I-Biochemistry ye-DNA Methylation

Isingeniso kuMethylation

I-Methylation, eyaziwa ngokuba yi-one-carbon metabolism, yinkqubo ye-biochemical eyenza umsebenzi we-methylation. Iqela le-methyl, enye yezona yunithi eziqhelekileyo zezakhiwo ze-organic compounds, zenziwe nge-athomu yekhabhoni enye edityaniswe kwii-athomu ezintathu ze-hydrogen (-CH3). Iqela le-methyl, elongezelelweyo okanye lisuswe kwiiprotheni okanye kwi-nucleic acids, ngokubanzi linokwenziwa ngeendlela ezimbini ezahlukeneyo, kubandakanywa:

1. Ukuqhotyoshelwa kwe-athomu ye-hydrogen kwi-athomu ye-methylene (-CH2-), ikhuthaza ukuveliswa kwe-enzyme methylenetetrahydrofolate reductase, okanye i-MTHFR. Imveliso yale mpendulo yaziwa ngokuba yi-5-methylTHF.
2. Utshintsho lweqela le-methyl, njenge-catechol-O-methyltransferase, eyaziwa ngokuba yi-COMT, kunye ne-DNA methyltransferase, eyaziwa ngokuba yi-DNMT enzymes. I-DNA methyltransferase enzymes zisebenzisa amaqela e-methyl ukusuka kwi-S-adenosylmethionine esebenzayo okanye i-SAMe.

I-SAMe iguqulela kwi-S-adenosyl homocysteine, okanye i-SAH, kwaye emva koko i-homocysteine ​​​​iboniswe kuMfanekiso 1. I-Homocysteine ​​​​inokuguqula kwi-methionine ngenye yeendlela ezimbini ezahlukeneyo. Indlela ehamba phambili, ngokuguqulwa kwe-methionine synthase, idinga ukutshintshiselwa kweqela le-methyl ukusuka kwi-5-methyltetrahydrofolate, okanye i-5-mTHF, apho yenziwe yi-enzyme methylenetetrahydrofolate reductase, okanye i-MTHFR, eyona enzyme eyaziwayo kakhulu kwiindlela ze-folate metabolic. .

Indlela yesibini ye-methionine biosynthesis esuka kwi-homocysteine ​​​​nge-betaine homocysteine ​​methyltransferase, eyenzeka esibindini nasezintso. I-Homocysteine ​​​​inokuthi iqalise enye indlela ye-biochemical, ngakumbi ngexesha lokunyuka koxinzelelo lwe-oxidative, eguqula i-homocysteine ​​ukuya kwi-cystathionine ukuya kwi-taurine, i-glutathione, okanye i-sulfate. Umzila we-transsulfuration usisigxina, nangona kunjalo, ukwenzela ukuvelisa i-glutathione, i-homocysteine ​​​​inokusetyenziswa ukuvelisa i-SAMe, phakathi kwezinye iindlela.

I-folate yokutya inokufumaneka kwiindidi zokutya njengezinto ezibizwa ngokuba yi-pteropolyglutamates. Ukuze ifakwe ngokufanelekileyo, i-polyglutamate ifakwe kwi-hydrolyzed emathunjini ibe yi-monoglutamate eyaziwa ngokuba yi-tetrahydrofolate okanye i-THF. I-folic acid, ngakolunye uhlangothi, eyona ndlela eyaziwa kakhulu yokwenziwa kwesondlo esisetyenziselwa ukuqiniswa kokutya, kufuneka incitshiswe yi-enzyme i-dihydrofolate reductase, okanye i-DHFR, kabini esibindini apho iya kufuna ukongezwa kwe-athomu ezimbini ze-hydrogen ngaphambili. inokuguqula ibe yiTHF.

Eyona nto ibalulekileyo, umsebenzi we-DHFR unokwahluka kwaye unokuncipha ekugqibeleni. Umsebenzi we-DHFR kwisibindi kwakhona ngamaxesha e-56 ahamba kancinci kubantu, ngokutsho kwezifundo zophando, oku kuthetha ukuba kufuneka siqaphele xa siguqulela imilinganiselo yesiphumo se-pharmacokinetic ye-folic acid kwizilwanyana. Ngamaxesha amaninzi, oogqirha kunye nabasebenzi bamayeza asebenzayo baya kusebenzisa ezinye iindlela ze-folates ezongezelelweyo ezibandakanya i-5-mTHF kunye ne-folinic acid, okanye i-10-formyl THF, ukunqanda ukuvaleka kwe-DHFR, kwaye kwimeko ye-5-mTHF, ngenjongo yokuthintela i-polymorphism. ukuvaleka kwi-enzyme ye-MTHFR. Uninzi lwezifundo zophando ziye zabonisa ezi ziphumo.

Izifundo zophando ezithelekisa iziphumo ze-5-mTHF ngokuchasene ne-folic acid kwi-folate zibonise ukuba i-methylation inokusebenza ekunyuseni amanqanaba e-folate. I-Folinic acid ngamanye amaxesha isetyenziselwa ukuxhasa amanqanaba e-cerebral folate kwiimeko ezithile apho i-auto-antibodies ithutha i-folate kwiiprotheni kumqobo wegazi-ingqondo. Ukuqonda i-biochemistry ye-methylation kuphela isingeniso kwi-methylation. Isondlo kunye nokuguqulwa kwendlela yokuphila kuye kwaboniswa ukunceda inkxaso ye-methylation.

I-Methylation, ukudluliselwa kweqela le-methyl kwi-organic compound, inokwahlulwa ibe ziintlobo ezimbini ezisisiseko: iikhemikhali kunye ne-biological. Ukulawulwa kwe-methylation emzimbeni womntu kukhuthazwa ngokuguqulwa kwe-DNA kunye neeprotheni okanye i-enzymes. Injongo yale nqaku ilandelayo kukubonisa indlela imichiza kunye nezinto eziphilayo ezidlala indima ekulawuleni i-DNA methylation. Ukuqonda ezi nkqubo kubalulekile ekuphuculeni impilo jikelele yesigulane kunye nokuba sempilweni.

UDkt Alex Jimenez DC, i-CCST Insight

I-Smoothies neeJusi zeNkxaso ye-Methylation

Ngelixa uninzi lweengcali zokhathalelo lwempilo lunokucebisa ngezikhokelo zesondlo kunye notshintsho kwindlela ophila ngayo, zininzi iindlela zonyango onokukhetha kuzo onokuzizamela ekhaya. Njengoko kuchaziwe apha ngasentla, nangona kunjalo, ukongezwa kwenkxaso ye-methylation kufuneka kugqitywe ngokuchanekileyo yingcali yezempilo. I-Smoothies kunye neejusi ziyindlela ekhawulezayo nelula yokubandakanya zonke izakha mzimba eziyimfuneko ozifunayo ngenkxaso ye-methylation ekusebenzeni kube kanye. I-smoothies kunye neerandi ezingezantsi ziyingxenye yeSicwangciso sokutya seMethylation.

Sea Green Smoothie
IiNkonzo: 1
Ixesha lokupheka: I-5-10 imizuzu
1/2 yekomityi cantaloupe, cubed
1/2 ibhanana
isi-1 se-kale okanye isipinatshi
1 i-chard yaseSwitzerland
1/4 iavokhado
Iispuni ze-2 spirulina powder
1 ikomityi amanzi
Cub zi-3 okanye nangaphezulu iityhubhu zomkhenkce
Hlanganisa zonke izithako kwi-fast-blender blender uze uphelele kwaye ujabule!

Berry Bliss Smoothie
IiNkonzo: 1
Ixesha lokupheka: I-5-10 imizuzu
1/2 yekomityi yeblueberries (entsha okanye efriziwe, ngokukhethekileyo isendle)
1 umnqathe ophakathi, osikiweyo
Tables icephe 1 yomhlaba yeflakisi okanye imbewu ye-chia
1 icephe yeeamangile
Amanzi (ukungqinelana okufunwayo)
Cub Iityhubhu zomkhenkce (ngokuzithandela, zinokuyeka xa usebenzisa iiblueberries ezinqabileyo)
Hlanganisa zonke izithako kwi-speed knight blender de i-smooth and creamy. Eyona nto yakhonza ngokukhawuleza!

SwI-eet kunye neJaji eNandi
IiNkonzo: 1
Ixesha lokupheka: I-5-10 imizuzu
1 indebe yehoneydew melon
Cups Iikomityi ezi-3 zesipinatshi, ezihlanjwe
Cups Iikomityi ezi-3 zaseSwitzerland, zihlanjwe
1 bunch cilantro (amagqabi kunye neziqu), zihlanjwe
Ob I-1-intshi ye-ginger knob, ihlanjwe, ihlanjululwe kwaye ihlulwe
I-2-3 knobs ingcambu ye-turmeric (ngokuzithandela), ihlanjwe, ihlutshiwe kwaye iyanqunyulwa
IJusi zonke izithako kwi-juicer ephezulu. Eyona nto yakhonza ngokukhawuleza!

Ijusi yemifino yeGinger
IiNkonzo: 1
Ixesha lokupheka: I-5-10 imizuzu
1 indebe yephayinaphu ityhubhu
I-apile eli-1, lisikiwe
Ob I-1-intshi ye-ginger knob, ihlanjwe, ihlanjululwe kwaye ihlulwe
Cups Iikomityi ezi-3 ze-kale, zihlanjwe kwaye ziqwengwe kancinci okanye zakrazulwa
Cups Iikomityi ezi-5 ze-Swiss chard, zihlanjwe zaza zacolwa okanye zakrazulwa
IJusi zonke izithako kwi-juicer ephezulu. Eyona nto yakhonza ngokukhawuleza!

IJes Beet Juice
IiNkonzo: 1
Ixesha lokupheka: I-5-10 imizuzu
1 i-grapefruit, ixotyulwe yacolwa
Apple 1 i-apile, ihlanjwe yasikwa
1 i-beet iphelele, kunye namagqabi ukuba unayo, uhlanjiwe kwaye usikiwe
Ob I-1-intshi ye-ginger knob, ihlanjwe, ihlanjululwe kwaye ihlulwe
IJusi zonke izithako kwi-juicer ephezulu. Eyona nto yakhonza ngokukhawuleza!

IProteyini Power Smoothie
Ukukhonza: 1
Ixesha lokupheka: imizuzu ye-5
1 iprotein powder
Tables icephe 1 yomhlaba neflakisi
1/2 ibhanana
1 i-kiwi, iyaxobuka
1/2 itispuni sinamoni
Incindi yekhamiyam
Ubisi olungenalo ubisi okanye amanzi, anele ukufezekisa ukungqinelana okufunwayo
Hlanganisa zonke izithako kwi-blender ephakamileyo ephakamileyo kude kube lula. Eyona nto yakhonza ngokukhawuleza!

Ukutya ukutya kweProLonim yokuDibanisa

Inkxaso ye-methylation elinganayo inokufumaneka ngokutya okufanelekileyo. Ukutya okulingisa ukutya kwe-ProLon kunikezela ngenkqubo yokutya yeentsuku ezi-5 epakishwe umntu ngamnye kwaye ibhalwe ukuba inike ukutya okudingayo kwe-FMD ngobungakanani kunye neendibaniselwano ezichanekileyo. Inkqubo yokutya yenziwe ngokulungele ukutyiwa okanye ukulungiseka ngokulula, ukutya okusekelwe kwizityalo, kubandakanywa iibhari, isuphu, i-snacks, izongezelelo, i-concentrate yesiselo, kunye neeti. Iimveliso zenziwe ngokwesayensi kwaye zingcamla kakhulu. Phambi kokuba uqalise iProLon ukuzila ukutya okulingisa ukutya, inkqubo yokutya yeentsuku ezi-5, nceda uqiniseke ukuba uthethe nengcali yezempilo ukufumanisa ukuba i-FMD ikulungele na. Ukuzila ukutya okulingisa iProLon kunokunceda ukukhuthaza inkxaso ye-methylation, phakathi kwezinye izinto ezahlukeneyo enempilo inzuzo.

Oogqirha abaninzi kunye noogqirha bezonyango ezisebenzayo banokuthi bancome amanqanaba aphezulu abaxhasi be-methyl kwizigulane eziliqela, nangona kunjalo, uphando olongezelelweyo uphando lubaluleka ukucacisa inani elifanelekileyo lokuncedisa i-methylation. Ubungakanani benkcazelo yethu lukhawulelwe kwi-chiropractic, i-musculoskeletal kunye neengxaki zempilo yeentlanzi kunye namayeza anemisebenzi, izihloko kunye neengxoxo. Ukuqhubela phambili ukuxoxa ngale ngongentla apha, nceda ukhululeke ukucela uDkt Alex Jimenez okanye uqhagamshelane nathi 915-850-0900 .

Ikhutshwe nguDkt. Alex Jimenez

Ingxoxo eyongezelelweyo yesihloko: Ubuhlungu obuBuya buhlungu

Umqolo obuhlungu enye yezona zizathu ezibangeleko zokukhubazeka kunye neentsuku eziphosakeleyo emsebenzini jikelele. Iintlungu ezibuhlungu emva kwesizathu sesibini esivakalayo sokutyelela iofisi yee-dokotela, zibalwa kuphela ngezifo eziphezulu zokuphefumula. Phantse i-80 ipesenti yoluntu iya kubakho ubuhlungu ubuncinane kanye kanye ebomini babo. Umgudu wakho uyisakhiwo esiyinkimbinkimbi esakhiwa ngamathambo, amajoyina, iigaments, kunye nezihlunu, phakathi kwezinye iifomthi ezithambileyo. Ukulimala kunye / okanye imeko ekhutshweyo, njengaye disni, ekugqibeleni unokukhokelela kwiimpawu zentlungu. Ukulimala kwezemidlalo okanye ukulimala kwengozi yeemoto ngokuqhelekileyo kubangelwa yintlungu yokubuhlungu, kodwa ngamanye amaxesha ukuhamba kwezinto ezilula kunokuba neziphumo ezibuhlungu. Ngethamsanqa, ezinye iindlela zokhathalela unyango, ezifana nokunyamekelwa kwe-chiropractic, kunokunceda ukubuyisela intlungu emva kokusetyenziswa kwemilenze kunye nokunyanzeliswa kwemigaqo, ekugqibeleni ukuphucula intlungu.

Iifomu zeNkxaso yeMethylation

XYMOGEN's Iifomula zeeNgqungquthela zodwa zifumaneka ngokukhetha abaqeqeshi bezempilo abanemvume. Intengiso ye-intanethi kunye nokuhlaziywa kwamafomula e-XYMOGEN ayinqatshelwe.

Iqhayiya, UDkt. Alexander Jimenez yenza i-XYMOGEN ifomula ifumaneka kuphela kwizigulane ezingaphantsi kwethu.

Nceda ufonele iofisi yethu ukuze sikwazi ukudlulisela udokotela ngokubonisana nokufikelela ngokukhawuleza.

Ukuba uyigulane Iiklinikhi zoNyango kunye neKliniki yeChiropractic, unokubuza malunga ne-XYMOGEN ngokubiza 915-850-0900.

Ukuze ube lula kwaye uhlaziywe XYMOGEN mveliso nceda uhlolisise le nxu lumene. *I-XYMOGEN-Inkcazo-umxokozelo

* Zonke iipolisi ze-XYMOGEN ezingentla zihlala zisebenza ngokuthe ngqo.

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