I-DNA isekela iigciwane ze-20,000, nganye ibambe inkqubo yokudala iprotheni okanye i-enzyme efunekayo yokuphila ngendlela enempilo. Yonke enye yala maphepha idinga ukuba ilawulwe rhoqo ngohlobo "lomgqugquzeli" olawula ngokuthe ngqo ukuba yeyiphi imveliso nganye kunye / okanye ikhemikhali eyenziwa kwaye phantsi kwayo le miqathango iya kuphuhliswa.
Ngokudibanisa uhlobo oluthile lweendawo ezikhuthaza ukutshintshana, ezibizwa ngokuba yi-Antioxidant Response Element, okanye i-ARE, Nrf2Ixhasa isantya sendalo kumakhulu ohlobo lwento eyahlukileyo ezenza ukuba iiseli ziphile phantsi koxinzelelo. Ezi zofuzo zivelisa ukhetho lwee-enzyme ze-antioxidant eziphuhlisa uthungelwano lokhuselo ngokuthomalalisa ii-oxidants kunye nokucoca iimveliso ezinobuthi ezishiyeke kwimveliso yazo, ukongeza ekuncedeni ukubuyisela umonakalo owenzileyo.
Contents
Ii-oxidants ezininzi ezifana ne-superoxide radical, okanye i-O2-, kunye ne-hydrogen peroxide, okanye i-H2O2, zenziwe ngokwenza ukutshisa izinto kunye / okanye iikhemikhali ezigcina umzimba womntu. Umzimba womntu ufumene ii-enzyme zokulwa ne-antioxidant ezingathathi hlangothi kwaye zikhuphe ukutya okusebenzayo kunye neziselo esizisebenzisayo. I-Nrf2 imodareyitha imveliso yazo ukugcina ulingano kwaye igxininisa imfuno yazo zonke ezi enzymes. Olu bhalansi lunokuphazanyiswa zizinto ezininzi, kubandakanya ubudala.
Njengokuba sikhula, bodyumzimba womntu wenza i-Nrf2 encinci kwaye oku kulungelelana okuethe-ethe kungathi ngokuthe ngcembe kuqalise ukubuyela kwicala le-oxidative, ilizwe ekubhekiswa kulo njengoxinzelelo lwe-oxidative. Isifo sisenokubangela ukuveliswa kakhulu kwee-oxidants. Usulelo, isifo somzimba, kunye nokuphazamiseka komzimba kungenza ukuba iiseli zethu zomzimba zenze i-oxidants esebenzayo, njenge-O2-. , H2O2, OH kunye ne-HOCl, apho iiseli ezisempilweni zonakaliswa kwaye ziphendule ngokudumba. Izifo ezinxulunyaniswa nokwaluphala, kubandakanya ukubetha kwentliziyo, ukubetha, umhlaza, kunye neemeko ze-neurodegenerative ezinje ngesifo se-Alzheimer, zikwonyusa ukukhula kwe-oxidants, ezenza uxinzelelo kunye nokuphendula kokudumba.
Iprotheni ye-Nrf2, ebizwa ngokuba yi-factual factor ngenxa yendlela yokwenza inkxaso nokulawula ii-enzyme kunye nejeni, yinto eyimfihlo yokulandelelana kweempendulo ze-biochemical ngaphakathi kweseli ephendula ngokuguqulwa kwendlela yokulinganisa kwengqondo kunye ne-balance balance. Izinto ezivelayo zalo mzila ziguqula kwaye zikhupha i-Nrf2, ibangela ukuba ikwazi ukusasazeka kwinucleus yesisele kwi-DNA. I-Nrf2 ingaphinde ivule okanye isuse amajeni kunye ne-enzyme exhasa ukukhusela iseli.
Ngethamsanqa, iintlobo ezahlukeneyo zezinto ezisetyenziswayo yi-Nrf2 ziphuhlisa ngokusebenzisa izityalo ezithile kunye nezicatshulwa ezisetyenziswa kwiminyaka emininzi edlulileyo kwizonyango zorhwebo zaseShayina naseNative American. Ezi zixhobo zeprotochemicals zibonakala zinamandla kunye neempembelelo ezingaphantsi, njengemveliso ye-Nrf2 eyenza imveliso yezobisi esetyenziswa namhlanje.
Isisombululo senkampani ye-erythroid I-2, eyaziwa ngokuba yi-Nrf2, yinto ebhaliweyo yokukhusela iseli ngokulawula i-gene, i-enzyme kunye nezimpendulo zokulwa ne-antioxidant. Imiba yombhalo we-Transcription iyinhlobo yeprotheni enamathele kwi-DNA ukukhuthaza ukuveliswa kwezinto ezithile kunye neekhemikhali, kuquka i-glutathione S-transfases, okanye i-GSTs. Ukusebenza kwe-Nrf2 kukhuthaza ukuveliswa kweeprotheni ezisebenzayo ezibonisa amandla anamandla okukhusela i-antioxidant ukusiza ukunciphisa uxinzelelo lwe-oxidative.
UDkt Alex Jimenez DC, i-CCST Insight
Emva kokuba i-Nrf2-supplement supplementary supplement yenziwe kwi-2004, ulwazi oluncinci lwaziwa malunga nomsebenzi weNrf2. Malunga namaphephandaba e-200 kwincwadi ka-Nrf2, eyaziwa ngokuba yi-2 okanye i-NFE2L2, ikhona kwaye abaphandi baqala ukufumana impendulo ye-anti-oxidant ye-Nrf2 kwizilwanyana ezincelisayo. Njengoko i-2017, nangona kunjalo, ngokuphanda kwe-9,300 uphando lwezemfundo kulo "mlawuli olawulayo," lishicilelwe.
Enyanisweni, i-Nrf2 ilawula ama-enzyme amaninzi angakhuselekanga kwiijethi, endaweni yoko, inika ukukhuselwa kwiimeko ezinxulumene noxinzelelo ezijongene neengqungquthela, izitho kunye neziganeko ekugqibeleni, phantsi kweemeko ezinempilo kunye nezifo. Ngokusekelwe kulo mbandela omtsha wolwazi oluvela kwizifundo zophando lwezemfundo, abaphandi bangakwazi ukuphucula ngakumbi I-Nrf2 izondlo zokutya.
Ukusukela ngo-2007, izifundo zophando zibonise umsebenzi onzima wendlela yeNrf2. I-Nrf2 activators ifunyenwe ukuba ilinganise izinto zezakhiwo ezahlukeneyo emzimbeni womntu. Ngale ndlela, i-Nrf2 activators ixhotyisiwe ukuba izive zitshintsha imeko kwiseli ukuze kugcinwe ibhalansi kwaye iphendule kwiimfuno eziguqukayo zofuzo.
Njengoko i-Nrf2-amandla okuqalisa iyancipha kunye nobudala kwizinto eziphilayo, utshintsho lunokuqala ukuvela. Uphando luye lwabonisa ukuba i-Nrf2 ekujoliswe kuyo kwiiseli iyancipha kunye nobudala, ibonisa ukunyuka kwamanqaku okuxinzezeleka kwengcinezelo. Izifo ezahlukeneyo ezinxulumene neminyaka ezinjenge-atherosclerosis kunye nesifo senhliziyo, isifo samathambo, umdlavuza, ukukhuluphala, uhlobo lwe-2 yesifo sikashukela, uxinzelelo lwegazi, i-cataracts, nesifo se-Alzheimer kwakunye nezifo ze-Parkinson ziyakhula ngenxa yezi nguqu. Uxinzelelo oluxhasayo lufunyenwe nale miba yempilo.
Ngokukhuthaza amandla eseli ukunyusa umveliso we-Nrf2, I-Nrf2 izondlo zokutya inokukunceda ukuvuselela amandla omzimba womntu ukulwa nemiphumo yokuxinzezeleka kwengcinezelo. I-Polyunsaturated fatty acids, okanye i-PUFAs, enye yee-molecule ezinomsoco kakhulu kwaye zixhatshazwa ngokubhekiselele kwimonakalo ye-radicals yamahhala. I-acid ye-Thiobarbituric, okanye i-TBARS, umveliso unokunyuka ngobudala, obonisa ukunyamezeleka kokuxhamla kunye ne-drop in Nrf2-indlela elawulwayo.
Ngokwebhayoloji, ukungeniswa kofuzo yindlela ecothayo, efuna iiyure zokugqithisa kwindlela. Ngenxa yoko, ii-enzyme ezininzi zinezixhobo zazo zokucima / zokucima ezinokubangelwa yimizuzu ngee-enzymes ezahlukeneyo zolawulo. Abaphandi baye baqulunqa iziqulatho zobunini bezinto ezisebenzayo zeNrf2 ezisebenzisa esi siseko solwazi sokwenza kusebenze. Ukwenza ukuba i-Nrf2 isebenze ayibunjwanga nje kuphela ngento ekhutshelweyo yeNrf2 ekhutshiweyo kwi-inhibitor yayo kunye nokufudukela kwiseli yeseli, kodwa ikwabopha kulandelelwano oluthile lwe-DNA ukukhuthaza intetho yohlobo lwe-cytoprotective, ukulawula isantya sokuba i-Nrf2 ikhutshiwe ngaphandle kwenucleus.
Ukuqonda inkqubo yokupheliswa kunye nokusebenza kwe-Nrf2 emzimbeni womntu kuye kwavumela abaphandi ukuba bakhe indibaniselwano yeentshukumo ezahlukeneyo ze-Nrf2 ukufezekisa ukubonakaliswa kwemfuza ngokumodareyitha kwayo. Umdibaniso wesiseko solwazi, kunye nolunye uphononongo olwahlukileyo lwezifundo zincedile ukuvelisa i-Nrf2 activators ukuba isetyenziswe njengezongezo zokutya. Ubungakanani bolwazi lwethu lukhawulelwe kwimicimbi ye-chiropractic kunye nempilo yomqolo. Ukuxoxa ngomxholo, nceda ukhululeke ukubuza uGqirha Jimenez okanye unxibelelane nathi ku915-850-0900 .
Ikhutshwe nguDkt. Alex Jimenez
Intlungu yedolo luphawu olwaziwayo olunokuthi lwenzeke ngenxa yeengozi zamadolo kunye / okanye iimeko, kubandakanya ukulimala kwezemidlalo. Amadolo ngenye yezona zinto ezinzima kakhulu emzimbeni womntu njengoko zenziwe yintlupheko yamathambo amane, iigamente ezine, iintlobo ezihlukahlukeneyo, i-menisci emibini, kunye ne-cartilage. Ngokwe-American Academy ye-Family Physicians, izizathu eziqhelekileyo zokubandezeleka kwamadolo zibandakanya i-patellar subluxation, i-patellar tendinitis okanye i-jumper, kunye ne-Osgood-Schlatter. Nangona ubuhlungu beentolo buya kwenzeka kubantu abantu abangaphezu kwe-60 ubudala, ubuhlungu beendolo buya kwenzeka kubantwana nakwishumi elivisayo. Iintlungu zesisu zingaphathwa ekhaya emva kweendlela ze-RICE, nangona kunjalo, ukulimala kwamadolo amakhulu kunokufuna ukunyangwa kwangoko kunyango, kubandakanya ukunakekelwa kwe-chiropractic.
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Iintsikelelo
UDkt Alex Jimenez D.C., I-MSACP, RN*, I-CCST, IFMCP*, I-CIFM*, I-ATN*
email: qeqeshi@elpasofunctionalmedicine.com
Ilayisenisi njengoGqirha weChiropractic (DC) kwi Texas & New Mexico*
Texas DC Ilayisensi # TX5807, New Mexico DC Ilayisensi # I-NM-DC2182
Unikwe Ilayisensi njengoMongikazi oBhalisiweyo (RN*) in Florida
Florida License RN Ilayisensi # I-RN9617241 (Nombolo yolawulo. 3558029)
Ubume obubambeneyo: ILayisensi yeeNkcazo ezininzi: Ugunyaziswe Ukuziqhelanisa I-40 States*
UGqr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
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