UJanus Kinase Inhibitors woNyango lwe-Ankylosing Spondylitis

Umntu ngamnye kunye i-ankylosing spondylitis Unokhetho olutsha olwalusetyenziselwa isifo samathambo. Lunyango lweklasi eyaziwa njenge I-JAK inhibitors. I-Ankylosing spondylitis idibanisa iintlungu ngokudibeneyo kunye nokuncipha kokuhamba. I-Ankylosing spondylitis yahlukile kuba kwiimeko ezinzima, amathambo emqolo anokudibana kunye, ukunciphisa ukunciphisa ukuhamba.   The isifo siqala ngentlungu kunye nokuqina emqolo. Oku kuhlala kusemva kwexesha lokungasebenzi. Iimpawu ziqala ngaphambi kweminyaka engama-45 kwaye zikhula kancinci. Akukho lunyango lwe-ankylosing spondylitis kodwa lukhona unyango olunokuphucula iimpawu kwaye lubeke imeko kuxolelo. Unyango lwe-Ankylosing spondylitis lolona luphumeleleyo xa kusonjululwa kwangethuba ngaphambi kokuba kulungiswe umonakalo kumalungu.  

UJanus Kinase Inhibitors

UJanus kinase inhibitors ngokwesiko ebesetyenziselwa ukunyanga:

• Irheumatoid arthritis
• Isifo samathambo
• Ulcerative colitis

Iyeza lisebenza ngokunciphisa ukusebenza kwamajoni omzimba Amachiza kaJanus kinase inhibitor achaphazela iikhompawundi zeselfowuni ezibalulekileyo kuphuhliso kunye nokuqhubela phambili kwe-ankylosing spondylitis. Okwangoku, kukho amayeza amathathu kaJanus kinase inhibitor afumanekayo e-United States kunye ne-FDA-evunyiweyo ukunyanga isifo samathambo:

• Xeljanz
• Irinvoq
• Olumiant
• Nganye yezivunyiweyo Inhibitors ijolise kwii-enzymes ezithile

Unyango lwangoku lwe-Ankylosing Spondylitis

I-Janus kinase inhibitors ayinikwa abantu kwangoko. Nangona kunjalo, kunokuba yinto enokuyenza ukuba unyango lokuqala kunye nolwesibini alusebenzi. Unyango luhlala lubandakanya:

Unyango lokuqala

 

NSAID

Amayeza anti-ukudumba zezona ziqhele ukusetyenziswa ukunyanga ukudumba kwe-ankylosing, iintlungu kunye nokuqina.

Chiropractic

Unyango lwe-Chiropractic ngokomzimba yinxalenye enkulu yonyango lwe-ankylosing spondylitis egcina umqolo uguquguquka kwaye usempilweni kangangoko. A Uyilo lweqela le-chiropractic / yomzimba kunye nophuhliso lweempawu ezithile ukuze zilungele iimfuno zomntu ngamnyeezibandakanya:

• Ukolula kunye neRange-of-motion-exercises kunceda ukugcina ukuguquguquka kumalungu
• Ukulala kunye nokuhamba komzimba uhlengahlengiso
• Ukuzivocavoca isisu kunye nomqolo ukugcina imeko esempilweni
• Uqeqesho lwamandla

Unyango loLwesibini

If amayeza okuchasana nentsholongwane musa ukunciphisa iimpawu, ngoko amayeza endalo anokumiselwa. Olu klasi lwamayeza lubandakanya:

• I-tumor necrosis factor blockers
• I-Interleukin-17 inhibitors

Itumor Necrosis Factor

I-tumor necrosis factor blockers isebenza ngokujolisa kwiprotein yeseli eyinxalenye yenkqubo yomzimba yokuzikhusela, eyaziwa njenge alpha ithumba. Le protein ibangela ukudumba emzimbeni, kwaye iibhlokhi ziyayicinezela.  

I-Interleukin 17 Inhibitors

I-Interleukin 17 kumajoni omzimba ayazikhusela kusulelo. Isebenzisa impendulo yokuvuvukala ukulwa nosulelo. I-IL-17 inhibitors icinezela impendulo yokuvuvukala kwaye inceda ukunciphisa iimpawu.  

Ezinye iindlela zokonyango

 

Uhlengahlengiso kwindlela yokuphila

Ukulandela isicwangciso sonyango rhoqo kuhlala kudityaniswa kunye ukutya kunye nohlengahlengiso kwindlela yokuphila Kucetyiswa ukunceda ngale meko, kubandakanya:

• Ukusebenza ngokwasemzimbeni kangangoko kunceda:

1. Ukuphucula / ukugcina imeko esempilweni
2. Gcina ubhetyebhetye
3. Nciphisa iintlungu

• Ukufaka ubushushu kunye nomkhenkce kuya kunceda ukunciphisa:

1. Ubuhlungu
2. Ubunzima
3. Ukuvuvukala

• Ukuziqhelanisa ukuzilolonga komzimba

Ukuhlinzwa

Uninzi lwabantu abane-ankylosing spondylitis aludingi kuqhaqho. Nangona kunjalo, ugqirha unokucebisa utyando ukuba lukhona umonakalo odibeneyo, i-joint-hip-joint idinga ukutshintshwa, okanye ukuba intlungu ibuhlungu.  

Isithinteli esinokubakho

Izifundo ziyaqhubeka kunyango lwe-ankylosing spondylitis. Iyeza okwangoku likulingo lweSigaba 3 kunyango lwabantu abadala. Iziphumo zolingo zibonise izigulana ezine-ankylosing spondylitis esebenzayo zibonisa ukuphucuka:

• Ukukhathala
• Ukuvutha
• Umqolo obuhlungu

Uphononongo lubhalise abantu abadala abane-ankylosing spondylitis esebenzayo abathathe ubuncinci ii-NSAID ezimbini ezazingasebenzi kunyango. Uninzi lwabathathi-nxaxheba yayingamadoda, i-avareji yobudala be-41, kwaye akukho kusetyenziswa kwangaphambili kwezifo ze-biologic eziguqula iziyobisi kwi-antirheumatic.

UJanus kinase unokuba lonyango oluqhelekileyo

Alukabikho uphando olwaneleyo lokwenza uqikelelo, kodwa idatha iyathembisa. I-inhibitors ibonakala iyindlela ekhuselekileyo xa isetyenziswe kwisikrini esifanelekileyo, esilungelelaniswe kakuhle esibandakanya ukubeka iliso rhoqo. Izithinteli zibonakala zisebenza kwaye zinezibonelelo zokuthathwa ngomlomo kunye nokusebenza ngokukhawuleza.

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UkuBumbiswa kweBhunga

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I-Osteoarthritis kunye nokwehla kobunzima

Ukutyeba kakhulu kubonise njengeyona nto iphambili yomngcipheko kuphuhliso lwe osteoarthritis. Oku akubikho kuphela kwiziphumo zobunzima obongezelelekileyo kumalungu omzimba kodwa nanjengesiphumo sokudumba kwethishu yeadipose. Umqolo osezantsi, iinyonga, kunye namadolo, kuthwala uninzi lobunzima bomzimba. Inani elingaphezulu kwesihlunu se-adipose kumzimba ophakathi nasemilenzeni ibonakalisiwe ukuba nefuthe elibi kwi amalungu athwele ubunzima. Ukukhuthaza ukuTyeba kweLungu loMzimba kunye nokukhuthaza ukunciphisa umzimba kunciphisa umngcipheko we-osteoarthritis kunye nokuphucula umgangatho wobomi bomntu. Ukuzivocavoca kuthathwa njengokukhuselekileyo kubantu abane-osteoarthritis kwaye kufuneka kubandakanywe ukuphucula ukwakheka komzimba, ukunciphisa umzimba weFat Mass, phucula Ubuninzi boMzimba kunye nokugcina ubunzima obusempilweni.  

UGqr Alex Jimenez's Iposti yeBlog

Ubungakanani bolwazi lwethu lukhawulelwe kwi-chiropractic, musculoskeletal, amayeza omzimba, impilo, kunye nemicimbi yezempilo ebuthathaka kunye / okanye amanqaku amayeza asebenzayo, izihloko kunye neengxoxo. Sisebenzisa iinkqubo zempilo kunye nezempilo ukunyanga kunye nenkxaso yokhathalelo lokonzakala okanye ukuphazamiseka kwenkqubo yemisipha. Izithuba zethu, izihloko, izifundo, kunye nokuqonda kugubungela imicimbi yeklinikhi, imiba kunye nezihloko ezinxulumene nokuxhasa ngokuthe ngqo okanye ngokungathanga ngqo kwinqanaba lethu lonyango. * Iofisi yethu yenze iinzame ezifanelekileyo zokubonelela ngeziqendu ezixhasayo kwaye ichonge uphando olufanelekileyo okanye izifundo ezixhasa izithuba zethu. Senza ikopi yezifundo zophando ezixhasayo ukuba zifumaneke ebhodini nakuluntu xa kuceliwe. Siyaqonda ukuba sigubungela imicimbi efuna inkcazo eyongezelelweyo malunga nendlela enokunceda ngayo kwisicwangciso esithile sokhathalelo okanye kwinkqubo yonyango; Ke, ukuqhubeka nokuxoxa ngalo mbandela ungentla, nceda ukhululeke ukubuza uGqirha Alex Jimenez okanye unxibelelane nathi apha 915-850-0900. Umboneleli (s) unelayisensi eTexas naseNew Mexico *  

Ucaphulo

Hammitzsch A, Lorenz G, Moog P. Impembelelo ye-Janus Kinase Inhibition kuNyango lwe-Axial Spondyloarthropathies. Imida kwi-Immunology 11:2488, Oct 2020; doi 10.3389/fimmu.2020.591176.�www.frontiersin.org/article/10.3389/fimmu.2020.591176, kufumaneka ngoJan 21, 2021. van der Heijde D, Baraliakos X, Gensler LS, et al. Ukusebenza kunye nokukhuseleka kwe-filgotinib, i-Janus kinase 1 inhibitor ekhethiweyo, kwizigulana ezine-ankylosing spondylitis (TORTUGA): iziphumo ezivela kwilingo elilawulwa ngokungacwangciswanga, elilawulwa yi-placebo, kwinqanaba lesibini.Lancet.I-2018 Dec 1; 392 (10162): 2378-2387. ikhonkco: 10.1016 / S0140-6736 (18) 32463-2. Epub 2018 Oktobha 22. PMID: 30360970. yentshutshiso.ncbi.nlm.nih.gov/30360970/Kufunyenwe ngoJanuwari 19, 2021.