Umsebenzi we-Endocrinology: Gut kunye ne "Chemo-Brain" Unxibelelwano

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Ukuba ufumana naziphi na kwezi meko, ke into inokuba iphosakele kwisisu sakho kunye nokunxibelelana kwengqondo emzimbeni wakho.

Uqhagamshelo lwe-Gut-Brain

Ukudibana kwesisu kunye nobuchopho zihamba kunye njengoko zithumela imiqondiso ukubuyela umva nokuqinisekisa ukuba umzimba womntu uqala ukusebenza ngokuchanekileyo. Isisu siqinisekisa ukuba yonke inkqubo yesisu, inkqubo ye-endocrine, kunye ne-hepatic system isebenza ngokufanelekileyo. Ngelixa ubuchopho buqinisekisa ukuba inkqubo yemithambo-luvo iyasebenza kodwa nokuthumela imiqondiso kuwo wonke umzimba kunye nokuqinisekisa ukuba iihomoni zisasazwa kumalungu afunekayo.

I-Chemo-Brain kunye noQhagamshelo lwe-Gut

Nokuba uxhulumaniso lwesisu kunye nobuchopho lubalulekile ukuze umzimba ube sempilweni, nangona kunjalo, xa kufikwa kumntu onomhlaza unokuba nawo I- chemo-brain kunye nokudibana kwamathumbu Xa belufumana unyango machiza. Kuba ichemotherapy ngumgangatho oqhelekileyo wokukhathalela umhlaza ngokudibanisa ngokuthe ngqo amachiza athile abulala iiseli zomhlaza. Ehlabathini lonke, zingaphezu kwe-100 iintlobo zomhlaza ezinokuthi zihlasele iiseli emva koko zisasaze amalungu awo omzimba ahlukeneyo. Ngoku ka uphando kwi-CDC, yatsho ukuba umhlaza ungowesibini unobangela wokubulawa kwabantu e-US.

Nantsi lapho Iinkcukacha ezithe xaxe malunga nokwenziwa yikhemotherapy emzimbeni kuba ichemotherapy isebenza ngokubeka iiseli zomhlaza ekubeni zanda okanye zinciphisa izinga lokukhula kweseli yomhlaza. Okulusizi kukuba, nangona ichemotherapy inokujolisa kwiseli esikhula ngokukhawuleza somhlaza, ikwabulala iiseli zomzimba ezinempilo. Xa iiseli ezisempilweni zihlaselwa yi-chemotherapy, iiseli zinokubangela uluhlu olude lweziphumo ezibi. Umzekelo, iiseli ze-epithelial ezikwi-GI trem zinokonakala, kwaye zinokubangela ukuba izigulana ezininzi ezinomhlaza ziyeke unyango lwe-chemo ngaphambi kwexesha.

In uphando olutshanje eyayipapashwe eFrontier kwi-Chemacology, yabonisa ukuba izazinzulu zifumene indlela entsha yokuhambisa ichemotherapy enokuhlasela iiseli eziyingozi emzimbeni ngelixa beshiya iiseli zempilo zodwa. Ngale ndlela, inokubonelela ngethemba elincinci ngokuvumela oogqirha ukuba behlise iidosi zonyango lwe-chemo ukunciphisa ukubandezeleka kwezigulana nakweziphi na iziphumo ezibi ze-chemo, ezinokuthi zonyuse ukuthotyelwa kunye nokuphuculwa kwesifo sezigulana.

In Uphononongo lwamva lwentatheli, isazinzulu sophando esivela kwiYunivesithi yaseOhio State sifumene isisombululo esinokubanceda ekuphuculeni ukungafuneki kwesisu kunye nokuchaphazela iziphumo ebezingalindelekanga ezibangelwa yikhemotherapy. Ngokophando, imodeli ibonise indlela unxibelelwano phakathi kweempawu zesisu kunye nengqondo zenza kunyango lwe chemotherapy. Iziphumo zibonisiwe indlela amachiza e-chemo ayitshintshe ngayo ngokupheleleyo i-microbiome yomntu. Batsho ukuba iibacteria zesisu kunye nezicubu zomzimba zitshintshile ngelixa igazi nengqondo emzimbeni zibonisa iimpawu zokuvuvukala okubangela ukudinwa kunye nokukhubazeka kwengqondo. Xa unyango lwe-chemo lubangela ukuvuvukala kukwinkqubo yemithambo-luvo, inokwenza inkqubo yonke ukuba idityaniswe kunye nokuphazamiseka kwekholoniyiti kunye ne-bacteria homeostasis emzimbeni.

Nge chemotherapy, kunokubangela ukuvunywa kwamathumbu. Inokubangela ukuba amajoni omzimba asemzimbeni agqithise ekusebenzeni nasekubonakaliseni iiseli zomzimba zengqondo ukuba zitshiswe ngelixa ikwangunobangela “wengqondo yengqondo.” I-Chemo-kwengqondo ichazwa njengokuchaphazeleka kwengqondo kwaye ibangela umntu ukuba abe nengqondo engapheliyo enokuhlala iinyanga okanye iminyaka emva kokuba umhlaza uhambile. Kuyamangalisa nge le nto intsha, I-chemo-brain ichaphazele ngaphezulu kwesiqingatha sabasindileyo bomhlaza ngelixa iyinto eqhelekileyo njengoko unyango lomhlaza lunokwandisa ixesha lokuphila lesigulana.

Ngolu hlobo lophando, kunokusikhanyisela ngakumbi ukuba impilo ye-gut micobiome inokuthi ichaphazeleke ngakumbi kunendlela yokugaya, kuba isisu sidlala indima ebaluleke kakhulu kuzo zonke ezinye iinkqubo emzimbeni, ingakumbi kwinkqubo yokhuseleko lomzimba . Ngokujonga ubungqina obukhoyo, bonisa indlela impilo kunye nokuphila kwesisu kunye nengqondo zixhunyiwe. Ingakhokelela kongenelelo olungcono kwizigulana ezininzi ezinomhlaza ngokunyusa ukwakheka kwebhaktheriya enenzuzo esiswini kwaye kungakhusela nakweyiphi na i-neuroinfigueation ukunciphisa naziphi na iimpawu ze-chemo-brain.

Izibulala-zintsholongwane kunye neziBonelelo zezifo

U-Hippocrates wayenyanisile xa wathi "zonke izifo ziqala emathunjini." Olu lwazi luvule indlela yonyango oluninzi olusebenzayo ukunceda abaguli abaninzi abanomhlaza. Ngokongeza nakuphi na ukutya okuchasene nokuvuvukala kukutya komntu njengokutya kweMedithera okanye nokutya okususelwa kwisifo se-ketogenic kulungele abaguli abanomhlaza. Kucetyiswa izigulana ezinomhlaza ukuba zonyuse ukutya kwazo kwe-prebiotic kunye nokutya okucebileyo kwe-probiotic. Kuyangqinwa ukuba iprobiektha kunye nee-prebiotic inokunceda ukunciphisa Iziphumo ebezingalindelekanga ezichasene nezigulana ezininzi ngexesha lokunyanga kwamachiza. Ngee-prebiotic kunye nee-probiotic, kukutya okune-fiber ezinobisi kwaye zinokutya ukuze abantu bafumane iibacteria eziyinzuzo kunye ne-commensal ezihlala esiswini kwaye zinokuphucula ukwakheka kwentsholongwane.

isiphelo

Ngonxibelelwano lwe-gut kunye nengqondo, basebenza kunye ngokuqinisekisa ukuba umzimba usebenza ngokuchanekileyo. Xa i-chemo-kwengqondo, nangona kunjalo, inokubangela ukungasebenzi emzimbeni ngokuchaphazela inkqubo yonke yomzimba ngokusebenzisa ichemotherapy. Ngokongeza i-probiotics kunye ne-prebiotic kukutya kwesigulana esinomhlaza kunokubanceda okungenani bafumane imizimba yabo yesondlo kunye neepropati ezifanelekileyo abazifunayo. Abanye iimveliso ziluncedo emzimbeni ngokuxhasa kungekuphela i-gut kodwa nangokuqinisekisa ukuba kwengqondo iyaxhaswa ngokunjalo.

Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic, musculoskeletal, kunye nemicimbi yezempilo yovalo okanye amanqaku amayeza asebenzayo, izihloko kunye neengxoxo. Sisebenzisa iiprothokholi zempilo ezisebenzayo ukunyanga ukwenzakala okanye ukuphazamiseka kwenkqubo yemusculoskeletal. Iofisi yethu yenze umzamo oqinisekileyo wokubonelela ngezikhokelo ezixhasayo kwaye ichonge isifundo sophononongo esifanelekileyo okanye izifundo ezixhasa izithuba zethu. Sikwenza iikopi zezifundo zophando ezixhasayo ziya kufumaneka ebhodini okanye kuluntu xa luceliwe. Ukuqhubeka nokuxoxa ngomxholo ongentla, nceda ukhululeke ukubuza uGqirha Alex Jimenez okanye unxibelelane nathi apha 915-850-0900.

Iingxelo:

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UCaldwell, uEmily. Unxibelelwano olunokwenzeka lwe-Gut-Brain ku 'Chemo Brain' Unyango lwe-Xpress yoNyango-ukuPhambili koPhando ngezoNyango kunye neeNdaba zezeMpilo, Ugqirha Xpress, 23 Oct. 2019, medicalxpress.com/news/2019-10-gut-brain-chemo-brain.html.

UCaldwell, uEmily. GI-Gut inokuba liTikiti lokuCutha iZiphumo eziLungileyo zeChemo Unyango lwe-Xpress yoNyango-ukuPhambili koPhando ngezoNyango kunye neeNdaba zezeMpilo, Medical Xpress, 11 Nov. 2019, medicalxpress.com/news/2019-11-gut-ticket-chemo-side-effects.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter.

Loman, BR, okqhubekayo. NeI-Chemotherapy-i-Neuroinfigueation eyenziweyo inxulunyaniswa ne-Colonic kunye ne-Bacterial Homeostasis kwiimpuku zabasetyhini. Iindaba zeNdalo, Iqela lokuPapasha kwiNdalo, nge-11 Novemba.2019, www.nature.com/articles/s41598-019-52893-0.

UNeumann-Raizel, uHagit, et al. I--2-APB kunye ne-CBD-Mediated Targeting ye-Cytotoxic iikhompawundi kwiiTum Cells Icebisa ngokubandakanywa kwe-TRPV2 Channel. ezihlobene, Frontiers, 17 Septemba.2019, www.frontiersin.org/articles/10.3389/fphar.2019.01198/full.

abasebenzi, iSayensi X. 'Chemo Brain 'ebangelwa kukungasebenzi kakuhle kwiindidi ezintathu zeeseli zobuchopho, uPhando lufunyenwe. Unyango lwe-Xpress yoNyango-ukuPhambili koPhando ngezoNyango kunye neeNdaba zezeMpilo, Unyango lwe-Xpress, ye-6 ngo-Okthobha ka-2018, i- Medicalxpress.com/news/2018-12-chemo-brain-malfunction-cells.html.

Abasebenzi, iSayensi X. Ubuchule bujolise kwiiseli zomhlaza kunye namagqabi aphilileyo eyedwa. Unyango lwe-Xpress yoNyango-ukuPhambili koPhando ngezoNyango kunye neeNdaba zezeMpilo, Unyango lwe-Xpress, i-27 Novemba ngo-2019, i-medicalxpress.com/news/2019-11-technique-cancer-cell-healthy.html.

Iqela, iDFH. Uphando olutsha-Izisombululo zesisu kwiChemotherapy Uyilo lwezeMpiloNge-2 kaJanuwari 2020, ibhlog.designsforhealth.com/node/1179.

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