I-Glutathione: I-Antioxidant Inamandla kakhulu

I-Antioxidants ichongiwe ngokwesayensi njengamacandelo avimbela inkqubo ye-oxidation emzimbeni womntu, ukuba ukuba ingashiywa ingagqalwa, ingenza i-radicals ekhululekile ekwazi ukuvelisa iimpendulo ezininzi ezinokubangela ukuba umonakalo weselula. Ngethamsanqa, umzimba womntu unokwenza izinto ezinjengezixhobo zokuzikhusela, nangona kunjalo, xa ukukhupha iintlobo ze-oksijeni ezisebenzayo, okanye i-ROS, abakwazi ukuphelelwa yinto engatshatyalaliswayo, bacinge ngelitye elincinci eliphuma ngaphandle kokulawulwa xa lichithwa yi-oksijeni. .

Ukuqhubela phambili ukwandisa kwisalathiso selangatye, umkhiqizo wokugqibela wokungakwazi ukunciphisa impembelelo ye-ROS, okanye iintlobo ze-oksijeni esebenzayo, umonakalo kunye nokuvuvukala, ngamanye amazwi, umzimba womntu uphile ngomlilo. Into emnandi kukuba kukho i-antioxidants enokunceda kakhulu ukulwa nale ngxaki yempilo kwaye le antioxidant yi-glutathione. Nangona ifunyenwe kwi-1889, i-glutathione yempembelelo ye-antioxidant ibe yenye yezona zihloko ezinomdla kakhulu kwizifundo zophando zanamhlanje.

I-Master of Antioxidants: Glutathione

I-substance enamandla yi-tripeptide ephuma kwi-cysteine, i-glutamic acid, kunye ne-glycine. Ngenxa yokukwazi ukukhusela umzimba womntu ekudalweni kweeradicals zamahhala, i-glutathione ekugqibeleni inokunceda ukukhuthaza amajoni omzimba asempilweni. Ngenxa ye IiNgxelo zeSayensi kwi2015, kwakunqunywe ukuba amandla e-glutathione okusebenza ngokubambisana kunye ne-peroxiredin kunye ne-catalase inceda ulinda i-hydrogen peroxide. Ifom ye-synergistic isebenzelana neentlobo ze-oksijeni ezisebenzayo, okanye i-ROS. I-Glutathione, i-peroxidredin kunye ne-catalase zizinto ezibalulekileyo ekunyuseni kwe-homeostasis yamaselula, yinkqubo ebalulekileyo yamaseli enempilo, izicubu kunye nezitho ngokupheleleyo.

Ukongezelela, i-glutathione yandisa isistim somzimba jikelele kunye nomsebenzi usebenzisa umphumo wayo obalulekileyo kwimisebenzi ye-lymphocyte. Ngokutsho kwe KwiSebe le-Immunochemistry, amanqanaba afanelekileyo okongeza i-glutathione emzimbeni womntu inokuphucula kakhulu iimpendulo zomzimba. Ngokomzekelo, izilingo ezimbini ezilawulwa yi-placebo ezilawulwa yi-placebo zibonise ukuba unyango lwonyango lwezigulane ezixhatshazwa ngumzimba nge-N-acetyl-cysteine, okanye i-NAC, kubangele, kuzo zombini matyala, ngokukhula okukhulu kwiinkqubo ezininzi ze-immunological ezibandakanya ukuhlaziywa konke yomsebenzi wecala lombulali. I-N-acetyl-cysteine, okanye i-NAC, isebenzisa isulfure ephuma kwi-glutathione kwaye idibanisa ne-molecule ezinetyhefu, ezo zibe zizinzileyo kwaye zikhutshwe emzimbeni womntu.

I-Glutathione nayo inokukwazi ukuvuselela i-lipoic acid kunye nokubuyisela kwakhona iiVithamini C ne-E, eziyimfuneko ukuze kuqaliswe iinkqubo ezithile zeenkqubo ngokuthumela ama-electron ukuba angadambisi i-radicals yamahhala. Ngokusekelwe kuphando lokuphanda I-PLOS ONE, i-glutathione ichaphazele izigulane ezine-diabetes metillus, okanye i-T2DM, kunye ne-mycobacterium isifo sofuba. Ngokuqhelekileyo, abantu abaneendlela zokuzivikela ezibuthakathaka banomdla wokubonisa ukugqithisa okukhulu kuMn. Tb, okanye i-mycobacterium isifo sofuba, isifo okanye isifo. Ukongezelela, abantu abane-Type 2 i-diabetes metilllus, okanye i-T2DM, babini ngokuphindwe kathathu banokutheleleka kwi-TB kunabantu abangenawo i-T2DM. Uphando olwenziwe uphando luye lwaphakamisa ukuba ukuphakamisa amanqanaba e-glutathione kwi-macrophages ekhulile kwizigulane ezine-T2DM kukhokelela ekulawuleni ukuphucula izifo ze-M.Tb okanye intsholongwane. Ezi ziphumo zibonisa ukuba amanqanaba aphantsi e-glutathione kwizigulane ezine-T2DM inegalelo kwithuba eliphakamileyo le-M TB okanye isifo. Ngaphezu koko, kuxhomekeke kuyo UDietro Ghezzi eBrighton naseSussex Medical School, uxinzelelo lweengcinezelo lunokubangela ukuba i-system immune system kunye nomsebenzi.

Ngethamsanqa, i-glutathione idlala indima ebalulekileyo ekuqiniseni nasekulawuleni umkhuhlane. Ngokomzekelo, i-glutathione ibalulekile kwiinkqubo zangasese kunye nezilungelelaniso kwisistim somzimba sokuzikhusela, kuquka i-T-lymphocyte ukuqhubela phambili, umsebenzi we-phagocytic we-polymorphonic neutrophils, kunye nemisebenzi yeseli ye-dendritic, enokubaluleka ngenxa yokuba le yenziwe ngamaseli a-antigen . Ukuxilongwa kwe-Cell-meditated immunication kubandakanya i-protein antigen eqala ukuhlakala kwi-vesocytic vesicles ze-macrophages kunye neeseli ze-dendritic, ngoko ke, iip peptides ezincinci ziboniswa emzimbeni ukuze kusebenze ukwanda kwamaseli e-antigen. Ukongeza, i-glutathione inceda ekudalweni kwe-cytokines, kwaye kuyimfuneko ukugcina imveliso ye-interferon-gamma ngamaseli e-dendritic, okubalulekileyo ekukhuseleni ama-intracellular pathogens kuquka i-mycobacteria.

I-N-acetyl-cysteine, okanye i-NAC, ebizwa ngokuba ngu-precursor of glutathione, nayo inamandla kakhulu anesifo esithintekayo se-antioxidant esetyenzisiweyo njenge-free radical scavenger antioxidant. Ngokuqhelekileyo iyaqaphela inxaxheba yayo ukukhupha i-acetaminophen yetyhefuI-NAC, okanye�N-acetyl-cysteine, ibonakaliswe ineenzuzo ezininzi zempilo kunye nokuba sempilweni. Ngoku ka Cell Journal, I-NAC inceda ukunika inkxaso impendulo enobulunga obuphilileyo kwaye inokuthi ithintele ngokufanelekileyo ukusebenza kwexesha lomntu kunye nokusebenza kwangaphambili. Uphando olwenziwe uphando lwagqitywa ukuba kubasetyhini abathandana nokuzalwa kwangaphambili kunye ne-bacteria vaginosis, i-0.6 gram ye-NAC ngosuku esetyenziswe ngomlomo kunye neprogesterone emva kweveki ye-16 yokukhulelwa okukhuselekileyo ekukhuselweni kokuzalwa kwangaphambi kokuzalwa nokuphucula iziphumo ze-neonatal. Ekugqibeleni, iziphumo ezilungileyo ze-NAC kwisakhiwo se-muscle nazo zafunyanwa. Emva kwemizuzu emithathu yokuphambaniswa okuqhubekayo, kukho i-15 yepesenti ephuculweyo, kubonisa indlela iNAC idlala ngayo indima ebalulekileyo ekuphuculeni isakhiwo se-muscle nokunciphisa ukukhathala ngexesha lobasebenzi.

Abaphandi baye bafumanisa ukuba i-NAC, okanye N-acetyl-cysteine, inokunceda abo bane-polycystic ovarian syndrome, okanye i-PCOS. I-PCOS, okanye i-polycystic ovarian syndrome, sisifo esixhaphakileyo esinxulumene ne-endocrine echaphazela malunga ne-5 ukuya kwi-10 ekhulwini labasetyhini abaneminyaka yobudala. Kwizigulane ezinjalo, kukho umngcipheko omkhulu wokufumana isifo se-metabolic syndrome, apho ukusetyenziswa kwe-NAC kwanceda ukubuyisela amanqanaba e-insulin enempilo kunye novelwano.

Insight of Dr. Alex Jimenez

I-Glutathione ibizwa ngokuba "yinkosi yama-antioxidants" ngenxa yendima ebalulekileyo ekufezekiseni nasekugcineni impilo nempilo yonke. Nangona umzimba womntu unako ukuvelisa i-glutathione yayo, ukungondleki kakuhle, ukucoceka, i-toxin, ukusetyenziswa kakubi kweziyobisi kunye / okanye unyango, ukuxinezeleka, ukunyamekela, ukuguga, izifo kunye nokusabalaliswa kwemitha kunokunciphisa amanqanaba ethu okwenyama ye-glutathione. Oku kunokukwenza ukuba abantu banomdla wokulimala kwesoli, ukuxilwa kwamahhala, izifo kunye nomhlaza. I-Glutathione supplementation ingaba neenzuzo ezinkulu kumzimba womntu. Kanye kunye nezinye iindlela zokonyango, ezifana nokunyamekela kwe-chiropractic, amazinga a-glutathione angaphinda alawulwe ukuze kuphuculwe impilo.

Ukongezelela, ootitshala bezonyango baye baphakamisa ukuphunyezwa kokusetyenziswa kwe-glutathione kunye nezinye iindlela zokonyango, ezifana ukunakekelwa kwe-chiropractic, ukuphucula uphuculo lwempilo kunye nokuphila kakuhle. I-antioxidants ibalulekile ekugcineni ubume benhlalakahle kunye nokuvimbela ukuphendulwa kweetyuli ze-free radicals ezibangelwa yingozi okanye isonakaliso eselula. Ama-antioxidants anamandla afana ne-glutathione, njengoko kuchazwe ngasentla, ekugqibeleni uncedo lulawula ukuphuhliswa kwezi radicals kunye nonikezelo lwe-immune system. Iziphumo zophando zifumene ukuba ukunakekelwa kwe-chiropractic nazo zinokudlala indima ebalulekileyo kule nkqubo, ngokusesikweni ukukhuthaza umsebenzi we-antioxidants emzimbeni womntu. Ukunyamekela kwe-Chiropractic yindlela ekhuselekileyo neyinkqubo yokunyanga eyenza ukulungiswa kwemigudu kunye neendlela zokuziphatha ngokufanelekileyo ukulungisa ukuphambana kwamagciwane, okanye ukuxhomekeka, ukuze uvumele umzimba womntu ukuba uphilise ngokwawo ngaphandle kokusetyenziswa kweziyobisi / okanye unyango olungenelelo.

Okokugqibela, i-antioxidants ibonisa iipropathi zabo zebhayoloji ngobuninzi bezibonelelo zempilo, ezinokuba yimfuneko ngoku kunanini na ngaphambili ngalo lonke uhlaselo olunyukayo loxinzelelo, izifo kunye nongcoliseko kwihlabathi lethu lanamhlanje, ezithi zonke zibe negalelo kumonakalo weseli kunye / okanye umonakalo. . I-Glutathione kunye ne-precursor yayo, i-NAC, okanye i-N-acetyl-cysteine, iyaqhubeka nokubonisa isimo sabo esinamandla kwindawo ye-antioxidants. Kunye nezinye iindlela zonyango, ezifana nokhathalelo lwe-chiropractic, abantu banokuthatha inzuzo yazo zonke izibonelelo ezinokuthi zinikezelwe yile antioxidant enamandla. Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic kunye nokulimala komgogodla kunye neemeko. Ukuxoxa ngalo mbandela, nceda uzive ukhululekile ukubuza uGqr. Jimenez okanye uqhagamshelane nathi apha915-850-0900 .

Ikhutshwe nguDkt. Alex Jimenez

Imixholo eyongezelelweyo: Ubunzima bokubuyisela

Umqolo obuhlungu enye yezona zizathu ezibangeleko zokukhubazeka kunye neentsuku eziphosakeleyo emhlabeni wonke. Njengokuba kunjalo, iintlungu zenziwa emva kweyona sibini isizathu esivakalayo sokutyelela iofisi yee-dkt. Ngokumalunga neepesenti ze-80 zabemi ziya kuba nolunye uhlobo lweentlungu zentlungu ubuncinane kanye kanye ebomini babo. Umgudu uyisakhiwo esiyinkimbinkimbi esakhiwa ngamathambo, amajoyina, iigaments kunye nezihlunu, phakathi kwezinye iifomthi ezithambileyo. Ngenxa yoko, ukulimala kunye / okanye iimeko ezihlaziyiweyo, ezifana disni, ekugqibeleni unokukhokelela kwiimpawu zentlungu. Ukulimala kwezemidlalo okanye ukulimala kwengozi yeemoto ngokuqhelekileyo kubangelwa yintlungu yokubuhlungu, kodwa ngamanye amaxesha ukuhamba kwezinto ezilula kunokuba neziphumo ezibuhlungu. Ngethamsanqa, ezinye iindlela zokhathalela unyango, ezifana nokunyamekelwa kwe-chiropractic, kunokunceda ukubuyisela intlungu emva kokusetyenziswa kwemilenze kunye nokunyanzeliswa kwemigaqo, ekugqibeleni ukuphucula intlungu.

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