Ukuphelisa imiba yamathumbu ngeNutraceuticals

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The Inkqubo yamathumbu sisixokelelwano esikhulu sendalo esinceda ekulungiseni umzimba inkqubo yomzimba kwaye utshintsho lwemetabolism ukuba umzimba ngokwawo udlulayo. Inkqubo yamathumbu ibonelela umzimba ngezondlo eziyimfuneko ukuze usebenze ngokuchanekileyo kwaye uhambisa ezi zondlo ukuya kumacandelo awo ahlukeneyo njenge inkqubo ye endocrine, i luvo, kwaye i inkqubo yemisipha ukwenza imisebenzi yabo. Xa ukuphazamiseka kwamathumbu kuqala ukuchaphazela iindonga zamathumbu, kunokubangela ukuba ii-cytokines ezivuthayo zihlasele iindonga zamathumbu ngenxa yeebhaktheriya kunye nezondlo eziphuma kwiindawo eziqinileyo. Ngethamsanqa, kukho iindlela zonyango zokunceda inkqubo yamathumbu kunye nokuthintela ukuvuvukala kubangele imiba emininzi emathunjini. Inqaku lanamhlanje lijonga kwi-gut metainflammation kunye nendlela i-nutraceuticals enokubanceda ngayo abantu abaninzi abane-gut metainflammation. Ukubhekisa izigulana kubaboneleli abaqeqeshiweyo, abanezakhono abaziingcali kunyango lwe-gastroenterology. Sinikezela ngesikhokelo kwizigulana zethu ngokubhekisa kubaboneleli bethu bezonyango abanxulumeneyo ngokusekelwe kuvavanyo lwabo xa kufanelekile. Sifumanisa ukuba imfundo ibalulekile ekubuzeni imibuzo eqondayo kubaboneleli bethu. UDkt Alex Jimenez DC unikezela ngolu lwazi njengenkonzo yemfundo kuphela. isikhanyeli

Ngaba i-inshorensi yam ingayihlawula? Ewe, kunokwenzeka. Ukuba akuqinisekanga, nali ikhonkco kubo bonke ababoneleli beinshorensi esibakhuselayo. Ukuba unemibuzo okanye iinkxalabo, nceda ufowunele uDkt Jimenez kwi-915-850-0900.

Yintoni iGut Metainflammation?

Ngaba inkqubo yakho yamathumbu ivakala ibuhlungu okanye ithenda xa uyibamba? Ngaba izinto eziqhelekileyo ezifana noxinzelelo, iingxaki zokulala, ukungalingani kwehomoni, kunye nemiba ye-cardiovascular kuchaphazela ngaphezu kokuba kufuneka babe nayo? Ngaba ukhe wahlangabezana nemiba yokukrala kwamathumbu njenge-IBS okanye amathumbu avuzayo? Ukuba naluphi na ukuphazamiseka kwamathumbu akukho nto ihlekisayo kwimpilo yakho. Xa inkqubo yamathumbu ifumana i-sequela engapheliyo yokuvuvukala okukwibakala elisezantsi, yile nto i-gut metainflammation ikuyo emzimbeni. I-Gut metainflammation ichazwa njengokusebenza ngokugqithisileyo kokugonyeka emathunjini okukhokelela ekwandeni kwemveliso ye-cytokines evuthayo, ngaloo ndlela ibhekisa kwi-metabolism-induced inflammation. Izifundo zophando zibonisile ukuba xa amathumbu efumana i-metainflammation, ibangela ukuphazamiseka kwiindlela ze-neurometabolic. Oku kubangela ukwanda kweenkqubo zokuguga kunye nemiba yokubonakaliswa kwe-metabolic amathumbu azama ukubonelela umzimba. Ezinye izifundo zophando zibonisile ukuba i-metainflammation yenye yeempawu eziphambili zokuphazamiseka kwemetabolism njengokutyeba, uhlobo lwe-2 yeswekile, kunye ne-NAFLD (isifo sesibindi esinamafutha e-nonalcoholic). I-Gut metainflammation ikwabangela ukonyuka kwe-peripheral kunye nokudumba okuphakathi okunokubangela ukuphazamiseka kwamathumbu njengokuvuza kwamathumbu ukuvumela iibhaktheriya kunye ne-toxins ukuba zingene egazini, nto leyo ekhokelela ekudumbeni kwe-peripheral kunye nombindi womzimba.

Unyango lwe-GI Disorders-Ividiyo

Ngaba ukhe wadibana namathumbu avuzayo? Ngaba uziva udiniwe imini yonke? Ngaba ukhe wanamava obuthathaka okutya emathunjini akho? Le miba yamathumbu ibangelwa kukudumba kwe-metainflam enokuthi ibe nefuthe kwimpilo yomntu kunye nomgangatho wobomi. Xa oku kusenzeka, umzimba uya kuba ungasebenzi, kwaye eminye imiba iya kuvela ngaphandle kokuba inyangwe kwangoko. Le vidiyo ingasentla ibonisa ukuba lufumaneka njani unyango lokunciphisa ukuphazamiseka kokuhamba kunye nokuphazamiseka kwe-GI okuchaphazela inkqubo yamathumbu. Ukusebenzisa unyango oluluncedo kwinkqubo yamathumbu kunokunceda ukuthomalalisa iziphumo ze-metainflammation kunye nolunye ukuphazamiseka kwamathumbu ekuqhubeleni phambili emzimbeni. Olunye unyango olunokunceda ngokukhupha i-metainflammation kwi-gut system inokufumaneka ngokuguqula indlela yokutya kunye nokubandakanya i-nutraceuticals enenzuzo emathunjini.

Ukulawula i-Gut Metainflammation ngokusebenzisa i-Nutraceuticals

Izifundo zophando zibonisile ekubeni iitriliyoni zeeseli ze-microbial zenza i-gut microbiota xa izinto ezifana nokutyeba, i-metainflammation, kunye nokuphazamiseka komsebenzi we-insulin kuchaphazela amathumbu, kunokubangela ukuba iiseli zokuzivikela ziphinde zisebenze kwaye zomeleze inkqubo yokuvuvukala ukuhlasela inkqubo yamathumbu. Xa inkqubo yamathumbu ingasebenzi, abantu abaninzi bazama ukufumana iindlela zokuphelisa ukudumba kwamathumbu. Olunye lonyango kukubandakanya i-nutraceuticals ukunika isiqabu kwi-gut metainflammation. Uphando lophando lukhankanyile ezidityaniswe nokutya okusebenzayo kunokunceda ukunika impembelelo entle kwimetabolism yomzimba kunye ne-gut microbiota. I-Nutraceuticals inceda ukunika umzimba izondlo eziyimfuneko kwaye incede ekudambiseni naziphi na iziphumo zokuphazamiseka okuchaphazela amathumbu omzimba, amajoni omzimba, kunye namalungu e-metabolic. I-nutraceuticals ezimbini zinokunceda ukulawula i-metainflammation yamathumbu: i-curcumin kunye ne-peptides.

I-Curcumin kunye neePeptides zeGut Metainflammaion

Ukusuka kwi-turmeric (i-Curcuma longa) ingcambu / irhizome kwaye isetyenziswa ngokwesiko kwiimeko ze-dyspeptic, uphando lophando lukhankanyile ukuba i-curcumin kunye ne-anti-inflammatory metabolites inokunceda ukuchaphazela i-gut microbiota. Yintoni eyenziwa yi-curcumin emathunjini kukuba inceda ukunciphisa ukubonakaliswa kwe-inflammasome ngelixa inciphisa uxinzelelo lwe-oxidative nge-Nrf2-keap1 indlela. I-Curcumin inokunceda ukuphucula ukuguquguquka kunye nokuhamba emzimbeni ngelixa inqanda ukusebenza kwe-peroxisome proliferator-activated receptor-gamma indlela. Ulwazi olongezelelweyo lunikiwe ukuba i-curcumin ayinakunceda kuphela ukunciphisa uxinzelelo lwe-oxidative kunye nokukhusela i-neurodegeneration.

Iipeptides okanye i-BPC-157 (iCompound yoKhuseleko loMzimba) ziphuma kwijusi yesisu somntu ene-cytoprotective kunye ne-anti-inflammatory enceda ukuxhasa i-gut mucosal lining. Izifundo zophando zibonisile ukuba i-peptides idlala indima ebalulekileyo ekugcineni i-homeostasis yamathumbu ngelixa isebenza kakuhle ekunciphiseni ukubonakaliswa kwe-metainflammatory kwi-gut microbiota. Xa kukho i-metainflammation emathunjini, iipeptides zinokunceda ukuphucula ukusinda kweeseli phantsi kweemeko zoxinzelelo lwe-oxidative ngokuthoba i-TNF-alpha emzimbeni. Ukubandakanya iipeptide kunokunceda ukuphucula ingqibelelo ye-mucosal ye-GI ukusuka kwi-meta yokuvuvukala kunye nokunceda amathumbu asebenze ngokuqhelekileyo.

isiphelo

Amathumbu likhaya leetriliyoni zeemicroorganisms ezinceda ukugcina ukusebenza komzimba kunye nokulawula ukhuseleko kwizifo ezahlukeneyo. Xa izinto ezingafunekiyo ezifana ne-metainflammation iqala ukungena emathunjini, inokukhokelela kwi-dysbiosis kwaye ichithe iindonga zamathumbu. I-Nutraceuticals efana ne-curcumin kunye ne-peptides ineepropathi eziluncedo ezinceda ukulungisa iindonga zamathumbu ngelixa zithomalalisa iziphumo ezivuthayo ezivela ekuqhubeleni phambili kwinkqubo yamathumbu. Ukubandakanya i-nutraceuticals luncedo kubantu abaninzi abanengxaki yokuphazamiseka kwamathumbu kunye nokuphucula impilo yabo ngokuzalisa izondlo zabo emzimbeni.

Ucaphulo

Boulangé, Claire L, et al. "Impembelelo yeGut Microbiota ekuKhumbeni, ukutyeba, kunye neSifo seMetabolic." Amayeza eGenome, BioMed Central, 20 Epreli 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4839080/.

UDi Meo, uFrancesco, kunye nabanye. "I-Curcumin, i-Gut Microbiota, kunye ne-Neuroprotection." Amanzi, MDPI, 11 Okt. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6835970/.

Gubatan, John, et al. "I-Peptides ye-Antimicrobial kunye ne-Gut Microbiome kwiSifo sokuKhuleka kwamathumbu." Ijenali yehlabathi ye-Gastroenterology, Baishideng Publishing Group Inc, 21 Nov. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8613745/.

Laparra, JM, kunye noY Sanz. "Intsebenziswano ye-Gut Microbiota kunye nezixhobo eziSebenzayo zokutya kunye neNutraceuticals." Uphando lwezeMpilo, Ilayibrari yeSizwe yaseMelika yoNyango, nge-13 kaNovemba 2009, yentshutshiso.ncbi.nlm.nih.gov/19914380/.

Scazzocchio, Beatrice, et al. "Intsebenziswano phakathi kwe-Gut Microbiota kunye ne-Curcumin: Isitshixo esitsha sokuqonda kwiimpembelelo zeMpilo ye-Curcumin." Amanzi, MDPI, 19 Agasti 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7551052/.

Scheithauer, Torsten PM, et al. "I-Gut Microbiota njengeNtshukumo yokuKhuleka kweMetabolic kuKutyeba kakhulu kunye noHlobo lwesi-2 seswekile." Imida e-Immunology, Frontiers Media SA, 16 Okt. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7596417/.

Tilg, Herbert, et al. "I-Intestinal Microbiota iFakela ukudumba kweMetabolic." UPhononongo lweNdalo. Ugonyo, Ilayibrari yeSizwe yezeMithi yase-US, nge-6 ka-Agasti 2019, yentshutshiso.ncbi.nlm.nih.gov/31388093/.

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