Ukuqonda uQhagamshelwano lweMetabolic kunye neZifo eziNgapheliyo (Icandelo 2)

intshayelelo

UDkt Jimenez, DC, ubonisa indlela uxhulumaniso lwe-metabolic olungapheliyo njengokuvuvukala kunye nokuxhatshazwa kwe-insulin kubangela ukusabela kwekhonkco emzimbeni kule nxalenye ye-2. Izinto ezininzi zihlala zinendima kwimpilo nakwimpilo yethu. Kwinkcazo yanamhlanje, siza kuqhubeka malunga nokuba ezi zifo ze-metabolic zichaphazela njani amalungu abalulekileyo kunye neenkqubo zamalungu. Ingakhokelela kwimiba egqithileyo yengozi ehambelana neempawu ezinjengeentlungu kwimisipha, amalungu, kunye namalungu abalulekileyo. Icandelo 1 ivavanye indlela iiprofayili zomngcipheko ezityhutyhayo ezifana nokunganyangeki kwe-insulin kunye nokudumba okuwuchaphazela ngayo umzimba kwaye kubangele izihlunu kunye namalungu iimpawu ezinjengeentlungu. Sikhankanya izigulana zethu kubaboneleli bezonyango abaqinisekisiweyo ababonelela ngonyango olufumanekayo kubantu abaneemeko ezingapheliyo ezinxulumene noqhagamshelo lwe-metabolic. Sikhuthaza isigulane ngasinye xa kufanelekile ngokuthumela kubaboneleli bezonyango abanxulumeneyo ngokusekelwe kukuxilongwa okanye iimfuno zabo. Siyayiqonda kwaye siyayamkela into yokuba imfundo yindlela engummangaliso xa sibuza imibuzo ebalulekileyo yababoneleli bethu ngokwesicelo sesigulana kunye nokuvuma. UDkt Alex Jimenez, DC, usebenzisa olu lwazi njengenkonzo yemfundo. isikhanyeli

Indlela isibindi esiNxulumaniswa ngayo neZifo zeMetabolic

Ke sinokujonga esibindini ukufumana iindlela zangaphambili zomngcipheko wentliziyo. Sinokukwenza njani oko? Ewe, masiqonde i-biochemistry yesibindi. Ngoko kwi-hepatocyte yesibindi sesibindi esinempilo, xa uye wandisa i-insulin efihliweyo ngenxa yokuba kwakukho isidlo esasifuna ukuba i-glucose ifakwe, yintoni okulindeleyo ukuba i-insulin receptor isebenza kukuba i-glucose iya kungena. Emva koko i-glucose yayiza kufumana i-oxidized kwaye yajika yaba ngamandla. Kodwa nantsi ingxaki. Xa i-hepatocyte ine-insulin receptors engasebenziyo, unayo loo insulin ngaphandle, kwaye i-glucose ayizange iyenze. Ngena. Ke into eyenzayo kukucima iasidi enamafutha, ucinga, “Madoda, akufuneki sitshise iiasidi zethu ezinamafutha. Kungene iglucose."

Ke xa i-glucose ingekho, kwaye awutshisi i-acids enamafutha, ixhaphake kakhulu ukuba abantu bazive bediniwe kuba akukho nto itshisa amandla. Kodwa nantsi i-sequela yesibini; ziya phi zonke ezo asidi ezinamafutha, akunjalo? Ewe, isibindi sinokuzama ukuwapakisha kwakhona njenge-triglycerides. Ngamanye amaxesha, bahlala kwi-hepatocyte okanye batshintshelwe ngaphandle kwesibindi ukuya egazini njenge-VLDL okanye i-lipoprotein ephantsi kakhulu. Unokuyibona njengokutshintsha kwe-triglyceride ephezulu kwiphaneli yelipid esemgangathweni. Ke, xa sonke sithetha ngokufumana inqanaba le-triglyceride ukuya malunga nama-70 njengenjongo yakho ye-8+, xa ndiqala ukubona i-triglycerides inyuka, silinda de ibeyi-150, nangona ikukunqunyulwa kweelebhu zethu. Xa siyibona kwi-150, siyazi ukuba bakhupha i-triglycerides ngaphandle kwesibindi.

Ke oko kuya kwenzeka amaxesha amaninzi ngaphambi kokuba sifumane i-glucose engasebenzi kakuhle. Ke jonga i-triglycerides yakho, ukuzila i-triglycerides, njenge-biomarker evelayo okanye yokuqala yokungasebenzi kakuhle kwe-insulin. Ngoko ke lo ngomnye umzobo othi ukuba i-triglycerides iyadalwa ngenxa yokuba i-acids enamafutha i-oxidized, inokuhlala esibindi. Ke loo nto yenza i-steatosis okanye isibindi esinamafutha, okanye zinokukhutshelwa ngaphandle, kwaye ziguquke zibe lipoprotein. Siza kuthetha ngaloo nto ngomzuzwana nje. Umzimba unje, "Siza kwenza ntoni ngala ma-acids anamafutha?" Asinakuzama ukuzityhala kwiindawo kuba akukho mntu uzifunayo. Ukuza kuthi ga ngelo xesha, isibindi sifana nokuthi, “Andizifuni, kodwa ndiza kuhlala ndinazo.” Okanye isibindi besiya kuthuthwa la mafutha anamafutha aze ancamathele kwiindonga zemithambo yegazi.

Ke ngoko imithambo yegazi kunye nemithambo ifana, “Ke, andiyifuni; Ndiza kuzifaka ngaphantsi kwe-endothelium yam. Kwaye yile ndlela ufumana i-atherogenesis. Imisipha ifana, "Andizifuni, kodwa ndiza kuthatha." Yiloo ndlela ofumana ngayo amanqatha kwizihlunu zakho. Ke xa isibindi sixinga yi-steatosis, ukudumba kwenzeka emzimbeni kwaye kuvelisa lo mjikelo wokutyisa ngaphakathi kwe-hepatocyte, ukonakalisa isibindi. Ufumana ukufa kweseli; ufumana i-fibrosis, elulwandiso nje lwento eyenzekayo xa singajongi imiba engundoqo yesibindi esinamafutha: ukudumba kunye nokunganyangeki kwe-insulin. Ke, sijonge ukunyuka okuchuliweyo kwi-AST, ALT, kunye ne-GGT; khumbula ukuba yi-enzyme esekwe esibindini.

IHormone Enzymes & Ukudumba

Ii-enzymes ze-GGT esibindini zizichongi zomsi kwaye zisixelela ukuba lungakanani uxinzelelo lwe-oxidative oluqhubekayo. Ngaba siya kujonga kwi-HSCRP kunye ne-APOB ukuze sibone ukuveliswa kwesi sibindi? Ngaba iqala ukulahla i-acids enamafutha amaninzi nge-VLDL, i-APOB, okanye i-triglycerides? Kwaye indlela ekhethwa ngayo yimfuzo nje, ngokunyanisekileyo. Ke ndikhangela abamakishi besibindi ukuba bandixelele ukuba kuqhubeka ntoni esibindini njengophawu lwento eyenzekayo kuyo yonke indawo. Kuba loo nto inokuba yindawo ebuthathaka yemfuza yomntu, abanye abantu basengozini ngokwemfuza nje ngokweprofayili zabo zelipid. Ukuza kuthi ga ngoku, sinokujonga into ebizwa ngokuba yi-metabolic dyslipidemia. Uyazi oku njenge-triglycerides ephezulu kunye ne-HDL ephantsi. Unokujonga ngokuthe ngqo umlinganiselo; ibhalansi eyiyeyona ntathu nangaphantsi. Iqala ukusuka kwisithathu ukuya kwisihlanu kwaye emva koko ezintlanu ukuya kwisibhozo, njengesibhozo siphantse sibe yi-pathognomonic yokumelana ne-insulin. Ufikelela ekubeni uxhathise i-insulin ngakumbi nangakumbi.

Njengoko inani linyuka kwi-trig phezu komlinganiselo we-HDL, leyo yindlela elula, elula yokukhusela i-insulin. Ngoku abanye abantu bajonge i-3.0 kule nto kodwa basenokumelana ne-insulin. Ngoko kukho ezinye iimvavanyo ozenzayo. Le yindlela yokufumana abo babonisa ukunganyangeki kwe-insulin ngeelipids. Kwaye khumbula, wonke umntu wahlukile. Abasetyhini abane-PCOS banokuba ne-lipids emangalisayo kodwa banokubonisa ukwanda okanye ukuncipha kwamahomoni ahambelana ne-insulin, i-estrogen, kunye nokuvuvukala. Ngoko khangela enye into ngaphandle kovavanyo olunye okanye umlinganiselo ukubonisa ukuba bayifumene na. Ujonge ukubona ukuba yeyiphi indawo apho siya kufumana khona umkhondo.

Ngoko ke masisebenzise igama elithi impilo. Umntu osempilweni uneVLDL ebonakala isempilweni eqhelekileyo kumlinganiselo oqhelekileyo emizimbeni yakhe, yaye uneLDL neHDL eqhelekileyo. Kodwa ngoku jonga into eyenzekayo xa ufumana ukuxhathisa kwe-insulin. Ezi VLDL ziqala ukumpompa ngeetriglycerides. Yiyo loo nto betyeba. Yi-lipotoxicity. Ke ukuba uqala ukujonga amanani amathathu e-VLDL kwiprofayili ye-lipoprotein, uya kubona ukuba elo nani liyarhubuluza, kwaye zininzi, kwaye ubukhulu bawo bukhulu. Ngoku nge-LDL, into eyenzekayo kukuba isixa se-cholesterol ngaphakathi nasezantsi siyafana. Ukuba ndikhupha zonke ezi bhaloni zamanzi, ngumlinganiselo ofanayo we-cholesterol ye-LDL. Nangona kunjalo, eso sixa se-LDL cholesterol ekuxhathiseni i-insulin sipakishwa kwakhona kwi-LDL encinci exineneyo.

I-Functional Medicine iyidlala njani indima yayo?

Ngoku siyaqonda ukuba kusenokubakho abanye benu abangakwaziyo okanye abangakwaziyo ukufikelela kolu vavanyo, okanye abaguli bakho abanako ukuyifikelela, yiyo loo nto siyiphendule imibuzo kwaye sijonge ezinye iindlela zokunganyangeki kwe-insulin kwaye sinyange ingcambu engunobangela okhoyo. echaphazela umzimba. Jonga iimpawu zokudumba kunye nezinye iiprofayili ezihambelanayo zokunganyangeki kwe-insulin. Inani lesuntswana liphezulu xa bexhathisa i-insulin. Ngoko i-cholesterol iyafana, ngelixa inani lamasuntswana liphezulu, kwaye i-LDL encinci exineneyo inamandla ngakumbi. Yiphathe ngenxa yokuba nokuba unakho ukufikelela ekwazini i-LDL, kufuneka kubekho into entloko yakho ethi, "Mntu, nangona i-cholesterol ye-LDL yomntu ibonakala ilungile, banetoni zokudumba kunye nokuxhathisa i-insulin; Andiqinisekanga ukuba abanalo inani eliphezulu lamasuntswana.” Usenokucinga ukuba benza oku ukuze bakhuseleke.

Enye into eyenzekayo kukumelana ne-insulin kukuba i-HDL okanye i-cholesterol esempilweni ithande ukuba ncinci. Ke akulunganga kakhulu kuba umthamo we-efflux we-HDL uyancitshiswa xa incinci. Ke siyayithanda i-HDL enkulu, ukuba uyathanda. Ukufikelela kolu vavanyo kuya kukunika isalathiso esiluqilima sento eyenzekayo ngesigulana sakho ngokwembono ye-cardiometabolic.

Xa kuziwa kolu vavanyo, kubalulekile ukuzisebenzisa ukujonga ixesha lesigulana xa sinokudumba okanye ukuxhathisa kwe-insulin emizimbeni yabo, okuchaphazela umgangatho wobomi babo. Nangona kunjalo, abantu abaninzi badla ngokuchaza ukuba olu vavanyo luyabiza kwaye luya kuhamba nomgangatho wegolide wovavanyo lokufikeleleka kwaye bakwazi ukwenza isigqibo sokuba kufanelekile ukwenza ngcono impilo kunye nempilo yabo.

Jonga iipateni zoMngcipheko weCardiometabolic

Ke xa kufikwa kwiipatheni zomngcipheko we-cardiometabolic, sijonga inkalo ye-insulin kunye nendlela enxibelelana ngayo ne-mitochondrial dysfunction ehambelana nokuxhathisa kwe-insulin kunye nokudumba. Inqaku lophando likhankanya indlela ukungasebenzi kakuhle kwemitochondrial kunokuchaphazela ngayo umzimba. Kulungile, masithethe ngomba wokuqala, ongumba wobungakanani. Enye inokuba yi-endotoxins esidibana nayo kwindawo esihlala kuyo, okanye ezimbini; inokudluliselwa ngokwemfuza ukusuka kwisizukulwana ukuya kwesinye. Ke ezi ntlobo zimbini zinokubonisa ukuba awunayo imitochondria eyaneleyo. Ngoko ke ngumba wobungakanani. Enye ingxaki ngumba womgangatho. Unazo zininzi; ayisebenzi kakuhle, ngoko ke ayinayo imveliso ephezulu okanye iziphumo eziqhelekileyo. Ngoku le nto idlala njani emzimbeni? Ke ngaphandle kwi-periphery, izihlunu zakho, i-adipocytes, kunye nesibindi, une-mitochondria kwezo seli, kwaye ngumsebenzi wabo ukunika amandla eso sitshixo kunye ne-jiggle. Ke ukuba i-mitochondria yakho ikwinani elichanekileyo, unokuninzi kokunika amandla i-insulin ye-cascade lock kunye ne-jiggle.

Inika umdla, akunjalo? Ke nantsi isishwankathelo, ukuba awunayo i-mitochondria eyaneleyo, eyingxaki kwiperiphery, ufumana uxhathiso lwe-insulin ngenxa yokuba isitshixo kunye ne-jiggle ayisebenzi kakuhle. Kodwa ukuba awunayo i-mitochondria esebenza kakuhle kwi-pancreas, ngakumbi kwiseli ye-beta, awuyikhuphi i-insulin. Ngoko usenokufumana i-hyperglycemia; awunayo imeko ephezulu ye-insulin. Xa oku kusenzeka, siyazi ukuba ingqondo yakho kufanele ukuba ibebuhlungu, kodwa ngethemba, iyakuhlangana kancinane.

Elinye inqaku likhankanya ukuba lidibanisa ukungasebenzi kakuhle kwe-mitochondrial kunye nohlobo lwesibini seswekile, kwaye ukondleka kukamama okungahambi kakuhle kunokuphambili. Lo uthetha malunga nendlela isibindi esinamafutha anxulumene ngayo ne-lipotoxicity, akunjalo? Yiyo loo nto yanda i-asidi enamafutha, kunye noxinzelelo lwe-oxidative, leyo, khumbula, yimveliso yokudumba. Ukuchithwa kwe-ATP kunye nokungasebenzi kakuhle kwe-mitochondrial. Xa oku kusenzeka, kunokusichaphazela isibindi, esithi ke sijike sibe sisibindi esinamafutha, kwaye sinokunxulunyaniswa nokungasebenzi kakuhle kwamathumbu, okukhokelela ekudumbeni okungapheliyo, ukuxhathisa kwe-insulin, ukungasebenzi kakuhle kwe-mitochondrial, kunye nokunye okuninzi. Ezi zifo zemetabolism ezingapheliyo zidibene, kwaye kukho iindlela zokunciphisa ezi mpawu zichaphazela umzimba.

isiphelo

Xa bencokola noogqirha babo, izigulana ezininzi ziyazi ukuba kwa abaqhubi abafanayo bachaphazela inkitha yezinye iiphenotypes, zonke ziqhele ukudumba, i-insulin, kunye netyhefu. Ke xa abantu abaninzi beqonda ukuba ezi zinto zingunobangela, oogqirha baya kusebenza nababoneleli bezonyango abanxulumeneyo ukuphuhlisa izicwangciso zonyango olusebenzayo lomntu. Ke khumbula, kufuneka usoloko usebenzisa umda wexesha kunye ne-matrix kuhlobo loncedo olwaziyo ukuba uqala phi ngesi sigulana, kwaye kwabanye abantu, inokuba uzakwenza kancinci indlela yokuphila kuba bonke Umsebenzi wabo kukutshintsha inani lemizimba yabo. Ngoko ke yenye yeentsikelelo amayeza asebenzayo ukuba sakwazi ukucima ukudumba emathunjini, nto leyo enceda ukunciphisa impembelelo eyityhefu umthwalo isibindi. Ikwavumela umntu ukuba afumanise ukuba yintoni esebenzayo okanye engasebenziyo ngemizimba yakhe kwaye athathe la manyathelo mancinci ukuphucula impilo yakhe.

Siyathemba ukuba unamehlo amatsha malunga nokudumba, i-insulin, kunye netyhefu kunye nendlela eyingcambu yeemeko ezininzi ezijongene nezigulana zakho. Kwaye indlela yokuphila elula kakhulu kunye nesebenzayo kunye nongenelelo lwezondlo, unokutshintsha oko kubonakaliswa kwaye utshintshe ikhondo leempawu zabo namhlanje kunye nobungozi abanabo ngomso.

isikhanyeli