Contents
intshayelelo
UDkt Alex Jimenez, DC, ubonisa indlela uxhulumaniso lwe-metabolic lubangela ukusabela kweketane kwizifo eziphambili ezingapheliyo kule nxalenye ye-2. Izinto ezininzi zihlala zinendima kwimpilo nakwimpilo yethu. Ingakhokelela kwimiba egqithileyo yengozi ehambelana neempawu ezinjengeentlungu kwimisipha, amalungu, kunye namalungu abalulekileyo. Icandelo 2 liza kuqhubeka nenkcazo malunga noqhagamshelwano lwe-metabolic kunye nezifo ezingapheliyo. Sikhankanya izigulana zethu kubaboneleli bezonyango abaqinisekisiweyo ababonelela ngonyango olufumanekayo kubantu abaneemeko ezingapheliyo ezinxulumene noqhagamshelo lwe-metabolic. Sikhuthaza isigulane ngasinye xa kufanelekile ngokuthumela kubaboneleli bezonyango abanxulumeneyo ngokusekelwe kukuxilongwa okanye iimfuno zabo. Siyayiqonda kwaye siyayamkela into yokuba imfundo yindlela engummangaliso xa sibuza imibuzo ebalulekileyo yababoneleli bethu ngokwesicelo sesigulana kunye nokuvuma. UDkt Jimenez, DC, usebenzisa olu lwazi njengenkonzo yemfundo. isikhanyeli
Indlela Ukuvuvukala Okuwuchaphazela Ngayo Umzimba
UGqr. Alex Jimenez, DC, unikezela: Ke apha uneseti ebhityileyo yee-adipocytes ngasekhohlo, kwaye xa ziqala ukutyeba ngobunzima beselula obuninzi, unokubona ezo macrophage, ii-boogies eziluhlaza zijikeleza zijonga, zisithi, “Heyi, kuqhubeka ntoni apha? Ayibonakali ilungile.” Ngoko bayaphanda, kwaye oku kubangela ukufa kweeseli zendawo; yinxalenye nje yokudumba kwebhola. Ke kukho enye indlela eyenzekayo apha. Ezo adipocyte azikho nje ukuba zibe manzi ngempazamo; ihlala inxulumene ne-calorie surfette. Ke oku kugqithiswa kwezondlo kuyonakalisa i-endoplasmic reticulum, okukhokelela ekudumbeni ngakumbi. Yintoni ezi seli kunye ne-adipocytes ezizama ukuyenza kukuzikhusela kwi-glucose kunye ne-lipo toxicity.
Kwaye yonke iseli, iseli ye-adipocyte, idala ezi caps zizama ukuthi, "Nceda uyeke, asinakuthatha enye i-glucose, asinakuthatha ezinye iilipids." Yindlela yokukhusela eyaziwa ngokuba kukunganyangeki kwe-insulin. Asiyonto nje eyenzekileyo. Yindlela yomzimba yokuzama ukuthintela iswekile kunye ne-lipotoxicity. Ngoku ukuba i-alamu yokuvuvukala iyenzeka ngaphezu kwe-adipocytes, ifumana inkqubo. Ezinye izicubu kunye namalungu aqala ukuva umthwalo ofanayo wekhalori surfette, ebangela ukuvuvukala kunye nokufa kweeseli. Ke i-glucose kunye ne-lipotoxicity zibukeka njengesibindi esinamafutha xa sisebenza nesibindi. Kwaye unokuba nayo kanye njengokuba isibindi esinamafutha siqhubela phambili kwi-cirrhosis ngokufa kwe-hepatocyte. Indlela efanayo eyenzekayo kwiiseli zezihlunu. Ke iiseli zethu ze-skeletal muscle zibona ngokuthe ngqo ukufa kweeseli emva kokudumba kwaye zibone ukubekwa kwamafutha.
Eyona ndlela ingcono yokucinga ngayo, umzekelo, iinkomo ezikhuliselwa ukutyiwa kunye nendlela eziye zabhatalwa ngayo. Ngoko ke loo nto yokubeka amanqatha. Kwaye ebantwini, unokucinga malunga nendlela abantu ababa ngayo i-sarcopenic njengoko besiya bexhathisa i-insulin. Yinto efanayo xa izicubu zomzimba zizama ukuzikhusela kwi-glucolipotoxicity, ebangela impendulo yendawo yokudumba. Iba yimpendulo ye-endocrine xa iqala ukujolisa kwezinye izicubu kwi-periphery, nokuba isibindi, imisipha, ithambo, okanye ingqondo; yinto nje eyenzekayo; bakwi-visceral adipocytes enokuthi yenzeke kwezinye izihlunu. Ke leyo yimpembelelo yakho yeparacrine. Kwaye ke inokuhamba yintsholongwane, ukuba uyathanda.
Ukuvuvukala okuNxulunyaniswe noKuchasa i-insulin
UGqr. Alex Jimenez, DC, unikezela: Ufumana le mpendulo yasekhaya kunye nenkqubo yepro-ukudumba edityaniswa nokuxhathisa kwe-insulin, ubuyela kule ndlela yokukhusela ngokuchasene neglucose kunye ne-lipotoxicity. Apha ubona ukuba imithambo yegazi kwimithambo yethu ibanjwa njani kwi-loop yokufaka amafutha kunye nokufa kweeseli. Ke uya kubona imithambo yegazi evuzayo kunye neediphozithi ezinamafutha, kwaye uya kubona umonakalo kunye ne-pro-atherogenesis. Ngoku, le yinto esiyichazile kwi-AFMCP yemodyuli ye-cardiometabolic. Kwaye leyo yiphysiology emva kwe-insulin receptor. Oku kwaziwa njengobuchule bokutshixa kunye ne-jiggle. Ke kuya kufuneka utshixe i-insulin kwi-insulin receptor phezulu phezulu., eyaziwa ngokuba sisitshixo.
Kwaye ke kukho i-phosphorylation cascade ebizwa ngokuba yi-jiggle ethi emva koko idale le cascade ekugqibeleni ibangele i-glucose-4 channels ukuba ivule i-glucose-4 receptors ukuba ingene kwiseli ukuze ibe yi-glucose, ethi ke isetyenziswe amandla. ukuveliswa yi-mitochondria. Ewe, ukuxhathisa kwe-insulin kulapho i-receptor ingancangathi okanye iphendule. Kwaye ke awupheleli nje ekusileleni ukufumana i-glucose kwiseli yokuvelisa amandla, kodwa unikezela ngemeko ye-hyper insulin kwi-periphery. Ke ufumana i-hyperinsulinemia kunye ne-hyperglycemia kule ndlela. Yintoni ke esinokuyenza ngaloo nto? Ewe, izondlo ezininzi zibonakaliswe ukuphucula ukutshixa kunye nokuxubha izinto ezinokuphucula i-glucose-4 abathuthi abaza beza kwi-periphery.
Izongezelelo ezichasayo eziNcincisa ukuDumba
UGqr. Alex Jimenez, DC, unikezela: Uyabona ezi zidweliswe apha: vanadium, chromium, cinnamon alpha lipoic acid, biotin, kunye nomnye umdlali omtsha, berberine. I-Berberine yibhotanical enokuthi ithobe zonke iimpawu eziphambili zokudumba. Ke yintoni eyandulela ezi zi-comorbidities rhoqo kwaye kukungasebenzi kakuhle kwe-insulin. Ewe, yintoni eyandulela ukungasebenzi kakuhle kwe-insulin amaxesha amaninzi? Ukudumba okanye ubuthi. Ke ukuba i-berberine inceda umba ophambili wokudumba, iya kujongana nokunganyangeki kwe-insulin esezantsi kunye nazo zonke izinto ezinokuthi zenzeke. Ke jonga iberberine njengokhetho lwakho. Ke kwakhona, oku kukubonisa ukuba ukuba unokunciphisa ukudumba apha phezulu, unokunciphisa iziphumo ezininzi ze-cascade ezantsi. IBerberine ibonakala isebenza ngokuthe ngqo kumaleko we-microbiome. Imodareyitha i-gut microbiota. Isenokwenza unyamezelo lwe-immune, ngoko ke ayinikezeli ukuvuvukala okuninzi.
Ke jonga i-berberine njengenye yezixhobo onokuzisebenzisa ukuxhasa ukungasebenzi kakuhle kwe-insulin kunye ne-insulin enxulumene nokuxhathisa. I-Berberine ibonakala inyusa i-insulin receptor expression, ngoko ke ukutshixa kunye ne-jiggle isebenza ngokufanelekileyo kwaye iphucule i-cascade kunye nabathuthi be-glucose-4. Le yenye indlela onokuthi ngayo uqalise ukufumana oyena nobangela weemeko ezininzi ebesixoxile ngazo xa ubona i-paracrine kunye ne-endocrine glucose toxicity, umonakalo we-lipotoxicity organ. Ngoku enye indlela omawuyithathele ingqalelo kukusebenzisa iNF kappa B. Ngoko ke injongo kukugcina iNF kappa B isekelwe kuba okoko ingafuduki, inkitha yemiqondiso yokudumba ayiqali.
Ngoko ke injongo yethu kukugcina iNF kappa B ihleli. Sinokukwenza njani oko? Ewe, sinokusebenzisa i-NF kappa B inhibitors. Ke kulo mboniso wokhetho lonyango lwazo naziphi na izinto ezidibene nokungasebenzi kakuhle kwe-insulin, zininzi iindlela zokunciphisa ezi meko zigqubanayo zichaphazela imizimba yethu. Ke unokuchaphazela ngokuthe ngqo ukunganyangeki kwe-insulin ngokusebenzisa izongezo ezichasene nokudumba okanye ngokungathanga ngqo uncede ukuxhathisa kwe-insulin okanye ukungasebenzi kakuhle kwe-insulin ngokunyusa izinto ngokuchasene nokudumba. Isizathu ukuba uyakhumbula, ukungasebenzi kakuhle kwe-insulin yinto ebangela zonke ezo zinto zidibene. Kodwa yintoni ebangela ukungasebenzi kakuhle kwe-insulin ngokuqhelekileyo kukuvuvukala okanye ityhefu. Ke injongo yethu kukujongana nezinto ezibangela ukudumba. Kuba ukuba sinokujongana nezinto ezi-pro-ukudumba kunye nokungasebenzi kakuhle kwe-insulin kwi-bud, sinokuthintela wonke umonakalo welungu elisezantsi okanye ukungasebenzi kakuhle kwamalungu.
Ukunciphisa Ukuvuvukala Emzimbeni
UGqr. Alex Jimenez, DC, unikezela: Masiqhubele phambili kwicandelo elilandelayo onokuthi unciphise okanye unciphise ukudumba kunye nomonakalo wesuphu ye-insulin ukuba uyathanda, ukuba iijini zihlamba emzimbeni. Le yile uya kuhlala uyiva kwiprizenteyishini yethu, kwaye kungenxa yokuba, eneneni, kumayeza asebenzayo, siyanceda ukulungisa amathumbu. Ngokuqhelekileyo kulapho kufuneka uye khona. Kwaye le yi-pathophysiology yokuba kutheni sisenza oko kumayeza e-cardiometabolic. Ke ukuba unokutya okungalunganga okanye okulusizi, oko kutya kwanamhlanje kwasentshona okunamafutha amabi, kuya kuyonakalisa ngqo i-microbiome yakho. Olo tshintsho kwi-microbiome lunokwenza ukwanda kwamathumbu emathunjini. Kwaye ngoku i-lipopolysaccharides inokudluliselwa okanye ivuze egazini. Ukuza kuthi ga ngelo xesha, amajoni omzimba athi, “Owu hayi mfondini. Akufanelanga ukuba ube apha." Unazo ezi endotoxins apho, kwaye ngoku kukho impendulo yokuvuvukala yasekhaya kunye nenkqubo yokuba ukudumba kuya kuqhuba ukungasebenzi kakuhle kwe-insulin, okuya kubangela ukuphazamiseka kwemetabolism ezayo emva koko.
Nokuba yeyiphi na imfuzo yomntu ethambekele kuyo, icofa kwi-epigenetically. Ke khumbula, ukuba unokukuphelisa ukudumba kwi-microbiome, oku kuthetha ukuba wenze le microbiome inonyamezelo kwaye yomelele, unokunciphisa ithowuni yokukrala yomzimba wonke. Kwaye xa unciphisa oko, kubonisiwe ukuba ibeka ubuntununtunu be-insulin. Ke okukhona usezantsi ukudumba, kokukhona kunyuka uvakalelo lwe-insulin olunxulumene ne-microbiome. Okothusayo, kubonisiwe ukuba iiprobiotics zinxulunyaniswa nokuphuculwa kobuntununtunu kwi-insulin. Ngoko iiprobiotics ezifanelekileyo ziya kudala ukunyamezela komzimba. Amandla e-Microbiome kunye nokumodareyitha kwenzeka ngeeprobiotics. Ke ngoko ubuntununtunu be-insulin bugciniwe okanye bufunyanwa kwakhona ngokusekwe kwindawo okuyo. Ke nceda uqwalasele oko njengenye indlela engathanga ngqo okanye ukhetho lonyango lokuphucula impilo ye-cardiometabolic kwizigulana.
Probiotics
UGqr. Alex Jimenez, DC, unikezela: Ke xa kufikwa kwiiprobiotics, siya kuzisebenzisa kumntu onokuthi ngaxeshanye abe nesifo samathumbu esicaphukisayo okanye aleji yokutya. Singakhetha iiprobiotics ngaphezu kwe-NF kappa B inhibitors ukuba nazo zinemiba yokumelana ne-insulin. Kodwa ukuba baneengxaki ezininzi ze-neurocognitive, sinokuqala nge-NF kappa B. Ngoko ke, yindlela onokuthi ukhethe ngayo. Ngoku, khumbula, xa uthetha nezigulana, kubalulekile ukuxoxa ngendlela ukutya kwazo okubangela ngayo ukudumba emizimbeni yazo. Kukwabalulekile ukuqaphela ukuba ayiyoncoko nje esemgangathweni; yincoko yobuninzi kunye nencoko yomzimba.
Oku kukukhumbuza ukuba xa ulungisa amathumbu ngokuwondla kakuhle kunye nokunciphisa ithoni yayo yokuvuvukala, ufumana inkitha yezinye izibonelelo zokuthintela; uyeka okanye ubuncinci ukunciphisa amandla okungasebenzi. Kwaye uyayibona loo nto, ekugqibeleni inokunciphisa umngcipheko wokutyeba, isifo seswekile, kunye nesifo se-metabolic. Sizama ukuqhubela ekhaya ukuba i-endotoxemia ye-metabolic, okanye ukulawula nje i-microbiome, sisixhobo esinamandla sokunceda izigulana zakho ezinganyangekiyo kwi-insulin okanye i-cardiometabolic. Idatha eninzi isixelela ukuba asinakwenza nje incoko malunga nokutya ngokufanelekileyo kunye nokwenza umthambo.
Kungaphezulu koko. Ke okukhona sinokuphucula i-gut microbiota, sinokutshintsha imiqondiso yokudumba ngokutya okufanelekileyo, umthambo, ukulawula uxinzelelo, ukulala, zonke ezinye izinto ebesithetha ngazo, kunye nokulungisa iintsini namazinyo. Okukhona ukudumba kuncinci, kokukhona ukungasebenzi kakuhle kwe-insulin kwaye, ngenxa yoko, iyancipha zonke ezo ziphumo zesifo esisezantsi. Ke into esifuna ukuqiniseka ukuba uyazi kukuya emathunjini kwaye uqiniseke ukuba i-microbiome yamathumbu iyonwabile kwaye iyanyamezela. Yenye yeendlela ezinamandla zokuphembelela impilo ye-cardiometabolic phenotype. Kwaye ngaphandle, nangona yayiyinto enkulu kwishumi leminyaka eyadlulayo, ii-sweeteners ezenziwe nge-caloric zenza njengoko zisenokungabi yi-caloric. Kwaye ke abantu banokukhohliswa ukuba bacinge ukuba yi-zero yeswekile.
Kodwa nantsi ingxaki. Ezi sweeteners ezenziweyo zinokuphazamisana nokuqamba kwe-microbiome esempilweni kwaye zenze uhlobo olungakumbi lweephenotypes ezimbini. Ke, nangona ucinga ukuba ufumana inzuzo ngaphandle kweekhalori, uya kwandisa umngcipheko wesifo seswekile ngempembelelo yaso kwi-gut microbiome. Kulungile, siphumelele kwinjongo yokuqala. Ngethemba, uye wafunda ukuba i-insulin, ukuvuvukala, i-adipokines, kunye nazo zonke ezinye izinto ezenzeka kwimpendulo ye-endocrine zichaphazela amalungu amaninzi. Ke ngoku makhe siqale ukujonga iimpawu zomngcipheko ezivelayo. Kulungile, sithethe kancinci nge-TMAO. Kwakhona, oko kusengumbono ofanelekileyo apha ngamathumbu kunye nokumelana ne-insulin. Ke sifuna ukuqiniseka ukuba ujonga i-TMAO hayi njengesiphelo sonke kodwa njengenye i-biomarker esakhulayo enokunika umkhondo malunga nempilo ye-microbiome ngokubanzi.
Ukukhangela iimpawu zokukrala
UGqr. Alex Jimenez, DC, unikezela: Sijonge kwi-TMAO ephakamileyo ukunceda isigulane siqonde ukuba sitshintshe indlela yokutya. Uninzi lwexesha, sinceda izigulana zokunciphisa iiprotheyini zezilwanyana ezingenampilo kunye nokwandisa izondlo ezisekelwe kwizityalo. Ngokuqhelekileyo bangaphi oogqirha abayisebenzisayo kunyango oluqhelekileyo. Kulungile, ngoku enye i-biomarker evelayo, kulungile, kwaye kuvakala kuhlekisa ukuyibiza ngokuba iyavela kuba ibonakala icacile, kwaye yi-insulin. Umgangatho wethu wokunyamekela uphakathi kwi-glucose, i-glucose yokuzila, kwi-postprandial glucose yethu ye-A1C njengomlinganiselo weglucose. Siyi-glucose ephakathi kwaye sifuna i-insulin njenge-biomarker evelayo ukuba sizama ukuthintela kunye nokusebenza.
Kwaye njengoko ukhumbula, sithethile izolo ukuba i-insulin yokuzila ukutya ezantsi kwekota yokuqala yoluhlu lwakho lwereferensi ye-insulin yokuzila inokuba apho ufuna ukuya khona. Kwaye kuthi e-US, oko kuthande ukuba phakathi kwesihlanu kunye nesixhenxe njengeyunithi. Ke qaphela ukuba le yi-pathophysiology yohlobo lwesibini seswekile. Ngoko chwetheza isifo seswekile esibini sinokwenzeka ngenxa yokunganyangeki kwe-insulin; inokuthi yenzeke nakwiingxaki zemitochondrial. Ke i-pathophysiology yohlobo lwesibini seswekile inokuba kungenxa yokuba i-pancreas yakho ayikhuphi i-insulin eyaneleyo. Ke kwakhona, le yilaa 20% incinci sithetha ngayo uninzi lwabantu abafumana uhlobo lwesibini seswekile; kukunganyangeki kwe-insulin, njengoko sinokukrokrela, kwingxaki ye-insulin ephezulu. Kodwa kukho eli qela labantu elonakalise i-mitochondria, kwaye abayikhuphi i-insulin.
Ke iswekile yegazi iyanyuka, kwaye bafumana isifo seswekile esibini. Kulungile, ke umbuzo ngulo, ukuba kukho ingxaki ngeeseli ze-beta ze-pancreatic, kutheni kukho ingxaki? Ngaba i-glucose iyenyuka ngenxa yokuba izihlunu zinokumelana ne-insulin, ngoko ke azikwazi ukubamba kunye nokuzisa i-glucose? Ke ngaba sisibindi esixhathisa i-insulin esibindini esingakwaziyo ukufaka iswekile ukuze sibe namandla? Kutheni le glucose ijikeleza egazini? Yiloo nto ke le nto ithetha ngayo. Ngoko indima enegalelo, kufuneka ujonge i-adipocytes; kufuneka ujonge i-visceral adiposity. Kuya kufuneka ubone ukuba lo mntu sisisu esikhulu esityebileyo esifana ne-catalyst. Yintoni esinokuyenza ukunciphisa oko? Ngaba ukudumba kuvela kwi-microbiome?
isiphelo
UGqr. Alex Jimenez, DC, unikezela: Nkqu nezintso zinokudlala indima kule nto, akunjalo? Njengokungathi mhlawumbi intso iye yonyusa i-glucose reabsorption. Ngoba? Ngaba kungenxa yoxinzelelo lwe-oxidative olubethe kwizintso, okanye ngaba ikwi-axis ye-HPA, i-hypothalamus pituitary adrenal axis apho ufumana le mpendulo ye-cortisol kunye nale mpendulo yenkqubo ye-nervous inovelwano eyenza ukudumba kunye nokuqhuba i-insulin yegazi kwaye ukuphazamiseka kweswekile yegazi? KwiCandelo 2, siza kuthetha apha ngesibindi. Ingumdlali oqhelekileyo kubantu abaninzi, nokuba abanaso isifo sesibindi esinamafutha; sidla ngokuba ngumdlali ofihlakeleyo noqhelekileyo kubantu abanokungasebenzi kakuhle kwe-cardiometabolic. Ke khumbula, sine-visceral adiposity ebangela ukudumba kunye nokunganyangeki kwe-insulin kunye ne-atherogenesis, kwaye isibindi sifana nalo mntu ubukeleyo umsulwa ubanjwe kumdlalo weqonga. Kwenzeka ngaphambi kokuba ngamanye amaxesha i-atherogenesis iqale.
isikhanyeli
Umgangatho wobuchule wokuSebenza *
Ulwazi olulapha ku "Unxibelelwano lweMetabolic phakathi kweZifo eziNgapheliyo (Icandelo 1)"Akujoliswanga ukuthatha indawo yobudlelwane obubodwa kunye nomntu oqeqeshiweyo wezempilo okanye ugqirha onelayisensi kwaye akusiyo isiluleko sonyango. Sikhuthaza ukuba wenze izigqibo zezempilo ngokusekelwe kuphando lwakho kunye nentsebenziswano kunye nochwepheshe bezempilo abaqeqeshiweyo.
Ulwazi lweBlog kunye neengxoxo zoMda
Umda wethu wolwazi ilinganiselwe kwiChiropractic, i-musculoskeletal, amayeza omzimba, impilo, igalelo le-etiological ukuphazamiseka kwe-viscerosomatic ngaphakathi kweentetho zeklinikhi, ezinxulumene ne-somatovisceral reflex clinical dynamics, i-subluxation complexes, imiba yezempilo ebuthathaka, kunye / okanye amanqaku amayeza asebenzayo, izihloko kunye neengxoxo.
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Iividiyo zethu, izithuba, izihloko, imixholo, kunye nokuqonda zibandakanya imiba yezonyango, imiba, kunye nezihloko eziyelelene kwaye zixhase ngokuthe ngqo okanye ngokungathanga ngqo umda wokuziqhelanisa wethu.
I-ofisi yethu izamile ngokufanelekileyo ukubonelela ngeengcaphulo ezixhasayo kwaye ichonge uphando olufanelekileyo lophando okanye izifundo ezixhasa izithuba zethu. Sinikezela ngeekopi zophando ezixhasayo ezifumanekayo kwiibhodi ezilawulayo nakuluntu ngesicelo.
Siyaqonda ukuba sigubungela imicimbi efuna inkcazo eyongezelelweyo yokuba inganceda njani kwisicwangciso esithile sokhathalelo okanye inkqubo yonyango; ke, ukuqhubeka nokuxoxa ngombandela ongentla, nceda ukhululeke ukubuza UDkt Alex Jimenez, DC, okanye qha ga mshelana nathi 915-850-0900.
Silapha ukunceda wena kunye nosapho lwakho.
Iintsikelelo
UDkt Alex Jimenez D.C., I-MSACP, RN*, I-CCST, IFMCP*, I-CIFM*, I-ATN*
email: qeqeshi@elpasofunctionalmedicine.com
Ilayisenisi njengoGqirha weChiropractic (DC) kwi Texas & New Mexico*
Texas DC Ilayisensi # TX5807, New Mexico DC Ilayisensi # I-NM-DC2182
Unikwe Ilayisensi njengoMongikazi oBhalisiweyo (RN*) in Florida
Florida License RN Ilayisensi # I-RN9617241 (Nombolo yolawulo. 3558029)
Ubume obubambeneyo: ILayisensi yeeNkcazo ezininzi: Ugunyaziswe Ukuziqhelanisa I-40 States*
UGqr. Alex Jimenez DC, MSACP, RN* CIFM*, IFMCP*, ATN*, CCST
Ikhadi lam loShishino lweDijithali
