Isishwankathelo seSifo sikaParkinson esichaphazela uMzimba

intshayelelo

The ngengqondo lelinye lawona malungu anamandla abonelelayo somatic kwaye kwipheripheral iimpawu kuwo wonke umzimba. Ingqondo iqinisekisa ukuba umzimba uhlala usebenza kwaye uthumela inani elifanelekileyo le-neurons kunye nezinye izinto eziyimfuneko kwiimisipha ezahlukahlukeneyo, izitho ezibalulekileyo, i-tendon, kunye ne-ligaments ukwenzela ukuba umkhosi uqhubeke nokuhamba, nokuba ukwimeko esebenzayo okanye yokuphumla. Nangona kunjalo, njengoko umzimba uguga ngokwendalo, kunjalo nengqondo, njengoko izinto ezininzi zinokuchaphazela umzimba ngeendlela ezininzi. Iimeko ezingapheliyo ezifana ukuphazamiseka kwemithambo-luvo inokuchaphazela indlela ubuchopho obusebenza ngayo emzimbeni kwaye inokubangela impembelelo ye-cascading emzimbeni echaphazela kungekuphela nje izakhono zemoto kodwa izihlunu, iigaments, kunye namalungu abalulekileyo. Inqaku lanamhlanje lijonga enye yeengxaki ze-neurodeergenerative eyaziwa ngokuba sisifo sikaParkinson, ukuba siwuchaphazela njani umzimba, kunye nendlela yokulawula i-Parkinson's kwangethuba ukuyithintela ukuba ingachaphazeli ingqondo. Sithumela izigulane zethu kubaboneleli abaqinisekisiweyo ababandakanya ubuchule kunye neendlela ezahlukeneyo zonyango kubantu abaninzi abasuka kwisifo sikaParkinson kunye neempawu zayo ezihambelanayo ezinokuchaphazela inkqubo ye-musculoskeletal system. Sikhuthaza kwaye siyasixabisa isigulana ngasinye ngokusithumela kubaboneleli bezonyango abanxulumeneyo ngokusekelwe kuxilongo lwaso xa kufanelekile. Siyaqonda ukuba imfundo yeyona ndlela imangalisayo xa ubuza ababoneleli bethu imibuzo entsonkothileyo ngokwesicelo sesigulana kunye nokuqonda kwakhe. UDkt Jimenez, DC, usebenzisa le ngcaciso kuphela njengenkonzo yemfundo. isikhanyeli

Yintoni isifo sikaParkinson?

Ngaba udla ngokuzibona sele ukrwaqula amazwi akho? Ngaba uye waqaphela ukuba uhlala ucofa, kwaye ichaphazela ukuma kwakho? Okanye ngaba ujongene nokuqina kwiindawo ezahlukeneyo zemisipha? Ukuba ukhe wafumana nayiphi na kwezi mpawu, inokunxulumana neempawu zokuqala zesifo sikaParkinson. Uphando lutyhila ukuba isifo sikaParkinson sisimo esicothayo, esiqhubela phambili kwi-neurodeergenerative disorder echaphazela malunga ne-1% yabemi behlabathi abangaphezu kweminyaka engama-60. Le ngxaki ye-neurological ixhaphakile, kwaye ngelixa ichaphazela amadoda ngaphezulu kwabasetyhini, ibangela ukuba i-basal ganglia ibe mandundu ngokuhamba kwexesha kwaye ibangela iimpawu ezininzi. ukuchaphazela ukusebenza kweemoto zomzimba. Izifundo ezongezelelweyo zityhila ukuba iimpembelelo zokusingqongileyo ezifana nokutshaya kunye nezinto ze-endocrine zinokubangela ukuphindaphindana kweeprofayili zomngcipheko ezibangela ukukhula kwangoko kwesifo sikaParkinson. Ezinye zeempawu eziqhelekileyo kwisifo sikaParkinson ziquka:

• Ukulahleka komsebenzi wemoto ezandleni nasezinyaweni
• Ukungcangcazela komzimba xa uphumle
• Ukuqina kwemisipha
• Ukuma okungazinzanga
• Akakwazi ukubhala, ukuthetha okanye ukuginya
• Imiba yokulala
• Ukungasebenzi kakuhle
• Ukuphazamiseka komchamo

Ezi mpawu zahlukeneyo zibangela ukungasebenzi komzimba kwizihlunu ezininzi kunye namalungu abalulekileyo kwaye kunokukhokelela kwimiba egqithileyo yengozi enokusifihla isifo sikaParkinson.

Ingaba iParkinson iwuchaphazela njani umzimba?

Xa isifo sikaParkinson sichaphazela indlela ubuchopho obuthumela ngayo imiqondiso ye-neuron ukuvumela izakhono zomzimba ukuba zisebenze kwiqela ngalinye lezihlunu, iimpawu kunye neempawu zinokwahluka kumntu ngamnye. Iimpawu zokuqala zincinci kwaye azibonakali. Nangona kunjalo, ekubeni isifo sikaParkinson sichaphazela izakhono zomzimba, ubuthathaka bemisipha buhambelana neempawu ezinxulumene ne-Parkinson. Uphando lutyhila ukuba i-Parkinson's sisifo se-neurodeergenerative edla ngokubonakala ngeempawu ezahlukeneyo zeemoto; ukusilela kwemisipha kunokubangela ukungazinzi kwamalungu kunye nezihlunu kunye netorque. Ukunqongophala kwemisipha emzimbeni kunokubangela ukuba ingqondo ibonise amajoni omzimba ukuba athumele i-cytokines evuthayo kwizihlunu ezahlukeneyo kunye namalungu abalulekileyo kwaye ibangele ukungaqhelekanga emzimbeni, nto leyo echaphazela unxibelelwano lwe-gut-brain kwaye ikhokelele kwi-gut dysbiosis ehambelana nokuqina kwemisipha. .

Ukuqonda isifo sikaParkinson-Ividiyo

Ngaba uye wafumana ubuthathaka bemisipha kwiindawo ezahlukeneyo zomzimba wakho? Ngaba uziva uqhinwe rhoqo? Okanye ngaba ujongene nemiba yokuqonda echaphazela umgangatho wobomi bakho? Uninzi lwezi mpawu kunye neempawu zinxulunyaniswa nesifo se-neurodeergenerative eyaziwa ngokuba sisifo sikaParkinson. Le vidiyo ingentla ichaza ukuba yintoni isifo sikaParkinson kunye nokuba siyichaphazela njani ingqondo. Uphando lutyhila ukuba unxulumano phakathi kwesakhiwo sobuchopho kunye nesifo sikaParkinson sihambelana nokusilela kwemisipha emzimbeni. Kuba i-Parkinson's isiphazamiseko esicothayo, esiqhubekayo kwi-neurodeergenerative, enye yeempawu bubuthathaka bezihlunu. Ubuthathaka bemisipha buyenzeka emzimbeni xa isifo sikaParkinson siqala ukuqhubela phambili kwaye sibangela intsilelo ekusebenzeni okuphakathi kweqela ngalinye lemisipha. Xa oku kusenzeka, imiba emininzi iya kuqala ukukhula ngokuhamba kwexesha ecaleni kweParkinson. Kwicala eliqaqambileyo, kukho iindlela ezahlukeneyo zokucothisa ukuqhubeka kwesifo sikaParkinson kunye nokubuyisela ukusebenza komzimba.

Indlela yokulawula isifo sikaParkinson kwangethuba

Kukho iindlela ezininzi apho abantu abaninzi banokucothisa ukuqhubeka kwesifo sikaParkinson kwangethuba ukuthintela imiba emininzi ekuchaphazeleni izakhono zomzimba. Ukwenza umthambo owaneleyo kunokunceda ekuphuculeni impilo-ntle yomntu kunye nobuchule bokusebenza komzimba. Ukubandakanya ukutya okunempilo kunye nezongezo ezinokuphucula ukusebenza kwengqondo kunye nokunciphisa ezinye iimpawu ezinjengokuvuvukala kunokunceda ukuphucula ukusebenza kwemisipha kunye nomzimba. Kwaye ekugqibeleni, ukufumana izinto zokuzilibazisa kunye nokubeka imida kunokunciphisa amanqanaba e-cortisol kunye nokunciphisa uxinzelelo kunokuba yimpembelelo enhle kwingqondo; ukulawula ukuqhubela phambili kweParkinson kunokuqinisekisa impilo-ntle yomntu ngelixa usenza ingqondo iphinde idibanise ezo zibonakaliso ze-neuron ukusuka kwi-haywire.

isiphelo

Isifo sikaParkinson sisifo esicothayo, esiqhubela phambili esibangela ukuba i-basal ganglia yobuchopho ibe mandundu kwaye ibangele ukungasebenzi kakuhle kwezakhono zomzimba. Xa imiqondiso ye-neuron yobuchopho iba yi-haywire ngenxa ye-Parkinson's, inokukhokelela kubuthathaka bemisipha emzimbeni, kwaye oko kunokubangela ukugcwala kweeprofayili zomngcipheko emzimbeni, kubangele iimpawu ezininzi zokufihla isifo sikaParkinson. Ngethamsanqa, kukho iindlela ezininzi zokunciphisa ukuqhubela phambili kwesifo sika-Parkinson ekuqaleni kunokunciphisa iimpawu ze-Parkinson:

• Ukutya ukutya okunesondlo kwingqondo
• Ukusebenzisa
• Ukuba nengqondo

Xa abantu bebandakanya obu buchule kwindlela yabo yokuphila, banokuphinda bawufumane umgangatho wobomi babo.

Ucaphulo

Frazzitta, Giuseppe, et al. "Umahluko kumandla emisipha kwizigulana zeParkinsonian ezichatshazelwe ngasekunene nangasekhohlo." PloS One, Ithala Leencwadi Lesizwe laseMelika laseMelika, nge-25 Matshi 2015, www.ncbi.nlm.nih.gov/pmc/articles/PMC4373899/.

Kouli, Antonina, et al. "Isahluko 1: Isifo sikaParkinson: I-Etiology, Neuropathology, kunye nePathogenesis." Ku: Stoker TB, Greenland JC, Abahleli. Isifo sikaParkinson: I-Pathogenesis kunye neMiba yeKlinikhi [i-Intanethi]. EBrisbane (AU), Codon Publications, 21 Dec. 2018, www.ncbi.nlm.nih.gov/books/NBK536722/.

UZafar, uSaman, kunye noSridhara S Yaddanapudi. "Isifo sikaParkinson-iStatpearls-kwishelufu yeencwadi yeNCBI." Ku: StatPearls [Internet]. Isiqithi saseTreasure (FL), StatPearls Publishing, 8 Aug. 2022, www.ncbi.nlm.nih.gov/books/NBK470193/.

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