UDkt Alex Jimenez Unikezela: Ukuvavanya kunye nokuNyanga i-Hormonal Dysfunction

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UDkt Alex Jimenez, DC, ubonisa indlela ukungasebenzi kakuhle kwe-hormonal kunokuhlolwa kwaye kuphathwe ngeendlela ezahlukeneyo zonyango ezikhethekileyo kwiihomoni kunye nendlela yokulawula kule nxalenye ye-3. Lo mboniso uza kubonelela ngolwazi oluxabisekileyo kubantu abaninzi abajongana nokungasebenzi kakuhle kwehomoni kunye nendlela yokusebenzisa iindlela ezahlukeneyo ezipheleleyo zokuphucula impilo kunye nokuba sempilweni. Icandelo 2 liya kujonga uvavanyo lokungasebenzi kakuhle kwehomoni. Icandelo lesi-3 liza kujonga unyango olukhoyo lokungasebenzi kakuhle kwehomoni. Sithumela izigulane kubaboneleli abaqinisekisiweyo ababandakanya iindlela ezahlukeneyo zonyango ze-hormone ukuqinisekisa impilo efanelekileyo kunye nokuphila kakuhle. Sikhuthaza kwaye siyasixabisa isigulana ngasinye ngokusithumela kubaboneleli bezonyango abanxulumeneyo ngokusekwe kuxilongo lwaso xa kufanelekile. Siyaqonda ukuba imfundo yeyona ndlela ibalaseleyo xa ubuza ababoneleli bethu imibuzo entsonkothileyo ngokwesicelo sesigulana kunye nokuqonda kwakhe. UDkt Alex Jimenez, DC, usebenzisa le ngcaciso kuphela njengenkonzo yemfundo. isikhanyeli

 

Yintoni IiHormones?

UGqr. Alex Jimenez, DC, unikezela: Namhlanje, siza kujonga ekusebenziseni amanyathelo asisiseko onyango lwe-PTSD. Njengesicwangciso sonyango, malunga nokuveliswa, ukuthuthwa, uvakalelo, kunye ne-detoxification ye-hormone kwi-PTSD. Ke masiqale ngendlela ungenelelo kunye nezinto eziphambili eziphembelela ezi ndlela ngaphakathi kwimpembelelo yokufikelela kwezinye iindawo zomzimba. Ukungenelela kwihomoni enye kuchaphazela njani amanye amahomoni? Ngaba uyazi ukuba ukutshintshwa kwe-thyroid kunokutshintsha ukufikelela kwe-HPATG emzimbeni? Ke xa abantu bejongana ne-hypothyroidism okanye i-subclinical hyperthyroidism kwaye benyangwa ngokutshintshwa kwehomoni yegilo ecinezelayo, yenza utshintsho emizimbeni yabo. Oku kuthetha ukuba baya kuba ne-hypersensitive ukusuka kwi-ACTH ukuya kwi-CRH okanye ihomoni ekhupha i-corticotropin.

 

Oku kuthetha ukuba baya kuvelisa kwaye bakhuphe i-ACTH eninzi. Xa isigulana sisiba ne-hypersensitive ukusuka ekungeneni kweehomoni, kunokukhokelela kwimicimbi eyahlukeneyo kunye nezinye iinkqubo zomzimba ezichaphazela ukusebenza kwamalungu kunye nezihlunu. Esi sesinye isizathu sokuba izigulana zizive zilungile nakwidosi ephantsi yokutshintshwa kwedlala lengqula; ivuselela i-adrenals. Izigulana ezininzi zidla ngokugqithisa iiadrenals zazo, kwaye xa zifumana unyango, ziye zibethe kancinci kwii-adrenals zazo xa oogqirha babo benceda idlala labo. Ngoko xa sijonga idlala lengqula, sibona idlala lengqula livelisa i-t4, lenza i-reverse T3 kunye ne-t3. Ke xa oogqirha bejonga i-thyroid pharmacological doses ye-glucocorticoids, nto leyo abayinika unyango oluchasayo kwizigulana zabo, okanye ukuba abantu baye banyusa i-glucocorticoids njengakwi-Cushing syndrome, yintoni eyenzayo kukuthintela ukukhuselwa kwe-thyroid ngenxa yokuba yehlisa i-TSH. impendulo kwi-TRH, eyenza i-TSH encinci. Xa kukho ukukhuselwa okuncinci kwi-thyroid kunokukhokelela kwimibandela ehambelanayo ehambelana nokufumana ubunzima obungeyomfuneko, intlungu edibeneyo, kunye nesifo se-metabolic syndrome.

 

 

Ukuza kuthi ga ngoku, uxinzelelo luthintela i-thyroid. Ngokwahlukileyo, i-estrogens inempembelelo echaseneyo, apho yandisa i-TSH secretion kunye nomsebenzi we-thyroid gland. Ke sisizathu esibangela ukuba abasetyhini bazive bebhetele kakhulu nakwidosi ephantsi yokutshintshwa kwe-estrogen. Ke njengokutshintshwa kwedlala lengqula ngezixa eziphantsi ezibetha iiadrenals, ukuba sinika iidosi ze-estrogen ephantsi, zinokunyusa ukusebenza kwedlala lengqula. Nangona kunjalo, oogqirha abaninzi kufuneka bahambe kancinci xa bebonelela ngonyango lwehomoni kwizigulana kuba iihomoni ezongezelelweyo ziya kuchaphazela ezinye iihomoni emzimbeni. Xa kuziwa kunyango lokutshintshwa kwehomoni, kubalulekile ukufunda ukuba ungenelelo phakathi kwendawo yonxibelelwano luchaphazela njani ezinye iindawo ezikwi-matrix. Ngoko, umzekelo, makhe sijonge indlela i-node yonxibelelwano echaphazela ngayo i-node yokukhusela kunye nokulungisa emzimbeni. Uphononongo lophando lutyhila iziphumo ze-HRT kwiziphawuli zokudumba kwaye zijonge kubafazi abangama-271 abasebenzisa i-equine ye-conjugated estrogen kuphela, ababenokwanda kwe-121% kwi-CRP emva konyaka.

 

Kwaye ukuba basebenzisa oko ngaphezu kweprogestin yokwenziwa, babenokwanda kwe-150% kwi-CRP emva konyaka. Ngoko i-estrogen yokwenziwa ayifani ngokwezinto eziphilayo; lo ngumchamo wemazi ekhulelweyo, kwaye iiprogestin zokwenziwa zixhasa ukudumba. Kuthekani ngendawo yonxibelelwano kunye ne-assimilation node? Olu luphando olunomdla kuba oogqirha abaninzi bazama ukunceda izigulane zabo kunye nesizukulwana esizayo kuluntu. Ke kubalulekile ukwazi xa umama enoxinzelelo ngexesha lokukhulelwa kuba oko kunokutshintsha i-microbiome yomntwana. Oko kuthetha ukuba oogqirha banethuba lokuxhasa ukungenelela kwangaphambili kwinkxaso ye-microbiome. Ukwazi oku kubalulekile kuxinzelelo lwaphambi kokubeleka olusekwe kuluhlu lwemibuzo okanye i-cortisol ephakamileyo yayinxulunyaniswa ngamandla kwaye ngokuqhubekayo ne-microbiome yeentsana kunye neepateni zekoloni.

 

Ke sikwalapha ukuze sifunde ukuba ungenelelo kwi-matrix luyichaphazela njani i-node yehomoni okanye indawo yonxibelelwano. Ngoko njengomzekelo, siza kujonga okwenzekayo kwi-node yokudibanisa ebandakanya i-node yonxibelelwano, njengoko oku kuchaphazela i-antibiotics kwi-intestinal metabolome. Wonke umntu uyazi malunga nefuthe le-antibiotics kwi-microbiome, kodwa i-metabolome yinguqu kumsebenzi we-metabolic welungu elithile, amathumbu. Ukuza kuthi ga ngelo xesha, xa kukho iindlela ezininzi zemetabolism ezichaphazela i-antibiotics, i-metabolism yeehomoni ze-steroid yayiyeyona ichaphazeleka kakhulu. Ke ii-metabolites ezisibhozo eziyinxalenye yale ndlela yehomoni, esinika i-PTSD, yonyuswa kwilindle emva konyango lokubulala iintsholongwane. Ke sinenye indlela amathumbu achaphazela ngayo iihomoni, kwaye oku kujonge kwi-endotoxemia ye-metabolic. Oogqirha abaninzi bafunda malunga ne-metabolic endotoxemia kwi-AFMCP, ekhankanya amathumbu avuzayo okanye ukwanda kwamathumbu emathunjini. Xa abantu abaninzi bejongene nemiba yamathumbu echaphazela impilo-ntle yabo, njengeengxaki kumalungu abo okanye izihlunu ezibangela ukuba babe buhlungu, sibonelela ngezisombululo ezahlukeneyo kwaye siphuhlise isicwangciso sonyango kunye nababoneleli bethu abanxulumeneyo ngokusekwe kuxilongo.

 

Ii-Endotoxins ezichaphazela iiHormones

UGqr. Alex Jimenez, DC, unikezela: Ii-endotoxins okanye i-lipopolysaccharides zisuka kwiinwebu zeeseli zebhaktheriya. Ke i-endotoxins yebhaktiriya ifuduswa isuka kwilumen yamathumbu ngenxa yokwanda kokungena kwamathumbu. Ke ngoko kunyuka kokungena, ezo zi-endotoxins ziyafuduswa, nto leyo eqala ukudumba kwe-cascade. Xa i-endotoxins ibangela imiba ye-GI, iimpawu ezivuthayo zinokuchaphazela iindawo eziphezulu kunye nezisezantsi zomzimba kunye ne-gut-brain axis. Xa i-axis ye-gut-brain ichaphazeleka kukudumba, kunokukhokelela kwiintlungu ezidibeneyo kunye nezihlunu ezinxulumene neengxaki ze-somato-visceral kunye ne-visceral-somatic. Ukuza kuthi ga ngelo xesha, i-cascade evuthayo evela emathunjini avuzayo ichaphazela i-ovary, iyanciphisa imveliso yeprogesterone, kwaye inegalelo ekuswelekeni kwesigaba se-luteal. Oko kubaluleke kakhulu ukuba oogqirha banakekele izigulana ezikhona ukuze bakhulise ukuchuma. Kubaluleke kakhulu ukuba izigulana zazise oogqirha bazo xa zine-estrogen egqithisileyo kwaye zivelisa iprogesterone eninzi kangangoko kunokwenzeka. Ke kufuneka sikhathazeke malunga nokungena kwamathumbu kwi-ovulation, ukusilela kwesigaba se-luteal, kunye nokungalingani kwe-estrogen-progesterone. Kuthekani nge-biotransformation node? Ngaba oko kuyichaphazela njani indawo yonxibelelwano? Kubantwana basesikolweni, i-phthalates kunye nomsebenzi we-thyroid unobudlelwane obuphambeneyo phakathi kwe-metabolites okanye inani le-folate kunye nomsebenzi we-thyroid kwinkqubo elinganiswa kubantwana abaneminyaka emithathu ubudala. Xa imiba yokuvuvukala ichaphazela umsebenzi we-thyroid kubantwana, inokuchaphazela iziphumo zokuqonda, ngaloo ndlela inciphisa ukuveliswa kwe-phthalates kwi-thyroid, ekhokelela kwiingxaki zengqondo.

 

Ulwazelelelo ngokwasengqondweni, ngokweemvakalelo nangokomoya lunegalelo njani kwindawo yonxibelelwano? Sifuna ukuqala ngezantsi kwe-matrix njengoko sihlala sisenza, ebandakanya iyeza elisebenzayo. Iyeza elisebenzayo libonelela ngeendlela ezipheleleyo zokuchonga ingxaki eyingcambu echaphazela umzimba kunye nokuphuhlisa isicwangciso sonyango lomntu kwisigulana. Ngokujonga izinto zokuphila ezisezantsi kwe-Living Matrix, sinokubona indlela ukungasebenzi kwehomoni kuchaphazela ngayo iindawo zokunxibelelana emzimbeni. Iphepha lakutshanje lifumanise ukuba kukho ubudlelwane obuhle phakathi kweempawu zokuyeka ukuya exesheni kunye nenkxaso yentlalontle kunye nokuba iimpawu zokuyeka ukuya exesheni ziyehla njengoko inkxaso yoluntu isanda. Ngoku makhe sithethe ngendlela uxinzelelo oluchaphazela ngayo ufikelelo lwe-HPA. Ngokujonga indlela ukuvuselela ukusuka kwiindawo ezivelisa i-hormone yesini zomzimba okanye iimviko, ukufikelela kwe-thyroid, i-adrenals, kunye nenkqubo ye-nervous enovelwano (umlo okanye indiza) inokongeza zonke iingcinezelo ezisichaphazelayo, ezibizwa ngokuba yi-allostatic load.

 

Kwaye i-allostasis ibhekisela kumandla ethu okuphendula abo bacinezelayo ngokusebenzisa iindlela zokujongana noxinzelelo. Izigulana ezininzi zisicela isikhokelo. Babuza ukuba bangawabeka njani amava abo kunye noxinzelelo. Nangona kunjalo, bayabuza ukuba bayilungiselela njani imisitho yoluntu kwimeko enkulu, Kwaye uninzi lwethu njengamagcisa asebenzayo afuna into enye. Ke ngoko, siza kukubonisa ngokweenkcukacha ukuba lwenziwa ntoni uxinzelelo emzimbeni kunye nendlela yokufumana iindlela zokunciphisa ixhala okanye uxinzelelo emzimbeni ukuthintela imiba yexesha elizayo kumalungu, izihlunu kunye namalungu.

 

Uxinzelelo luyithintela njani iEstrogen

UGqr. Alex Jimenez, DC, unikezela: Ngaba uxinzelelo ludala uxinzelelo lwe-adrenal, kwaye luchaphazela ukulwa kwethu okanye i-flight primary response hormone (adrenaline)? Uxinzelelo lunokubangela ukuba inkqubo ye-nervous enovelwano yonyuse uxinzelelo lwegazi, ukuphefumla, izinga lokubetha kwentliziyo, kunye nokuphaphama ngokubanzi ngelixa sihambisa igazi lethu ukonyusa iadrenaline yethu. Ke xa ukwimeko ethile, iadrenaline yakho inokubangela ukuba ulwe okanye ubaleke, nto leyo ebangela ukuba izihlunu zakho zifumane igazi, elinciphisa igazi ukuya kumbindi wakho okanye kumalungu akho angabalulekanga. Ke imodeli yeyeza esebenzayo inokuchonga izinto ezahlukeneyo ezibangela okanye abalamli, nokuba zibukhali okanye zingapheliyo, ezinokusebenza njengomphembeleli wokungasebenzi kakuhle kwehomoni enokudala imiba edlulanayo enokuphazamisa ukusebenza kwe-adrenal kwi-thyroid.

 

Ngoko, ukujonga ezi mpendulo kunokusinceda sibone iingxaki zomzimba ezenzekayo ukuba i-adrenaline inyuka ngokuqhubekayo kwixesha elide, elikhokelela ekuxhalabeni, iingxaki zokugaya, kunye nokunye. Ngoku i-cortisol yihomoni yethu yokulinda enceda ukugcina impendulo engxamisekileyo ukuxhasa okanye ukuxhasa i-adrenaline. Umzekelo uya kuba yiloli yomlilo okanye amapolisa angena emva komphenduli wokuqala okhawulezayo. Ke i-cortisol iququzelela impendulo ekhawulezayo ye-adrenaline ukugcina umzimba uhamba njengoko kufuneka. Kwaye linezinye iindima ezininzi ngokunjalo. Inceda ngokunyuka kweswekile yegazi kwaye ibangela ukugcinwa kwamafutha. Ke xa abantu bengena benobunzima obuphakathi kwaye bejongana nemicimbi edlulayo emzimbeni wabo, cinga nge-cortisol kuba ichasene nokudumba kwaye ilawula inkqubo yemithambo-luvo. I-Cortisol inokuba yinto enhle kwaye embi emzimbeni, ngakumbi xa umntu ejongene neziganeko ezixinzelelekileyo ezichaphazela impilo yakhe kwaye zibangele imiba echaphazela ukuhamba kwabo.

 

Ke ngoku, makhe sithethe malunga nokuba uxinzelelo luwuchaphazela njani umzimba wonke kunye namajoni omzimba. Uxinzelelo lunokonyusa ukuchaphazeleka kosulelo, okonyusa ubukhali babo emzimbeni. Ke apha sibona uxinzelelo oluchaphazela i-node yokuzikhusela kunye nokulungisa, okukhokelela kukungasebenzi kakuhle kwamajoni omzimba kunye noxinzelelo-olubangela ukungasebenzi kakuhle kwamajoni omzimba. Umzekelo unokuba ukuba umntu ujongene nengxaki echaphazela amathumbu akhe, njenge-SIBO okanye amathumbu avuzayo; inokunyusa ukuveliswa kwe-cytokines e-pro-inflammatory kwaye ibangele intlungu edibeneyo kunye ne-muscle kumqolo ophantsi, ezinqeni, emadolweni, kunye nokuphila kakuhle. Xa i-cytokines e-pro-inflammatory ichaphazela inkqubo yamathumbu, inokubangela ukungasebenzi kakuhle kwe-thyroid, ukuphazamisa ukuveliswa kwehomoni.

 

 

Ke ukuba umntu uthatha olu nyango lokubuyisela ihomoni (HRT), lunokonyusa ukudumba kwabo, ngakumbi ukuba banoxinzelelo. Ke, njengabasebenzi bamayeza asebenzayo, sihlala sicinga kwaye sijonge ukuqondwa kwepateni njengoko siqala ukucinga ngezinto ngokwahlukileyo kwiindlela eziqhelekileyo malunga nempilo kunye nokuba sempilweni.

 

Yintoni eyenzekayo xa ubona umntu ojongene noxinzelelo olungapheliyo, kwaye ithini impendulo yakhe? Badla ngokuphendula bathi, “Ndibila kakhulu; Ndiba novalo nexhala ndikhumbula nje into eyenzeke kum. Ndiyoyika ukuphinda ndihlangane naloo nto. Ngamanye amaxesha ezi ndlela zindenza ndibe namaphupha amabi. Nanini na ndisiva ingxolo enkulu, ndicinga ngeeringi zekhabhoni ndize ndibe nesicaphucaphu.” Ezi zezinye zeempawu ezixelayo zomntu ojongene noxinzelelo olungapheliyo olunxulunyaniswa nePTSD, ezinokuchaphazela amanqanaba ehomoni emzimbeni. Uninzi lwababoneleli ngamayeza asebenzayo banokusebenzisa unyango olukhoyo malunga nokungasebenzi kakuhle kwehomoni kwi-PTSD. Ke isicwangciso esiqhelekileyo sokunyanga ukungasebenzi kakuhle kwehomoni kukuvelisa, ubuntununtunu bothutho, kunye nokukhutshwa kwehomoni emzimbeni. Khumbula ukuba xa unomntu ojongene nemiba yehomoni, kungcono ukwenza isicwangciso sokujongana nalo mbandela.

 

Ke sinokwenza ntoni ukuchaphazela indlela iihomoni eziveliswa ngayo okanye zenziwe ngokugqithisileyo emzimbeni? Sifuna ukujonga ukuba iihomoni zenziwa njani, zingafihlwa njani ngaphakathi emzimbeni, kwaye zithuthwa njani. Kuba kuthekani ukuba zithuthwa ngendlela yokuba i-molecule yezothutho iphantsi ekugxininiseni, ivumela ukuba ibe ngamahomoni amahhala? Ke lunxibelelwano kunye nobunye ubuntununtunu behomoni, kwaye sitshintsha njani okanye sijonge njani ubuntununtunu beselula kumqondiso wehomoni? Ngokomzekelo, i-progesterone ichaphazela i-estrogen receptors ebangela ukuchithwa okanye ukukhutshwa kwehomoni.

 

Ngoko ngaphambi kokuba sicinge ngokunika okanye ukutshintsha ihomoni, sibuza into esinokuyenza ukuchaphazela loo hormone emzimbeni. Ngokukodwa, sinokuyiphembelela njani imveliso yehomoni, uthutho, ubuntununtunu, i-detoxification, okanye ukupheliswa? Ke xa kufikwa kwimveliso yehomoni, zeziphi iibhloko zokwakha iihomoni zegilo kunye ne-cortisol? Ke ukuba siphantsi kwiihomoni zedlala lengqula, sifuna ukuqinisekisa ukuba sineebhloko zokwakha ze-serotonin. Ke yintoni echaphazela i-synthesis? Ukuba idlala livutha nge-autoimmune thyroiditis, ayinakukwazi ukwenza ihomoni yegilo eyaneleyo. Yiyo loo nto abantu abane-autoimmune thyroiditis benomsebenzi ophantsi we-thyroid. Kuthekani ngokuthuthwa kwehomoni? Ngaba amanqanaba ehomoni enye emzimbeni anempembelelo kumanqanaba yenye? I-Estrogen kunye neprogesterone zihlala zisemdaniso emzimbeni. Ke ngaba ihomoni iyathutha ukusuka kwimvelaphi yamadlala ukuya kwizicubu ekujoliswe kuzo, ezinokuchaphazela ukusebenza kwayo?

 

Ukuba kukho ukuveliswa kweehomoni ezidityanisiweyo kwiprotheni yokuthutha, akuyi kuba nehomoni yaneleyo yamahhala, kwaye kunokubakho iimpawu zokunqongophala kwehomoni. Okanye ingaba yinto echaseneyo ukuba kufuneka kubekho iprotheni yezothutho eninzi, ngoko kuya kuba neemolekyuli ze-hormone zamahhala kunye neempawu ezigqithisileyo ze-hormone. Ke ngoko, sifuna ukwazi ukuba sinokuchaphazela inqanaba lehomoni yasimahla kwaye sibone ukuba iyaguqulwa na. Ke siyazi ukuba i-T4 iba yindlela esebenzayo ye-T3 okanye i-thyroid inhibitor, i-reverse T3, kwaye singakwazi ukulungelelanisa ezo ndlela? Kuthekani ngovakalelo? Ngaba izinto ezinomsoco okanye zokutya ezichaphazela impendulo yeselula kwi-cortisol, ihomoni ye-thyroid, i-testosterone, i-estrogen, kunye ne-cetera? Ngamaproteni amaninzi e-cell membrane abophayo, i-membrane yeseli ibandakanyeka kwi-hormone metabolism. Kwaye ukuba iiseli zeseli ziqinile, i-insulin, umzekelo, inobunzima bokungena kuyo ngoku njengoko sijonga kwi-hormone detoxification. Siyitshintsha njani i-metabolism ye-estrogens okanye i-testosterone?

 

Kwaye sinokwenza ntoni ukuchaphazela ukubopha kunye nokukhutshelwa kwe-estrogen? Ke, ngaba i-estrogen inokupheliswa ngokusempilweni? Kwaye oko kuxhomekeke ekubeni kukho i-hydroxylation kwikhabhoni ethile, kodwa kwakhona kufuneka ikhutshwe ngokwexabiso lilonke. Ngoko ke ukuqhinwa, umzekelo, kuya kunciphisa ubungakanani be-estrogen ekhutshiweyo. Ke sisebenzisa ivault njengesikweko kunye nomxholo, njengoko besitshilo, kukunyanga imatrix kuqala ngaphambi kokujongana ngqo nokungasebenzi kakuhle kwehomoni.

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ICortisol echaphazela iiNodi zoNxibelelwano

UGqr. Alex Jimenez, DC, unikezela: Kwi-Living Matrix, kufuneka sivule okanye siphathe zonke iindawo zokuvula i-vault ukuze singene ngaphakathi kwaye silungise iihomoni. Oku kungenxa yokuba inkqubo ye-endocrine intsonkothile kangangokuba ihlala izilungisa ngokwayo xa kusonjululwa okunye ukungalingani. Kwaye khumbula, ukungalingani kwehomoni kuhlala kuyimpendulo efanelekileyo ngumzimba ukungalingani kwenye indawo. Yiyo loo nto ukunyanga okunye ukungalingani kuhlala kujongana nomba wehomoni. Kwaye kwakhona, khumbula iihomoni ezinjengeefotogram zikwindawo ephantsi kakhulu. Ke kunzima kakhulu ukuchaneka xa sinika izigulana iihomoni kwaye sivumele umzimba ukuba uzilungise ngokuzenzekelayo. Yiyo loo nto sithi ukunyanga i-matrix kuqala. Kwaye xa singena ngaphakathi kwi-node yonxibelelwano emzimbeni, sijonga embindini we-matrix kwaye sifumanise imisebenzi yeemvakalelo, yengqondo, kunye neyomoya ukunceda ukuqhelanisa amahomoni. Kwaye ngelixa ezi ziqwalaselwe, sinokuzilungisa njani ii-node zonxibelelwano zehomoni?

 

Xa ungaphakathi kwi-node yonxibelelwano, unyango kufuneka lulandele umyalelo: i-adrenal, i-thyroid, kunye ne-sex steroids. Ke ezi ziingcinga ezibalulekileyo ekufuneka uzikhumbule, ukunyanga i-adrenals, i-thyroid gland, kwaye ekugqibeleni, i-sex steroids. Kwaye indlela esibonisa ngayo iindlela iya kuhambelana. Ke apha ubona ukumelwa okusemgangathweni esiza kuwusebenzisa kwindlela ye-steroidogenic. Kwaye ubona zonke iihomoni ezahlukeneyo apha. I-enzymes kwindlela ye-steroidogenic inemibala, ngoko oogqirha abaninzi banokwazi ukuba yeyiphi i-enzyme echaphazela inyathelo. Okulandelayo, siza kujonga ukumodareyithwa kweendlela ze-steroid ngendlela yokuphila, njengokuzilolonga, kunye nendlela uxinzelelo oluchaphazela ngayo i-aromatase, ukwenza i-estrogen.

 

Ngoku, njengoko singena kwindawo yangempela, enzima apha malunga neendlela ze-steroid, siyazisa ezininzi izigulane zethu ukuba zithathe umoya ophefumlelweyo njengoko kubonisa ukuba ukuthatha umoya onzulu kunokunyusa ukuqonda komntu kunye nokubonelela ngokukwazi ukuqonda yonke into. Ke umfanekiso omkhulu apha yonke into iqala nge-cholesterol kunye nendlela echaphazela ngayo iihomoni emzimbeni. Ke i-cholesterol yenza imineral corticoid aldosterone, ethi emva koko iphuhlise i-cortisol, ekugqibeleni idale i-androgens kunye ne-estrogens. Xa izigulana zinikwa uthethwano malunga nokuba kuqhubeka ntoni ngemizimba yazo, abaninzi abaqondi ukuba i-cholesterol ephezulu inokukhokelela kuxinzelelo olungapheliyo, olunxulunyaniswa nemiba yentliziyo enokuthi ekugqibeleni ibangele ukuphazamiseka kwe-visceral-somatic.

 

Ukudumba, i-insulin, kunye neCortisol echaphazela iiHormones

UGqr. Alex Jimenez, DC, unikezela: Xa isigulana esisetyhini sijongana ne-fibroids okanye i-endometriosis, oogqirha abaninzi baqulunqa isicwangciso sonyango nabanye ababoneleli bezonyango ukunciphisa ukwakheka kweehomoni ze-estrogen ngokuthintela kunye nokumodareyitha i-aromatase enzymes. Oku kuvumela isigulana ukuba senze utshintsho oluncinci kwimikhwa yabo yokuphila ngokuqinisekisa ukuba amanqanaba abo e-zinc aqhelekile, angaseli utywala rhoqo, ukufumana iindlela zokunciphisa amanqanaba abo oxinzelelo, kunye nokulungelelanisa ukutya kwabo kwe-insulin. Isicwangciso sonyango ngasinye sijongene nomntu njengoko befumana iindlela zokunciphisa amanqanaba e-cortisol kunye nokulawula ukuveliswa kwehomoni enempilo. Oku kuya kuvumela umzimba ukuba unyuse imveliso ye-estrogen ngelixa unciphisa i-aromatase. Ngoko xa sixoxa ngoxinzelelo, kunokuchaphazela kakubi iindlela zehomoni ngokuthe ngqo ngokunyusa i-cortisol, ngaloo ndlela ibangela ukuba i-pituitary glands ikhulise i-CTH xa uxinzelelo luphendula umzimba. Abantu abaninzi bajongana noxinzelelo olungapheliyo emizimbeni yabo, enokubangela ukugqithisela kweeprofayili zomngcipheko kwinkqubo ye-musculoskeletal, ebangela iintlungu zemisipha kunye namalungu.

 

Ngoko inkqubo yepituitary ivelisa i<em>cortisol xa umzimba uyibiza ngokuthe ngqo xa umntu ejongene noxinezeleko oluqatha. Nangona kunjalo, uxinzelelo olungapheliyo lunokunyusa ngokungathanga ngqo amanqanaba e-cortisol; ibangela ukuba i-enzyme 1720 lyase ithintelwe emzimbeni, ibangele ukuncipha kwe-anabolism, ngaloo ndlela ithoba amanqanaba amandla omzimba. Ngoko uxinzelelo luyayithintela le enzyme. Ke xa uxinzelelo luthintela i-enzyme ye-1720 lyase emzimbeni, inokubangela ukuba inkqubo yepituitary ivelise i-cortisol eninzi kwaye ibangele imiba engakumbi efana nejoyinti ukuba ichaphazele umntu. Ke ezo zindlela zimbini zokuthi uxinzelelo lukhokelela kwi-cortisol engaphezulu ngokuthe ngqo nge-ACTH kwaye ngokungathanga ngqo ngokuthintela i-1720 lyase.

 

 

Ukudumba kubalulekile emzimbeni njengoko nako kuneendlela ezimbini, njengoko kunokuchaphazela ezi ndlela ngendlela efanayo noxinzelelo. Ukuvuvukala kunokuthintela i-enzyme ye-1720 lyase, ebangela ukuba umzimba ube ne-pro-inflammatory kwaye unokuvuselela i-aromatase. Njengoxinzelelo, xa umzimba ujongene nokuvuvukala, i-cytokines e-pro-inflammatory ivuselela i-aromatase enzymes ukuba ibangele ukwanda kwe-estrogen ukubunjwa. Xa oku kusenzeka, kuvumela oogqirha ukuba baqaphele ukuba kutheni izigulana zabo zixinezeleke kakhulu kwaye zineempawu ezivuthayo emathunjini abo, kwizihlunu kunye namalungu. Ukuza kuthi ga ngelo xesha, ukudumba kunokunyusa i-enzyme ebizwa ngokuba yi-5alpha reductase. Ngoku, i-5alpha reductase ibangela ukwakheka kwehomoni ebizwa ngokuba yi-dihydrotestosterone (ifomu esebenzayo ye testosterone kwiiseli zomzimba ngaphandle kwemisipha, ebangela ukulahleka kweenwele. Ngoko i-insulin, uxinzelelo, kunye nokudumba kunegalelo ekulahlekeni kweenwele kuba i-insulin inesiphumo esifanayo. okanye iswekile esegazini inika umzimba amandla okuhamba imini yonke.Xa umntu ene-insulin eninzi okanye encinci kakhulu emzimbeni, oko kunokukhokelela ekunganyangekiyo kwe-insulin, okuhambelana nesifo semetabolism esihambelana nokuqothuka kweenwele.

 

Iindlela ezipheleleyo zeeHormones

UGqr. Alex Jimenez, DC, unikezela: I-insulin, i-cortisol, kunye nokudumba ziyidlala njani indima yazo kwidlala lengqula? Ewe, zonke ezi hormone zinceda ukwenza umzimba usebenze. Xa indlala yegilo inemeko esisiseko efana ne-hypo okanye i-hyperthyroidism, inokubangela ukuba umzimba ugqithise okanye uvelise iihomoni ezingaphantsi kokulawula imisebenzi eqhelekileyo yomzimba. Ke lo mjikelo wesondlo sangaphambili unokubangela ukuba umntu abe nemiba eyahlukeneyo echaphazela umzimba wabo ngenxa yokungasebenzi kakuhle kwehomoni. Oku kudityaniswa kokumelana ne-insulin, i-insulin ephezulu, ukufumana ubunzima, kunye noxinzelelo luchaphazela izigulane ezininzi, ezibangela isifo se-metabolic syndrome. Ukulungelelanisa ukusebenza kwehomoni, kufuneka sijonge zonke ezi zinto ziqhuba ukungasebenzi kakuhle kwehomoni kwizigulana.

 

Xa usiya kunyango lwe-hormonal, kubalulekile ukwazi malunga neentlobo ezahlukeneyo ze-nutraceuticals kunye ne-botanicals kuba ngaphambili, kwakubizwa ngokuba yinguqu yokuphila emva kwemini. Kwiklinikhi yezempilo, i-neutraceuticals ethile kunye ne-botanicals inokuchaphazela ukubunjwa kwe-estrogen nge-enzyme aromatase. Nangona kunjalo, izinto ezahlukeneyo ezifana nezifo, amayeza, i-toxins, kunye ne-insulin ephezulu inokunyusa i-aromatase enzymes, ekhokelela kwi-estrogen eninzi emzimbeni. Kwaye ke izifo, amayeza, kunye neetyhefu zenza into enye. Uphononongo lophando lubonisa ukuba xa amadoda nabasetyhini benxibelelana, ukusebenza kwengqondo kwamadoda kuyehla, kulandele ukudibana ngokwesini. Oku kunokutshintsha indlela ihomoni esebenza ngayo emzimbeni xa kukho utshintsho kumsebenzi osemthethweni onokuchaphazela umsebenzi wokuqonda wenkqubo ye-nervous emzimbeni.

 

Xa izigulana ezikwiminyaka ephakathi zixilongwa ngoogqirha bazo, iziphumo zinokubonisa ukuba zinyukile i-insulin, ukonyuka koxinzelelo kunye nokuba kukho ukudumba emizimbeni yabo. Oku kuvumela oogqirha ukuba basebenze neengcali ezinxulumeneyo ukuphuhlisa isicwangciso sonyango esibonelela isigulana ukuba siqale utshintsho oluncinci kuhambo lwabo lwezempilo kunye nempilo.

 

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