Ukulwa ne-Neurodegeneration eMzimbeni

intshayelelo

Owona msebenzi wengqondo kukugcina umzimba ushukuma kwaye unike ukusebenza kuwo onke amalungu amakhulu ngokusayina kwe-neuro ukusuka kwiingcambu ezininzi zemithambo-luvo ezijikeleze umzimba wonke. Njengenxalenye yenkqubo ye-nervous ephakathi emzimbeni, ingqondo inobudlelwane obuqhelekileyo kunye umqolo, inkqubo yomzimba, yaye Inkqubo yamathumbu. Nangona kunjalo, njengoko umzimba uguga ngokwendalo, kunjalo nengqondo, njengoko iipathogens ezininzi ezichaphazela umzimba ngokuhamba kwexesha zichaphazela ingqondo kunye nezinxulumani zayo. Iintsholongwane eziyingozi ezichaphazela umzimba zinokuphazamisa inkqubo yokubonisa ingqondo, nto leyo ebangela ukuba umzimba ube semngciphekweni wokuphuhlisa ukuphazamiseka kwe-neurodeergenerative. Inqaku lanamhlanje lijonga i-neurodegeneration, ukuba iwuchaphazela njani umzimba kunye nengqondo, kunye neendlela zokuphucula impilo yengqondo. Sithumela izigulana kubaboneleli abaqinisekisiweyo abaziingcali kunyango lwe-neurological ukunceda abantu abaninzi abajongana ne-neurodegeneration. Sikwakhokela izigulana zethu ngokubhekisa kubaboneleli bethu bezonyango abanxulumeneyo ngokusekelwe kuvavanyo lwabo xa kufanelekile. Sifumanisa ukuba imfundo sisisombululo sokubuza ababoneleli bethu imibuzo ecacileyo. UDkt Alex Jimenez DC unikezela ngolu lwazi njengenkonzo yemfundo kuphela. isikhanyeli

Yintoni iNeurodegeneration?

Ngaba ubuphethwe kukudumba emathunjini akho? Uziva njani iintlungu kunye neentlungu emzimbeni wakho wonke? Ngaba ufumana ukuqina kwemisipha kwiindawo ezithile ecaleni komqolo wakho? Uninzi lwale miba luphawu lwabantu abaninzi abasemngciphekweni wokukhula kwe-neurodegeneration. I-Neurodegeneration sisifo esixhomekeke kwiminyaka yobudala abantu abaninzi, ngakumbi abantu abadala. Izinto ezininzi zivumela ukuqhubeka kokuphazamiseka kwe-neurodeergenerative ukuba kuchaphazele ingqondo nomzimba. Ezinye zeengxaki eziqhelekileyo ze-neurodeergenerative ezichaphazela umntu zezi:

• Izifo ze-Alzheimer's
• Isifo sikaParkinson
• Isifo sikaHuntington
• Dementia
• I-Multiple and lateral sclerosis

Ezi ziphazamiso ziqhelekileyo ze-neurodeergenerative zichaphazela umzimba ngokuhamba kwexesha ngokubangela ukudumba kunye nokuphazamisa umqondiso wobuchopho kwiindawo ezahlukeneyo zomzimba. 

Ichaphazela Njani Ingqondo kunye Nomzimba?

Ke i-neurodegeneration iyichaphazela njani ingqondo kunye nomzimba? Njengoko bekutshiwo ngaphambili, ubuchopho bunobudlelwane be-causal kunye namathumbu, intambo yomgogodla, kunye nenkqubo yomzimba yokuzikhusela. Ingqondo ivelisa imiqondiso ye-neuron ukuqinisekisa ukuba amajoni omzimba akhusela umzimba, intambo yomgogodla ibonelela ngomsebenzi we-sensory-motor kumqolo, kwaye Inkqubo yamathumbu ilawula kwaye igcine umzimba. Xa umzimba unengxaki yokonzakala okanye iintsholongwane eziyingozi zibangela ukuba imiqondiso ye-neuron ihambe i-haywire, inokuchaphazela iindawo ezininzi ezahlukeneyo kwaye ibangele. iintlungu ezibhekisiweyo kumalungu abalulekileyo kunye nezihlunu ezinxulumene nazo. Umzekelo uya kuba ukuba umntu unengxaki yokwenzakala kwengqondo ehambelana nemiba yamathumbu kunye nokudumba. Xa ingqondo inengxaki yokwenzakala okanye ukwenzakala, izinto ezininzi ezinokuthi zibandakanyeke emathunjini, zibangele imiba emininzi enokuchaphazela umzimba. Ezinye zeengxaki ezinxulumene nokwenzakala kwengqondo kunokubangela: 

• Utshintsho olubukhali kwi-intestinal permeability
• Yandisa ukungeneka kwisithintelo segazi-ingqondo (BBB)
• Ukonyuka koxinzelelo lwe-oxidative, ukuvuvukala, ukusebenza kwe-microglia
• Iimpawu eziqhubekayo kunye nenkqubela phambili ye-neurobehavioral
• Umngcipheko we-hormonal compromise

Uphando lutyhila ukuba i-pathology ye-neurodeergenerative disorders ihlala ingaziwa; nangona kunjalo, abaninzi baye bacinga ukuba iimeko zokusingqongileyo zinokudlala indima engunobangela. Imiba yokusingqongileyo efana nokukhetha indlela yokuphila, indlela yokutya, kunye nokusebenza komzimba kuchaphazela ubomi bomntu. Xa ezi zinto zenzakalisa umzimba, zinokuba ngumlamli wokuphazamiseka kwe-neurodeergenerative ukuqhubela phambili kwaye kubangele imiba emzimbeni.

Isishwankathelo seZifo zeNeurodeergenerative-Ividiyo

Ngaba ufumana inkungu yengqondo rhoqo kunesiqhelo? Ngaba uziva iingxaki ezichaphazela amathumbu akho? Kuthekani ngokuva intlungu okanye ukuqina kwemisipha echaphazela intamo okanye umva wakho? Eminye yale miba inyanyaniswa nezifo ze-neurodeergenerative ezichaphazela umzimba. Le vidiyo ingentla inika isishwankathelo sezifo ze-neurodeergenerative kunye nokuba ziwuchaphazela njani umzimba. Indlela yezifo ze-neurodeergenerative ayaziwa, kodwa iimeko zokusingqongileyo zibangela impembelelo emzimbeni, zibangela ukugcwala kweeprofayili zomngcipheko ezinxulumene nemiba emininzi engapheliyo. Ngethamsanqa, zininzi iindlela zokuthoba iziphumo zezifo ze-neurodeergenerative ekubeni ziqhubele phambili emzimbeni.

Iindlela zokuphucula impilo yeBrain

Xa kuziwa kwimpilo yobuchopho kunye nokuthintela ukuphazamiseka kwe-neurodeergenerative ekuqhubeleni phambili, abantu abaninzi baye bafumana iindlela zokuphucula ingqondo kunye nomzimba wabo. Uphando lutyhila ukuba ukubonelela ngeendlela zonyango ezinokubakho kwiimeko ze-neurological kunokunceda ingqondo ithathe ulwazi olutsha kwaye incede umzimba usebenze. Iintsika ezintandathu ezithathelwa ingqalelo impilo yengqondo ziquka:

• Umsebenzi wezobugcisa
• Ukuzivocavoca ngengqondo
• Ukutya okunempilo kunye nesondlo
• Intsebenziswano yoluntu
• Ubuthongo obuninzi
• Ukulawula izinto ezinobungozi be-vascular

Iintsika nganye ibonelela ngempilo yobuchopho egqibeleleyo ngokwenza umntu ajonge imeko yakhe ngokwahlukileyo. Umzekelo, umntu onemiba yamathumbu enxulunyaniswa nokudumba kwengqondo unokutshintsha indlela abatya ngayo kwaye adibanise iziqhamo kunye nemifuno. Uphando lutyhila ukuba xa abantu benxulunyaniswa nemvakalelo yoxinzelelo kunye nelahleko evela kwisiganeko esinempembelelo bakholisa ukulawula amanqanaba abo oxinzelelo. Ukubandakanya imida esempilweni ukuthoba amanqanaba oxinzelelo kunokuba nempembelelo entle kwingqondo ngokuthatha into entsha yokuzonwabisa, ukuthetha nomhlobo wakudala, kunye nokwenza izinto ezizisa ulonwabo ebantwini, ezinokulawula ukuqhubeka kokuphazamiseka kwe-neurodeergenerative kunye nokubonelela ngolonwabo olugqibeleleyo.

isiphelo

Ingqondo ngumlawuli osembindini womzimba njengoko ibonelela ngemiqondiso ye-neuron kwilungu ngalinye eliphambili kunye nezihlunu ngophawu lwe-neuro olusuka kwiingcambu zemithambo-luvo ezijikelezileyo. Xa umzimba unengxaki yokwenzakala okanye ukwenzakala ngenxa yeentsholongwane eziyingozi, kunokuchaphazela impilo yengqondo ngokuphazamisa imiqondiso ye-neuron. Ngamanye amaxesha, inokuba kukwaluphala kwendalo okuchaphazela ingqondo, kubangele ukuphazamiseka kwe-neurodeergenerative. Iziphazamiso ze-Neurodeergenerative ezinxulumene nemiba engapheliyo zinokubangela ukungasebenzi kakuhle emzimbeni, kubangele ukudityaniswa kweeprofayili zomngcipheko wezifo ezingapheliyo. Ukubandakanya izinto eziluncedo ukukhuthaza impilo yobuchopho kunempembelelo entle ekugcineni ingqondo isempilweni kwaye icothisa ukuqhubeka kokuphazamiseka kwe-neurodeergenerative kwingqondo.

Ucaphulo

UBrown, uRebecca C, et al. "Izifo ze-Neurodeergenerative: Isishwankathelo seMingcipheko yeNdalo." Imiba yezeMpilo, Iziko leSizwe leSayensi yezeMpilo yeNdalo, ngoSeptemba 2005, www.ncbi.nlm.nih.gov/pmc/articles/PMC1280411/.

Gitler, uAron D, et al. "Isifo se-Neurodeergenerative: Iimodeli, iiMechanism, kunye neThemba elitsha." Iimodeli zeSifo kunye neeNdlela zokuSebenza, Inkampani yeBiologists Ltd, ngomhla woku-1 kuCanzibe ngo-2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5451177/.

Mintzer, Jacobo, et al. "Ukhetho lwendlela yokuphila kunye nempilo yengqondo." Imida kwezamayeza, Frontiers Media SA, 4 Okt. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6787147/.

Wang, Yongjun, et al. "Yintoni Impilo Yengqondo kwaye Kutheni Kubalulekile?" I-BMJ (uPhando lwezonyango u-Ed.), BMJ Publishing Group Ltd., 9 Okt. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7555053.

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