenzelwe ukunceda ukuxhasa i-metabolism ye-estrogen kuyo yomibini imizimba yabasetyhini kunye neyamadoda iimveliso ukunceda ukuxhasa ukulingana kwehomoni kunye nokuya esikhathini kubafazi kubafazi.

Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic, musculoskeletal, kunye nemicimbi yezempilo yovalo okanye amanqaku amayeza asebenzayo, izihloko kunye neengxoxo. Sisebenzisa iiprothokholi zempilo ezisebenzayo ukunyanga ukwenzakala okanye ukuphazamiseka kwenkqubo yemusculoskeletal. Iofisi yethu yenze umzamo oqinisekileyo wokubonelela ngezikhokelo ezixhasayo kwaye ichonge isifundo sophononongo esifanelekileyo okanye izifundo ezixhasa izithuba zethu. Sikwenza iikopi zezifundo zophando ezixhasayo ziya kufumaneka ebhodini okanye kuluntu xa luceliwe. Ukuqhubeka nokuxoxa ngomxholo ongentla, nceda ukhululeke ukubuza uGqirha Alex Jimenez okanye unxibelelane nathi apha 915-850-0900.

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Iingxelo:

Duggl, Neel. �Luyintoni unxulumano phakathi kokuyeka ukuya exesheni kunye nesifo samathambo? LwezeMpilo, Nge-11 kaMeyi, 2017, www.healthline.com/health/menopause/menopausal-arthritis.

UFinkelstein, uJoel S, et al. �Utshintsho lweMineral Density ngexesha loTshintsho lokuyeka ukuya exesheni kwiQela leeNtlanga ezininzi zabasetyhini.� Umbhalo we-Clinical Endocrinology kunye neMetabolism, Umbutho we-Endocrine, ngoMatshi 2008, www.ncbi.nlm.nih.gov/pmc/articles/PMC2266953/.

Rodriguez, Diana, et al. �Uqhagamshelo lweOsteoporosis-Menopause.� Imihla lemihla.com, Ngomhla we-16 kuFebruwari ka-2016, www.everydayhealth.com/menopause/steoporosis-and-menopause.aspx.

URosen, uClifford, kunye noRamon Martinez. �Emva kokuyeka ukuya exesheni kunye neOsteoporosis.� Inethiwekhi yeHormone Yezempilo, NgoMatshi 2019, www.hormone.org/diseases-and-conditions/menopause/post-menopause-and-osteoporosis.

Abahlwayeli, uMaryFran R, et al. �Ixabiso lokuLahleka kweBone ngokunxulumene nexesha elijikeleze iXesha lokuGqibela lokuya exesheni kunye neFollicle-Stimulating Hormone Staging of the Transmenopause. Umbhalo we-Clinical Endocrinology kunye neMetabolism, Umbutho we-Endocrine, ngoMeyi ka-2010, www.ncbi.nlm.nih.gov/pmc/articles/PMC2869543/.

Iqela, iPenn Medicine. �Ukuyeka ukuya exesheni kunye neOsteoporosis: Yintoni uQhagamshelwano? � Penn Medicine.� � Penn Medicine, Nge-18 Matshi 2016, www.pennmedicine.org/updates/blogs/womens-health/2016/march/menopause-and-osteoporosis.

UTella, uSri Harsha, kunye noJ Christopher Gallagher. �UThintelo kunye noNyango lwe-Postmenopausal Osteoporosis.� Ijenali ye-Steroid Biochemistry kunye neMoology Biology, I-US National Library of Medicine, nge-Julayi 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4187361/.

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