Ubuhlungu be-Neuropathic ne-Neurogenic Inflammation | El Paso, TX.

Ukuba inkqubo yezoluvo ichaphazeleka kukwenzakala okanye isifo, imithambo-luvo ekuloo nkqubo ayinakusebenza ekusasazeni imvakalelo ebuchotsheni. Oku kunokukhokelela ekubeni ube ndindisholo, okanye ungabi namvakalelo. Kwezinye iimeko xa i-sensory system yenzakele, abantu ngabanye banokufumana intlungu kummandla ochaphazelekayo. Intlungu ye-neuropathic ayiqali ngokukhawuleza okanye iphele ngokukhawuleza. Yimeko engapheliyo ekhokelela kwiimpawu ze intlungu eqhubekayo. Kwabaninzi, ubunzima beempawu ziza kwaye zihambe yonke imihla. Iintlungu ze-neuropathic zicingelwa ukuba zidibene neengxaki zentsholongwane yentsholongwane, oko kukuthi ingxaki yokuguquka kwesifo sikashukela, isisu somgulane, ukulimala kwengqondo okanye umthambo womgudu kunokukhokelela kwintlungu engapheliyo ye-neuropathic.

I-PAUROPATHIC PAIN

Iinjongo:

• Yintoni?
• Iyiphi ipathophysiology emva kwayo?
• Ziziphi izizathu
• Ziziphi ezinye zeendlela
• Sinokuyilungisa njani?

I-PAUROPATHIC PAIN

• Ubunzima buqaliswe okanye bubangelwa lilonda eliphambili okanye ukungasebenzi kwiinkqubo ze-nervosensory system.
• Iintlungu ze-neuropathic zihlala zingapheliyo, zinzima ukunyanga kwaye zisoloko zixhatshazwa kwi-analgesic management management.

I-PATHOGENESIS YENKQUBO YENKQUBO

• AMANCHANISMS OKUSEBENZA
• Emva kwentsholongwane yentsholongwane yomzimba, i-neurons ibe nefuthe ngakumbi kwaye ivelise ukukhupha okungavamile kunye nobuzwe obuphakamileyo ekuvuseleleni
• Oku kwaziwa ngokuba ... Ukwaziswa kwe-Peripheral Sensitization!

• AMANCHANISMS EMFUNDO
• Ngenxa yesenzo esenziwa ngokuqhubekayo esivela kwi-periphery, i-neurons yakha imisebenzi eyimvelaphi eyongeziweyo, iindawo ezandisiweyo zokuthobela kunye nezimpendulo ezongeziweyo kwiimpembelelo ezingafaniyo, kubandakanywa nesicatshulwa esiqhelekileyo
• Oku kwaziwa njenge…Sensitization ephakathi!

IINKCUKACHA EZIMALI

Izilonda okanye izifo zesistim se-somatosensory system zingakhokelela ekutshintshiseni nokutshatyalaliswa kwezibonakaliso zengqondo kwintambo yomgogodla kunye nengqondo; Iimeko eziqhelekileyo ezinxulumene nobuhlungu be-neuropathic ziquka:

• Postherpetic neuralgia
• I-neuralgia yamaTrigeminal
• I-radiculopathy ebuhlungu
• I-diabetes neuropathy
• Usulelo lweHIV
• Neqhenqa
• Ukukhutshwa
• Intlungu yomonakalo weentlungu
• Isibetho (ngesimo seentlungu eziphambili kwintlungu)

IINTLUNGU ZEMILIMBO YEPHANTOM & NOKWENZEKA NGOKWENZEKILEYO

• I-Phantom Limb Pain kunye ne-AR

INUROGENIC INFLAMMATION

Iinjongo:

• Yintoni?
• Iyiphi ipathophysiology emva kwayo?
• Ziziphi izizathu
• Sinokuyilungisa njani?

INUROGENIC INFLAMMATION

• Ukuvutha kwe-Neurogenic iyimfuneko eyenziwe ngokwemvelo, impendulo yendawo yokuvuvukala yendawo eyenziwa yi-vasodilation, ukunyuka kwe-vascular cell, i-cell cell degranulation kunye nokukhululwa kwama-neuropeptides kuquka i-SP ne-calcitonin echaphazelekayo ye-peptide (i-CGRP)
• Kubonakala kudlala indima ebalulekileyo kwi-pathogenesis yezifo ezininzi kuquka i-migraine, i-psoriasis, i-asthma, i-fibromyalgia, i-eczema, i-rosacea, i-dystonia kunye ne-multiple chemical sensitivity

IINKCUKACHA EZIMALI

• Kukho iindlela ezininzi apho ukuvuvukala kwe-neurogenic kungaqaliswa. Kucaciswe kakuhle, usebenzisa iiforms zezilwanyana kunye nama-neurons ahlukeneyo kwi-vitro, ukuba i-capsaicin, ukushisa, i-proton, bradykinin, kunye ne-tryptase ngabalawuli abaphezulu be-intracellular calcium influx, ephumela ekukhululweni kwe-neuropeptide. Ngokwahlukileyo, kucatshangelwa ukuba i-prostaglandin i-E2 kunye ne-I2, i-cytokines, i-interleukin-1, i-interleukin-6, kunye ne-tumor necrosis nto ayibangela ukuba i-neurotransmitter ikhululwe ngokwayo, kodwa kunokuba ivule i-neurons ye-sensor ize iyanciphise umda wokudubula kwaye ibangele ukukhululwa neuropeptides.
• Nangona i-neurogenic inflammation iye yafundwa ngokubanzi kwaye ichaneke kakuhle kwiimfucu zephersi, kwaze kwangoku ingqungquthela ye-neurogenic inflammation ngaphakathi kwe-CNS iye yahlala ingabonakali. Ukunikezelwa kwamandla okuvuvukala kwe-neurogenic ukuphazamisa ukuphazamiseka kwe-vascular kunye nokukhokelela kwi-genesis ye-edema, ngoku uphando ngokubanzi malunga nokukwazi ukuchaphazela iBBB ukuphelela kunye ne-edema ye-vasogen ngaphakathi kwengqondo kunye nomgudu womgudu phantsi kweemeko zesifo.

Anatomy Of The Brain