I-Gut-Brain Axis: Iziphazamiso zeGut & Metainflammation

intshayelelo

The Inkqubo yamathumbu likhaya leetriliyoni zeebhaktheriya eziluncedo ezinceda ukutya okuguqulwe ngebhayoloji kube izondlo ukuze umzimba usebenze ngokuchanekileyo. Amathumbu nawo ahlala enxibelelana nengqondo njengoko imiqondiso ye-neuron ikwi- ubude bemaza obu-bi-directional oko kunceda ukuhambisa izondlo kwiindawo zabo ezichongiweyo emzimbeni. Ezi ndawo zichongiweyo zinceda umzimba ngokunjalo, njengoko zineseti yazo yemiyalelo yokusebenza ngokuchanekileyo ngelixa umzimba usashukuma. Xa ukuphazamiseka kwamathumbu okufana ne-metainflammation kuqala ukuphazamisa imiqondiso ebuyela umva naphambili phakathi kwengqondo kunye namathumbu, kunokubangela imiba eyahlukeneyo enokubangela ukuba umzimba ungasebenzi kakuhle kwaye uqhubele phambili ekudumbeni okungapheliyo. Inqaku lanamhlanje lixoxa ngento eyenziwa yi-metainflammation kwi-axis ye-gut-brain kunye nendlela ii-inflammasomes ezidlala ngayo indima yazo kwi-axis yesibindi emzimbeni. Ukubhekisa izigulana kubaboneleli abaqeqeshiweyo, abanezakhono abaziingcali kunyango lwe-gastroenterology. Sinikezela ngesikhokelo kwizigulana zethu ngokubhekisa kubaboneleli bethu bezonyango abanxulumeneyo ngokusekelwe kuvavanyo lwabo xa kufanelekile. Sifumanisa ukuba imfundo ibalulekile ekubuzeni imibuzo eqondayo kubaboneleli bethu. UDkt Alex Jimenez DC unikezela ngolu lwazi njengenkonzo yemfundo kuphela. isikhanyeli

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I-Metainflammation echaphazela i-Gut-Brain Axis

Ngaba ukhe waphawula ukwanda kokungadibani nokutya okanye ukunganyamezeli okukuchaphazelayo? Kuthekani ngokuziva iingxaki zokwetyisa zinyuka ngamaxesha amaninzi? Uninzi lwezi mpawu zibangelwa kukuphazamiseka kwamathumbu okufana ne-metainflammation, enokuthi ichaphazele i-axis yobuchopho emzimbeni. Uphando lophando lukhankanyile ukuba inkqubo ye-nervous ichaphazela ngokuthe ngqo amathumbu ngokusebenzisa abalamli be-endocrine abasebenzisana ne-microbial receptors. Xa i-metainflammation iqala ukuchaphazela amathumbu, iba sisiphumo se-dysbiosis yamathumbu ehlukeneyo njenge:

• Ukunyuka kokulala kunye nokuphazamiseka kwemizwelo
• Ukukhathala
• Ukunciphisa ukusebenza kunye nekhono lokuzilolonga
• Ukunqongophala kwezondlo - i-vitamin D, iivithamini B
• Ukungalingani kwedlala lengqula

Ezinye izifundo zophando zibonisile ukuba ekubeni ukudumba kuyinto eqhelekileyo kwiziphazamiso ezahlukeneyo ezichaphazela umzimba, kunokwenza umonakalo omkhulu xa ii-cytokines ezivuthayo zichaphazela i-axis ye-gut-brain kunye ne-immune system. Ukudumba kwe-Meta kubangela ukuncipha kokufunxa kwamathumbu kunye nokucutheka, kodwa kunokonyusa iindawo ezixineneyo ezineziphene kunye nokungena kwamathumbu. Oku kubangela ukuba imiba yamathumbu ikhule njenge-Crohn's kunye nesifo se-celiac, ebangela ukunyuka kwe-insulin kunye nokukhubazeka komzimba kunye nemiba yengqondo efana nokulala, ukuqonda, ukuphazamiseka kwemizwelo, ukuxhalaba kunye nokuphazamiseka kwengqondo.

Isishwankathelo kwividiyo ye-Gut-Brain-Axis-Video

Ngaba ufumene ubunzima malunga necandelo lakho eliphakathi? Kuthekani ngokunyuka kwenkumbulo kunye nokuncipha kwengqondo? Ngaba ukhe waziva ukunyuka kokudumba okungapheliyo okanye iingxaki zokhuselo lomzimba? Zonke ezi zimpawu ziimpawu zokuba unokuba ne-metainflammation echaphazela i-axis yobuchopho emzimbeni wakho. Le vidiyo ingasentla icacisa i-axis ye-gut-brain kunye nokuba ukuphazamiseka kwe-neurodevelopment kunokuchaphazela njani ingqondo. Izifundo zophando zifumene ukuba umxube we-dysbiosis kunye nokuvuvukala kuchaphazela amathumbu, kwaye kunokubangela ukuba ingqondo idibaniswe nezifo ezininzi ze-neurological. Ngonxibelelwano lwe-bi-directional ingqondo kunye namathumbu analo, izinto ezininzi zihlala zicela umngeni kuzo zombini ii-microbiomes ezinokuqhubela phambili iimpawu zokuvuvukala ukuba zinyuke emzimbeni.

Yintoni I-Inflammasomes?

I-Inflammasomes yintsapho yeeprotheni ezijongene nokuqalisa inkqubo yokuvuvukala ngexesha lokuphendula kwe-immune. I-Inflammasomes ziziintsholongwane ezikhuselayo ezibangela iziphumo zokudumba ngokuchasene nosulelo kwaye zinokuchaphazela i-axis yesibindi emzimbeni ukuba ijika ingapheli. Yintoni eyenziwa yi-inflammasomes kukuba inceda i-receptors yokuqaphela ipateni ukwazi xa umzimba uziva ucinezelekile okanye usengozini, njengoko bengabadlali ababalulekileyo kwi-metaflammation construct. Izifundo zophando zibonisile ukuba i-inflammasomes emzimbeni inokunceda ukukhupha i-toxins kwii-microbes ezihlaselayo ezibangela ukuphazamiseka kwamathumbu.

I-Inflammasome iyichaphazela njani i-Gut-Liver Axis?

I-axis yesibindi se-gut idityaniswe namathumbu nge-bile acid metabolism. I-Bile acid dysregulation ingakhokelela kwi-intestinal dysbiosis, evumela ukuba i-gram-negative erogenous pathogenic bacteria kunye ne-LPS ukuba ingene esibindini. Xa oku kwenzeka, kubangela ukuvuvukala kwesibindi nge-inflammasomes. Izifundo zophando zibonisile ukuba ukuvuvukala okungapheliyo okuchaphazela i-axis yesibindi se-gut kunokubangela ukuba i-inflammasomes ichaphazele ingqibelelo yodonga lwe-epithelial kwaye ibangele nokuveliswa kwe-cytokine ye-pro-inflammatory, ebangela imiba emininzi emzimbeni. Ngokwahlukileyo, i-NLRP3 inflammasome ngokuyintloko yenza i-IL-1beta ngokubangela i-bile acids ukuba isebenze i-NLRP3 inflammasome kwi-macrophages. Oku kubangela ukudluliselwa kwebhaktheriya ukuvumela iintsholongwane, okt, i-Bacteroidetes (ibhaktheriya ye-Gram-negative) kunye ne-LPS, kwisibindi.

isiphelo

Ngokubanzi, i-axis ye-gut-brain ivumela unxibelelwano lwe-bi-directional kuwo wonke umzimba njengoko uncedo lwamathumbu lulawula umsebenzi we-metabolic womzimba. Kwangaxeshanye, ingqondo ilawula imiqondiso kunye neenkqubo ezidibana nomzimba. Xa imiba engapheliyo efana ne-metainflammation okanye i-inflammasomes engapheliyo iqala ukuchaphazela amathumbu, inokuphazamisa unxibelelwano lwe-bidirectional kwingqondo, ebangela ukuba umzimba ungasebenzi. Ukubandakanya utshintsho oluncinci kukhetho lobomi oluqinisekileyo njengokongeza izongezo kunye nezakhamzimba ukuthomalalisa ukudumba, ukutya okunempilo, kunye nokwenza umthambo kunokunceda ukukhulula amathumbu. Xa abantu abaninzi besenza olu tshintsho luncinci kuhambo lwabo lwezempilo kunye nokuba sempilweni, banokuziva benamandla angakumbi, bazive ukudumba okuncinci okuchaphazela amathumbu abo, kwaye bajikeleze ngakumbi.

Ucaphulo

UClapp, uMegan, kunye nabanye. "Impembelelo yeGut Microbiota kwiMpilo yengqondo: I-Gut-Brain Axis." Iiklinikhi kunye nokuziqhelanisa, IPHEPHAPress Scientific Publications, Pavia, Italy, 15 Sept. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5641835/.

de Zoete, Marcel R, et al. "Izinto ezivuthayo." Iingqungquthela zeCold Spring Harbour kwi-Biology, iCold Spring Harbour Laboratory Press, 16 Okt. 2014, www.ncbi.nlm.nih.gov/pmc/articles/PMC4292152/.

Herradon, Gonzalo, et al. "Ukudibanisa i-Metainflammation kunye ne-Neuroinflammation ngokusebenzisa i-PTN-Mk-Rptpβ / ζ i-Axis: Ukufaneleka kuPhuhliso lwezoNyango." Imida kwi-Pharmacology, Frontiers Media SA, 12 Epreli 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6474308/.

Osadchiy, Vadim, et al. "I-Gut-Brain Axis kunye neMicrobiome: Iinkqubo kunye neeMpembelelo zoNyango." I-Clinical Gastroenterology kunye ne-Hepatology: iJenali yokuSebenza yeKlinikhi esemthethweni ye-American Gastroenterological Association, ILayibrari yeSizwe yezeMithi yase-US, uJanuwari 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6999848/.

Wang, Junfeng, et al. "Iindima ze-Inflammasome kwi-Gut-Liver Axis (Uphononongo)." Iingxelo zeMolekyuli yamayeza, DA Spandidos, ngoJan. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6297761/.

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