Ukwenzakala okungeyongozi yoMnqonqo

Ukwenzakala komnqonqo okanye ii-SCI azenzeki nje kumandla amakhulu/umonzakalo wamandla aphezulu njengokuwa kanzima okanye iingozi zemoto. Ukulimala kwentambo yomgogodla okungenangozi kuxhaphake kakhulu. Nangona kunjalo, ukulimala kwentambo yomgogodla kudla ngokufumana ingqalelo enkulu. Oku kunokubangela iingxaki njengoko kunokulibazisa unyango kubantu abanokwenzakala okungonakaliyo. Ukuqonda kubalulekile kuba iziphazamiso zomnqonqo zithande ukungaqatshelwa ngempembelelo yazo kwimpilo iyonke.

I-Non-traumatic Spinal Cord Injury

Ukwenzakala okungonakaliyo kwentambo yomqolo ligama leambrela elibandakanya ukuphazamiseka okuninzi, okunje:

• I-myelopathy yomlomo wesibeleko ewohlokayo
• I-spondylosis ewohlokayo
• Irheumatoid arthritis
• Isifo sephepha
• Isifo sokugubhuka
• Umhlaza wamathumbu
• Iziphazamiso zophuhliso ezifana Umqolo Bifida kunye ne-cerebral palsy
• Ukuhamba kwe-myelitis
• I-Amyotrophic lateral sclerosis okanye isifo sikaLou Gehrig
• I-ataxia kaFriedreich

Ukuqonda ezi ngxaki kunceda ukufumanisa ukuxilongwa ngokuchanekileyo. I-myelopathy yomlomo wesibeleko ewohlokayo okanye i-DCM yeyona ndlela ixhaphakileyo yokwenzakala okungonakaliyo. Kukwenzakala okucothayo okuqhubelekayo okudala uxinezeleko oludla ngokuziswa si-spondylosis okanye i-osteoarthritis yamalunga omqolo. I-DCM inokuba nefuthe elibi kumgangatho wobomi ukuba ayifunyaniswanga kwaye iphathwe njengoko inokuba nefuthe le-ripple ngokuphakamisa umngcipheko wokuwa, okukhokelela ekuhlaselweni kwentambo yomgogodla. Ukuqonda kunokunceda ekuthinteleni umonakalo.

Ezinye oonobangela kunye neeNgxaki

Ezinye izinto ezibangela ukwenzakala okungonanzelekiyo komnqonqo ziquka:

• Umonakalo wemisipha
• Ilahleko yokunikezelwa kwegazi kwintambo yomgogodla
• Uxinzelelo oluvela kwithumba okanye ihlwili legazi
• Sulelo
• Ithumba lomqolo
• Atherosclerosis

Enye yezona zinto zibalulekileyo ezinobungozi bubudala. Oku kungenxa yomngcipheko onyukileyo weemeko ezifana ne-osteoarthritis kunye noxinzelelo lwegazi njengoko abantu besiya bekhula, yiyo loo nto abantu abanokwenzakala okungonakali kwentambo yomqolo, ngokomyinge, badala kunabantu abafumana ukwenzakala okubuhlungu. Ubuthathaka, ukungazinzi, kunye nokulahlekelwa kolawulo lwemisipha zizinto ezixhaphakileyo ezinokuthi ziphuhliswe njengoko i-non-traumatic cord yokulimala iqhubela phambili. Ezinye iingxaki ezinokubakho ziquka:

• Ubuhlungu obungapheliyo
• Ukuphazamiseka kokulala
• Ukutyunjwa
• Ukungabikho kwamanzi e-Urinary
• Izifo zogqirha
• Ukungabi namandla
• Izilonda zoxinzelelo / izilonda ebhedini ukuba ayishukumi
• Amahlwili egazi anokwenzeka angakhokelela kwi-vein thrombosis enzulu
• Ukuxinezeleka nokuxhalaba

impatho

Ngokulimala kwentambo yomgogodla, unyango luxhomekeke kubukhulu bokulimala. Nge ukwenzakala okungahambi kakuhle, unyango luxhomekeke kuluphi uhlobo lwemeko echaphazelekayo. Unyango oluphambili lokulimala okungenabuhlungu kwintambo yomgogodla ngokuqhelekileyo kubandakanya iindlela ezahlukeneyo zokuvuselela ukunciphisa umonakalo ongakumbi kwintambo yomgogodla. Ukuhlinzwa kunokuba yimfuneko ukuba umnqonqo ufuna ukuthotywa.

UkuBumbiswa kweBhunga

Amanzi angaphandle kunye naManzi e-Intracellular

Amanzi angaphandle kwe-Extracellular - ECW

• I-Extracellular ngamanzi angaphandle kweeseli zomzimba.
• Amanzi egazini awela kolu didi.
• Malunga ne-1/3 yolwelo lomzimba kuthiwa yi-ECW, kwaye la manzi afumaneka kwi ulwelo lwangaphakathi, ulwelo lwe-transcellular, yaye iplasma yegazi.
• La manzi abalulekile kuba:
• Inceda ukulawula ukuhamba kwee-electrolytes.
• Ivumela ukuhanjiswa kweoksijini kwiiseli.
• Icoca inkunkuma kwiinkqubo zemetabolism.

Amanzi e-Intracellular - ICW

• I-Intracellular ngamanzi angaphakathi kwiiseli zomzimba.
• Iquka i-70% ye-cytosol, engumxube wamanzi kunye nezinye izinto ezinyibilikayo.
• Yenza enye i-2/3 yamanzi ngaphakathi emzimbeni.
• Amanzi e-intracellular abalulekile kuba:
• Kuyanceda ngaphakathi iinkqubo zeselula.
• Ivumela iimolekyuli ukuba zihanjiswe kwii-organelles ezahlukeneyo ngaphakathi kwiseli.
• Iphakamisa apho amanzi angaphandle aphuma khona ngokuqhubeka nomzila we-fuel / amandla ukuba ahanjiswe kwiiseli.

Ucaphulo

Badhiwala, Jetan H et al. "I-myelopathy yomlomo wesibeleko ewohlokayo - uhlaziyo kunye nezikhokelo zexesha elizayo." Uphononongo lwendalo. I-Neurology vol. 16,2 (2020): 108-124. doi:10.1038/s41582-019-0303-0

Handbook of Clinical Neurology (2012) "Spinal Cord Injury." www.sciencedirect.com/topics/medicine-and-dentistry/non-traumatic-spinal-cord-injury

Milligan, James et al. "I-myelopathy yomlomo wesibeleko ewohlokayo: Ukuxilongwa kunye nolawulo kwinkathalo ephambili." Ugqirha wosapho waseKhanada Medecin de famille canadien vol. 65,9 (2019): 619-624.

Ulawulo loMzimba kwi-Neurological Rehabilitation (2004) "Ukulimala kwentambo yomgogodla." www.sciencedirect.com/topics/medicine-and-dentistry/non-traumatic-spinal-cord-injury