Unyango olwahlukeneyo lweSifo seLyme (Icandelo 3)

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intshayelelo

UDkt Jimenez, DC, ubonisa indlela isifo seLyme esinokubangela ngayo intlungu ebhekiswe kumzimba kule nxalenye ye-3. Izinto ezininzi zokusingqongileyo zinokubangela imiba emininzi emzimbeni enokukhokelela kwiimpawu zeprofayili yomngcipheko kwimisipha kunye namalungu. Kwinkcazo yanamhlanje, sivavanya iindlela ezahlukeneyo zonyango zesifo seLyme. Icandelo 1 ujonga imizila yemfuza yomzimba aze ajonge imibuzo efanelekileyo anokuyibuza. Icandelo 2 ijonga indlela isifo seLyme esinxulumene ngayo nosulelo olungapheliyo kunye nendlela oluchaphazela ngayo umzimba. Sikhankanya izigulana zethu kubaboneleli bezonyango abaqinisekisiweyo ababonelela ngonyango olukhoyo kubantu abaphethwe ziimeko ezingapheliyo ezinxulumene nesifo seLyme. Sikhuthaza isigulane ngasinye xa kufanelekile ngokuthumela kubaboneleli bezonyango abanxulumeneyo ngokusekelwe kukuxilongwa okanye iimfuno zabo. Siyayiqonda kwaye siyayamkela into yokuba imfundo yindlela emangalisayo xa sibuza imibuzo ebalulekileyo yababoneleli bethu ngokwesicelo sesigulana kunye nokuvuma. UDkt Alex Jimenez, DC, usebenzisa olu lwazi njengenkonzo yemfundo. isikhanyeli

 

I-Biofilm eMzimbeni

UGqr. Alex Jimenez, DC, unikezela: Ukupheliswa kwazo zonke iifilimu zebhayoloji akunangqiqo kunokuzama ukucocisa amathumbu. Ke iifilimu zebhayoloji yile matrix yepolysaccharide ebambelelayo. Sithanda ukucinga ngayo njenge jello yeziqhamo. Ke unayo ijelo kunye nazo zonke iziqwenga ezahlukeneyo zeziqhamo apho, kwaye enye nenye isiqhamo inokuba luhlobo olwahlukileyo lwebhaktiriya. Kwaye enye yezo bhaktiriya inokwenza i-penicillinase, kwaye inokucacisa ngakumbi ilifu lepenicillinase kwimatrix, ikhusela neentlobo ezingakwaziyo ukuyenza. Kwaye sele sithethile malunga nokuba ezi biofilm zinokusebenza njani kwi-probiotic colonization, kodwa zikwayinxalenye yosulelo oluyingxaki.

 

Ke kukho izicwangciso ezininzi zokuguqula i-biofilms, izenze zibe ne-porous kumajoni omzimba kunye namayeza okubulala iintsholongwane. Ke iLactoferrin yenye, iColostrum, equlathe iLactoferrin kwiqela lezinye iimveliso ngokunjalo. I-Serum-derived bovine immune globulin yi-immune globulin ephuma kwiqanda kwizigulana zakho ezibuthathaka. Iiprobiotics kunye ne-prebiotics zinokuba nomsebenzi we-biofilm. Kwaye ke i-enzymes, njengoko besitshilo ngaphambili, yisakhiwo se-carbohydrate, kwaye i-enzymes inokudiliza loo matrix kwaye iyenze ibe ne-porous ngakumbi. Ngaba iXylitol kunye ne-EDTA zinokuba ngabadlali befilimu abanamandla kunye ne-stevia?

 

Uvavanyo lweLyme Serology

UGqr. Alex Jimenez, DC, unikezela: Ke uvavanyo lweLyme serology kufuneka lube novakalelo ngakumbi kuxilongo, ngakumbi kumanqanaba okuqala okanye kade. Kwaye siza kubona ukuba kutheni ngomzuzu. Ngoko ke uvavanyo oluqhelekileyo olunamanqanaba amabini lufuna uvavanyo lokuhlola nokuba luvavanyo lwe-ELISA okanye lwe-IFA kunye novavanyo lokuqinisekiswa kwe-Western blot. I-International Lyme kunye ne-Associated Disease Society okanye i-ILADS kunye nabanye baphikisa ukuba olu vavanyo lunamanqanaba amabini kufuneka lube lokuhlola kuphela okanye iinjongo zophando kodwa kungekhona ukuxilongwa kwabantu. Ke nantsi indlela esikhangeleka ngayo eso sikimu, unokufumana i-EIA okanye i-IFA, kwaye ukuba ilungile okanye iyalingana, uya kwiblothi yaseNtshona. Ukuba uneempawu ezingaphantsi kweentsuku ezingama-30, ufumana zombini i-IGM kunye ne-IGG. Ukuba uneempawu ezingaphezu kweentsuku ezingama-30, ufumana i-IGG kuphela. Ngoku, kukho iindlela ezikhethekileyo zokufunda i-Western blot. Zifuna iibhendi ezininzi ezilungileyo ngokuxhomekeke ekubeni yi-IGM okanye iblot ye-IGG. Ukuba uvavanyo lwakho lovavanyo alunayo kwaye ugule ixesha elingaphantsi kweentsuku ezingama-30, kufuneka uphinde uvavanywe, uyazi, kwindawo ethile yokuchacha. Kuya kufuneka ucinge ngoxilongo olwahlukileyo ukuba ubugula ngaphezulu kweentsuku ezingama-30. Kwaye siza kuthetha malunga nokuba kutheni le nkqubo iyingxaki.

 

Ngoko ixhomekeke kakhulu. Olu vavanyo lunamanqanaba amabini luthe ngqo kwi-99 ukuya kwikhulu leepesenti, kodwa ubuntununtunu balo bubuthathaka, mhlawumbi bungaphantsi kwama-50%. Ke, nantsi idatha kuloo nto. Sibona inani lezigulane kuphononongo, izigulane ezichasene nolawulo, kunye novelwano kunye neenkcukacha. Kwakhona sibona iitotali, kwaye uvakalelo lulonke lwaluyi-46%, ngelixa i-specific iyonke yayingu-99%. Ngoko njengovavanyo, cinga ngako; sonke safunda malunga ne-appendicitis kwisikolo se-med. Kufuneka ukhuphe izihlomelo ezimbalwa zesiqhelo ukuqinisekisa ukuba ufumana zonke ezimbi. Ukuba ulahlekile isiqingatha seemeko zesifo seLyme, abantu abaninzi baya kungena kwisifo semfundo ephakamileyo.

 

Uvavanyo lweSifo seLyme

UGqr. Alex Jimenez, DC, unikezela: Ngoko kuthekani nge-seronegative Lyme? Ke abantu ababenalo uvavanyo kwaye kwaba negative. Ewe, nasi isigulana esisetyhini ebesinento ebonakala ngathi sisifo samathambo eLyme ngaphandle kovavanyo oluphindaphindiweyo lweBorrelia Burgdorferi. Ke kwafunyaniswa ukuba uneentlobo ezahlukeneyo ze-Borrelia garinii, kwaye iikhosi ezininzi zamayeza okubulala iintsholongwane aziwenzanga amaqhinga. Ngoko wayenezifundo ezininzi zokubulala iintsholongwane kunye ne-synovectomy, eyathi ekugqibeleni yanceda. Olu vavanyo luthi izigulane ze-Lyme borreliosis ezine-spirochetes eziphilayo kumanzi omzimba zinezinga eliphantsi okanye elibi le-borrelia antibodies kwi-serum yazo. Oku kubonisa ukuba ukuxilongwa ngokufanelekileyo kwe-Lyme borreliosis kufuneka kusekelwe kwiindlela ezahlukeneyo ezifana ne-serology, i-PCR, kunye nenkcubeko. Kwaye kolu phononongo, i-spirochetes yahlukaniswa kwiinkcubeko zesikhumba ezifunyenwe kwizilonda ezininzi. Ezi spirochetes zachongwa njenge-Borrelia Bergdorferi kodwa endaweni yoko njenge-Borrelia Afzelii.

 

Nangona kunjalo, iimvavanyo zeSerum Borellia Burgdorferi zaziphindaphinda zingalunganga. Enye yeengxaki zolu vavanyo kukuba ikiti efika ivunyiwe isekelwe kwi-Borelli Burgdorferi, i-B-31 strain. Kwaye sibona kolu vavanyo lwe-seronegative Lyme ukuba ezinye iintlobo kunye neentlobo zinokubandakanyeka. Ke izikhokelo ze-IDSA zixela ukuba akukho bungqina bebhayoloji obukholisayo bosulelo olungapheliyo lwe-Borrelia Burgdorferi phakathi kwezigulana emva kweerejimeni zonyango ezicetyiswayo zesifo seLyme. Oku kwaphawulwa kwimeko engqinwe yinkcubeko yokusilela kwe-antibiotic kunye nosulelo lwe-Borrelia Burgdorferi ngo-1989.

 

Ngoko, kuthekani ngemodeli yezilwanyana? Kwakukho ukusilela kwe-antibiotic kwimodeli yezilwanyana, le modeli yempuku. Kule modeli yenja, kukho ukungaphumeleli kwe-antibiotic. Kule modeli yenkawu ye-Macaque, kukho ukungaphumeleli kwe-antibiotic. Kwaye kolu phononongo, i-Borrelia Burgdorferi inokumelana nonyango lwe-antibiotics xa ilawulwa emva kokusasazwa kwiiprimates. Kwaye njengoko siza kubona kancinci, izigulana ezininzi ezinesifo seLyme zifunyaniswa emva kokusasazwa. Ke ezi ziphumo ziphakamisa imibuzo ebalulekileyo yokuxoxa kunye nezigulana malunga ne-pathogenicity ye-antibiotic-tolerant persist kunye nokuba ingaba banokuba negalelo kusini na kwiimpawu emva konyango kwi-Lyme disease. Uphononongo lwabantu lucebisa ukuba ama-25 ukuya kuma-80% ezigulane zineempawu ezithe gqolo emva kweeveki ezimbini ukuya kwezine zonyango lokubulala iintsholongwane. Kolu phononongo, ukuya kuthi ga kwi-40% yezigulane zifunyenwe zinosulelo oluzingileyo emva konyango olucetyiswayo lwe-IDSA. Ke kolu phononongo, imeko yesigulana iye yaba mandundu nangona ifunyenwe iikhosi zokuphinda zonyango lwe-antibiotic kwiminyaka emibini.

 

IiProtocol

UGqr. Alex Jimenez, DC, unikezela: Emva koko bafumana iinyanga ezili-12 ze-antibiotics kunye neenyanga ezili-11 ze-oral inter condition ziphuculwe kakhulu. Uza kubona ukuba akufuneki sibhenele kwezi khosi zinde zamayeza okubulala iintsholongwane kakhulu kuba sinezixhobo ezahlukeneyo. Kodwa oku kubonisa ukuba ixesha elide kunokuba luncedo. Uphononongo lwethu luqinisekisa ukunyamezela kwe-Borrelia kwezinye izigulane ze-erythema migraine kwindawo ye-lesion yesifo esosulelayo, nangona unyango lwe-antibiotics ngamaxesha afanelekileyo. Kwaye oku kwakungekho ngenxa yokunyuka kwamanqanaba e-MIC (i-borreliacidal encinci) amanqanaba. Ke ngoko, iindlela zokuxhathisa ngaphandle kokuxhathisa okufunyenweyo kwi-antimicrobial agents kufuneka ziqwalaselwe kwizigulana ezineLyme Borrelia ezixhathisayo kunyango. Kwaye kolu phononongo, ukuhla kwempendulo ye-antibody, ephawulwe emva kokunyangwa kwe-antibiotics kwiimpuku nakwizinja ezinyangelwe ngamayeza okubulala iintsholongwane, kwenzeka ngaphandle kwamanqanaba aphantsi e-spirochetes eqhubekayo. Iziphumo zethu zibonisa ukuba i-spirochetes iyasebenza kwaye iyasulela kwaye iveze ii-antigens ezilandela unyango lwe-antibiotic.

 

Olu luphononongo lwe-biostatistical yamaphepha i-IDSA ewasebenzisayo ukuxoxa ukuba akukho bungqina bunyanzelisayo beempawu eziqhubekayo emva konyango kwaye unyango oluphindaphindiweyo lwe-antibiotic alusebenzi. Kwaye bagqiba kwelokuba olu hlaziyo lwe-biostatistical lubonisa ukuba unyango kwakhona lunokuba luncedo. Iziphumo eziphambili ezichazwe njengezingabalulekanga ngokweenkcukacha-manani kusenokwenzeka ukuba ziphantsi kwamandla. Iziphumo ezilungileyo zonyango lwe-Ceftriaxone ziyakhuthaza kwaye zihambelana nokusuleleka ngokuzingisileyo, i-hypothesis efanelwe isifundo esongezelelweyo. Kulungile, ke ngoku siza kuqalisa ukusebenzisa amanyathelo afanelekileyo oxilongo ngokulandelelana kwesifo seLyme.

 

Zeziphi iimpawu onokuzijonga?

UGqr. Alex Jimenez, DC, unikezela: I-International Lyme kunye ne-Associated Disease Society, okanye i-ILADS, ipapashe izikhokelo ezisekelwe kubungqina bokulawula kunye nokunyanga iLymeLyme, kwaye baye benza into ekhethekileyo kwindawo yezikhokelo zokuziqhelanisa. Bapapasha isihlomelo, baze ke kwesi sihlomelo, bathelekise i-ILADS ngokuchasene nezikhokelo ze-IDSA ngesincomo ngasinye. Ke sibona ulawulo lwe-exodus uhlobo lokuluma. Ke, ukulunywa kwamakhalane e-exodus kuneempawu ezininzi eziluncedo, kodwa olona nyango lulungileyo lwesifo esingapheliyo seLyme lunyango lwakwangoko lwesifo esiqatha seLyme. Kodwa oku kunzima kuba irhashalala ye-erythema migraines ibonakala kuphela kwisiqingatha sezigulane ezinesifo seLyme. Kwaye ukucocwa okuphakathi kwenza ukuba kubonakale ngathi i-bullseye rash, eyi-stereotypical okanye i-classical erythema migraines rash. Oko kucocwa okusembindini kubonisa kuphela malunga nesiqingatha serhashalala. Enyanisweni, kwelinye icala le-11 erythema migraine rashes, abazange baxilongwe njenge-cellulitis, nangona zonke izigulane ze-11 zibonise ubungqina bekliniki ye-Lyme isifo.

 

Ukuza kuthi ga ngelo xesha, okwenza kube nzima ngakumbi kukuba sisiqingatha kuphela sabaguli abanesifo seLyme abakhumbula ukulunywa kwamakhalane. Ke kubalulekile ukucinga ngesifo seLyme ngalo naliphi na ixesha uvavanya umntu ophethwe ziimpawu ezinjengomkhuhlane ngaphandle kwexesha lonyaka. Ke ukuba banomkhuhlane wehlobo, baziva benesifo seLyme. Zeziphi ke ezinye iimpawu? Ukudinwa okukhulu okungapheliyo, okuguqula ubomi. Ngoku sithetha ngesifo seLyme esingapheliyo apha, hayi isifo seLyme esiqatha. Iimpawu ze-Acute Lyme zibandakanya umgangatho ophantsi ukuya kumkhuhlane omkhulu, umkhuhlane, iintlungu zomzimba kunye nokubila. Kodwa sithetha ngesifo seLyme esinganyangekiyo kunye neempawu zaso, ezibandakanya ukungayekeleli, ukudinwa okutshintsha ubomi, ukufuduka kwe-arthralgias, kunye ne-myalgias enokuqhubela phambili ngokuhamba kwexesha. Liyintoni eli shishini lokufuduka? Kuthetha ukuba idolo lasekhohlo libuhlungu kangangokuba umntu akakwazi nokuhamba, kodwa ngoku sele kudlule iintsuku ezintathu, idolo lasekhohlo alibuhlungu kwaphela, kodwa igxalaba lasekhohlo liyababulala. Oku kwaziwa ngokuba yintlungu ebhekiswayo, apho indawo enye emzimbeni ijongene nentlungu endaweni yomthombo oyintloko oye wachaphazeleka. Oku kubangela ukuba ii-sensory nerves zibe phezulu ukuya kwi-haywire emzimbeni kwaye, ngokuhamba kwexesha, ziphuhlise iimpawu ezihambelanayo ezinokuchaphazela amalungu abalulekileyo, imisipha, amalunga kunye nezicubu.

 

Ezi mpawu zihambelana nokudumba kwamalungu okwenzeka apha. Ukuphazamiseka kwememori, inkungu yengqondo, ukutshintshatshintsha kweemvakalelo, kunye nexhala yonke inkqubela phambili. Kuthekani ngembali yomguli? Ukuhlala okanye ukuya kwindawo enamakhalane yimbali ebalulekileyo. Ukulunywa kwamakhalane okwaziwayo, nangona isiqingatha sezigulane singayazi loo nto, ingaluncedo. Irhashalala, nangona isiqingatha sezigulane singenayo, oko kunokuba luncedo. Kwaye ke iimpawu esizichazileyo.

 

Ngoko kuthekani ngovavanyo lomzimba? Ngelishwa, ngokuqhelekileyo ayithethi ngokuthe ngqo, kodwa kufuneka uqwalasele ngokucophelela iimpawu ze-neurological, rheumatological, kunye nenhliziyo xa ukrokrela isifo seLyme. Uyazi, unokufumana iintlobo zeempawu ze-arthritis. Unokufumana iimpawu ze-meningtic. Kwaye nabani na oneBell's Palsy kufuneka akhutshelwe ngaphandle kwesifo seLyme. I-Bell's Palsy sisifo seLyme de kuqinisekiswe ngenye indlela.

 

Enye into enika umdla kukwenza uvandlakanyo lwengqiqo ngokushukuma. Kwaye into enomdla kukuba uyenza, faka umnwe wakho ezantsi kwe-metatarsal kwaye ubeke ifolokhwe yokulungisa phezulu kwe-metatarsal okanye i-metacarpal. Kwaye ulinda de ungeva ukuba uhambisa ithambo, ekunene, kwaye ukuba isigulana sithi abaziva, kwaye usenjenjalo, oko mhlawumbi akuqhelekanga.

 

isiphelo

UGqr. Alex Jimenez, DC, unikezela: Xa kunyangwa isifo seLyme esinxulunyaniswa nosulelo olungapheliyo, ukuba amajoni omzimba akaphenduli ngendlela esinokulindela ukuba amajoni omzimba womntu osempilweni aphendule, emva koko abonelele ngovavanyo olongezelelweyo ukufumanisa iimpawu ezibangela ukuba izinto eziyingozi ezidlulayo ziluncedo. Khumbula ukuba ukunyanga usulelo olungapheliyo yiklasi yenkosi kwiyeza elisebenzayo. Kufuneka sisebenzise zonke izixhobo zethu kwaye sijikeleze i-matrix. Ngalo lonke ixesha ufumana idatha entsha, inomdla. Kufuneka sicinge malunga ne-matrix ngokupheleleyo. Kufuneka siqwalasele iinkalo ezintlanu eziguquguqukayo ezingokwengqondo, ngokomoya, ngokwasengqondweni, ngokweemvakalelo, nangokomoya koko umguli atyhubela kuko. Kwaye khumbula ukuba ii-ATM zakho azikho ikamva lakho. Kwaye ukuba iiarhente ezosulelayo zihlala ziguqula impendulo yasekhaya kunye nenkqubo yomzimba yokuzikhusela ebonisa i-self-stealth pathology, enokubakho emzimbeni iminyaka. Ukuthetha nesigulana sakho malunga nokwenzekayo kwimizila yabo kunye nokubonelela ngesicwangciso sonyango lomntu ukubanika izixhobo zempilo kunye nokuphila kakuhle.

 

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